hat1

Histone acetyltransferase type B catalytic subunit

570 amino acids

Catalytic component of the histone acetylase B (HAT-B) complex. Acetylates 'Lys-12' of histone H4 which is required for telomeric silencing. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair.

Belongs to the HAT1 family.

65.962 kDa

MALILERLYLLSSPRNAIIRNTRSEAGRELIFSFGLPSLSLPSCIASQYGKRRRLYFTTQLHVNSFLHWTCDANDAVNITLVQPDEQKLKTVSSFHPQFTYPIFGDDERIFGYKGLIIRLRFAAHDLRPQLHISYDEKFKPVEDIAAVDIPKTLKPWIPEDAFVTLPDYEKAVLEDKAAKDFKPPGKLVHCYVSRNRNFEIWAGSLADPEVRRLLDRAQIFVSLFIEAGTPLATDDPEWTLQRWTVYFVYEIVKPPTPTASKYSIVGYATTYRWWHYRRDRTQVPVVKNDPFPSGPEIHPSQLPSRLRIAQFLILPPHQNSGHGRHLYTAIHSACVQDPSVVELTVEDPNEAFDVLRDSADYHILRPEFIKHEVNINPDPYEAHSRNQRPRRVPTAALIPVKLLHDIRTSYKIDSTQFAHILEMFLLSQIPLKNRHAGGANMSRLLIKKHRAEDPNERRYYWWRMLTKQRLYKRSKDILIQLDLDERIQKLEETVSNVEEGYEVLLKEFSEREEKLKARGVVESPAATVSDDASAGPSGTSRDQRVKRKFTVEDDEDKVEEEDTAKRTKV

hat1

Histone acetyltransferase type B catalytic subunit

511 amino acids

Catalytic component of the histone acetylase B (HAT-B) complex. Acetylates 'Lys-12' of histone H4 which is required for telomeric silencing. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair.

Belongs to the HAT1 family.

58.62 kDa

MASEGDWTCDANDAVQITLVQPGEQKPKTLSSFHPQFTYPIFGDDETIFGYKGLIIRLRFAAHDLRPHIHISYDEKFKTVGDTSAVDLIKTLSPFIPEEAFSTLPDYENAVQEDKDAKDFVPPGKLVHNYVTRGRTYEIWAASLADPQVRRLLDRAQVFVSLFIEAGTPLETEDPEWTLERWTVYFVYEKVKPPTPTASQYSIVGYATTYRWWFYQRDSPEKGTVTNDPFPGPEIRPAQLPARLRIAQFLILPPHQGSGHGTHLYTTIHTACFNDSTIVELTVEDPNEAFDALRDTADFHILRPEFLKHNVNINPDPYAELSKKQRPRRVPTSALIPTKLLHDIRSTYKIASTQFAHVLEMFLLGEIPTKNRHAGGANMSRLLVKKYNATDPNERRYYWWRMLVKQRLFKRSRDILIQLEMSDRIEKLEETVTNVEEGYEALIKVFTAREEALMAKQEESGESPETAVLEDSVASSSDSSTRDQRTKRKFTVEDEDEEEEGESEVSKRPKV

hat1

Histone acetyltransferase type B catalytic subunit

496 amino acids

Catalytic component of the histone acetylase B (HAT-B) complex. Acetylates 'Lys-12' of histone H4 which is required for telomeric silencing. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair (By similarity).

Belongs to the HAT1 family.

57.779 kDa

MSAEGEWSCDANDAVQITIVHPDQQKPKTLSSFHPQFTYPIFGEEERIFGYKGLIIRLRFAAHNLRPHVHVSYDEKFTAVDDAEPVDIIGALKEFLPEEAFSSLPEFESAVQEEDAKEFVPPGKLSHSYSIRGRNYEIWAASLADPQVQLLLNRFQIMVSFYIEAGTPLSTDDPEWTLDRWTVYFVLTAARYEKVEPPTPTASSYSIVGYATTYRWWFYKRDRSENPMPRDGPFPPPELVRPGELPSRLRIAQFLILPPHQGTGHGVNLYNTIHKTCLDDPTIMELTVEDPNESFDVLRDSADYHILRPEFLKHNIQINPDPWSDFSKKTKRVPTSSLLPLKTLNEIRTAYKIEPTQFAHIQEMFLLGQIPLKNRRKGGANMARLLVKKYRDDDPNNRRYYWWRMLTKQRLYKRSRDVLIQLKMSERHKALEDTVTNVEDGYEQLFGFFNEREERLRAQQEEAETSNNRDQRTKRKFTVEDEDDEDESAAAKRPKA

HAT1

Histone acetyltransferase type B catalytic subunit

477 amino acids

Catalytic component of the histone acetylase B (HAT-B) complex. Acetylates Lys-12 of histone H4 which is required for telomeric silencing. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair.

Belongs to the HAT1 family.

54.38 kDa

MEDTTQWLSDASTAIHISLVSPSESGLQHVATFNPRHTYSIFGDDEKIFGYQDLKVNLRYRANDMRPHLNISYSKKSGTINELEPTDVAAILDEGNHLPKIAFAKARDFEESSKQLSDDWTPPGKLHTTFDSPEGQYEIWCGNLADPAVKQLNSRLQIFVPLFIEGGTYIGQDPDEDSAELDLSDADRWTFFSLYQKRKVGDKTAYVFVGYSTIYRFYYFQPPTPPASPQSDEWELPNGNMDLGELPCRTRLSQFIILPPFQGKGNGARLYKTIFEHYHKIPQTYEFTVEDPNEAFDDLRDICDLQFLRKMPEFNNLLVDTNIKIPKKGFLPKLIIGSSLLEEIRLRAKIAPRQFGRVLEMHLMSKLPVSVRPTMAIEDQPAATKADQHEAKVWGLIVKQRLYRHNKEVLSQIEPAERVEKLDDTLHGVGLEYARILAAVDRSDKYEGQTTASSKRKLDADEITEDLSNKKARVEDA

HAT1

Histone acetyltransferase type B catalytic subunit

468 amino acids

Catalytic component of the histone acetylase B (HAT-B) complex. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG (By similarity). Involved in DNA double-strand break repair (PubMed:30776962). Required for appressorium turgor pressure, autophagy and conidial nuclear degradation (PubMed:30776962). During the germination process and upon starvation conditions, translocates from the nucleus to the cytoplasm where it acetylates ATG3 at 'lys-262' and 'Lys-267', thus influencing autophagy through controlling ATG3-ATG8 interaction (PubMed:30776962). Also acetylates ATG9 at 'Lys-621' to regulate ATG9 binding to vesicles, which is also important for autophagy and pathogenicity (PubMed:30776962).

Belongs to the HAT1 family.

53.988 kDa

MAESDLWSVDANSALELSLVEPTEDGLTTVTRFHPRFTYPLFGEEEQIFGYQDLKINLQYHAPDMRPNVKITHSKKFKSIGETQPTDLDALLQGYLPPVAFAKKREFEDAIRLMPADWTPPGEILSEFDGVDGAKFEIRRSNLADDASRQIIDRVQLLILLFIEGGSYIGTDTTDSLDRWDIFFLYNIKPSTTDGTSRYQFAGYSTVYKFFPLQRFPLEPKEAHENLELPSGEFPFSNLRSRTRISQFLILPPFQKSGNGSRLYRTIYDYCLRDPNVIEVTVEDPNEAFDDMRDVADLDFLRQKSEFTDLRINTDIHIPKQGAAPRGVVDEVKSEEARCLYRIAPRQFSRVLEMHLMSRLAETVRPTLVDDKVVAKPTKIETHEYDLWKLFVKQRLYRHNKEVLSQLDRHDRIERLNETLGSVELEYARILALAERRTQATSSNLKRKLDDDENTEGSSSKKARVEDA

HAT1

Histone acetyltransferase type B catalytic subunit

468 amino acids

Acetylates newly synthesized histones during DNA replication. Highly specific in vitro for the non-acetylated H4 which is acetylated sequentially at 'Lys-12' and 'Lys-5' into a di-acetylated form.

Belongs to the HAT1 family.

52.721 kDa

MALKQKDTDAAATATGTKKRRRVFFSDTDAGVEANECMKVFLVWNPGEVSSVDCTAIQPFDLNHFFGEDGKIYGYKNLKINVWISAKSFHGYADVSFDETSDGGKGITDLKPVLQNIFGENLVEKEEFLHTFSKECEYIRTAVTNGSAIKHDGSYESDPAVEIVRVELQGAAAFLYSRLVPLVLLLVEGSTPIDIGEHGWEMLLVVKKATQEAGSKFELLGFAAVHNFYHYPESIRLRISQILVLPPYQGEGHGLGLLEAINYIAQSENIYDVTIESPSDYLQYVRSSIDCLRLLMFDPIKPALGAIVLSLKETNLSKRAQSLRMVPPADLMETVRQKLKINKKQFLRCWEILVFLSLDSQDHKSMDNFRACIYDRMKGEILGSASGTNRKRLLQMPTSFNKEASFAVYWTQEIEDEDEQTVEQQPEDLKTQEQQLNELVDIQIEEIAGVAKNVTSRCKDKMTELVVQ

HAT1

Histone acetyltransferase type B catalytic subunit

451 amino acids

Catalytic component of the histone acetylase B (HAT-B) complex. Acetylates 'Lys-12' of histone H4 which is required for telomeric silencing. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair.

Belongs to the HAT1 family.

52.089 kDa

MDIATEWTTNANEALTITLEPSKGKGKGKEVSNGSEKSHVFNPIFTYPIYGDVETILGYKNFELNLKMDASTMLPLVTVKFSDKLEFDGISFDDPVERLLEFLPEETATDEAEWEEKRVKELGDGFKPVGKEFGTFSVNSEKYTVHRSTLLDPETLKLHLRLQIFVPLFIEAGSYIDNEDDRWEIYIVYNAEKEIVGFSTVYCYWFYEPSAKESKAPKDASLEQLQKQPFSPTLRKRISQYVILPPFQGKGLGGQLYTLLFSRFYADPNVYEITVEDPSEAFDDLRDRCDLKWLADQGFPSEVFRMLQTTSAHGEKAGDNRTGRTKVVAGAFWTKWLEEHRLKYKLAHRQFARCFEMILLACLEVSSPTKKRNIKDARLFIKKRVYVRNREFLEELGGKIEVMSKLQETYESMEEDYARIMKPVLGYVKDGLKKRDRNDAGNEEAKRVKVE

HAT1

Histone acetyltransferase type B catalytic subunit

448 amino acids

Catalytic component of the histone acetylase B (HAT-B) complex. Acetylates 'Lys-12' of histone H4 which is required for telomeric silencing. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair.

Belongs to the HAT1 family.

51.083 kDa

MKDSWSSNSTTSTAIRLVGSPYGTDSPFQPTFTYPIYGEAETIYGYEGLAIKLSVASGSLVPLLEVTYRAKNEATTAEIDDVEGKIKEFLAPDFLSTSSPSAMEEFETVVKADKEFRPLGDKVHSYTRGKVDKGKAKSSTASLASSTLSASDPNARVFEIYRSTWHTPGFREYHRRMQLFTLLFIEGASYIQEDETNWEFFTLYEKVSRDDKQTWHFMGYTSLYKFWCWPDSSRIRLSQFVILPPFQKQGHGGALYTTVYDQIRERANVTELTVEDPSEDFDRLRDGNDLRRLLAPGGFADSAKAQNKLHAPLDKEWIESQRLQHKLAPRQWSRVLEMVQLMNLDTTDHEQVKQYRLQVKARIYRQNKDILMQLEKQQQRSKLQETFEGVVEEYGDMVGVDVEDLLDDGPSGTGALYGADEEEDQEQGQGDRHYSNGNGPPRKMARLA

HAT1

Histone acetyltransferase type B catalytic subunit

419 amino acids

Acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. May be involved in nucleosome assembly during DNA replication and repair as part of the histone H3.1 and H3.3 complexes. May play a role in DNA repair in response to free radical damage.

Belongs to the HAT1 family.

49.513 kDa

MAGFGAMEKFLVEYKSAVEKKLAEYKCNTNTAIELKLVRFPEDLENDIRTFFPEYTHQLFGDDETAFGYKGLKILLYYIAGSLSTMFRVEYASKVDENFDCVEADDVEGKIRQIIPPGFCTNTNDFLSLLEKEVDFKPFGTLLHTYSVLSPTGGENFTFQIYKADMTCRGFREYHERLQTFLMWFIETASFIDVDDERWHYFLVFEKYNKDGATLFATVGYMTVYNYYVYPDKTRPRVSQMLILTPFQGQGHGAQLLETVHRYYTEFPTVLDITAEDPSKSYVKLRDFVLVKLCQDLPCFSREKLMQGFNEDMAIEAQQKFKINKQHARRVYEILRLLVTDMSDAEQYRSYRLDIKRRLISPYKKKQRDLAKMRKCLRPEELTNQMNQIEISMQHEQLEESFQELVEDYRRVIERLAQE

Hat1

Histone acetyltransferase type B catalytic subunit

419 amino acids

Acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. May be involved in nucleosome assembly during DNA replication and repair as part of the histone H3.1 and H3.3 complexes.

Belongs to the HAT1 family.

49.241 kDa

MAGFGAMEKFLVEYKSAVEKKLAEYKCNTNTAIELKLVRFPEDLENDIRTFFPEYTHQLFGDDETAFGYKGLKILLYYIAGSLSTMFRVEYASKVDENFDCVEADDVEGKIRQIIPPGFCTNTNDFLSLLEKEADFKPFGTLLHTYSVPSPTGGENFTFQIYKADMTCRGFREYHERLQTFLMWFIETASFIDVDDERWHYFLVFEKYNKDGATLFATVGYMTVYNYYVYPDKTRPRVSQMLILTPFQGQGHGAQLLETVHRYYIASSSVLDITAEDPSKSYVKLRDFVLVKLCQDLPCFSRERLLQGFNEDMAIQAQQKFKINKQHARRVYEILRLLVTDMSDAEQCRSYRLDIKRRLISPYKKKQTDLAKMRKCLRPEELTNQMNQIEISVQHEQLEEQFQELVEDYRRVIERLAQE

HAT1

Histone acetyltransferase type B catalytic subunit

416 amino acids

Catalytic component of the histone acetylase B (HAT-B) complex. Acetylates 'Lys-12' of histone H4 which is required for telomeric silencing. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair.

Belongs to the HAT1 family.

48.537 kDa

MAETLEEWISDSNQVLNLQMVRTPEDASLLQYEEQQNIDVFNPAFTYPIFGDNEKIFGYKGLDIKLHFASGSLRQYLDISYDAKLASSTTPPDEIEGALYKFIPPDYTKSEVEFQKRVAGDAETFKPLGEKIGSYAHPSAGRKGKGQGDSGMAAGKAIEDNEDVVEYEMYKATWSTPGFREYHRRMQIFVLLFIEGGSYVHEDEDAWEFIVLYERRTRPDSGIFTYHFVGYVSVYPFWCYPDRVRLRLSQFVILPPYQHQGHGSKLYNMLFRHMLDRSEVAELTIEDPAEAFEDLRDRNDLRFLVKEGIVKDPMLYVDVGKGKRGSRVEWELAIRRKYKIAQRQFDRLLEMLLFRQLDKGNPDKVKAYRLHVKARLYRFNYEMLSQMTVEERKEALAKTYESVVEDYKRILGMTFG

HAT1

Histone acetyltransferase type B catalytic subunit

416 amino acids

Catalytic component of the histone acetylase B (HAT-B) complex. Acetylates 'Lys-12' of histone H4 which is required for telomeric silencing. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair (By similarity).

Belongs to the HAT1 family.

48.537 kDa

MAETLEEWISDSNQVLNLQMVRTPEDASLLQYEEQQNIDVFNPAFTYPIFGDNEKIFGYKGLDIKLHFASGSLRQYLDISYDAKLASSTTPPDEIEGALYKFIPPDYTKSEVEFQKRVAGDAETFKPLGEKIGSYAHPSAGRKGKGQGDSGMAAGKAIEDNEDVVEYEMYKATWSTPGFREYHRRMQIFVLLFIEGGSYVHEDEDAWEFIVLYERRTRPDSGIFTYHFVGYVSVYPFWCYPDRVRLRLSQFVILPPYQHQGHGSKLYNMLFRHMLDRSEVAELTIEDPAEAFEDLRDRNDLRFLVKEGIVKDPMLYVDVGKGKRGSRVEWELAIRRKYKIAQRQFDRLLEMLLFRQLDKGNPDKVKAYRLHVKARLYRFNYEMLSQMTVEERKEALAKTYESVVEDYKRILGMTFG

Hat1

Histone acetyltransferase type B catalytic subunit

416 amino acids

Acetylates soluble but not nucleosomal histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, acetylates histone H2A at 'Lys-5' (H2AK5ac). Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. May be involved in nucleosome assembly during DNA replication and repair as part of the histone H3.1 and H3.3 complexes.

Belongs to the HAT1 family.

49.278 kDa

MAALEKFLVEYKSAVEKKLAEYKCNTNTAIELKLVRFPEDLENDIRTFFPEYTHQLFGDDETAFGYKGLKILLYYIAGSLSTLFRVEYSSKVDENFDCVEADDVEGKIRQIIPPGFCTNTNDFLSLLEKETNFKPFGTLLHTYTVPSQTGGETFTFQIHKADMTCRGFREYHERLQTFLMWFIETASFIDVDDERWHYFLVFEKYNKDGATLFATVGYMTVYNYYVYPDKTRPRVSQMLILTPFQGQGHGAQLLETVHRYYISFPTVLDITAEDPSRSYLKLRDFVLVKFCQFLPSFSRERLLQGFSEDMAIQAQQMFKINKQHARRVYEILRLLVTDMSDAEQYRSYRLDIKRRLISPYKKKQRDLAKMKKCLRPEELTNQMNQIEISVQHEQLEERFQELVEDYRRVIERLAQE

HAT1

Histone acetyltransferase type B catalytic subunit

413 amino acids

Catalytic component of the histone acetylase B (HAT-B) complex. Acetylates 'Lys-14' of histone H4 which is required for telomeric silencing. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair.

Belongs to the HAT1 family.

48.355 kDa

MSSAKEQSSVTAALQPEQWTTSSNEALKLFVTNPEAALNFQPTFTYPIFGDAETIYGYKDLDIFLCFDHYTFKPFLNIKYSAKLTDDPEIIDIKKTIDEFLPKSTIFKDEVKWVDSIKEEKDNGYKIPGKLIDSFSENDKEYDIYKIDLKSDNGYELHQRLQILVLLFIEAGSFIDAKDELWNLYVLYEKDNKSTSNNEPSIVGFTTAYNYWKYPGAKKFDSTEQESRIKISQFIILPIYQGQGLGQLFYSHLFDKWLAQDDIIEVVVEDPNESFDDLRDRADLKRLNTSEQFDFKAVTPKVDKEWVEKTRRALKLEKRQFARLLEIILLYKLKHGYPGITKRDVRLFIKKRLYDKNKEGLATLDDNTKKDKLQTAYQALEDDYYRILGDLKLNIKRENDEEETDTVSKKQKV

HAT1

Histone acetyltransferase type B catalytic subunit

409 amino acids

Catalytic component of the histone acetylase B (HAT-B) complex. Acetylates 'Lys-12' of histone H4 which is required for telomeric silencing. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair.

Belongs to the HAT1 family.

47.711 kDa

MSDNSPITSITAASLQPELWTSSSNDALQIYITDSDGTALNFHPNFTYPIFGDSEQIFGYRDLVIFLCFDHCTFYPFLNVKYSDKLNDDTLEDPREKLLSYLPESTIFKDEVKWVDSINKEKEGFEIPGELVGNIFTHGDDKFGIYKLDLKNAQGLELHKRLQILVLLFIEAGSYIDHQDELWDIYVMYKVTDEKTPSIIGFCTAYNYWKYGGFEKFDSNQQEVRKKISQFIVLPMYQGLKLGGRFYNKLYEYWMQDPRVIEVVVEDPSESFDDLRDRCDLTRLCQNTIKVASVDLPLINTEWATKLRQEQKLEKRQFSRLLEMILIYQLEHNLTNITKKQVRLFIKKRLYEKNKEILDGLDEPTRLDKLQTAYASLESDYKRILSGLSLHKRALDSTEGSSKKSKPNV

HAT1

Histone acetyltransferase type B catalytic subunit

391 amino acids

Catalytic component of the histone acetylase B (HAT-B) complex. Acetylates 'Lys-12' of histone H4 which is required for telomeric silencing. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair.

Belongs to the HAT1 family.

45.208 kDa

MAEELKPELWTTSSNSALKLSLVNDENAVQFSPIFTYPIFGQAEQLFGYQDLNILLAFDSVTFKPFLNIKYTKKLERGLDDVEGSILKFLPEGDVILKDEVEWVDAFNGEREKFALPNSESKVAEYTSGGESFAIFKVHLSDPNIRQLHRRMQIFTLLFIEAASYIDEDDSAWDIFMTFNTSTRQCIGYTTTYKHWRYINGQEFDSSEKTTKRAKISQFIIFPPYQSKSHGSHLYSAAIDVWSKEEKISEVTVEDPNEAFDDLRDRCDFMRLSGSGLSSSIPEDVPIPRTWLTEQARKYKLSLVQFTRLVEMILLYDNSPNFEIQVKARLYQKNHEVLTGMDSDTRKAKLQEAFTSLKEDYARILQKVPNRRRVLPSDEENAGESKRHKKE

HAT1

Histone acetyltransferase type B catalytic subunit

390 amino acids

Catalytic component of the histone acetylase B (HAT-B) complex. Acetylates 'Lys-12' of histone H4 which is required for telomeric silencing. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair.

Belongs to the HAT1 family.

45.913 kDa

MAVDLRPETWTVSSNEALNLSLVDENGAVNFKPTFTYPIYGDSEQIFGYKNLQIFLAFDSITFKPFVNVKYDAKLNNEIEDVQKLLLDKLPEDDVIIKDEEAWIKTFTKEQETFALPEKDKLVEEYEIGDQEFVIYRVSLQDPAIKMLHKRMQIFTLLFIESASYIDENDSSWEIFIVFNKNSKKCIGYTTTYQFWKYLGAQSFDSSKADEQKCRAKISQFLIMPPYQGHGHGKRLYQAIVKQWMNDLSVVEITVEDPNESFDDLRDRCDFERVINKNSLADCPNELPINIDWITKKQAQLKLEKRQFMRILEMFLLYQKSPNYRLQLKKRIYEKNFEALMDMDESLKKDKLQTAFQSLTEDYNRILSKVAIRKRTFSDSQGESDKRLKA

HAT1

Histone acetyltransferase type B catalytic subunit

388 amino acids

Catalytic component of the histone acetylase B (HAT-B) complex. Acetylates 'Lys-12' of histone H4 which is required for telomeric silencing. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair.

Belongs to the HAT1 family.

45.819 kDa

MSIDDFKPEKWTISSNEALKLSLVSEDNAIQFSPTFTYPIFGTEEQIFGYKDLVIHLAFDAITFKPFLNVKFSSKFEGSEEELVNIKEKLLEYLPIDDTIYKDEEKWIDSFKKEQESIEAYKNDQNIDEYKIDNADFEIYKVNLQDPKMKRFHRRIQIFSLLFIEAASYIDEDDPKWEIFIVQTKKDKKFVGYATAYNYWYYPGANNFDSESKYRYRGKISQFLILPPYQGRGHGSHLYNSIVKNWRNDSSILEIVVEDPNESFDDLRDVNDLEMLYKDGFFNKLPQERPIPNAWIESTRLKYKIEKRQFSRLLEMILLSTGSNNFEYQVKQRLLIKNKDGLEGMEVSDIKDALNKSFESLREDYDRILGKCQFSNDADGPSKKKIKT

hat1

Histone acetyltransferase type B catalytic subunit

378 amino acids

Catalytic component of the histone acetylase B (HAT-B) complex. Acetylates 'Lys-12' of histone H4 which is required for telomeric silencing. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair.

Belongs to the HAT1 family.

44.051 kDa

MSAVDEWVHNANECIEIVQVNEKHEKDCQYHPSNTYAIFGDAEVIYGYKDLNVTITYECPLMVPKLEISYSERLAPDSGVEPTDIEGTLNTYLKDRSIKVEGNSFDVHSANSIHNYSFNGKTFKILQATVLEASEIMQHLQIFSLFFIEGGSFIDLNDPRWMVYLLYETTEDDYCLRGYCTVYKYYKWDKLIHDGIRARISQFVILPPFQHQGHGSQLYNAIVSTFLKNPKILDFTVEDASEAFDSLRDHCDYKRLLSMGIFSEPDFHPSLSRQWINSKIAETKLTQRQFSRCCELAFTTKLKKLSLLERKSVRLGIKERIFRQNLDVLLQLDKSERIEKIHNAYENQFDEYKQIVKKLPKLKEDSPRKRQKLAQSSS

HAT1

Histone acetyltransferase type B catalytic subunit

374 amino acids

Catalytic component of the histone acetylase B (HAT-B) complex. Acetylates 'Lys-12' of free histone H4 in the cytoplasm. The complex is also found in the nucleus, however it is not certain that it modifies histone H4 when packaged in chromatin. Histone H4 'Lys-12' acetylation is required for telomeric silencing. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair.

Belongs to the HAT1 family.

43.873 kDa

MSANDFKPETWTSSANEALRVSIVGENAVQFSPLFTYPIYGDSEKIYGYKDLIIHLAFDSVTFKPYVNVKYSAKLGDDNIVDVEKKLLSFLPKDDVIVRDEAKWVDCFAEERKTHNLSDVFEKVSEYSLNGEEFVVYKSSLVDDFARRMHRRVQIFSLLFIEAANYIDETDPSWQIYWLLNKKTKELIGFVTTYKYWHYLGAKSFDEDIDKKFRAKISQFLIFPPYQNKGHGSCLYEAIIQSWLEDKSITEITVEDPNEAFDDLRDRNDIQRLRKLGYDAVFQKHSDLSDEFLESSRKSLKLEERQFNRLVEMLLLLNNSPSFELKVKNRLYIKNYDALDQTDPEKAREALQNSFILVKDDYRRIIESINKSQG

HAT1

Homeobox-leucine zipper protein HAT1

282 amino acids

Probable transcription factor.

Belongs to the HD-ZIP homeobox family. Class II subfamily.

31.555 kDa

MMMGKEDLGLSLSLGFAQNHPLQLNLKPTSSPMSNLQMFPWNQTLVSSSDQQKQQFLRKIDVNSLPTTVDLEEETGVSSPNSTISSTVSGKRRSTEREGTSGGGCGDDLDITLDRSSSRGTSDEEEDYGGETCRKKLRLSKDQSAVLEDTFKEHNTLNPKQKLALAKKLGLTARQVEVWFQNRRARTKLKQTEVDCEYLKRCVEKLTEENRRLEKEAAELRALKLSPRLYGQMSPPTTLLMCPSCERVAGPSSSNHNQRSVSLSPWLQMAHGSTFDVMRPRS