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HA-17

Gene
HA-17
Protein
Hemagglutinin component HA-17 type C
Organism
Clostridium botulinum C phage
Length
146 amino acids
Function
The hemagglutinin (HA) component of the progenitor toxin protects the structural integrity of botulinum neurotoxin; may increase internalization of the neurotoxin into the bloodstream of the host (PubMed:9421908). The HA component is involved in binding to the upper small intestine through interactions with glycolipids and glycoproteins containing sialic acid moieties (Probable).
Mass
16.663 kDa
Sequence
MSSERTFLPNGNYKIKSLFSDSLYLTYSSGALSFSNTSSLDNQKWKLEYISSSNGFRFSNVAEPNKYLAYNDYGFIYLSSSSNNSLWNPIKIAINSYIICTLSIVNVTDYAWTIYDNNNNITDQPILNLPNFDINNSNQILKLEKL

Gene
ha-17
Protein
Hemagglutinin component HA-17 type D
Organism
Clostridium botulinum D phage
Length
146 amino acids
Function
The hemagglutinin (HA) component of the progenitor toxin protects the structural integrity of the neurotoxin; may increase internalization of the neurotoxin into the bloodstream of the host (By similarity). Involved in binding to the small intestine through interactions with glycolipids and glycoproteins containing sialic acid moieties (Probable). The hemagglutinin complex composed of HA-70, HA-33 and HA-17 agglutinates erythrocytes, whereas the individual compenents do not (PubMed:11713244). Erythrocyte agglutination also occurs with the entire toxin complex (PubMed:11713244, PubMed:17581814).
Mass
16.705 kDa
Sequence
MSSERTFLPNGNYKIKSLFSDSLYLTYSSGSLSFLNTSSLDNQKWKLEYISSSNGFRFSNVAEPNKYLAYNDYGFIYLSSSSNNSLWNPIKIAINSYIICTLSIVNVTDYAWTIYDNNNNITDQPILNLPNFDINNSNQILKLEKL