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Gale

Gene
GALE
Protein
UDP-glucose 4-epimerase
Organism
Homo sapiens
Length
348 amino acids
Function
Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconversions are important in the synthesis of glycoproteins and glycolipids.
Similarity
Belongs to the NAD(P)-dependent epimerase/dehydratase family.
Mass
38.282 kDa
Sequence
MAEKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEFEEMDILDQGALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMKAHGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADKTWNAVLLRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGNDYDTEDGTGVRDYIHVVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMVQAMEKASGKKIPYKVVARREGDVAACYANPSLAQEELGWTAALGLDRMCEDLWRWQKQNPSGFGTQA
Protein
UDP-glucose 4-epimerase: GALE

Gene
GALE
Protein
UDP-glucose 4-epimerase
Organism
Pongo abelii
Length
348 amino acids
Function
Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconversions are important in the synthesis of glycoproteins and glycolipids.
Similarity
Belongs to the NAD(P)-dependent epimerase/dehydratase family.
Mass
38.265 kDa
Sequence
MAEKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEFEEMDILDQGALQRLFKKHSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMKAHGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADKTWNAVLLRYFNPTGAHASGCIGEDPQGIPNNLMPYVSQVAIGRREALNVFGNDYDTEDGTGVRDYIHVVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQMVQAMEKASGKKIPYKVVARREGDVAACYANPSLAHEELGWTAALGLDRMCEDLWRWQKQNPSGFGTQA
Protein
UDP-glucose 4-epimerase: GALE

Gene
Gale
Protein
UDP-glucose 4-epimerase
Organism
Rattus norvegicus
Length
347 amino acids
Function
Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconversions are important in the synthesis of glycoproteins and glycolipids.
Similarity
Belongs to the NAD(P)-dependent epimerase/dehydratase family.
Mass
38.225 kDa
Sequence
MEEKVLVTGGAGYIGSHTVLELLEAGYSPVVIDNFHNSIRGEDSMPESLRRVQELTGRSVEFEEMDILDQAALQHLFKKHNFKAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMRAMGVKSLVFSSSATVYGKPVPASGRGPPHRGCTKPYGKSKFFIEEMIQDLCRADTAWNAVLLRYFIPIGAHRSARIGEDPQGIPNNLMPYVSQVAIGRREALNVFGDDYATEDGTGVRDYIHVVDLAKGHIAALKKLKEQCGCRIYNLGTGTGYSVLQMVQAMEKASGKKIPYKVVARREGDVAACYANPSLAHEELGWTAALGLDRMCEDLWRWQKQNPSGLGAHG
Protein
UDP-glucose 4-epimerase: Gale

Gene
Gale
Protein
UDP-glucose 4-epimerase
Organism
Rattus norvegicus
Length
347 amino acids
Function
Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconversions are important in the synthesis of glycoproteins and glycolipids.
Similarity
Belongs to the NAD(P)-dependent epimerase/dehydratase family.
Mass
38.225 kDa
Sequence
MEEKVLVTGGAGYIGSHTVLELLEAGYSPVVIDNFHNSIRGEDSMPESLRRVQELTGRSVEFEEMDILDQAALQHLFKKHNFKAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMRAMGVKSLVFSSSATVYGKPVPASGRGPPHRGCTKPYGKSKFFIEEMIQDLCRADTAWNAVLLRYFIPIGAHRSARIGEDPQGIPNNLMPYVSQVAIGRREALNVFGDDYATEDGTGVRDYIHVVDLAKGHIAALKKLKEQCGCRIYNLGTGTGYSVLQMVQAMEKASGKKIPYKVVARREGDVAACYANPSLAHEELGWTAALGLDRMCEDLWRWQKQNPSGLGAHG
Protein
UDP-glucose 4-epimerase: Gale

Gene
Gale
Protein
UDP-glucose 4-epimerase
Organism
Mus musculus
Length
347 amino acids
Function
Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconversions are important in the synthesis of glycoproteins and glycolipids.
Similarity
Belongs to the NAD(P)-dependent epimerase/dehydratase family.
Mass
38.225 kDa
Sequence
MEKVLVTGGAGYIGSHTVLELLEAGYSPVVIDNFHNAIRGEDSMPESLRRVQELTGRSVEFEEMDILDQAALQHLFKKHSFKAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMRAHGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCRADTAWNAVLLRYFNPIGAHASGRIGEDPQGIPNNLMPYVSQVAIGRREALNVFGDDYATEDGTGVRDYIHVVDLAKGHIAALKKLKEQCGCRTYNLGTGTGYSVLQMVQAMEKASGKKIPYKVVARREGDVAACYANPSLAHEELGWTAALGLDRMCEDLWRWQKQNPSGFGAQA
Protein
UDP-glucose 4-epimerase: Gale

Gene
galE
Protein
UDP-glucose 4-epimerase
Organism
Mycoplasma genitalium (strain ATCC 33530 / G-37 / NCTC 10195)
Length
340 amino acids
Function
Involved in the metabolism of galactose. Catalyzes the conversion of UDP-galactose (UDP-Gal) to UDP-glucose (UDP-Glc) through a mechanism involving the transient reduction of NAD (By similarity).
Similarity
Belongs to the NAD(P)-dependent epimerase/dehydratase family.
Mass
38.425 kDa
Sequence
MIGAKTRVAIVGGIGYIGSCFASFIKEQNDKLIVTVIDNNKNNHVIKLLKKIGIEFYFADLLDRHKLTEVIAAIQPDVVFHFAAKTSVSESVHNPLKYFDCNVIGTLNLISAISNLQKPIKLFFASSAAVYGQTTNSYISEEIVITETQATNPYGLSKFLDELILNAVAKNSQLQVVCLRFFNVAGAILPFGNFNGNTTLLIPNLVKAFLKQTPFFLYGNDYATKDGSCIRDYIHVYDICNAHFLLWKWLNDHRQIKFETFNLGSGIGTSNLEVIDIAKKVFYPSRLNLEIRPKRSWDPAILVANVAKAKQTFQFKITRNLKDMISDERNFYENFYNDAY
Protein
UDP-glucose 4-epimerase: galE

Gene
galE
Protein
UDP-glucose 4-epimerase
Organism
Neisseria meningitidis serogroup A / serotype 4A (strain Z2491)
Length
339 amino acids
Function
Involved in the metabolism of galactose. Plays an essential role in the incorporation of galactose into meningococcal lipopolysaccharide surface molecules, which are important for pathogenesis. Catalyzes the conversion of UDP-galactose (UDP-Gal) to UDP-glucose (UDP-Glc) through a mechanism involving the transient reduction of NAD (By similarity).
Similarity
Belongs to the NAD(P)-dependent epimerase/dehydratase family.
Mass
37.066 kDa
Sequence
MKNILVTGGTGFIGSHTVVSLLKSGHQVVILDNLCNSSINILPRLKTITGQEIPFYQGDIRDREILRRIFAENRIDSVIHFAGLKAVGESVAEPMKYYDNNVSGSLVLAEEMARAGVFSIVFSSSATVYGDPGKVPYTEDMPLGDTTSPYGTSKSMVERILTDIQKADPRWSMILLRYFNPIGAHESGLIGEQPNGIPNNLLPYICQVASGRLPQLSVFGGDYPTPDGTGMRDYIHVMDLAEGHVAAMQAKSNVAGTHLLNLGSGRASSVLEIIRAFEAASGLTIPYEVKPRRAGDLACFYADPSYTKAQIGWQTQRDLAQMMEDSWRWVSNNPNGYDD
Protein
UDP-glucose 4-epimerase: galE

Gene
galE
Protein
UDP-glucose 4-epimerase
Organism
Neisseria meningitidis serogroup B (strain MC58)
Length
339 amino acids
Function
Involved in the metabolism of galactose. Plays an essential role in the incorporation of galactose into meningococcal lipopolysaccharide surface molecules, which are important for pathogenesis. Catalyzes the conversion of UDP-galactose (UDP-Gal) to UDP-glucose (UDP-Glc) through a mechanism involving the transient reduction of NAD.
Similarity
Belongs to the NAD(P)-dependent epimerase/dehydratase family.
Mass
37.062 kDa
Sequence
MKKILVTGGTGFIGSHTVVSLLKSGHQVVILDNLCNSSINILPRLKTITGQEIPFYQGDIRDREILRRIFAENRIDSVIHFAGLKAVGESVAEPMKYYDNNVSGSLVLAEEMARAGVFSIVFSSSATVYGDPGKVPYTEDMPPGDTTSPYGASKSMVERILTDIQKADPRWSMILLRYFNPIGAHESGLIGEQPNGIPNNLLPYICQVAAGKLPQLAVFGDDYPTPDGTGMRDYIHVMDLAEGHVAAMQAKSNVAGTHLLNLGSGRASSVLEIIRAFEAASGLTIPYEVKPRRAGDLACFYADPSYTKAQIGWQTQRDLTQMMEDSWRWVSNNPNGYDD
Protein
UDP-glucose 4-epimerase: galE

Gene
galE
Protein
UDP-glucose 4-epimerase
Organism
Neisseria meningitidis serogroup C
Length
339 amino acids
Function
Involved in the metabolism of galactose. Plays an essential role in the incorporation of galactose into meningococcal lipopolysaccharide surface molecules, which are important for pathogenesis. Catalyzes the conversion of UDP-galactose (UDP-Gal) to UDP-glucose (UDP-Glc) through a mechanism involving the transient reduction of NAD.
Similarity
Belongs to the NAD(P)-dependent epimerase/dehydratase family.
Mass
37.03 kDa
Sequence
MKKILVTGGTGFIGSHTVVSLLKSGHQVVILDNLCNSSINILPRLKTITGQEIPFYQGDIRDREILRRIFAENRIDSVIHFAGLKAVGESVAEPMKYYDNNVSGSLVLAEEMARAGVFKIVFSSSATVYGDPGKVPYTEDMQPGDTTSPYGTSKSMVERILSDIQKADPRWSVILLRYFNPIGAHESGLIGEQPNGIPNNLLPYICQVAAGKLPQLAVFGGDYPTPDGTGMRDYIHVMDLAEGHVAAMQAKSNVAGTHLLNLGSGRASSVLEIIRAFEAASGLTIPYEVKPRRAGDLACFYADPSYAKAQIGWQTQRDLTQMMEDSWRWVSNNPNGYDD
Protein
UDP-glucose 4-epimerase: galE

Gene
galE
Protein
UDP-glucose 4-epimerase
Organism
Salmonella typhi
Length
338 amino acids
Function
Involved in the metabolism of galactose. Catalyzes the conversion of UDP-galactose (UDP-Gal) to UDP-glucose (UDP-Glc) through a mechanism involving the transient reduction of NAD (By similarity).
Similarity
Belongs to the NAD(P)-dependent epimerase/dehydratase family.
Mass
37.096 kDa
Sequence
MRVLVTGGSGYIGSHTCVQLLQNGHDVVILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRNEALITEILHDHAIDTVIHFAGLKAVGESVAKPLEYYDNNVNGTLRLVSAMRAANVKNLIFSSSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPEWSIALLRYFNPVGAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRESLAVFGNDYPTEDGTGVRDYIHVMDLADGHVVAMEKLADKSGVHIYNLGAGVGSSVLDVVNAFSKACGKPINYHFAPRRDGDLPAYWADASKADRELNWRVTRTLDEMAQDTWHWQSRHPQGYSD
Protein
UDP-glucose 4-epimerase: galE

Gene
galE
Protein
UDP-glucose 4-epimerase
Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Length
338 amino acids
Function
Involved in the metabolism of galactose. Catalyzes the conversion of UDP-galactose (UDP-Gal) to UDP-glucose (UDP-Glc) through a mechanism involving the transient reduction of NAD (By similarity).
Similarity
Belongs to the NAD(P)-dependent epimerase/dehydratase family.
Mass
37.134 kDa
Sequence
MRVLVTGGSGYIGSHTCVQLLQNGHDVVILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRNEALITEILHDHAIDTVIHFAGLKAVGESVARPLEYYDNNVNGTLRLVSAMRAANVKNLIFSSSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPEWSIALLRYFNPVGAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRESLAVFGNDYPTEDGTGVRDYIHVMDLADGHVVAMEKLADKSGVHIYNLGAGVGSSVLDVVNAFSKACGKPINYHFAPRRDGDLPAYWADASKADRELNWRVTRTLDEMAQDTWHWQSRHPQGYPD
Protein
UDP-glucose 4-epimerase: galE

Gene
galE
Protein
UDP-glucose 4-epimerase
Organism
Yersinia pestis
Length
338 amino acids
Function
Involved in the metabolism of galactose. Catalyzes the conversion of UDP-galactose (UDP-Gal) to UDP-glucose (UDP-Glc) through a mechanism involving the transient reduction of NAD (By similarity).
Similarity
Belongs to the NAD(P)-dependent epimerase/dehydratase family.
Mass
36.732 kDa
Sequence
MYVLVTGGSGYIGSHTCVQLIEAGYKPVILDNLCNSKSSVLARIHSLTGYTPELYAGDIRDRTLLDSIFAAHPIHAVIHFAGLKAVGESVNRPLEYYNNNVFGTLVLLEAMRAAQVKNLIFSSSATVYGDQPQIPYVESFPTGSPSSPYGRSKLMVEQILQDVQLADPQWNMTILRYFNPVGAHPSGLMGEDPQGIPNNLMPFIAQVAVGRRESLAIFGNGYPTPDGTGVRDYIHVVDLADGHVAAMKTLHGKPGVHIFNLGAGVGHSVLQVVAAFSKACGKPLAYHFAPRREGDLPAYWADATKAAEQLGWRVSRSLDEMAADTWHWQSKNPQGYPD
Protein
UDP-glucose 4-epimerase: galE

Gene
galE
Protein
UDP-glucose 4-epimerase
Organism
Salmonella typhi
Length
338 amino acids
Function
Involved in the metabolism of galactose. Catalyzes the conversion of UDP-galactose (UDP-Gal) to UDP-glucose (UDP-Glc) through a mechanism involving the transient reduction of NAD (By similarity).
Similarity
Belongs to the NAD(P)-dependent epimerase/dehydratase family.
Mass
37.096 kDa
Sequence
MRVLVTGGSGYIGSHTCVQLLQNGHDVVILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRNEALITEILHDHAIDTVIHFAGLKAVGESVAKPLEYYDNNVNGTLRLVSAMRAANVKNLIFSSSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPEWSIALLRYFNPVGAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRESLAVFGNDYPTEDGTGVRDYIHVMDLADGHVVAMEKLADKSGVHIYNLGAGVGSSVLDVVNAFSKACGKPINYHFAPRRDGDLPAYWADASKADRELNWRVTRTLDEMAQDTWHWQSRHPQGYSD
Protein
UDP-glucose 4-epimerase: galE

Gene
galE
Protein
UDP-glucose 4-epimerase
Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Length
338 amino acids
Function
Involved in the metabolism of galactose. Catalyzes the conversion of UDP-galactose (UDP-Gal) to UDP-glucose (UDP-Glc) through a mechanism involving the transient reduction of NAD (By similarity).
Similarity
Belongs to the NAD(P)-dependent epimerase/dehydratase family.
Mass
37.134 kDa
Sequence
MRVLVTGGSGYIGSHTCVQLLQNGHDVVILDNLCNSKRSVLPVIERLGGKHPTFVEGDIRNEALITEILHDHAIDTVIHFAGLKAVGESVARPLEYYDNNVNGTLRLVSAMRAANVKNLIFSSSATVYGDQPKIPYVESFPTGTPQSPYGKSKLMVEQILTDLQKAQPEWSIALLRYFNPVGAHPSGDMGEDPQGIPNNLMPYIAQVAVGRRESLAVFGNDYPTEDGTGVRDYIHVMDLADGHVVAMEKLADKSGVHIYNLGAGVGSSVLDVVNAFSKACGKPINYHFAPRRDGDLPAYWADASKADRELNWRVTRTLDEMAQDTWHWQSRHPQGYPD
Protein
UDP-glucose 4-epimerase: galE

Gene
galE
Protein
UDP-glucose 4-epimerase
Organism
Yersinia pestis
Length
338 amino acids
Function
Involved in the metabolism of galactose. Catalyzes the conversion of UDP-galactose (UDP-Gal) to UDP-glucose (UDP-Glc) through a mechanism involving the transient reduction of NAD (By similarity).
Similarity
Belongs to the NAD(P)-dependent epimerase/dehydratase family.
Mass
36.732 kDa
Sequence
MYVLVTGGSGYIGSHTCVQLIEAGYKPVILDNLCNSKSSVLARIHSLTGYTPELYAGDIRDRTLLDSIFAAHPIHAVIHFAGLKAVGESVNRPLEYYNNNVFGTLVLLEAMRAAQVKNLIFSSSATVYGDQPQIPYVESFPTGSPSSPYGRSKLMVEQILQDVQLADPQWNMTILRYFNPVGAHPSGLMGEDPQGIPNNLMPFIAQVAVGRRESLAIFGNGYPTPDGTGVRDYIHVVDLADGHVAAMKTLHGKPGVHIFNLGAGVGHSVLQVVAAFSKACGKPLAYHFAPRREGDLPAYWADATKAAEQLGWRVSRSLDEMAADTWHWQSKNPQGYPD
Protein
UDP-glucose 4-epimerase: galE

Gene
galE
Protein
UDP-glucose 4-epimerase
Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Length
338 amino acids
Function
Involved in the metabolism of galactose. Catalyzes the conversion of UDP-galactose (UDP-Gal) to UDP-glucose (UDP-Glc) through a mechanism involving the transient reduction of NAD. By controlling the internal galactose concentration, it may be linked to the biosynthesis of lipopolysaccharide surface molecules, which are important for the pathogenesis of H.influenzae.
Similarity
Belongs to the NAD(P)-dependent epimerase/dehydratase family.
Mass
37.165 kDa
Sequence
MAILVTGGAGYIGSHTVVELLNVGKEVVVLDNLCNSSPKSLERVKQITGKEAKFYEGDILDRALLQKIFAENEINSVIHFAGLKAVGESVQKPTEYYMNNVAGTLVLIQEMKKAGVWNFVFSSSATVYGDPKIIPITEDCEVGGTTNPYGTSKYMVEQILRDTAKAEPKFSMTILRYFNPVGAHESGLIGEDPNGIPNNLLPYISQVAIGKLAQLSVFGSDYDTHDGTGVRDYIHVVDLAVGHLKALQRHENDAGLHIYNLGTGHGYSVLDMVKAFEKANNITIAYKLVERRSGDIATCYSDPSLAAKELGWVAERGLEKMMQDTWNWQKNNPKGYRD
Protein
UDP-glucose 4-epimerase: galE

Gene
galE
Protein
UDP-glucose 4-epimerase
Organism
Mannheimia haemolytica
Length
338 amino acids
Function
Involved in the metabolism of galactose. Catalyzes the conversion of UDP-galactose (UDP-Gal) to UDP-glucose (UDP-Glc) through a mechanism involving the transient reduction of NAD.
Similarity
Belongs to the NAD(P)-dependent epimerase/dehydratase family.
Mass
37.036 kDa
Sequence
MAILVTGGAGYIGSHTLVELLNENREIVVLDNLSNSSEVSLERVKQITGKSVKFYQGDILDRDILRKIFAENQIESVIHFAGLKAVGETSENRYVTIKNNVTGSIVLVEEMLKANVNTIVFSSSATVYGDPQIIPIVESCPVGGTTNPYGTSKYMVERILEDTVKAFPQLSAVVLRYFNRVGAHESGLIGEDPNGIPNNLMPFISQVAVGKLPQLSVFGGDYNTHDGTGVRDYIHVVDLALGHLKALDKHQNDAGFHVYNLGTGTGYSVLDMVKAFEAANGITIPYKVVDRRPGDIAVCYSAPQKALEQLGWETERGLEQMMKDTWNWQKNNPNGYKG
Protein
UDP-glucose 4-epimerase: galE

Gene
galE
Protein
UDP-glucose 4-epimerase
Organism
Mycoplasma pneumoniae (strain ATCC 29342 / M129)
Length
338 amino acids
Function
Involved in the metabolism of galactose. Catalyzes the conversion of UDP-galactose (UDP-Gal) to UDP-glucose (UDP-Glc) through a mechanism involving the transient reduction of NAD (By similarity).
Similarity
Belongs to the NAD(P)-dependent epimerase/dehydratase family.
Mass
38.133 kDa
Sequence
MSETKSKVLVLGGLGYIGSCFIDQLLKQYPDVTVSVIDINHTSLALQLLPRQVNVHFVNLLDRAQLTDTIAQINPDVVFHFAAKTSVKESTEQPLTYFDHNLVGTLNLLHALKELQKPIQLFFSSTAAVFGSASTLPIPENLVLEETLASNPYGISKFLSEIVLQTLTRSPHFQVIALRYFNVAGASNPFGNFNKNTTLLIPNLIKAFMEKRTFFLYGDDYDTKDGSCIRDYIHVVDLCDAHLLAWKWLQANPKVRFESFNLGSGQGFSNWEVINTAQAIFAPEQLQLKIESRRAGDPPVLVVDCTKAKRLLNFQPTRSLHKMLSDETIFYRDFYNRL
Protein
UDP-glucose 4-epimerase: galE

Gene
galE
Protein
UDP-glucose 4-epimerase
Organism
Neisseria gonorrhoeae
Length
338 amino acids
Function
Involved in the metabolism of galactose. Plays an essential role in the incorporation of galactose into meningococcal lipopolysaccharide surface molecules, which are important for pathogenesis. Catalyzes the conversion of UDP-galactose (UDP-Gal) to UDP-glucose (UDP-Glc) through a mechanism involving the transient reduction of NAD.
Similarity
Belongs to the NAD(P)-dependent epimerase/dehydratase family.
Mass
36.885 kDa
Sequence
MTVLITGGTGFIGSHTAVSLVQSGYDAVILDNLCNSSAAVLPRLRQITGRNIPFYQGDIRDCQILRQIFSEHEIESVIHFAGLKAVGESVAEPTKYYGNNVYGSLVLAEEMARAGVLKIVFSSSATVYGDAEKVPYTEDMRPGDTANPYGASKAMVERMLTDIQKADPRWSVILLRYFNPIGAHESGLIGEQPNGVPNNLLPYICQVASGRLPQLSVFGGDYPTPDGTGMRDYIHVMDLAEGHIAAMKAKGGVAGVHLFNLGSGRAYSVLEIIRAFEAASGLHIPYRIQPRRAGDLACSYADPSHTKQQTGWETKRGLQQMMEDSWRWVSRNPGRYGD
Protein
UDP-glucose 4-epimerase: galE

Gene
galE
Protein
UDP-glucose 4-epimerase
Organism
Pasteurella multocida (strain Pm70)
Length
338 amino acids
Function
Involved in the metabolism of galactose. Catalyzes the conversion of UDP-galactose (UDP-Gal) to UDP-glucose (UDP-Glc) through a mechanism involving the transient reduction of NAD (By similarity).
Similarity
Belongs to the NAD(P)-dependent epimerase/dehydratase family.
Mass
37.068 kDa
Sequence
MAILVTGGAGYIGSHTVVELLNANKDVVVLDNLCNSSPKSLERVAQITGKQVKFYQGDILDTALLQKIFAENQIQSVIHFAGLKAVGESVQKPAEYYMNNVTGSLVLIQEMKKAGVWNFVFSSSATVYGDPEIIPITESCKVGGTTNPYGTSKFMVEQILKDIAKATPEFSITILRYFNPVGAHESGLIGEDPNGIPNNLLPYISQVAIGKLPQLSVFGSDYETHDGTGVRDYIHVVDLAIGHLKALDRHEGDAGLHIYNLGTGSGYSVLDMVKAFEKVNDIKIPYKLVDRRPGDIATCYSDPSLAKTELNWTAARGLEQMMKDTWHWQKKNPKGYRD
Protein
UDP-glucose 4-epimerase: galE

Gene
galE
Protein
UDP-glucose 4-epimerase
Organism
Yersinia enterocolitica
Length
336 amino acids
Function
Involved in the metabolism of galactose. Catalyzes the conversion of UDP-galactose (UDP-Gal) to UDP-glucose (UDP-Glc) through a mechanism involving the transient reduction of NAD (By similarity).
Similarity
Belongs to the NAD(P)-dependent epimerase/dehydratase family.
Mass
37.057 kDa
Sequence
MSILITGGAGYIGSHTVLTLLEQGRNVVVLDNLINSSAESLARVSKICGRKPNFYHGDILDRSCLKLIFSSHKIDSVIHFAGLKSVGESVEKPIEYYQNNVVGSITLLEEMCLANVKKLIFSSSATVYGEPEFVPLTEKARIGGTTNPYGTSKVMVEQILKDFSLAHPDYSITALRYFNPVGAHPSGLIGEDPNGKPNNLLPFITQVAIGKLSKLLVYGNDYDTPDGSGIRDYIHVMDLAEGHLSTLINLTSGFRIYNLGTGVGYSVLHMIKEFERITGKNIPFDIVSRRPGDIAECWASPELAHLELGWYAKRTLVDMLQDAWKWQKMNPNGYNC
Protein
UDP-glucose 4-epimerase: galE

Gene
galE
Protein
UDP-glucose 4-epimerase
Organism
Yersinia enterocolitica
Length
336 amino acids
Function
Involved in the metabolism of galactose. Catalyzes the conversion of UDP-galactose (UDP-Gal) to UDP-glucose (UDP-Glc) through a mechanism involving the transient reduction of NAD (By similarity).
Similarity
Belongs to the NAD(P)-dependent epimerase/dehydratase family.
Mass
37.057 kDa
Sequence
MSILITGGAGYIGSHTVLTLLEQGRNVVVLDNLINSSAESLARVSKICGRKPNFYHGDILDRSCLKLIFSSHKIDSVIHFAGLKSVGESVEKPIEYYQNNVVGSITLLEEMCLANVKKLIFSSSATVYGEPEFVPLTEKARIGGTTNPYGTSKVMVEQILKDFSLAHPDYSITALRYFNPVGAHPSGLIGEDPNGKPNNLLPFITQVAIGKLSKLLVYGNDYDTPDGSGIRDYIHVMDLAEGHLSTLINLTSGFRIYNLGTGVGYSVLHMIKEFERITGKNIPFDIVSRRPGDIAECWASPELAHLELGWYAKRTLVDMLQDAWKWQKMNPNGYNC
Protein
UDP-glucose 4-epimerase: galE

Gene
galE
Protein
UDP-glucose 4-epimerase
Organism
Streptococcus mutans serotype c (strain ATCC 700610 / UA159)
Length
333 amino acids
Function
Involved in the metabolism of galactose. Catalyzes the conversion of UDP-galactose (UDP-Gal) to UDP-glucose (UDP-Glc) through a mechanism involving the transient reduction of NAD (By similarity).
Similarity
Belongs to the NAD(P)-dependent epimerase/dehydratase family.
Mass
36.921 kDa
Sequence
MAILVLGGAGYIGSHMVDRLIEKGEEEVVVVDSLVTGHRAAVHPAAKFYQGDLADREFMSMVFRENPDVDAVIHFAAYSLVAESMKKPLKYFDNNTAGMIKLLEVMSEFGVKYIVFSSTAATYGIPDEIPIKETTPQRPINPYGESKLMMETIMKWSDRAYGIKFVPLRYFNVAGAKPDGSIGEDHSPETHLLPIILQVAQGVREKIMIFGDDYNTPDGTNVRDYVHPFDLADAHLLALNYLRQGNPSTAFNLGSSTGFSNLQILEAARKVTGQKIPAEKAARRSGDPDTLIASSEKAREVLGWKPQFDDIEKIIASAWAWHSSYPKGYDDRD
Protein
UDP-glucose 4-epimerase: galE

Gene
galE
Protein
UDP-glucose 4-epimerase
Organism
Streptococcus mutans serotype c (strain ATCC 700610 / UA159)
Length
333 amino acids
Function
Involved in the metabolism of galactose. Catalyzes the conversion of UDP-galactose (UDP-Gal) to UDP-glucose (UDP-Glc) through a mechanism involving the transient reduction of NAD (By similarity).
Similarity
Belongs to the NAD(P)-dependent epimerase/dehydratase family.
Mass
36.921 kDa
Sequence
MAILVLGGAGYIGSHMVDRLIEKGEEEVVVVDSLVTGHRAAVHPAAKFYQGDLADREFMSMVFRENPDVDAVIHFAAYSLVAESMKKPLKYFDNNTAGMIKLLEVMSEFGVKYIVFSSTAATYGIPDEIPIKETTPQRPINPYGESKLMMETIMKWSDRAYGIKFVPLRYFNVAGAKPDGSIGEDHSPETHLLPIILQVAQGVREKIMIFGDDYNTPDGTNVRDYVHPFDLADAHLLALNYLRQGNPSTAFNLGSSTGFSNLQILEAARKVTGQKIPAEKAARRSGDPDTLIASSEKAREVLGWKPQFDDIEKIIASAWAWHSSYPKGYDDRD
Protein
UDP-glucose 4-epimerase: galE

Gene
galE
Protein
UDP-glucose 4-epimerase
Organism
Streptococcus thermophilus
Length
332 amino acids
Function
Involved in the metabolism of galactose. Catalyzes the conversion of UDP-galactose (UDP-Gal) to UDP-glucose (UDP-Glc) through a mechanism involving the transient reduction of NAD.
Similarity
Belongs to the NAD(P)-dependent epimerase/dehydratase family.
Mass
36.94 kDa
Sequence
MAILVLGGAGYIGSHMVDRLVEKGQEKVVVVDSLVTGHRAAVHPDAIFYQGDLSDQDFMRKVFKENPDVDAVIHFAAYSLVGESMEKPLKYFDNNTAGMVKLLEVMNECGVKYIVFSSTAATYGIPEEIPILETTPQNPINPYGESKLMMETIMKWSDQAYGIKYVPLRYFNVAGANLMVRLVRTRSETHLLPIILQVAQGVREKIMIFGDDYNTPDGTNVRDYVHPFDLADAHLLAVEYLRKGNESTAFNLGSSTGFSNLQILEAARKVTGKEIPAEKADRRPGDPDILIASSEKARTVLGWKPQFDNIEKIIASAWAWHSSHPKGYDDRG
Protein
UDP-glucose 4-epimerase: galE

Gene
galE
Protein
UDP-glucose 4-epimerase
Organism
Streptococcus thermophilus
Length
332 amino acids
Function
Involved in the metabolism of galactose. Catalyzes the conversion of UDP-galactose (UDP-Gal) to UDP-glucose (UDP-Glc) through a mechanism involving the transient reduction of NAD.
Similarity
Belongs to the NAD(P)-dependent epimerase/dehydratase family.
Mass
36.94 kDa
Sequence
MAILVLGGAGYIGSHMVDRLVEKGQEKVVVVDSLVTGHRAAVHPDAIFYQGDLSDQDFMRKVFKENPDVDAVIHFAAYSLVGESMEKPLKYFDNNTAGMVKLLEVMNECGVKYIVFSSTAATYGIPEEIPILETTPQNPINPYGESKLMMETIMKWSDQAYGIKYVPLRYFNVAGANLMVRLVRTRSETHLLPIILQVAQGVREKIMIFGDDYNTPDGTNVRDYVHPFDLADAHLLAVEYLRKGNESTAFNLGSSTGFSNLQILEAARKVTGKEIPAEKADRRPGDPDILIASSEKARTVLGWKPQFDNIEKIIASAWAWHSSHPKGYDDRG
Protein
UDP-glucose 4-epimerase: galE

Gene
galE
Protein
UDP-glucose 4-epimerase
Organism
Lactobacillus casei
Length
331 amino acids
Similarity
Belongs to the NAD(P)-dependent epimerase/dehydratase family.
Mass
36.338 kDa
Sequence
MTIAVLGGAGYIGSHTVKQLLAAGEDVVVLDNLITGHRKAVDPRARFYQGDIRDYHFLSQVFSQEKIDGIVHFAAFSIVPESMKDPLKYFDNNTGGMITLLEAMNQFGIKKIVFSSTAATYGEPKQVPIKETDPQVPTNPYGESKLAMEKIMHWADVAYGLKFVALRYFNVAGAMPDGSIGEDHHPETHIVPIILQVAAGTRTGLQIYGDDYPTKDGTNVRDYVHVVDLADAHILALKYLDAGNKSSAFNIGSAHGFSNLEILNAARKVTGQEIPATMGPRRAGDPSTLIASSEKARDILGWKPNYDDIDKIIETAWNWHENHPEGFGDRN
Protein
UDP-glucose 4-epimerase: galE

Gene
galE
Protein
UDP-glucose 4-epimerase
Organism
Lactobacillus helveticus
Length
330 amino acids
Function
Involved in the metabolism of galactose. Catalyzes the conversion of UDP-galactose (UDP-Gal) to UDP-glucose (UDP-Glc) through a mechanism involving the transient reduction of NAD. It also could be involved in preparation of carbohydrate residues for incorporation into complex polymers, such as exopolysaccharides.
Similarity
Belongs to the NAD(P)-dependent epimerase/dehydratase family.
Mass
36.429 kDa
Sequence
MKVLVIGGAGYIGSHAVRELVKEGNDVLVLDALYTGHRKAVDPKAKFYQGDIEDTFLVSKILRDEKIDAVMHFAAYSLVPESVKKPLKYYDNNVTGMISLLQAMNDANVKYLVFSSSAATYGIPKKLPITEDTPLNPINPYGETKMMMEKIMAWADKADGIKYTALRYFNVAGASSDGSIGEDHAPETHLIPNILKSAISGDGKFTIFGDDYDTKDGTNVRDYVQVEDLIDAHILALKHMMKTNKSDVFNLGTAHGYSNLEILESAKKVTGIDIPYTMGPRRGGDPDSLVADSTKARTVLGWKPKHENVDDVIATAWKWHKSHPKGYEDK
Protein
UDP-glucose 4-epimerase: galE

Gene
galE
Protein
UDP-glucose 4-epimerase
Organism
Streptomyces lividans
Length
329 amino acids
Function
Involved in the metabolism of galactose. Catalyzes the conversion of UDP-galactose (UDP-Gal) to UDP-glucose (UDP-Glc) through a mechanism involving the transient reduction of NAD (By similarity).
Similarity
Belongs to the NAD(P)-dependent epimerase/dehydratase family.
Mass
35.453 kDa
Sequence
MSGKYLVTGGAGYVGSVVAQHLVEAGNEVVVLHNLSTGFRAGVPAGASFYRGDIRDQDFMRKVFRGRLSFDGVLHFAAFSQVGESVVKPEKYWDNNVGGTMALLEAMRGAGVRRLVFSSTAATYGEPEQVPIVESAPTRPTNPYGASKLAVDHMITGEAAAHGLGAVSVPYFNVAGANRGVRLVHDPESHLIPLVLQVAQGRREAISVYGDDYPTPDTCVRDYIHVADLAEAHLLAVRRRPGNEHLICNLGNGNGFSVREVVETVRRVTGHPIPEIMAPRRGRDPAVLVASAGTAREKLGWNPSRADLAIVSDAWEWHSSHPKGYDDRG
Protein
UDP-glucose 4-epimerase: galE

Gene
galE
Protein
UDP-glucose 4-epimerase
Organism
Streptomyces lividans
Length
329 amino acids
Function
Involved in the metabolism of galactose. Catalyzes the conversion of UDP-galactose (UDP-Gal) to UDP-glucose (UDP-Glc) through a mechanism involving the transient reduction of NAD (By similarity).
Similarity
Belongs to the NAD(P)-dependent epimerase/dehydratase family.
Mass
35.453 kDa
Sequence
MSGKYLVTGGAGYVGSVVAQHLVEAGNEVVVLHNLSTGFRAGVPAGASFYRGDIRDQDFMRKVFRGRLSFDGVLHFAAFSQVGESVVKPEKYWDNNVGGTMALLEAMRGAGVRRLVFSSTAATYGEPEQVPIVESAPTRPTNPYGASKLAVDHMITGEAAAHGLGAVSVPYFNVAGANRGVRLVHDPESHLIPLVLQVAQGRREAISVYGDDYPTPDTCVRDYIHVADLAEAHLLAVRRRPGNEHLICNLGNGNGFSVREVVETVRRVTGHPIPEIMAPRRGRDPAVLVASAGTAREKLGWNPSRADLAIVSDAWEWHSSHPKGYDDRG
Protein
UDP-glucose 4-epimerase: galE

Gene
galE
Protein
UDP-glucose 4-epimerase
Organism
Vibrio cholerae
Length
328 amino acids
Function
Involved in the metabolism of galactose. Catalyzes the conversion of UDP-galactose (UDP-Gal) to UDP-glucose (UDP-Glc) through a mechanism involving the transient reduction of NAD (By similarity).
Similarity
Belongs to the NAD(P)-dependent epimerase/dehydratase family.
Mass
35.811 kDa
Sequence
MCTGDRKMPKSILLTGSTGFVGTNLVKSLTLKSDYIVKSAVRHAVNKDDGLLFEVGDINASTDFELPLKNTTVVVHCAARAHVMDDKEAEPLTLYREVNTAGTVNLAKQAIDSGVKRFIFISSIKVNGEGTLVGCPFKTEDNHAPEDDYGLSKSEAEKQLVALAKDSSMEVVIIRPTIVYGPGVKANFASLMRLVSKGIPLPFGSITQNKRSLVSINNLVDLIVTCIDHPKAANQVFLVSDGHDVSTAEMVRELAIALDKPTWQLPVPIWCYKLFGKLFGKSDIVDRLTGTLQVDISHTKETLGWKPPQTLQEGFKQTAQAFLQANNR
Protein
UDP-glucose 4-epimerase: galE

Gene
galE
Protein
UDP-glucose 4-epimerase
Organism
Vibrio cholerae
Length
328 amino acids
Function
Involved in the metabolism of galactose. Catalyzes the conversion of UDP-galactose (UDP-Gal) to UDP-glucose (UDP-Glc) through a mechanism involving the transient reduction of NAD (By similarity).
Similarity
Belongs to the NAD(P)-dependent epimerase/dehydratase family.
Mass
35.811 kDa
Sequence
MCTGDRKMPKSILLTGSTGFVGTNLVKSLTLKSDYIVKSAVRHAVNKDDGLLFEVGDINASTDFELPLKNTTVVVHCAARAHVMDDKEAEPLTLYREVNTAGTVNLAKQAIDSGVKRFIFISSIKVNGEGTLVGCPFKTEDNHAPEDDYGLSKSEAEKQLVALAKDSSMEVVIIRPTIVYGPGVKANFASLMRLVSKGIPLPFGSITQNKRSLVSINNLVDLIVTCIDHPKAANQVFLVSDGHDVSTAEMVRELAIALDKPTWQLPVPIWCYKLFGKLFGKSDIVDRLTGTLQVDISHTKETLGWKPPQTLQEGFKQTAQAFLQANNR
Protein
UDP-glucose 4-epimerase: galE

Gene
galE
Protein
UDP-glucose 4-epimerase
Organism
Klebsiella pneumoniae
Length
139 amino acids
Function
Involved in the metabolism of galactose. Catalyzes the conversion of UDP-galactose (UDP-Gal) to UDP-glucose (UDP-Glc) through a mechanism involving the transient reduction of NAD (By similarity).
Similarity
Belongs to the NAD(P)-dependent epimerase/dehydratase family.
Mass
15.156 kDa
Fragment
single
Sequence
MKVLVTGGSGYIGSHTCVQLLQRGHEVVILDNLCNSKRRILPVIERLGGKEATFIEGDIRNEARMTEILHDHAIEAVIHFAGLKAVGESVAKPLEYYDNNVTGTLKLVSAMRAAGVKNFIFSSSATVYGDQPKIPYVES
Protein
UDP-glucose 4-epimerase: galE