gyrB

DNA gyrase subunit B

815 amino acids

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Belongs to the type II topoisomerase GyrB family.

89.637 kDa

MEKTPATGSAVAPPPVEYGTDSITKLEGREAVRKRPGMYIGDTMAYGLHKLVYEVVDNAVDESLAGHCTDIEVVIHVDGSLSVQDNGRGIPVGPHPKFPGKDTLEVVLTELHAGSKFGNGAYKVSGGLHGVGVTCVNFLSEWFKVRVHRNGIVYEQAYAQGVPDTPPREVGTTDKRGTHIAFKPDATVMELVEFNFETLSQRLRELAFLNAGLHIVVRDERTNKEHDFKFDGGISSFVEYLNKSKQTLHDKPISFSTEREGVMLDIAMQWNDGYDERIYTFANNINTHEGGSHLSGFKAALTRTLNSYAEKGSLWKDLKETPTGEDAREGLSAVISVKLTNPQFEGQTKTKLGNSEVKGLVEQMVNDQLGSFLEETPMVAKKVVAKIGDACRARLAARKARETVRRKGVLDGGGLPGKLADCQIRDPNESELYIVEGDSAGGSAKQGRDRRNQAILPLRGKILNVEKLLREMLTSAEIVTLITALGNGIGAEDYDPEKARYHRIFLMTDADVDGSHIRTLLLTSSSGRCRSSCRRAISTSRSRRSYKVTRNKKDQYVKDEHALNEYLLKIASEHARVLTPGGELGGAELKALLEKVITYEERLEKQAKRRDARVVDALVQGARLSAETLTGRGCPGGGGEGRLMTPSSAACRTCWAACATSWCRTPSTTPRSWCSTPTRMEPCGRRCSTTPSCRRRSTWSCRLCAEHLRGAGQGAVQGPRGRGEITVFSVQEVLAAVRKDAQRGLGLQRYKGLGEMNPEQLWDTTMNPATRTLLQVRVEDAVESDEIFSLLMGEAVEPRREFIERNALDVQNLDI

gyrB

DNA gyrase subunit B

808 amino acids

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Belongs to the type II topoisomerase GyrB family.

90.843 kDa

MSEFEEKLNESSYGADSIKVLKGLEAVRKRPGMYIGDVGDGSGLHHMIYEVVDNAIDEALAGYCDLVRVVLNKNGSVTVSDNGRGIPVEIHEEEGISAAEVIMTQLHAGGKFDQNSYKVSGGLHGVGVSVVNALSDWLELRIWRNNTEHLIRFNNGITEAPLAVVKENVDKKGTEVTFFPSVETFTNIEFDFSIIEHRLRELAFLNSGVKILLTDNRFEEVKEVEFYYTGGIEAYVKYLDRAKHAVHSCIVVNADNTESGISLELAMHWNDSYHENILCFTNNIRQRDGGTHLSAFKSGLTRVITAYLENTGLNKKAKNAFSGEDTREGICCVLSVKVPDPKFSSQTKDKLVSSEVRPIVENAVYTKVLEWFEEHPADAKLIINKIMEAANAREAARKARELTRRKSVLEVSNLPGKLADCHAKDPAVSELFIVEGDSAGGTAKQGRDSKIQAILPLRGKILNVERARFDKMLGSDQIGTLITALGTGVDNREFSLEKLRYHKVIIMTDADVDGSHIRTLLLTFFYRHMPELINKGYLYIAQPPLYKVKKGASELYLKNEQALQDYLVKSAISDATLTLDNKEQLTNENLEELMSKVIKFNSLLDHASKKFNRSITEILAINDLLNNKIFDNESDSRLKKALNALNSLEQSPDKTDWEVLKHENKIEFFRFSRGLKERKILLREQLESFEFINISKLALTIFDVFNKQLKLVVKNQEFDILTPSILLNTIIECGKKGISVQRFKGLGEMNSDQLWDTTLDPKKRTLMQVRVAEVDEAEGIFSTLMGDVVEPRRQFIQSNALNVVNLDV

gyrB

DNA gyrase subunit B

808 amino acids

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Belongs to the type II topoisomerase GyrB family.

90.595 kDa

MSEIEEKFNESSYGADSIKVLKGLEAVRKRPGMYIGDVGDGSGLHHMIYEVVDNAIDESLAGYCDLVRVTLNKNGSVTVSDNGRGIPVEIHQEEGISAAEVIMTQLHAGGKFDQNSYKVSGGLHGVGVSVVNALSEWLELRIWRNNKEYLIRFNNGITEAPLAVVNEDINKKGTEVTFFPSVETFTNIEFDFGTIEHRLRELAFLNSGVKILLVDNRFEEAKEVEFYYTGGIEAYVKYIDRAKHAVHPCIVVNTENTESGISLELAMHWNDSYHENILCFTNNIRQRDGGTHLSAFKSAITRVITSYLDTTGLNKKSKNDFSGEDTREGLCCVLSVKVPDPKFSSQTKDKLVSSEVRPVVENAVYTKVLEWFEEHPAESKAIIAKIMEAANAREAARKARELTRRKSALEVSNLPGKLADCHAKDPAISELFIVEGDSAGGTAKQGRDSKIQAILPLRGKILNVERARFDKMLGSDQIGTLITALGTGVDNREFSLEKLRYHKVIIMTDADVDGSHIRTLLLTFFYRHMPELINKGYLYIAQPPLYKVKKGAAEFYLKNEQALQDYLIKSTINDATLTLDGKEQLVGDNLEELINKVVKFNGLLDHASKKFNRSITEILAINDLLNNKIFELESDSRLQKALDVLNSLEESPDKTNWEVLKHENKVEFFRFSRGLKESKILLKEQLESFEFVQISKLALTIFDIFDKQLKLIVKSQEFGILTASQLLNAIIECGKRGISIQRFKGLGEMNSNQLWETTLDPAKRTLLQVRVAEVDEAEGIFSTLMGDVVEPRRLFIQANALNVVNLDV

gyrB

DNA gyrase subunit B

808 amino acids

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Belongs to the type II topoisomerase GyrB family.

90.843 kDa

MSEFEEKLNESSYGADSIKVLKGLEAVRKRPGMYIGDVGDGSGLHHMIYEVVDNAIDEALAGYCDLVRVVLNKNGSVTVSDNGRGIPVEIHEEEGISAAEVIMTQLHAGGKFDQNSYKVSGGLHGVGVSVVNALSDWLELRIWRNNTEHLIRFNNGITEAPLAVVKENVDKKGTEVTFFPSVETFTNIEFDFSIIEHRLRELAFLNSGVKILLTDNRFEEVKEVEFYYTGGIEAYVKYLDRAKHAVHSCIVVNADNTESGISLELAMHWNDSYHENILCFTNNIRQRDGGTHLSAFKSGLTRVITAYLENTGLNKKAKNAFSGEDTREGICCVLSVKVPDPKFSSQTKDKLVSSEVRPIVENAVYTKVLEWFEEHPADAKLIINKIMEAANAREAARKARELTRRKSVLEVSNLPGKLADCHAKDPAVSELFIVEGDSAGGTAKQGRDSKIQAILPLRGKILNVERARFDKMLGSDQIGTLITALGTGVDNREFSLEKLRYHKVIIMTDADVDGSHIRTLLLTFFYRHMPELINKGYLYIAQPPLYKVKKGASELYLKNEQALQDYLVKSAISDATLTLDNKEQLTNENLEELMSKVIKFNSLLDHASKKFNRSITEILAINDLLNNKIFDNESDSRLKKALNALNSLEQSPDKTDWEVLKHENKIEFFRFSRGLKERKILLREQLESFEFINISKLALTIFDVFNKQLKLVVKNQEFDILTPSILLNTIIECGKKGISVQRFKGLGEMNSDQLWDTTLDPKKRTLMQVRVAEVDEAEGIFSTLMGDVVEPRRQFIQSNALNVVNLDV

gyrB

DNA gyrase subunit B

808 amino acids

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Belongs to the type II topoisomerase GyrB family.

90.595 kDa

MSEIEEKFNESSYGADSIKVLKGLEAVRKRPGMYIGDVGDGSGLHHMIYEVVDNAIDESLAGYCDLVRVTLNKNGSVTVSDNGRGIPVEIHQEEGISAAEVIMTQLHAGGKFDQNSYKVSGGLHGVGVSVVNALSEWLELRIWRNNKEYLIRFNNGITEAPLAVVNEDINKKGTEVTFFPSVETFTNIEFDFGTIEHRLRELAFLNSGVKILLVDNRFEEAKEVEFYYTGGIEAYVKYIDRAKHAVHPCIVVNTENTESGISLELAMHWNDSYHENILCFTNNIRQRDGGTHLSAFKSAITRVITSYLDTTGLNKKSKNDFSGEDTREGLCCVLSVKVPDPKFSSQTKDKLVSSEVRPVVENAVYTKVLEWFEEHPAESKAIIAKIMEAANAREAARKARELTRRKSALEVSNLPGKLADCHAKDPAISELFIVEGDSAGGTAKQGRDSKIQAILPLRGKILNVERARFDKMLGSDQIGTLITALGTGVDNREFSLEKLRYHKVIIMTDADVDGSHIRTLLLTFFYRHMPELINKGYLYIAQPPLYKVKKGAAEFYLKNEQALQDYLIKSTINDATLTLDGKEQLVGDNLEELINKVVKFNGLLDHASKKFNRSITEILAINDLLNNKIFELESDSRLQKALDVLNSLEESPDKTNWEVLKHENKVEFFRFSRGLKESKILLKEQLESFEFVQISKLALTIFDIFDKQLKLIVKSQEFGILTASQLLNAIIECGKRGISIQRFKGLGEMNSNQLWETTLDPAKRTLLQVRVAEVDEAEGIFSTLMGDVVEPRRLFIQANALNVVNLDV

gyrB

DNA gyrase subunit B

807 amino acids

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Belongs to the type II topoisomerase GyrB family.

90.795 kDa

MSEIEEKFNESSYGADSIKVLKGLEAVRKRPGMYIGDVGDGSGLHHMIYEVVDNAIDESLAGYCDLVRVTLNKNGSVTVSDNGRGIPVEIHGEEGISAAEVIMTQLHAGGKFDQNAYKVAGGLHGVGVSVVNALSEWLELRIWRNNKEYLMRFNNGITEAPLAVVKENIDKKGTEVTFFPSVETFTNIEFDFGTIEHRLRELAFLNSGVKILLVDNRFEEVKEVEFYYTGGIEAYVKYIDRAKHAIHPCIVVNTENAESGISLELAMHWNDSYHENILCFTNNIRQRDGGTHLSAFKSAITRVITSYLDTTGLNKKAKNYFSGEDTREGLCCVLSVKVPDPKFSSQTKDKLVSSEVRPVVENAVYTKVLEWFEEHPAEAKAIIAKIMEAANAREAARKARELTRRKSALEVSNLPGKLADCHAKDPAISELFIVEGDSAGGTAKQGRDSKIQAILPLRGKILNVERARFDKMLGSDQIGTLITALGISVEREFSLEKLRYHKVIIMTDADVDGSHIRTLLLTFFYRHMPELINKGYLYIAQPPLYKVKKGAAEFYLKNEQALQDYLIKSTINDATLILDDKERLVGDNLEELINKVVKFNGLLDHASKKFNRSITEILAINDLLNNKIFEPESDLRLKKALDVLNSLEDSPDKTNWEVLKHENKIEFFRFSRGLKESKILLKEQLESFEFVQISKFALTIFDIFSKQLKLIVKSQEFDILTPSQLLNTIIECGKRGINIQRFKGLGEMNSDQLWETTLDPTKRTLLQVRVAEIDEAEGIFSTLMGDVVEPRRLFIQANALNVVNLDV

gyrB

DNA gyrase subunit B

807 amino acids

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Belongs to the type II topoisomerase GyrB family.

90.823 kDa

MSVIEEKCNESSYSADSIKVLKGLEAVRKRPGMYIGDVGDGSGLHHMIYEVVDNSIDEALAGYCDLVQVTLNKNGSVTVSDNGRGIPVEIHEEEGISAAEVIMTQLHAGGKFDQQSYKISGGLHGVGVSVVNALSEWLELRIWRNNKEYFIRFNNGITEAPLSIVKENIDKKGTEVTFFPSVGTFTNIEFDFVTIEHRLRELAFLNSGVKILLVDNRFEEVKKVEFYYTGGIEAYVQYIDRAKHAIHPCIVVNTVHVESGISLELALHWNDSYHENILCFTNNIRQRDGGTHLSAFKSAITRVITSYLDTTGLNKKTKHDFSGEDTREGICCVLSVKVPDPKFSSQTKDKLVSSEVRPVVENAVYTKVLEWFEEHPTEAKAIIAKIMEAANAREAARKARELTRRKSALEVSNLPGKLADCHAKDPAISELFIVEGDSAGGTAKQGRDSKIQAILPLRGKILNVERARFDKMLGSDQIGTLITALGISVEREFSLEKLRYHKVIIMTDADVDGSHIRALLLTFFYRHMPELINKGYLYIAQPPLYKVKSGASELYLKNEKALQNYLIKSTINDTYLILDGQEQLVGENLEDLINKVVKFNNLLDHVSKKFNRSITEILAINDLFNKKIFEPESSARLQKALDILNNLEESPDKTNLQVLKHENKIEFFHFSRGLKETKILLKEQLELFEFVEISQFALSIFDIFSKRLKLIVKSKAFDILTPSQLLNTIIECGKKGITIQRFKGLGEMNSDQLWETTLDPTKRTLLQVRVAEVDEAEGIFSTLMGDVVEPRRLFIQANALNVMNLDV

gyrB

DNA gyrase subunit B

807 amino acids

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Belongs to the type II topoisomerase GyrB family.

90.952 kDa

MSGIEEKCNESSYSADSIKVLKGLEAVRKRPGMYIGDVGDGSGLHHMIYEVVDNSIDEALAGYCDLIRVTLNKNGSVTVSDNGRGIPVEIHEEEGISAAEVIMTQLHAGGKFDQHSYKISGGLHGVGVSVVNALSEWLELRIWRNNKEYFIRFNNGITEAPLSIVKENIDKKGTEVTFFPSVGIFTNIEFDFVTIEHRLRELAFLNSGVKILLIDNRFEEVKKVEFFYTGGIEAYVQYIDRAKHAIHPCIVVNTEHVESGISLELAIHWNDSYHENILCFTNNIRQRDGGTHLSAFKSAITRVITSYLDTTGLNKKTKHDFSGEDTREGICCVLSVKVPDPKFSSQTKDKLVSSEVRPVVENAVYTKVLEWFEEHPIEAKAIIAKIMEAANAREAARKARELTRRKSALEVSNLPGKLADCHAKDPAISELFIVEGDSAGGTAKQGRDSKIQAILPLRGKILNVERARFDKMLSSEQIGTLITALGISVEREFSLEKLRYHKVIIMTDADVDGSHIRTLLLTFFYRHMPELINKGYLYIAQPPLYKVKSGASELYLKNEQALQNYLIKSTINDTKLILDGQEQLIGYNLEDLINKVVQFNCLLDRASKKFNRSITEILAINDLFNKKIFEPESGSRLQKALDVLNNLEESPDKTNLQVLKHENRIEFFHFSRGLKNTKILLKEQLELFEFVEISQFALSIFDIFSKRLKLIVKGKEFDVVTPSQLLNTIIECGKKGITIQRFKGLGEMNSDQLWDTTLDPTKRTLLQVRVSEVDEAEGIFSTLMGDVVEPRRLFIQANALNVMNLDI

gyrB

DNA gyrase subunit B

807 amino acids

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Belongs to the type II topoisomerase GyrB family.

90.795 kDa

MSEIEEKFNESSYGADSIKVLKGLEAVRKRPGMYIGDVGDGSGLHHMIYEVVDNAIDESLAGYCDLVRVTLNKNGSVTVSDNGRGIPVEIHGEEGISAAEVIMTQLHAGGKFDQNAYKVAGGLHGVGVSVVNALSEWLELRIWRNNKEYLMRFNNGITEAPLAVVKENIDKKGTEVTFFPSVETFTNIEFDFGTIEHRLRELAFLNSGVKILLVDNRFEEVKEVEFYYTGGIEAYVKYIDRAKHAIHPCIVVNTENAESGISLELAMHWNDSYHENILCFTNNIRQRDGGTHLSAFKSAITRVITSYLDTTGLNKKAKNYFSGEDTREGLCCVLSVKVPDPKFSSQTKDKLVSSEVRPVVENAVYTKVLEWFEEHPAEAKAIIAKIMEAANAREAARKARELTRRKSALEVSNLPGKLADCHAKDPAISELFIVEGDSAGGTAKQGRDSKIQAILPLRGKILNVERARFDKMLGSDQIGTLITALGISVEREFSLEKLRYHKVIIMTDADVDGSHIRTLLLTFFYRHMPELINKGYLYIAQPPLYKVKKGAAEFYLKNEQALQDYLIKSTINDATLILDDKERLVGDNLEELINKVVKFNGLLDHASKKFNRSITEILAINDLLNNKIFEPESDLRLKKALDVLNSLEDSPDKTNWEVLKHENKIEFFRFSRGLKESKILLKEQLESFEFVQISKFALTIFDIFSKQLKLIVKSQEFDILTPSQLLNTIIECGKRGINIQRFKGLGEMNSDQLWETTLDPTKRTLLQVRVAEIDEAEGIFSTLMGDVVEPRRLFIQANALNVVNLDV

gyrB

DNA gyrase subunit B

807 amino acids

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Belongs to the type II topoisomerase GyrB family.

90.823 kDa

MSVIEEKCNESSYSADSIKVLKGLEAVRKRPGMYIGDVGDGSGLHHMIYEVVDNSIDEALAGYCDLVQVTLNKNGSVTVSDNGRGIPVEIHEEEGISAAEVIMTQLHAGGKFDQQSYKISGGLHGVGVSVVNALSEWLELRIWRNNKEYFIRFNNGITEAPLSIVKENIDKKGTEVTFFPSVGTFTNIEFDFVTIEHRLRELAFLNSGVKILLVDNRFEEVKKVEFYYTGGIEAYVQYIDRAKHAIHPCIVVNTVHVESGISLELALHWNDSYHENILCFTNNIRQRDGGTHLSAFKSAITRVITSYLDTTGLNKKTKHDFSGEDTREGICCVLSVKVPDPKFSSQTKDKLVSSEVRPVVENAVYTKVLEWFEEHPTEAKAIIAKIMEAANAREAARKARELTRRKSALEVSNLPGKLADCHAKDPAISELFIVEGDSAGGTAKQGRDSKIQAILPLRGKILNVERARFDKMLGSDQIGTLITALGISVEREFSLEKLRYHKVIIMTDADVDGSHIRALLLTFFYRHMPELINKGYLYIAQPPLYKVKSGASELYLKNEKALQNYLIKSTINDTYLILDGQEQLVGENLEDLINKVVKFNNLLDHVSKKFNRSITEILAINDLFNKKIFEPESSARLQKALDILNNLEESPDKTNLQVLKHENKIEFFHFSRGLKETKILLKEQLELFEFVEISQFALSIFDIFSKRLKLIVKSKAFDILTPSQLLNTIIECGKKGITIQRFKGLGEMNSDQLWETTLDPTKRTLLQVRVAEVDEAEGIFSTLMGDVVEPRRLFIQANALNVMNLDV

gyrB

DNA gyrase subunit B

807 amino acids

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Belongs to the type II topoisomerase GyrB family.

90.952 kDa

MSGIEEKCNESSYSADSIKVLKGLEAVRKRPGMYIGDVGDGSGLHHMIYEVVDNSIDEALAGYCDLIRVTLNKNGSVTVSDNGRGIPVEIHEEEGISAAEVIMTQLHAGGKFDQHSYKISGGLHGVGVSVVNALSEWLELRIWRNNKEYFIRFNNGITEAPLSIVKENIDKKGTEVTFFPSVGIFTNIEFDFVTIEHRLRELAFLNSGVKILLIDNRFEEVKKVEFFYTGGIEAYVQYIDRAKHAIHPCIVVNTEHVESGISLELAIHWNDSYHENILCFTNNIRQRDGGTHLSAFKSAITRVITSYLDTTGLNKKTKHDFSGEDTREGICCVLSVKVPDPKFSSQTKDKLVSSEVRPVVENAVYTKVLEWFEEHPIEAKAIIAKIMEAANAREAARKARELTRRKSALEVSNLPGKLADCHAKDPAISELFIVEGDSAGGTAKQGRDSKIQAILPLRGKILNVERARFDKMLSSEQIGTLITALGISVEREFSLEKLRYHKVIIMTDADVDGSHIRTLLLTFFYRHMPELINKGYLYIAQPPLYKVKSGASELYLKNEQALQNYLIKSTINDTKLILDGQEQLIGYNLEDLINKVVQFNCLLDRASKKFNRSITEILAINDLFNKKIFEPESGSRLQKALDVLNNLEESPDKTNLQVLKHENRIEFFHFSRGLKNTKILLKEQLELFEFVEISQFALSIFDIFSKRLKLIVKGKEFDVVTPSQLLNTIIECGKKGITIQRFKGLGEMNSDQLWDTTLDPTKRTLLQVRVSEVDEAEGIFSTLMGDVVEPRRLFIQANALNVMNLDI

gyrB

DNA gyrase subunit B

806 amino acids

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Belongs to the type II topoisomerase GyrB family.

90.189 kDa

MSENNTYDSSSIKVLKGLDAVRKRPGMYIGDTDDGTGLHHMVFEVVDNSIDEALAGYCSEISITIHTDESITVRDNGRGIPVDIHKEEGVSAAEVIMTVLHAGGKFDDNTYKVSGGLHGVGVSVVNALSHELRLTIRRHNKVWEQVYHHGVPQFPLREVGETDGSGTEVHFKPSPETFSNIHFSWDILAKRIRELSFLNSGVGILLRDERTGKEELFKYEGGLKAFVEYLNTNKTAVNEVFHFNVQREEDGVGVEVALQWNDSFNENLLCFTNNIPQRDGGTHLAGFRSALTRNLNNYIEAEGLAKKFKIATTGDDAREGLTAIISVKVPDPKFSSQTKDKLVSSEVKTAVEQEMGKYFADFLLENPNEAKAVVGKMIDAARAREAARKAREMTRRKGALDIAGLPGKLADCQEKDPALSELYIVEGDSAGGSAKQGRNRRTQAILPLKGKILNVEKARFDKMLSSQEVGTLITALGCGIGREEYNIDKLRYHNIIIMTDADVDGSHIRTLLLTFFFRQMPELIERGYIYIAQPPLYKVKRGKQEQYIKDDQAMEEYMTQSALEDASLHVNEHAPGLSGAALEKLVNEYRGVIATLKRLSRLYPQELTEHFIYLPTVSVDDLANESAMQGWLEKFQARLTAAEKSGLTYKASLREDRERHLWLPEVELVAHGLSSYVTFNRDFFASNDYRSVSLLGDQLNSLLEDGAYVQKGERKRPISAFKDGLDWLMAEGTKRHSIQRYKGLGEMNPEQLWETTMDPNVRRMLKVTIEDAIAADQIFNTLMGDAVEPRRDFIESNALAVSNLDV

gyrB

DNA gyrase subunit B

806 amino acids

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Belongs to the type II topoisomerase GyrB family.

90.078 kDa

MSENQTYDSSSIKVLKGLDAVRKRPGMYIGDTDDGSGLHHMVFEVVDNSIDEALAGHCDDITVIIHTDESISVRDNGRGIPVDVHKEEGVSAAEVIMTVLHAGGKFDDNSYKVSGGLHGVGVSVVNALSEKLVLTVRRSGKIWEQTYVHGVPQAPMAVVGESETTGTHIHFKPSAETFKNIHFSWDILAKRIRELSFLNSGVGILLKDERSGKEEFFKYEGGLRAFVEYLNTNKTPVNSQVFHFSVQREDGVGVEVALQWNDSFNENLLCFTNNIPQRDGGTHLVGFRSSLTRSLNSYIEQEGLAKKNKVATTGDDAREGLTAIISVKVPDPKFSSQTKDKLVSSEVKTAVEQEMNKYFSDFLLENPNEAKAVVGKMIDAARAREAARKAREMTRRKGALDIAGLPGKLADCQEKDPALSELYLVEGDSAGGSAKQGRNRRTQAILPLKGKILNVEKARFDKMISSQEVGTLITALGCGIGREEYNIDKLRYHNIIIMTDADVDGSHIRTLLLTFFFRQLPELVERGYIYIAQPPLYKVKKGKQEQYIKDDEAMEEYMTQSALEDASLHLDESAPAVSGVQLESLVNEFRSVMKTLKRLSRLYPEELTEHFVYLPEVTLEQLGDHAVMQAWLAKLQERLNSSQKSGLAYNASLREDKERNVWLPEVEITSHGLASYITFNRDFFGSNDYRTVVNIGAKLSSLLGEGAYVQRGERRKAIVEFKEGLDWLMNETTKRHTIQRYKGLGEMNPDQLWETTMDPTVRRMLKVTIEDAIAADQIFNTLMGDAVEPRREFIESNALSVSNLDF

gyrB

DNA gyrase subunit B

806 amino acids

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Belongs to the type II topoisomerase GyrB family.

90.189 kDa

MSENNTYDSSSIKVLKGLDAVRKRPGMYIGDTDDGTGLHHMVFEVVDNSIDEALAGYCSEISITIHTDESITVRDNGRGIPVDIHKEEGVSAAEVIMTVLHAGGKFDDNTYKVSGGLHGVGVSVVNALSHELRLTIRRHNKVWEQVYHHGVPQFPLREVGETDGSGTEVHFKPSPETFSNIHFSWDILAKRIRELSFLNSGVGILLRDERTGKEELFKYEGGLKAFVEYLNTNKTAVNEVFHFNVQREEDGVGVEVALQWNDSFNENLLCFTNNIPQRDGGTHLAGFRSALTRNLNNYIEAEGLAKKFKIATTGDDAREGLTAIISVKVPDPKFSSQTKDKLVSSEVKTAVEQEMGKYFADFLLENPNEAKAVVGKMIDAARAREAARKAREMTRRKGALDIAGLPGKLADCQEKDPALSELYIVEGDSAGGSAKQGRNRRTQAILPLKGKILNVEKARFDKMLSSQEVGTLITALGCGIGREEYNIDKLRYHNIIIMTDADVDGSHIRTLLLTFFFRQMPELIERGYIYIAQPPLYKVKRGKQEQYIKDDQAMEEYMTQSALEDASLHVNEHAPGLSGAALEKLVNEYRGVIATLKRLSRLYPQELTEHFIYLPTVSVDDLANESAMQGWLEKFQARLTAAEKSGLTYKASLREDRERHLWLPEVELVAHGLSSYVTFNRDFFASNDYRSVSLLGDQLNSLLEDGAYVQKGERKRPISAFKDGLDWLMAEGTKRHSIQRYKGLGEMNPEQLWETTMDPNVRRMLKVTIEDAIAADQIFNTLMGDAVEPRRDFIESNALAVSNLDV

gyrB

DNA gyrase subunit B

806 amino acids

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Belongs to the type II topoisomerase GyrB family.

90.078 kDa

MSENQTYDSSSIKVLKGLDAVRKRPGMYIGDTDDGSGLHHMVFEVVDNSIDEALAGHCDDITVIIHTDESISVRDNGRGIPVDVHKEEGVSAAEVIMTVLHAGGKFDDNSYKVSGGLHGVGVSVVNALSEKLVLTVRRSGKIWEQTYVHGVPQAPMAVVGESETTGTHIHFKPSAETFKNIHFSWDILAKRIRELSFLNSGVGILLKDERSGKEEFFKYEGGLRAFVEYLNTNKTPVNSQVFHFSVQREDGVGVEVALQWNDSFNENLLCFTNNIPQRDGGTHLVGFRSSLTRSLNSYIEQEGLAKKNKVATTGDDAREGLTAIISVKVPDPKFSSQTKDKLVSSEVKTAVEQEMNKYFSDFLLENPNEAKAVVGKMIDAARAREAARKAREMTRRKGALDIAGLPGKLADCQEKDPALSELYLVEGDSAGGSAKQGRNRRTQAILPLKGKILNVEKARFDKMISSQEVGTLITALGCGIGREEYNIDKLRYHNIIIMTDADVDGSHIRTLLLTFFFRQLPELVERGYIYIAQPPLYKVKKGKQEQYIKDDEAMEEYMTQSALEDASLHLDESAPAVSGVQLESLVNEFRSVMKTLKRLSRLYPEELTEHFVYLPEVTLEQLGDHAVMQAWLAKLQERLNSSQKSGLAYNASLREDKERNVWLPEVEITSHGLASYITFNRDFFGSNDYRTVVNIGAKLSSLLGEGAYVQRGERRKAIVEFKEGLDWLMNETTKRHTIQRYKGLGEMNPDQLWETTMDPTVRRMLKVTIEDAIAADQIFNTLMGDAVEPRREFIESNALSVSNLDF

gyrB

DNA gyrase subunit B

806 amino acids

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Belongs to the type II topoisomerase GyrB family.

89.885 kDa

MSETTNDNYGASSIKVLKGLDAVRKRPGMYIGDTDDGTGLHHMVFEVVDNAIDEALAGHCSDIIVTIHDDNSVSVQDDGGGIPVDIHPEEGVSAAEVIMTVLHAGGKFDDNSYKVSGGLHGVGVSVVNALSDKLQLTIRRQGHVHEQFYHLGEPQSPLTVIGETEATGTTVRFWPSSDIFAITTFDYKILAKRLRELSFLNSGVSIRLIDKRDGSEDHFHYEGGIQAFVEYLNKNKNPIHPKPFYFTAEKDGIGVEVALQWNDGVNENVYCFTNNIPQRDGGTHLAGFRGALTRSLNSYMENEGMLKKEKVATSGDDAREGLVAIISVKVPDPKFSSQTKDKLVSSEVKSAVESAMNEKMQEYLLENPADAKIIVNQIIMAARAREAARKAREMTRRKGALDIAGLPGKLADCQEKDPALSELYLVEGDSAGGSAKVGRDRKTQAILPLKGKILNVEKARFDKMLSSQEVGTLITALGCGIGRDEYNPDKLRYHHIIIMTDADVDGSHIRTLLLTFFYRQMPELIERGYVYIAQPPLYKVKKGKQERYIKDADEMEQYELTLALDGAELHISTNAPAMNALVFEKLVAEYNSVQKLIGRLNRHYPAPVLQGLIYQSPISIEMMKEESAVENWGKSFVEQLTAKETEAHQYSVRTQFNAERQVYEAVITVRKHGIDTDYFLNFDFVHGNEYAKIVSLNKQLNGLLEEGAYVIRGEKVQPVRSFEQAVEWLVKESRKGLEVQRYKGLGEMNADQLWETTMDPNSRRMLKVSIKDAVAADQLFTTLMGDEVEPRREFIELNALRANLDV

gyrB

DNA gyrase subunit B

805 amino acids

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Belongs to the type II topoisomerase GyrB family.

88.212 kDa

MTTEEAAAQYGADSIKVLKGLDAVRKRPGMYIGDTDDGSGLHHMVYEVVDNAIDEALAGHATKVQVILNADGSVTVTDDGRGIPVDMHEGEGVSAAEVIMTQLHAGGKFDQNSYKVSGGLHGVGVSVVNALSDWLELLIHRNGKVHQMRFERGDAVTSLKVTGDSPVRTEGPKAGETLTGTEVTFFPSKDTFAFIEFDRKTLEHRLRELAFLNSGVTIWFKDHRDVEPWEEKLFYEGGIEAFVRHLDKAKTPLLKAPIAVKGVKDKVEIDLALWWNDSYHEQMLCFTNNIPQRDGGTHLSAFRAALTRIITSYAESSGILKKEKVSLGGEDSREGLTCVLSVKVPDPKFSSQTKDKLVSSEVRPAVEGLVSEGLSTWFEEHPNEAKAIVTKIAEAAAAREAARKARELTRRKSALDITSLPGKLADCSERDPAKSEIFIVEGDSAGGSAKQARNRDNQAVLPLRGKILNVERARFDKMLSSDQIGTLITALGAGIGRDDFNPDKVRYHKIVLMTDADVDGAHIRTLLLTFFYRQMPELIERGYIYIAQPPLYKASKGKSSRYLKDDAEMDAFLVDEGVDGAELDLASGERMTGQDLLALVQTCRSAKANIDRLAARAPATAIEQAALSGLLGESPNAAAAATRLDLYAEEGDGPWSGERGDTGFVFSRVRRGVSERVVLDDVLLHAADARRLAERAVKLTEIFSGRAIFRRKDKSTTVRGPLDLVNAVLDAGRKGLTIQRYKGLGEMNPDQLWETTLDAEARTLLQVRVNHADDADDMFSRLMGDLVEPRREFIQENALDAEVDV

gyrB

DNA gyrase subunit B

805 amino acids

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Belongs to the type II topoisomerase GyrB family.

88.212 kDa

MTTEEAAAQYGADSIKVLKGLDAVRKRPGMYIGDTDDGSGLHHMVYEVVDNAIDEALAGHATKVQVILNADGSVTVTDDGRGIPVDMHEGEGVSAAEVIMTQLHAGGKFDQNSYKVSGGLHGVGVSVVNALSDWLELLIHRNGKVHQMRFERGDAVTSLKVTGDSPVRTEGPKAGETLTGTEVTFFPSKDTFAFIEFDRKTLEHRLRELAFLNSGVTIWFKDHRDVEPWEEKLFYEGGIEAFVRHLDKAKTPLLKAPIAVKGVKDKVEIDLALWWNDSYHEQMLCFTNNIPQRDGGTHLSAFRAALTRIITSYAESSGILKKEKVSLGGEDSREGLTCVLSVKVPDPKFSSQTKDKLVSSEVRPAVEGLVSEGLSTWFEEHPNEAKAIVTKIAEAAAAREAARKARELTRRKSALDITSLPGKLADCSERDPAKSEIFIVEGDSAGGSAKQARNRDNQAVLPLRGKILNVERARFDKMLSSDQIGTLITALGAGIGRDDFNPDKVRYHKIVLMTDADVDGAHIRTLLLTFFYRQMPELIERGYIYIAQPPLYKASKGKSSRYLKDDAEMDAFLVDEGVDGAELDLASGERMTGQDLLALVQTCRSAKANIDRLAARAPATAIEQAALSGLLGESPNAAAAATRLDLYAEEGDGPWSGERGDTGFVFSRVRRGVSERVVLDDVLLHAADARRLAERAVKLTEIFSGRAIFRRKDKSTTVRGPLDLVNAVLDAGRKGLTIQRYKGLGEMNPDQLWETTLDAEARTLLQVRVNHADDADDMFSRLMGDLVEPRREFIQENALDAEVDV

gyrB

DNA gyrase subunit B

805 amino acids

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Belongs to the type II topoisomerase GyrB family.

90.571 kDa

MDPKEKNYDASAITVLEGLQAVRERPGMYIGDTGITGLHHLVYEVVDNSIDEAMAGYCSRIDVRILEDGGIVIVDNGRGIPIEVHERESAKQGREVSALEVVLTVLHAGGKFDKDSYKVSGGLHGVGVSCVNALSEKLVATVFKDKKCYQMEFSRGIPVTPLQYVSVSDRQGTEIVFYPDPKIFSTCTFDRSILMKRLRELAFLNRGITIVFEDDRDVSFDKVTFFYEGGIQSFVSYLNQNKESLFSEPIYICGTRVGDDGEIEFEAALQWNSGYSELVYSYANNIPTRQGGTHLTGFSTALTRVINTYIKAHNLAKNNKLALTGEDIREGLTAVISVKVPNPQFEGQTKQKLGNSDVSSVAQQVVGEALTIFFEENPQIARMIVDKVFVAAQAREAAKKARELTLRKSALDSARLPGKLIDCLEKDPEKCEMYIVEGDSAGGSAKQGRDRRFQAILPIRGKILNVEKARLQKIFQNQEIGTIIAALGCGIGADNFNLSKLRYRRIIIMTDADVDGSHIRTLLLTFFYRHMTALIENECVYIAQPPLYKVSKKKDFRYILSEKEMDSYLLMLGTNESSILFKSTERELRGEALESFINVILDVESFINTLEKKAIPFSEFLEMYKEGIGYPLYYLAPATGMQGGRYLYSDEEKEEALAQEETHKFKIIELYKVAVFVDIQNQLKEYGLDISSYLIPQKNEIVIGNEDSPSCNYSCYTLEEVINYLKNLGRKGIEIQRYKGLGEMNADQLWDTTMNPEQRTLIHVSLKDAVEADHIFTMLMGEEVPPRREFIESHALSIRINNLDI

gyrB

DNA gyrase subunit B

804 amino acids

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Belongs to the type II topoisomerase GyrB family.

89.896 kDa

MSNSYDSSSIKVLKGLDAVRKRPGMYIGDTDDGTGLHHMVFEVVDNAIDEALAGHCKDIVVTIHADNSVSVTDDGRGIPTGIHPEEGVSAAEVIMTVLHAGGKFDDNSYKVSGGLHGVGVSVVNALSQKLELVIQRDGKIHRQIYEHGVPQAPLAVTGDTDKTGTMVRFWPSHETFTNVTEFEYEILAKRLRELSFLNSGVSIRLRDKRDGKEDHFHYEGGIKAFVEYLNKNKTPIHPNIFYFSTEKDGIGVEVALQWNDGFQENIYCFTNNIPQRDGGTHLAGFRAAMTRTLNAYMDKEGYSKKAKVSATGDDAREGLIAVVSVKVPDPKFSSQTKDKLVSSEVKSAVEQQMNELLSEYLLENPSDAKIVVGKIIDAARAREAARRAREMTRRKGALDLAGLPGKLADCQERDPALSELYLVEGDSAGGSAKQGRNRKNQAILPLKGKILNVEKARFDKMLSSQEVATLITALGCGIGRDEYNPDKLRYHSIIIMTDADVDGSHIRTLLLTFFYRQMPEIVERGHVYIAQPPLYKVKKGKQEQYIKDDEAMDQYQISIALDGATLHANAHAPALSGEALEKLVSEYNATQKMIGRMERRFPKALLKELVYQPTLTEADLSDEQTVTRWVNALITELNEKEQHGSQWKFDVHTNTEQNLFEPIVRVRTHGVDTDYPLDHEFVTGAEYRRICTLGEKLRGLIEEDAFIERGERRQPVTSFEQALEWLVKESRRGLAIQRYKGLGEMNPDQLWETTMDPESRRMLRVTVKDAIAADQLFTTLMGDAVEPRRAFIEENALKAANIDI

gyrB

DNA gyrase subunit B

804 amino acids

Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Belongs to the type II topoisomerase GyrB family.

89.896 kDa

MSNSYDSSSIKVLKGLDAVRKRPGMYIGDTDDGTGLHHMVFEVVDNAIDEALAGHCKDIVVTIHADNSVSVTDDGRGIPTGIHPEEGVSAAEVIMTVLHAGGKFDDNSYKVSGGLHGVGVSVVNALSQKLELVIQRDGKIHRQIYEHGVPQAPLAVTGDTDKTGTMVRFWPSHETFTNVTEFEYEILAKRLRELSFLNSGVSIRLRDKRDGKEDHFHYEGGIKAFVEYLNKNKTPIHPNIFYFSTEKDGIGVEVALQWNDGFQENIYCFTNNIPQRDGGTHLAGFRAAMTRTLNAYMDKEGYSKKAKVSATGDDAREGLIAVVSVKVPDPKFSSQTKDKLVSSEVKSAVEQQMNELLSEYLLENPSDAKIVVGKIIDAARAREAARRAREMTRRKGALDLAGLPGKLADCQERDPALSELYLVEGDSAGGSAKQGRNRKNQAILPLKGKILNVEKARFDKMLSSQEVATLITALGCGIGRDEYNPDKLRYHSIIIMTDADVDGSHIRTLLLTFFYRQMPEIVERGHVYIAQPPLYKVKKGKQEQYIKDDEAMDQYQISIALDGATLHANAHAPALSGEALEKLVSEYNATQKMIGRMERRFPKALLKELVYQPTLTEADLSDEQTVTRWVNALITELNEKEQHGSQWKFDVHTNTEQNLFEPIVRVRTHGVDTDYPLDHEFVTGAEYRRICTLGEKLRGLIEEDAFIERGERRQPVTSFEQALEWLVKESRRGLAIQRYKGLGEMNPDQLWETTMDPESRRMLRVTVKDAIAADQLFTTLMGDAVEPRRAFIEENALKAANIDI

gyrB

DNA gyrase subunit B

804 amino acids

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Belongs to the type II topoisomerase GyrB family.

89.95 kDa

MSNSYDSSSIKVLKGLDAVRKRPGMYIGDTDDGTGLHHMVFEVVDNAIDEALAGHCKEIIVTIHADNSVSVQDDGRGIPTGIHPEEGVSAAEVIMTVLHAGGKFDDNSYKVSGGLHGVGVSVVNALSQKLELVIQREGKIHRQIYEHGVPQAPLAVTGETEKTGTMVRFWPSLETFTNVTEFEYEILAKRLRELSFLNSGVSIRLRDKRDGKEDHFHYEGGIKAFVEYLNKNKTPIHPNIFYFSTEKDGIGVEVALQWNDGFQENIYCFTNNIPQRDGGTHLAGFRAAMTRTLNAYMDKEGYSKKAKVSATGDDAREGLIAVVSVKVPDPKFSSQTKDKLVSSEVKSAVEQQMNELLAEYLLENPTDAKIVVGKIIDAARAREAARRAREMTRRKGALDLAGLPGKLADCQERDPALSELYLVEGDSAGGSAKQGRNRKNQAILPLKGKILNVEKARFDKMLSSQEVATLITALGCGIGRDEYNPDKLRYHSIIIMTDADVDGSHIRTLLLTFFYRQMPEIVERGHVYIAQPPLYKVKKGKQEQYIKDDEAMDQYQISIALDGATLHTNASAPALAGEALEKLVSEYNATQKMINRMERRYPKAMLKELIYQPTLTEADLSDEQTVTRWVNALVSELNDKEQHGSQWKFDVHTNAEQNLFEPIVRVRTHGVDTDYPLDHEFITGGEYRRICTLGEKLRGLLEEDAFIERGERRQPVASFEQALDWLVKESRRGLSIQRYKGLGEMNPEQLWETTMDPESRRMLRVTVKDAIAADQLFTTLMGDAVEPRRAFIEENALKAANIDI

gyrB

DNA gyrase subunit B

804 amino acids

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Belongs to the type II topoisomerase GyrB family.

89.896 kDa

MSNSYDSSSIKVLKGLDAVRKRPGMYIGDTDDGTGLHHMVFEVVDNAIDEALAGHCKDIVVTIHADNSVSVTDDGRGIPTGIHPEEGVSAAEVIMTVLHAGGKFDDNSYKVSGGLHGVGVSVVNALSQKLELVIQRDGKIHRQIYEHGVPQAPLAVTGDTDKTGTMVRFWPSHETFTNVTEFEYEILAKRLRELSFLNSGVSIRLRDKRDGKEDHFHYEGGIKAFVEYLNKNKTPIHPNIFYFSTEKDGIGVEVALQWNDGFQENIYCFTNNIPQRDGGTHLAGFRAAMTRTLNAYMDKEGYSKKAKVSATGDDAREGLIAVVSVKVPDPKFSSQTKDKLVSSEVKSAVEQQMNELLSEYLLENPSDAKIVVGKIIDAARAREAARRAREMTRRKGALDLAGLPGKLADCQERDPALSELYLVEGDSAGGSAKQGRNRKNQAILPLKGKILNVEKARFDKMLSSQEVATLITALGCGIGRDEYNPDKLRYHSIIIMTDADVDGSHIRTLLLTFFYRQMPEIVERGHVYIAQPPLYKVKKGKQEQYIKDDEAMDQYQISIALDGATLHANAHAPALSGEALEKLVSEYNATQKMIGRMERRFPKALLKELVYQPTLTEADLSDEQTVTRWVNALITELNEKEQHGSQWKFDVHTNTEQNLFEPIVRVRTHGVDTDYPLDHEFVTGAEYRRICTLGEKLRGLIEEDAFIERGERRQPVTSFEQALEWLVKESRRGLAIQRYKGLGEMNPDQLWETTMDPESRRMLRVTVKDAIAADQLFTTLMGDAVEPRRAFIEENALKAANIDI

gyrB

DNA gyrase subunit B

804 amino acids

Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Belongs to the type II topoisomerase GyrB family.

89.896 kDa

MSNSYDSSSIKVLKGLDAVRKRPGMYIGDTDDGTGLHHMVFEVVDNAIDEALAGHCKDIVVTIHADNSVSVTDDGRGIPTGIHPEEGVSAAEVIMTVLHAGGKFDDNSYKVSGGLHGVGVSVVNALSQKLELVIQRDGKIHRQIYEHGVPQAPLAVTGDTDKTGTMVRFWPSHETFTNVTEFEYEILAKRLRELSFLNSGVSIRLRDKRDGKEDHFHYEGGIKAFVEYLNKNKTPIHPNIFYFSTEKDGIGVEVALQWNDGFQENIYCFTNNIPQRDGGTHLAGFRAAMTRTLNAYMDKEGYSKKAKVSATGDDAREGLIAVVSVKVPDPKFSSQTKDKLVSSEVKSAVEQQMNELLSEYLLENPSDAKIVVGKIIDAARAREAARRAREMTRRKGALDLAGLPGKLADCQERDPALSELYLVEGDSAGGSAKQGRNRKNQAILPLKGKILNVEKARFDKMLSSQEVATLITALGCGIGRDEYNPDKLRYHSIIIMTDADVDGSHIRTLLLTFFYRQMPEIVERGHVYIAQPPLYKVKKGKQEQYIKDDEAMDQYQISIALDGATLHANAHAPALSGEALEKLVSEYNATQKMIGRMERRFPKALLKELVYQPTLTEADLSDEQTVTRWVNALITELNEKEQHGSQWKFDVHTNTEQNLFEPIVRVRTHGVDTDYPLDHEFVTGAEYRRICTLGEKLRGLIEEDAFIERGERRQPVTSFEQALEWLVKESRRGLAIQRYKGLGEMNPDQLWETTMDPESRRMLRVTVKDAIAADQLFTTLMGDAVEPRRAFIEENALKAANIDI

gyrB

DNA gyrase subunit B

804 amino acids

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Belongs to the type II topoisomerase GyrB family.

89.95 kDa

MSNSYDSSSIKVLKGLDAVRKRPGMYIGDTDDGTGLHHMVFEVVDNAIDEALAGHCKEIIVTIHADNSVSVQDDGRGIPTGIHPEEGVSAAEVIMTVLHAGGKFDDNSYKVSGGLHGVGVSVVNALSQKLELVIQREGKIHRQIYEHGVPQAPLAVTGETEKTGTMVRFWPSLETFTNVTEFEYEILAKRLRELSFLNSGVSIRLRDKRDGKEDHFHYEGGIKAFVEYLNKNKTPIHPNIFYFSTEKDGIGVEVALQWNDGFQENIYCFTNNIPQRDGGTHLAGFRAAMTRTLNAYMDKEGYSKKAKVSATGDDAREGLIAVVSVKVPDPKFSSQTKDKLVSSEVKSAVEQQMNELLAEYLLENPTDAKIVVGKIIDAARAREAARRAREMTRRKGALDLAGLPGKLADCQERDPALSELYLVEGDSAGGSAKQGRNRKNQAILPLKGKILNVEKARFDKMLSSQEVATLITALGCGIGRDEYNPDKLRYHSIIIMTDADVDGSHIRTLLLTFFYRQMPEIVERGHVYIAQPPLYKVKKGKQEQYIKDDEAMDQYQISIALDGATLHTNASAPALAGEALEKLVSEYNATQKMINRMERRYPKAMLKELIYQPTLTEADLSDEQTVTRWVNALVSELNDKEQHGSQWKFDVHTNAEQNLFEPIVRVRTHGVDTDYPLDHEFITGGEYRRICTLGEKLRGLLEEDAFIERGERRQPVASFEQALDWLVKESRRGLSIQRYKGLGEMNPEQLWETTMDPESRRMLRVTVKDAIAADQLFTTLMGDAVEPRRAFIEENALKAANIDI

gyrB

DNA gyrase subunit B

804 amino acids

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Belongs to the type II topoisomerase GyrB family.

92.732 kDa

MKNTYTSSNIKILKGLDAVKKRPGMYIGNTDDGTGLHHMVFEVVDNSIDEALAGFCKNIIVTIHDDNSISIQDDGRGIPTDIHDEEGISAAEVIMTVLHAGGKFDNTSYKVSGGLHGVGVSVVNALSKKLELFIYRDKKIYYQIYKNGYPKNTLSIIGYTKITGTKIRFWPNLEIFTNVTQFNWEILSKRLRELSFLNSNVSIYLDDAKKHINENFYQQGGLKEFIIYLNKNKKPIHSKIFYFSSKKNNVEVEIAMQWNKGFQENIYCYTNNIPQQDGGTHLSGFRSALTRTMNNYLDKEGYIKKNKINIIGDDTREGLTAIISIKINDPKFSSQTKNKLVSSEVKSALESLVNEFLMEFLLENPQESKNIVTKIIESSRVRNAARRAREMTRKKGTLDLIGLPGKLSDCQERDPALSEIYLVEGDSAGGSAKQARNRKNQAILPLKGKILNVEKARYEKMLSSQEVTTLITALGCGIGKNEYNPEKLRYHRIIIMTDADVDGSHIRTLLLTFFYRYMPEIIQRGYLYIAQPPLYKVTKNNKTRYIKDKNTMENYKLSTALENTILESNTDKEIKIKCNYTLKKIISEYKIIQTIFFKIKDNFPLNILNEMLYHPKLNNLNDEVYVNNWINNFVIQLQKKSSSTRNYSAHITFNSKDKIFEPLIKIQKNAEVKEYKFDITFINSYEYQKIYSLGKKLQEMIQKNIHIKKNNKTYSIKNFQKNFELLIQNSFKNVLIQRYKGLGEMNPEQLWKTTMNPETRRMLKITLHNIDTTNKLFNTLMGDSVEPRKLFIELYALKASNIDI

gyrB

DNA gyrase subunit B

804 amino acids

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Belongs to the type II topoisomerase GyrB family.

89.584 kDa

MDAQEKKYDASAITVLEGLQAVRERPGMYIGDTGVTGLHHLVYEVVDNSIDEAMAGFCTEVVVRILEDGGISVSDNGRGIPVQIHEKESAKQGREISALEVVLTVLHAGGKFDKDSYKVSGGLHGVGVSCVNALSEKFIANVFKDGQAYSMEFSKGAPLTALQVLGSTDKRGTEILFYPDPTVFSTCVFDRAILMKRLRELAFLNRGITIIFEDDRDAGFDKVTFFYEGGIQSFVSYLNQNKESLFPTPIYIQGSKRGDDGDIEFEAALQWNSGYSELIYSYANNIPTRQGGTHLTGFSTALTRAVNSYIKSHNLAKSDKLSLTGEDIREGLVAIVSVKVPNPQFEGQTKQKLGNSDVGSVAQQISGEVLTTFFEENPQIAKTIVDKVFVAAQAREAAKRARELTIRKSALDSARLPGKLVDCLEKDPEKCEMYIVEGDSAGGSAKQGRDRRFQAILPIRGKILNVEKARLQKIFQNQEIGSIIAALGCGIGTDNFNLSKLRYKRVIIMTDADVDGSHIRTLLLTFFYRHMSALIENGCVYIAQPPLYRVSKKKDFRYILSEKEMDGYLLNLGTRESRVVFDDTARELEGTALESFVNLILEVESFIIALEKRAIPFSEFLDMFRDGAYPLYYYPPESGKQGGNYLYSNEEKEAAVAANEEAAARIIELYKASAFEEIQHNLNEYGYDIRHYLHPKGTGITVSTEDSKTPNYTCYTLKEVIDYLKGLGRKGIEIQRYKGLGEMNADQLWDTTMNPEQRTLVRVSLKDAVEADHIFTMLMGEEVPPRREFIESHALSIRMSNLDI

gyrB

DNA gyrase subunit B

804 amino acids

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Belongs to the type II topoisomerase GyrB family.

89.774 kDa

MDAQEKKYDASAITVLEGLQAVRERPGMYIGDTGVTGLHHLVYEVVDNSIDEAMAGFCTEVVVRILEDGGISISDNGRGIPIQIHEKESAKQGREISALEVVLTVLHAGGKFDKDSYKVSGGLHGVGVSCVNALSEKFIAKVFKDGQAYSMEFSRGAPLTTLQVLGPTDKRGTEVLFYPDPAIFSTCVFDRAILMKRLRELAFLNRGVTIVFEDDRDTGFDKVVFFYEGGIQSFVSYLNQNKEILFPNPIYMQGSRPGDDGDIEFEAALQWNSGYSELIYSYANNIPTRQGGTHLTGFSTALTRAVNSYIKAHNLSKSDKLSLTGEDIKEGLVAIVSVKVPNPQFEGQTKQKLGNSDVGSVSQQISGEVLTTFFEENPQIAKTIVDKVFVAAQAREAAKRARELTLRKSALDSARLPGKLIDCLEKDPEKCEMYIVEGDSAGGSAKQGRDRRFQAILPIRGKILNVEKARLQKVFQNQEIGSIIAALGCGIGKDNFNLSKLRYKRIIIMTDADVDGSHIRTLLLTFFYRHMSALIENECVYIAQPPLYRVSKKKDFRYILSEKEMDGYLLNLGTKESQIVFDDTLRDLRGEALETFVNLILEVESFIVSLEKKAIPFSEFLDMFRDGAYPLYYYPPESGKQGGSYLYSHEEKEAAIAANEESASRILELYKGSVLEELQRDLGDYGYDIRNYLHPKGSGITVSTEDPKISPYVCYTLKEVIDYLKGLGRKGIEIQRYKGLGEMNADQLWDTTMNPEQRTLVRVSLKDAVEADHIFTMLMGEEVPPRREFIESHALSIRMNNLDI

gyrB

DNA gyrase subunit B

804 amino acids

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Belongs to the type II topoisomerase GyrB family.

89.95 kDa

MSNSYDSSSIKVLKGLDAVRKRPGMYIGDTDDGTGLHHMVFEVVDNAIDEALAGHCKEIIVTIHADNSVSVQDDGRGIPTGIHPEEGVSAAEVIMTVLHAGGKFDDNSYKVSGGLHGVGVSVVNALSQKLELVIQREGKIHRQIYEHGVPQAPLAVTGETEKTGTMVRFWPSLETFTNVTEFEYEILAKRLRELSFLNSGVSIRLRDKRDGKEDHFHYEGGIKAFVEYLNKNKTPIHPNIFYFSTEKDGIGVEVALQWNDGFQENIYCFTNNIPQRDGGTHLAGFRAAMTRTLNAYMDKEGYSKKAKVSATGDDAREGLIAVVSVKVPDPKFSSQTKDKLVSSEVKSAVEQQMNELLAEYLLENPTDAKIVVGKIIDAARAREAARRAREMTRRKGALDLAGLPGKLADCQERDPALSELYLVEGDSAGGSAKQGRNRKNQAILPLKGKILNVEKARFDKMLSSQEVATLITALGCGIGRDEYNPDKLRYHSIIIMTDADVDGSHIRTLLLTFFYRQMPEIVERGHVYIAQPPLYKVKKGKQEQYIKDDEAMDQYQISIALDGATLHTNASAPALAGEALEKLVSEYNATQKMINRMERRYPKAMLKELIYQPTLTEADLSDEQTVTRWVNALVSELNDKEQHGSQWKFDVHTNAEQNLFEPIVRVRTHGVDTDYPLDHEFITGGEYRRICTLGEKLRGLLEEDAFIERGERRQPVASFEQALDWLVKESRRGLSIQRYKGLGEMNPEQLWETTMDPESRRMLRVTVKDAIAADQLFTTLMGDAVEPRRAFIEENALKAANIDI

gyrB

DNA gyrase subunit B

804 amino acids

DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner to maintain chromosomes in an underwound state (PubMed:186775, PubMed:3031051, PubMed:1323022, PubMed:8248233, PubMed:7811004, PubMed:8621650, PubMed:9657678, PubMed:12051842, PubMed:12051843, PubMed:18642932, PubMed:19060136, PubMed:19965760, PubMed:22457353, PubMed:23294697, PubMed:20356737, PubMed:20675723, PubMed:23352267, PubMed:24386374, PubMed:25202966, PubMed:25849408). This makes better substrates for topoisomerase 4 (ParC and ParE) which is the main enzyme that unlinks newly replicated chromosomes in E.coli (PubMed:9334322). Gyrase catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes (PubMed:22457352). Relaxes negatively supercoiled DNA in an ATP-independent manner (PubMed:337300). E.coli gyrase has higher supercoiling activity than other characterized bacterial gyrases; at comparable concentrations E.coli gyrase introduces more supercoils faster than M.tuberculosis gyrase, while M.tuberculosis gyrase has higher decatenation than supercoiling activity compared to E.coli (PubMed:22457352). E.coli makes 15% more negative supercoils in pBR322 plasmid DNA than S.typhimurium; the S.typhimurium GyrB subunit is toxic in E.coli, while the E.coli copy can be expressed in S.typhimurium even though the 2 subunits have 777/804 residues identical (PubMed:17400739). The enzymatic differences between E.coli gyrase and topoisomerase IV are largely due to the GyrA C-terminal domain (approximately residues 524-841) and specifically the GyrA-box (PubMed:8962066, PubMed:16332690).

Belongs to the type II topoisomerase family.

89.95 kDa

MSNSYDSSSIKVLKGLDAVRKRPGMYIGDTDDGTGLHHMVFEVVDNAIDEALAGHCKEIIVTIHADNSVSVQDDGRGIPTGIHPEEGVSAAEVIMTVLHAGGKFDDNSYKVSGGLHGVGVSVVNALSQKLELVIQREGKIHRQIYEHGVPQAPLAVTGETEKTGTMVRFWPSLETFTNVTEFEYEILAKRLRELSFLNSGVSIRLRDKRDGKEDHFHYEGGIKAFVEYLNKNKTPIHPNIFYFSTEKDGIGVEVALQWNDGFQENIYCFTNNIPQRDGGTHLAGFRAAMTRTLNAYMDKEGYSKKAKVSATGDDAREGLIAVVSVKVPDPKFSSQTKDKLVSSEVKSAVEQQMNELLAEYLLENPTDAKIVVGKIIDAARAREAARRAREMTRRKGALDLAGLPGKLADCQERDPALSELYLVEGDSAGGSAKQGRNRKNQAILPLKGKILNVEKARFDKMLSSQEVATLITALGCGIGRDEYNPDKLRYHSIIIMTDADVDGSHIRTLLLTFFYRQMPEIVERGHVYIAQPPLYKVKKGKQEQYIKDDEAMDQYQISIALDGATLHTNASAPALAGEALEKLVSEYNATQKMINRMERRYPKAMLKELIYQPTLTEADLSDEQTVTRWVNALVSELNDKEQHGSQWKFDVHTNAEQNLFEPIVRVRTHGVDTDYPLDHEFITGGEYRRICTLGEKLRGLLEEDAFIERGERRQPVASFEQALDWLVKESRRGLSIQRYKGLGEMNPEQLWETTMDPESRRMLRVTVKDAIAADQLFTTLMGDAVEPRRAFIEENALKAANIDI

gyrB

DNA gyrase subunit B

803 amino acids

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Belongs to the type II topoisomerase GyrB family.

92.411 kDa

MKNIYDSSNIKILRGLDAVRKRPGMYIGDTDDGSGLHHMVFEIVDNSIDEALSGYCKEIIVTIHSDNSVSVKDDGRGIPTDIHPEENISAAEVILTVLHSGGKFDNASYQISGGLHGVGISVVNALSEKLELIIDKNKKKYQQIYRHGKPENPLSIIGTTDTTGTYIRFWPSYKTFTNNIKFQYEILSKRLRELSFLNSNIAIYLEDNRTSIKNCYHYKGGIKAFIKFLNAKKTPIHTHIFYFRSTKDQIELEIAMQWNNSHQENILCFTNNIPQKDGGTHLAGFRSGMTRTLNLHIEREGYNKKNKTTIIGEDVREGLTAIISIKIPDPKFSSQTKDKLVSSEARSVIESLINENLIEYLLENPSDSKFIIQKIINAAKVREAARRAREINKKKSILDLGALPGKLSDCQENDPKFSEIYLVEGDSAGGSAKQGRNRKNQAILPLKGKILNVEKSKFDKMILSQEVASLITALGCGIGKNEYNIDKLRYHYIIIMTDADVDGAHIRTLLLTFFYRQLPELIEKGYVYIAQPPLYKLKKGRKEKYIKNDEEMNTYQIKNALKDLVLKSEDNLIINQKLKKFKKIMSEYHYIQIIMKQSKHYFPKLVFNELIYHNHLHNLKDIEIVKEWIYTLAENLNKKDNSNNHYSIEIKENLDKNIFEPTIKISRYAHYTKYDFKEEFLKSKEYLLITNLGESFKKYFSDKVLIEKSGSTYKIDSIKNTWKWLIKQSKRGLFIQRYKGLGEMNPEQLWNTTMNPETRNMLQVTIKDAVSANNLFNTLMGEAVEPRRQFIENNALKAENIDV

gyrB

DNA gyrase subunit B

803 amino acids

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Belongs to the type II topoisomerase GyrB family.

92.678 kDa

MIDTYDSSKIKILRGLDAVRKRPGMYIGDTDDGSGLHHMVFEIVDNSIDEALAGFCKEIKVVIHSDNSVSIKDDGRGIPTDIHPEEKISAAEVIMTVLHSGGKFDNASYKISGGLHGVGISVVNALSEKLELIIYKNKKKYRQQYKNGNPESPLCIIGATEITGTYIRFWPSYKIFTNKTQFQYEILSKRLRELSFLNSNILIHLKDNRTNLEEKYHYKGGIKAFIKFLNKNKFPINLNIFYFRCIKNQIELEIAIQWNNSHQENILCFTNNIPQKDGGTHLSGFRAGITRTLNLHIEREGYNKKNKTIITGEDTREGLTAIISIKIPDPKFSSQTKDKLVSSEVKSVIESLINENLIEYLLENPIDAKFIIQKIINSAKIREAARRAREINKKKGTLDLGTLPGKLSDCQENDPKLSEIYLVEGDSAGGSAKQGRNRKNQAILPLKGKILNVQKTKFDKIILSQELTSLITALGCSITKSEYSLDKLRYNHIIIMTDADVDGAHIRTLLLTFFYRQLPELIKKGYVYIAQPPLYKVKKGKQEKYIKNDEEMNKYQIKIALKEIVIKNKKNENCNKIIKEFQKIVSDFNHIQIKMKKNKNYFPELILNELIYHPRLYNLKNENVVQNWIEKLVEKLNKKDKNNTIYTSKIKRNENDSIFEPSIKLSRYANHTQYDLKNDFLESKEYFLITNLGEKFKKFQENENFIEKGEKIYKINDIKNTLEWLIKETKRGFFVQRYKGLGEMNPDQLWNTTMNPETRNMLQVTIKDAISANNLFNTLMGDLVEPRRKFIQKNALKAENIDI

gyrB

DNA gyrase subunit B

795 amino acids

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Belongs to the type II topoisomerase GyrB family.

88.164 kDa

MTEQKHEEYGADSIQVLEGLEAVPKRPGMYIGDTQDGSGLHHMVFEVLDNAIDEALAGHCDKITVTIHADHSVSVADNGRGMPTGIHPKEGRSAAEVIMTVLHAGGKFDNNSYKISGGLHGVGVSVVNALSDWVTLTIYRDGKEHFVRFVRGETEEPLKIVGDSDKKGTTVRFLAGTETFGNIEYSFDILAKRIRELSFLNNGVDIELTDERDGKHESFALSGGVAGFVQYMNRKKTPLHEKIFYAFGEKDGMSVECAMQWNDSYQESVQCFTNNIPQRDGGTHLTALRQVMTRTINSYIEANEVAKKAKVETAGDDMREGLTCVLSVKLPDPKFSSQTKDKLVSGEIGPVVNEVINQALTDFLEENPNEAKIITGKIVDAARARQAARKAREITRRKGLMDGLGLPGKLADCQEKDPALSELYLVEGNSAGGSAMQGRDRKFQAILPLKGKILNVEKARFEKMLASQEVATLITALGAGIGKEEFNPEKLRYHRIIIMTDADVDGAHIRTLLLTFFYRQMPDLVERGYIYIAQPPLYKAKYGKQERYLKDELEKDQWLLGLALEKAKIVSDGRTIEGAELADTAKQFLLAKTVIEQESRFVDELVLRAMLHASPIDLTSSENADKAVAELSGLLDEKEAALERIEGHEGHQFIKITRKLHGNVMVSYIEPKFLNSKAYQTLTQTAAALKGLVGEGAKLYKGENEYDADSFETALDILMSVAQKGMSIQRYKGLGEMNPEQLWETTMDPTVRRLLKVRIEDRIADEVFVTLMGDEVEPRRAFIENNALIAQNIDA

gyrB

Type 2 topoisomerase subunit B

792 amino acids

A type II topoisomerase. Despite its similarity to DNA gyrase, this enzyme is not able to supercoil DNA, and instead acts like topoisomerase IV. Relaxes both positively and negatively supercoiled DNA in an ATP-dependent fashion, decatenates interlocked circles. If this subunit is reconstituted with GyrA from E.coli the hybrid enzyme supercoils relaxed plasmid DNA; if paired with E.coli ParC supercoiling is not restored. This the first bacteria shown to not contain DNA gyrase, although it has 2 copies of a reverse gyrase that introduces positive supercoils. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner (PubMed:21076033).

Belongs to the type II topoisomerase GyrB family.

90.53 kDa

MKKRQSQTPQEYTAEAIKAVSGLEHVRLRPAMYIGDIGERGLHHLIWEILDNAVDEAVAGYARNISVTIHRDNSVTVEDDGRGIPVDIHPETGKPAVEMVFTMLGAGGKFEKKVYTYSGGLHGVGASVVNALSEWLIVEVYRDGKIYRMAFKRGEVVEPLHVVGETKKRGTKVSFKPDPEIFETTEIKFDIVEKRVRELAYLNPEVKFELTDERLGKHLIYKFDRGIEELVKYLNEGKEPLFKDIIRIQGEKEGVIVDIAFQYVKDYKERIESFVNNIKTVEGGTHVTGFRSGLSKAVIRMAQGLKLAKELKKSFTGEDVREGLTAVVACKVPNPQFEGQTKTKLGNQNVKQIVESITYDFLTSYFEKKRDVLKAIVEKAIEAALAREAAKKAKELVRRKSPLEEGVLPGKLADCSETDPSKCEIFLVEGDSAGGSAKQARDRRYQAILPLRGKIINVEKARIDKVLSNDEIKAIVSALGCGIGEDLDLKKLRYHKIILMTDADVDGSHIRTLLLTFFYRFMPKLVEEGYVYIAEPPLYRVKKGKKEIYIKDDKEFEHFLLNEIREKGRLVDAREKEFKGEELVRLLIDLKDYEDAYRALVKSKGENLVNFLLTHRVREEDLRNPARVKEITHLMEEELGDYRVDTKYNELEGAYDIIFYDDKLGTKTIIDVNFLSSLSYREVLEGIHLHLPVQVFFENKKVEINSLGEIYDKFMDFARSGMEVQRYKGLGEMNPEQLWETTMNPKTRRLKKVKIEDAAEADRIFTILMGEQVEPRREFIEAYAKEVKHLDV

gyrB

DNA gyrase subunit B

773 amino acids

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Belongs to the type II topoisomerase GyrB family.

87.439 kDa

MQNYQSHSIKVLKGLEGVRKRPGMYIGDTNVGGLHHMVYEVVDNAVDESMAGFCDTINITLTEEGSCIVEDNGRGIPVDIHPTEKIPACTVVLTILHAGGKFDNDTYKVSGGLHGVGVSVVNALSKRLIMTIKKEGQIYRQEFEKGIPISELEIIGKTKSAKESGTTIEFFPDESVMEVVEFQAGILQKRFKEMAYLNDGLKISFKEEKTQLQETYFYKDGLKQFVKDSAKKELLTPIIAFKSMDEETRTSIEVALAYADDYNENTLSFVNNIKTSEGGTHEAGFKMGLSKAILQYIDNNIKTKESRPISEDIKEGLIAVVSLKMSEPLFEGQTKSKLGSSYARALVSKLVYDKIHQFLEENPNEAKIIANKALLAAKAREASKKARELTRKKDNLSVGTLPGKLADCQSKDPLESEIFLVEGDSAGGSAKQGRDRVFQAILPLKGKILNVEKSHLSKILKSEEIKNMITAFGCGIQESFDIERLRYHKIIIMTDADVDGSHIQTLLMTFFYRYLRPLIEQGHVFIAQAPLYKYKKGKTEIYLKDSVALDHFLIEHGINSVDIEGIGKNDLMNLLKVARHYRYTLLELEKRYNLLEVLRFLIETKDALSLDMKVLEKSILEKLEGLNYQILRSFATEESLHLHAQTPKGLVEFNLDDNLFKDVLFEEAHYTYQKLMEYNLDFLENKDILAFLEEVENYAKKGANIQRYKGLGEMNPNDLWETTMHKENRSLIKLKIEDLEKTDAVFSLCMGDEVEPRRAFIQAHAKDVKQLDV

gyrB

DNA gyrase subunit B

773 amino acids

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Belongs to the type II topoisomerase GyrB family.

87.367 kDa

MQNYQSHSIKVLKGLEGVRKRPGMYIGDTNVGGLHHMVYEVVDNAVDESMAGFCDTINITLTDEGSCIVEDNGRGIPVDIHPTEKIPACTVVLTILHAGGKFDNDTYKVSGGLHGVGVSVVNALSKRLIMTIKKEGQIYRQEFEKGIPTSELEIIGKTKSAKESGTTIEFFPDESVMEVVEFQAGILQKRFKEMAYLNDGLKISFKEEKTQLQETYFYEDGLKQFVKDSAKKELLTPIISFKSMDEETRTSIEVALAYADDYNENTLSFVNNIKTSEGGTHEAGFKMGLSKAILQYIGNNIKTKESRPISEDIKEGLIAVVSLKMSEPLFEGQTKSKLGSSYARALVSKLVYDKIHQFLEENPNEAKIIANKALLAAKAREASKKARELTRKKDNLSVGTLPGKLADCQSKDPLESEIFLVEGDSAGGSAKQGRDRVFQAILPLKGKILNVEKSHLSKILKSEEIKNMITAFGCGIQESFDIERLRYHKIIIMTDADVDGSHIQTLLMTFFYRYLRPLIEQGHVYIAQAPLYKYKKGKTEIYLKDSVALDHFLIEHGINSVDIEGIGKNDLMNLLKVARHYRYALLELEKRYNLLEILRFLIETKDALSLDMKVLEKSILEKLEGLNYQILRSFATEESLHLHTQTPKGLVEFNLDDNLFKEVLFEEANYTYQKLMEYNLDFLENKDILAFLEEVENHAKKGANIQRYKGLGEMNPNDLWETTMHKENRSLIKLKIEDLEKTDAVFSLCMGDEVEPRRAFIQAHAKDVKQLDV

gyrB

DNA gyrase subunit B

769 amino acids

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Belongs to the type II topoisomerase GyrB family.

86.649 kDa

MQENYGASNIKVLKGLEAVRKRPGMYIGDTNIGGLHHMIYEVVDNSIDEAMAGHCDTIDVEITTEGSCIVSDNGRGIPVDMHPTENMPTLTVVLTVLHAGGKFDKDTYKVSGGLHGVGVSVVNALSKKLVATVERNGEIYRQEFSEGKVISEFGVIGKSKKTGTTIEFWPDDQIFEVTEFDYEILAKRFRELAYLNPKITINFKDNRVGKHESFHFEGGISQFVTDLNKKEALTKAIFFSVDEEDVNVEVALLYNDTYSENLLSFVNNIKTPDGGTHEAGFRMGLTRVISNYIEANASAREKDNKITGDDVREGLIAIVSVKVPEPQFEGQTKGKLGSTYVRPIVSKASFEYLTKYFEENPIEAKAIMNKALMAARGREAAKKARELTRKKESLSVGTLPGKLADCQSKDPSESEIYLVEGDSAGGSAKQGRERSFQAILPLRGKILNVEKARLDKILKSEQIQNMITAFGCGIGEDFDLSKLRYHKIIIMTDADVDGSHIQTLLLTFFFRFMNELVANGHIYLAQPPLYLYKKAKKQIYLKDEKALSEYLIETGIEGLNYEGIGMNDLKDYLKIVAAYRAILKDLEKRFNVISVIRYMIENSNLVKGNNEELFSVIKQFLETQGHNILNHYINENEIRAFVQTQNGLEELVINEELFTHPLYEEASYIFDKIKDRSLEFDKDILEVLEDVETNAKKGATIQRYKGLGEMNPEQLWETTMDPSVRRLLKITIEDAQSANDTFNLFMGDEVEPRRDYIQAHAKDVKHLDV

GYRB

DNA gyrase subunit B, chloroplastic/mitochondrial

731 amino acids

Seems to play a critical role in chloroplast nucleoid partitioning by regulating DNA topology. A type II topoisomerase that negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner.

Belongs to the type II topoisomerase GyrB family.

81.6 kDa

MALLKPFPLQHSLRCMASRFLLHSHYHTHTLSFSSISLSRPSIVLNPRVINKLRRLSDAILIRNMVSLRAFMSSSTTTEAFQENTKSKGYGSEQIQVLEGLDPVRKRPGMYIGSTGPRGLHHLVYEILDNAVDEAQAGFATKIDVVLHADNSVSIADNGRGIPTELHPVTKKSSLETVLTVLHAGGKFGGSSSGYNVSGGLHGVGLSVVNALSQALEVTIWRDGKEYQQKYSRGKPITTLICHDLPVEMRDRQGTAIRFWPDKEVFTTEMQFDYNTIAGRIRELAFLNPELTIALKKEDIDPEKIQCNEYFYAGGLVEYVKWLNADKKPLHDVLGFRKEADGITIDMALQWCSDAYSDTMLGYANSIRTIDGGTHIDGVKAALTRILNNLGKKSKTIKEKDISLSGEHVREGLTCVISVKVPNPEFEGQTKTRLGNPEVRKVVDQSVQEYLTEYLELHPDVLDSILSKSLNALKAALAAKRARELVRQKSVLKSSSLPGKLADCSATNPEEAEIFIVEGDSAGGSAKQGRDRRFQAILPLRGKILNIERKDEAAMYKNEEIQNLILGLGLGVKGEDFKKEALRYHKIIILTDADVDGAHIRTLLLTFFFRYQRALFEEGCIYVGVPPLYKVERGKQVYYCYDDAELKKVQRSFPSNASYNIQRFKGLGEMMPAQLWETTMNPETRLLKQLVVEDAAEANVVFSSLMGSRVDIRKQLIQNSASMMNLEQLDI

GYRB

DNA gyrase subunit B, chloroplastic/mitochondrial

731 amino acids

Seems to play a critical role in chloroplast nucleoid partitioning by regulating DNA topology. A type II topoisomerase that negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner.

Belongs to the type II topoisomerase GyrB family.

81.6 kDa

MALLKPFPLQHSLRCMASRFLLHSHYHTHTLSFSSISLSRPSIVLNPRVINKLRRLSDAILIRNMVSLRAFMSSSTTTEAFQENTKSKGYGSEQIQVLEGLDPVRKRPGMYIGSTGPRGLHHLVYEILDNAVDEAQAGFATKIDVVLHADNSVSIADNGRGIPTELHPVTKKSSLETVLTVLHAGGKFGGSSSGYNVSGGLHGVGLSVVNALSQALEVTIWRDGKEYQQKYSRGKPITTLICHDLPVEMRDRQGTAIRFWPDKEVFTTEMQFDYNTIAGRIRELAFLNPELTIALKKEDIDPEKIQCNEYFYAGGLVEYVKWLNADKKPLHDVLGFRKEADGITIDMALQWCSDAYSDTMLGYANSIRTIDGGTHIDGVKAALTRILNNLGKKSKTIKEKDISLSGEHVREGLTCVISVKVPNPEFEGQTKTRLGNPEVRKVVDQSVQEYLTEYLELHPDVLDSILSKSLNALKAALAAKRARELVRQKSVLKSSSLPGKLADCSATNPEEAEIFIVEGDSAGGSAKQGRDRRFQAILPLRGKILNIERKDEAAMYKNEEIQNLILGLGLGVKGEDFKKEALRYHKIIILTDADVDGAHIRTLLLTFFFRYQRALFEEGCIYVGVPPLYKVERGKQVYYCYDDAELKKVQRSFPSNASYNIQRFKGLGEMMPAQLWETTMNPETRLLKQLVVEDAAEANVVFSSLMGSRVDIRKQLIQNSASMMNLEQLDI

GYRB

DNA gyrase subunit B, chloroplastic/mitochondrial

729 amino acids

A type II topoisomerase that negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner.

Belongs to the type II topoisomerase GyrB family.

80.469 kDa

MGPLLRSSPPPRHLRLLLRRLLSTAAGRPSRLLPLPASSSARLLVRPRVAVAAAAAGAPLRRNGVAVRAFMASTAASEAMQEKRVAGEYTAANVQVLEALDGVRTRPGMYIGSTGSRGLHHLVYEILDNAVDEAQAGYATKVDVILHGDNSVSVTDNGRGIPTDIHPQTKKSCVETVLTLMHAGGKFGGSKSGYTVSGGLHGVGLSVVNALSEALEVTVWRDGKEYRQNYSRGKAITMLTSRTLSDESSSRQGTRIRFWPDKHIFTTTMDFDFNTIAGRIRELAFLNPELTIALTKEEDDLQVQHNEYCYAGGLVEYVKWLNTDKKSLHDPIAFRKEMDGITVDVSLQWCSDSYSDTVLGYANSIRTIDGGTHIDGLKTSLTRTINNFAKKSKTLKDKDISLSGEHVREGMTCIIAVKVPNPEFEGQTKTRLGNPEVRRIVEQSVQENLTEYLELHPDVLDSILSKSLNALKAALAAKRARELVRTKSVLKSSSLPGKLADCASSDPEESEIFIVEGDSAGGSAKQGRDRKFQAILPLRGKILNIERRDEAALYKNEEIQNLIVALGLGVKGEDFNKEALRYHKIVILTDADVDGAHIRTLLLTFFFRYQKALFDEGCIYVGVPPLYKVERGKQAHYCYDDADLKELVNTFPTNASYHIQRFKGLGEMMPAQLWETTMDPERRMLKQLKVEDAAEANVVFSSLMGTRVDVRKQLIQNAASMVNLEHLDI

GYRB

DNA gyrase subunit B, chloroplastic/mitochondrial

729 amino acids

A type II topoisomerase that negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner.

Belongs to the type II topoisomerase GyrB family.

80.469 kDa

MGPLLRSSPPPRHLRLLLRRLLSTAAGRPSRLLPLPASSSARLLVRPRVAVAAAAAGAPLRRNGVAVRAFMASTAASEAMQEKRVAGEYTAANVQVLEALDGVRTRPGMYIGSTGSRGLHHLVYEILDNAVDEAQAGYATKVDVILHGDNSVSVTDNGRGIPTDIHPQTKKSCVETVLTLMHAGGKFGGSKSGYTVSGGLHGVGLSVVNALSEALEVTVWRDGKEYRQNYSRGKAITMLTSRTLSDESSSRQGTRIRFWPDKHIFTTTMDFDFNTIAGRIRELAFLNPELTIALTKEEDDLQVQHNEYCYAGGLVEYVKWLNTDKKSLHDPIAFRKEMDGITVDVSLQWCSDSYSDTVLGYANSIRTIDGGTHIDGLKTSLTRTINNFAKKSKTLKDKDISLSGEHVREGMTCIIAVKVPNPEFEGQTKTRLGNPEVRRIVEQSVQENLTEYLELHPDVLDSILSKSLNALKAALAAKRARELVRTKSVLKSSSLPGKLADCASSDPEESEIFIVEGDSAGGSAKQGRDRKFQAILPLRGKILNIERRDEAALYKNEEIQNLIVALGLGVKGEDFNKEALRYHKIVILTDADVDGAHIRTLLLTFFFRYQKALFDEGCIYVGVPPLYKVERGKQAHYCYDDADLKELVNTFPTNASYHIQRFKGLGEMMPAQLWETTMDPERRMLKQLKVEDAAEANVVFSSLMGTRVDVRKQLIQNAASMVNLEHLDI

gyrB

DNA gyrase subunit B

720 amino acids

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Belongs to the type II topoisomerase GyrB family.

78.896 kDa

MVDAMPENPAEEPTAASAAPNPEAVPDAVGQPEAPVKDRKVPGEYGASAITVLEGLEAVRKRPGMYIGSTGPRGLHHLVYEVVDNSVDEALAGYATGIDVTLQADGGVRVADDGRGIPVDLHPTEGRPTVEVVMTILHAGGKFGGGGYAVSGGLHGVGISVVNALSRRVDTEVRRQGHVWRMSFADGGVPQGELVKGEATDATGTVQTFYPDAEIFDSIEFDYETLRARFQQMAFLNKGLRITLTDERVQESNEVVDDEIAGEGAAGEDVAENGLAEDAEQEPQRRSVTYLYENGLLDYVQHLNSAKKVEYVHDDVIAFEAEDFSDGRSMAVEVAMQWTSAYSESVHTYANTINTHEGGTHEEGFRAALTSLVNRYAREKEILKPKEDNLSGEDIREGLTAVISVKLSEPQFEGQTKTKLGNSEARGFVSKAVTDHLGDWFERNPGPAKEIIRKAIMASHARLAARKARDNARRKSPLESFGMPGKLADCSSKDPERCEVYIVEGDSAGGSAKQGRNPETQAILPLRGKILNVERARLDKALGNAEIQSMITAFGTNIGEEFDISKLRYHKIVLMADADVDGQHITTLLLTVLFRYMRPLIEAGHVFLAQPPLYRIKWSNAPHDYVFSDEERDAAVEAGLAKGWRYPKDNGVQRYKGLGEMNYQELWDTTMDPEHRTLLQVTMEDAAAADAVFSMLMGEDVESRRTFIQQNAKDIRFLDV

gyrB

DNA gyrase subunit B

678 amino acids

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state (PubMed:17325221). Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Belongs to the type II topoisomerase GyrB family.

74.674 kDa

MAAQRKAQDEYGAASITILEGLEAVRKRPGMYVGSTGERGLHHLIWEVVDNSVDEAMAGYATQVDVRLFDDGSVEVADNGRGIPVAVHATGVPTVDVVMTQLHAGGKFGGKDSGYNVSGGLHGVGVSVVNALSTRVEVDIKRDGYEWSQFYDKAVPGILKQGEATEATGTTIRFWADPDIFETTKYDFGTVARRIQEVAFLNKGLTINLVDERVKQDEVVDDVVSDTAEAPVAMTVEEKSTESSAPHKVRHRTFHYPGGLVDFVKHINRTKTPIQQSIIDFDGKGAGHEVEVAMQWNGGYSESVHTFANTINTHEGGTHEEGFRSALTSVVNKYAKDKKLLKDKDPNLTGDDIREGLAAVISVKVSEPQFEGQTKTKLGNTEVKSFVQRVCNEQLIHWFEANPVDAKAVVNKAISSAQARIAARKARELVRRKSATDLGGLPGKLADCRSTDPRSSELYVVEGDSAGGSAKSGRDSMFQAILPLRGKIINVEKARIDRVLKNTEVQAIITALGTGIHDEFDISRLRYHKIVLMADADVDGQHISTLLLTLLFRFMRPLIEHGYVFLAQPPLYKLKWQRMDPEFAYSDSERDGLLETGLKLGKKINKEDGIQRYKGLGEMDAKELWETTMDPSVRVLRQVTLDDAAAADELFSILMGEDVDARRSFITRNAKDVRFLDV

gyrB

DNA gyrase subunit B

677 amino acids

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Belongs to the type II topoisomerase GyrB family.

74.531 kDa

MAAQKKKAQDEYGASAITVLEGLEAVRKRPGMYIGSTGERGLHHLIWEVVDNSVDEAMAGYADRVDVRILDDGSVEVADNGRGIPVAMHATGAPTVDVVMTQLHAGGKFGGENSGYNVSGGLHGVGVSVVNALSTRLEVNIARDGYEWSQYYDHAVPGTLKQGEATKRTGTTIRFWADPDIFETTEYDFETVARRLQEMAFLNKGLTINLTDERVTNEEVVDEVVSDTADAPKSAQEKAAESAAPHKVKHRTFHYPGGLVDFVKHINRTKNPIHQSIIDFGGKGPGHEVEIAMQWNGGYSESVHTFANTINTHEGGTHEEGFRSALTSVVNKYAKDKKLLKDKDPNLTGDDIREGLAAVISVKVSEPQFEGQTKTKLGNTEVKSFVQKVCNEQLTHWFEANPADAKVIVNKAVSSAQARIAARKARELVRRKSATDLGGLPGKLADCRSTDPRKSELYVVEGDSAGGSAKSGRDSMFQAILPLRGKIINVEKARIDRVLKNTEVQAIITALGTGIHDEFDITKLRYHKIVLMADADVDGQHISTLLLTLLFRFMRPLIEHGHVFLAQPPLYKLKWQRSDPEFAYSDRERDGLLEAGLKAGKKINKDDGIQRYKGLGEMDAKELWETTMDPTVRVLRQVTLDDAAAADELFSILMGEDVDARRSFITRNAKDVRFLDV

gyrB

DNA gyrase subunit B

675 amino acids

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner (PubMed:8878580) to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Belongs to the type II topoisomerase GyrB family.

74.512 kDa

MAAQKNNAPKEYGADSITILEGLEAVRKRPGMYIGSTGERGLHHLIWEVVDNAVDEAMAGFATRVDVKIHADGSVEVRDDGRGIPVEMHATGMPTIDVVMTQLHAGGKFDGETYAVSGGLHGVGVSVVNALSTRLEATVLRDGYEWFQYYDRSVPGKLKQGGETKETGTTIRFWADPEIFETTDYNFETVARRLQEMAFLNKGLTIELTDERVTAEEVVDDVVKDTAEAPKTADEKAAEATGPSKVKHRVFHYPGGLVDYVKHINRTKTPIQQSIIDFDGKGPGHEVEIAMQWNAGYSESVHTFANTINTHEGGTHEEGFRAALTSVVNRYAKDKKLLKDKDPNLTGDDIREGLAAVISVKVAEPQFEGQTKTKLGNTEVKSFVQKICNEQLQHWFEANPAEAKTVVNKAVSSAQARIAARKARELVRRKSATDIGGLPGKLADCRSTDPSKSELYVVEGDSAGGSAKSGRDSMFQAILPLRGKIINVEKARIDRVLKNTEVQSIITALGTGIHDEFDISKLRYHKIVLMADADVDGQHISTLLLTLLFRFMKPLVENGHIFLAQPPLYKLKWQRSEPEFAYSDRERDGLLEAGRAAGKKINVDDGIQRYKGLGEMDAKELWETTMDPSVRVLRQVTLDDAAAADELFSILMGEDVEARRSFITRNAKDVRFLDV

gyrB

DNA gyrase subunit B

675 amino acids

Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Belongs to the type II topoisomerase GyrB family.

74.512 kDa

MAAQKNNAPKEYGADSITILEGLEAVRKRPGMYIGSTGERGLHHLIWEVVDNAVDEAMAGFATRVDVKIHADGSVEVRDDGRGIPVEMHATGMPTIDVVMTQLHAGGKFDGETYAVSGGLHGVGVSVVNALSTRLEATVLRDGYEWFQYYDRSVPGKLKQGGETKETGTTIRFWADPEIFETTDYNFETVARRLQEMAFLNKGLTIELTDERVTAEEVVDDVVKDTAEAPKTADEKAAEATGPSKVKHRVFHYPGGLVDYVKHINRTKTPIQQSIIDFDGKGPGHEVEIAMQWNAGYSESVHTFANTINTHEGGTHEEGFRAALTSVVNRYAKDKKLLKDKDPNLTGDDIREGLAAVISVKVAEPQFEGQTKTKLGNTEVKSFVQKICNEQLQHWFEANPAEAKTVVNKAVSSAQARIAARKARELVRRKSATDIGGLPGKLADCRSTDPSKSELYVVEGDSAGGSAKSGRDSMFQAILPLRGKIINVEKARIDRVLKNTEVQSIITALGTGIHDEFDISKLRYHKIVLMADADVDGQHISTLLLTLLFRFMKPLVENGHIFLAQPPLYKLKWQRSEPEFAYSDRERDGLLEAGRAAGKKINVDDGIQRYKGLGEMDAKELWETTMDPSVRVLRQVTLDDAAAADELFSILMGEDVEARRSFITRNAKDVRFLDV

gyrB

DNA gyrase subunit B

675 amino acids

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Belongs to the type II topoisomerase GyrB family.

74.091 kDa

MAAQKKKAQDEYGAASITILEGLEAVRKRPGMYIGSTGERGLHHLIWEVVDNAVDEAMAGYATTVNVVLLEDGGVEVADDGRGIPVATHASGIPTVDVVMTQLHAGGKFDSDAYAISGGLHGVGVSVVNALSTRLEVEIKRDGYEWSQVYEKSEPLGLKQGAPTKKTGSTVRFWADPAVFETTEYDFETVARRLQEMAFLNKGLTINLTDERVTQDEVVDEVVSDVAEAPKSASERAAESTAPHKVKSRTFHYPGGLVDFVKHINRTKNAIHSSIVDFSGKGTGHEVEIAMQWNAGYSESVHTFANTINTHEGGTHEEGFRSALTSVVNKYAKDRKLLKDKDPNLTGDDIREGLAAVISVKVSEPQFEGQTKTKLGNTEVKSFVQKVCNEQLTHWFEANPTDAKVVVNKAVSSAQARIAARKARELVRRKSATDIGGLPGKLADCRSTDPRKSELYVVEGDSAGGSAKSGRDSMFQAILPLRGKIINVEKARIDRVLKNTEVQAIITALGTGIHDEFDIGKLRYHKIVLMADADVDGQHISTLLLTLLFRFMRPLIENGHVFLAQPPLYKLKWQRSDPEFAYSDRERDGLLEAGLKAGKKINKEDGIQRYKGLGEMDAKELWETTMDPSVRVLRQVTLDDAAAADELFSILMGEDVDARRSFITRNAKDVRFLDV

gyrB

DNA gyrase subunit B

675 amino acids

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Belongs to the type II topoisomerase GyrB family.

74.091 kDa

MAAQKKKAQDEYGAASITILEGLEAVRKRPGMYIGSTGERGLHHLIWEVVDNAVDEAMAGYATTVNVVLLEDGGVEVADDGRGIPVATHASGIPTVDVVMTQLHAGGKFDSDAYAISGGLHGVGVSVVNALSTRLEVEIKRDGYEWSQVYEKSEPLGLKQGAPTKKTGSTVRFWADPAVFETTEYDFETVARRLQEMAFLNKGLTINLTDERVTQDEVVDEVVSDVAEAPKSASERAAESTAPHKVKSRTFHYPGGLVDFVKHINRTKNAIHSSIVDFSGKGTGHEVEIAMQWNAGYSESVHTFANTINTHEGGTHEEGFRSALTSVVNKYAKDRKLLKDKDPNLTGDDIREGLAAVISVKVSEPQFEGQTKTKLGNTEVKSFVQKVCNEQLTHWFEANPTDAKVVVNKAVSSAQARIAARKARELVRRKSATDIGGLPGKLADCRSTDPRKSELYVVEGDSAGGSAKSGRDSMFQAILPLRGKIINVEKARIDRVLKNTEVQAIITALGTGIHDEFDIGKLRYHKIVLMADADVDGQHISTLLLTLLFRFMRPLIENGHVFLAQPPLYKLKWQRSDPEFAYSDRERDGLLEAGLKAGKKINKEDGIQRYKGLGEMDAKELWETTMDPSVRVLRQVTLDDAAAADELFSILMGEDVDARRSFITRNAKDVRFLDV

gyrB

DNA gyrase subunit B

675 amino acids

Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Belongs to the type II topoisomerase GyrB family.

74.091 kDa

MAAQKKKAQDEYGAASITILEGLEAVRKRPGMYIGSTGERGLHHLIWEVVDNAVDEAMAGYATTVNVVLLEDGGVEVADDGRGIPVATHASGIPTVDVVMTQLHAGGKFDSDAYAISGGLHGVGVSVVNALSTRLEVEIKRDGYEWSQVYEKSEPLGLKQGAPTKKTGSTVRFWADPAVFETTEYDFETVARRLQEMAFLNKGLTINLTDERVTQDEVVDEVVSDVAEAPKSASERAAESTAPHKVKSRTFHYPGGLVDFVKHINRTKNAIHSSIVDFSGKGTGHEVEIAMQWNAGYSESVHTFANTINTHEGGTHEEGFRSALTSVVNKYAKDRKLLKDKDPNLTGDDIREGLAAVISVKVSEPQFEGQTKTKLGNTEVKSFVQKVCNEQLTHWFEANPTDAKVVVNKAVSSAQARIAARKARELVRRKSATDIGGLPGKLADCRSTDPRKSELYVVEGDSAGGSAKSGRDSMFQAILPLRGKIINVEKARIDRVLKNTEVQAIITALGTGIHDEFDIGKLRYHKIVLMADADVDGQHISTLLLTLLFRFMRPLIENGHVFLAQPPLYKLKWQRSDPEFAYSDRERDGLLEAGLKAGKKINKEDGIQRYKGLGEMDAKELWETTMDPSVRVLRQVTLDDAAAADELFSILMGEDVDARRSFITRNAKDVRFLDV

gyrB

DNA gyrase subunit B

650 amino acids

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Belongs to the type II topoisomerase GyrB family.

73.605 kDa

MEENNKANIYDSSSIKVLEGLEAVRKRPGMYIGSTGEEGLHHMIWEIVDNSIDEAMGGFASFVKLTLEDNFVTRVEDDGRGIPVDIHPKTNRSTVETVFTVLHAGGKFDNDSYKVSGGLHGVGASVVNALSSSFKVWVFRQNKKYFLSFSDGGKVIGDLVQEGNSEKEHGTIVEFVPDFSVMEKSDYKQTVIVSRLQQLAFLNKGIRIDFVDNRKQNPQSFSWKYDGGLVEYIHHLNNEKEPLFNEVIADEKTETVKAVNRDENYTVKVEVAFQYNKTYNQSIFSFCNNINTTEGGTHVEGFRNALVKIINRFAVENKFLKDSDEKINRDDVCEGLTAIISIKHPNPQYEGQTKKKLGNTEVRPLVNSVVSEIFERFMLENPQEANAIIRKTLLAQEARRRSQEARELTRRKSPFDSGSLPGKLADCTTRDPSISELYIVEGDSAGGTAKTGRDRYFQAILPLRGKILNVEKSNFEQIFNNAEISALVMAIGCGIKPDFELEKLRYSKIVIMTDADVDGAHIRTLLLTFFFRFMYPLVEQGNIFIAQPPLYKVSYSHKDLYMHTDVQLEQWKSQNPNVKFGLQRYKGLGEMDALQLWETTMDPKVRTLLKVTVEDASIADKAFSLLMGDEVPPRREFIEKNARSVKNIDI

gyrB

DNA gyrase subunit B

650 amino acids

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Belongs to the type II topoisomerase GyrB family.

73.81 kDa

MEDNNKTQAYDSSSIKILEGLEAVRKRPGMYIGSTGEEGLHHMIWEIIDNSIDEAMGGFASTVKLTLKDNFVTIVEDDGRGIPVDIHPKTNRSTVETVFTVLHAGGKFDNDSYKVSGGLHGVGASVVNALSSSFKVWVAREHQQYFLAFHNGGEVIGDLVNEGKCDKEHGTKVEFVPDFTVMEKSDYKQTVIASRLQQLAFLNKGIQIDFVDERRQNPQSFSWKYDGGLVQYIHHLNNEKEPLFEDIIFGEKTDTVKSVSRDESYTIKVEVAFQYNKTYNQSIFSFCNNINTTEGGTHVEGFRNALVKIINRFAVENKFLKETDEKITRDDICEGLTAIISIKHPNPQYEGQTKKKLGNTEVRPLVNSIVSEIFERFMLENPQEANAIIRKTLLAQEARRRSQEARELTRRKSPFDSGSLPGKLADCTTRDPSISELYIVEGDSAGGTAKTGRDRYFQAILPLRGKILNVEKSHFEQIFNNVEISALVMAVGCGIKPDFELEKLRYNKIIIMTDADVDGAHIRTLLLTFFFRFMYPLVEQGNIYIAQPPLYKVSYSNKDLYMQTDVQLEEWKQQHPNLKYNLQRYKGLGEMDAIQLWETTMDPKVRTLLKVTVEDASIADKAFSLLMGDEVPPRREFIEQNARNVKNIDI

gyrB

DNA gyrase subunit B

648 amino acids

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Belongs to the type II topoisomerase GyrB family.

73.713 kDa

MNNTKKDQYSSQSIKVLEGLSAVRKRPGMYIGSTDQKGLHHMIWEIIDNSVDEMMAGYGTTVKLTLKDNYLVEVEDDGRGIPVDIHEKTNKSTVETVLTILHAGGKFDSDTYSMSGGLHGVGASVVNALSSSFKVWVNRDYKIHYIEFKDGGVPLKPLEIIGTDSKKQGTRIQFVPDFSIMEQFEYDETIIADRIEQLAFLNKGIKFIFNDERTDKKTKQEWLYEGGIKQYVENLNASKEPIIPQIIYGEKKTKVTLPKRNLEVTMLLEVAFQYTNGYYNSTYSFCNNIHTNQGGTHEEGFKNALYKIINRYALEKKFIKETDGKISKEDLSEGLTAIISIKHSEPQYQGQTKDRLGNTEVREFTNSVVSELLERFFLENPEEAAKITAKAVSAMFSRKRSEAALESARKSPFESASLPGKLADCTTKDMEISELYIVEGDSAGGSAKSGRDRFYQAILPLRGKVLNVEKANHEKIFKNEEIRTLITAIGAGVNPEFSLDKIRYNKIIIMTDADVDGAHIRILLLTFFFRHMFPLIEKGHVYIAQPPLYRVSYNKQNKYIYSDAQLEEWKNQNPNVRYELQRYKGLGEMDDVQLWETTMDPEKRTLLKVSINDAANADKTFSLLMGDEVSPRRDFIEKNAKSVKNIDF

gyrB

DNA gyrase subunit B

648 amino acids

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Belongs to the type II topoisomerase GyrB family.

72.64 kDa

MDKIEEIHKYNADNIQILEGLEAVRKRPGMYIGSIGFKGLHHLLWEIVDNSVDEAMAGFATEIKIKLYPNNVIEVEDNGRGMPTGIHSGTKKSAVETILTVLHAGGKFDGSNYKVSGGLHGVGASVVNALSSEFEVWVKRDGKLHYQQFRNGGIPVKPLEVIGNVSEVETGTTIKFHPDYTIMEKENFDFDTIIDHSKQIAYLNKGLKITVENVEKNIIKVFCFEGGLIDYVKELNKGKKLIVPEVIYAEGVFNDKNFTNGQDVIVEVAMQYNEAYTNSIVSYANNIQTIDGGTHEQGFYDALVRIYNNYAETNKLFKTSSEKITREDVKEGLVAIISIKHTDPIFEGQTKGKLENKDARIATNKILSDSLERYLNENPEIARAIIEKCLLSQHTRLLEIKAREASRKGNGLDLGNLPGKLADCSSKNAEIRELFIVEGNSAGGSAKMGRDRSIQAILPLRGKVINAEKNSFASVLSNKEIATMIHALGTGINTEFDINKLKYHKIIIMTDADVDGAHITTLLLTFFYRYMKPLIEYGFVYLAQPPLYKITSGKNVEYAYNDLQKEQIMAKLEDKRNVAIQRYKGLGEMDPEQLWETTMDPETRKMLQVQIDDAAICDTVFATLMGEEIEPRHDFIQENAKYANNIDI

gyrB

DNA gyrase subunit B

644 amino acids

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Belongs to the type II topoisomerase GyrB family.

72.54 kDa

MVTALSDVNNTDNYGAGQIQVLEGLEAVRKRPGMYIGSTSERGLHHLVWEIVDNSIDEALAGYANQIEVVIEKDNWIKVTDNGRGIPVDIQEKMGRPAVEVILTVLHAGGKFGGGGYKVSGGLHGVGSSVVNALSQDLEVYVHRNETIYHQAYKKGVPQFDLKEVGTTDKTGTVIRFKADGEIFTETTVYNYETLQQRIRELAFLNKGIQITLRDERDEENVREDSYHYEGGIKSYVELLNENKEPIHDEPIYIHQSKDDIEVEIAIQYNSGYATNLLTYANNIHTYEGGTHEDGFKRALTRVLNSYGLSSKIMKEEKDRLSGEDTREGMTAIISIKHGDPQFEGQTKTKLGNSEVRQVVDKLFSEHFERFLYENPQVARTVVEKGIMAARARVAAKKAREVTRRKSALDVASLPGKLADCSSKSPEECEIFLVEGDSAGGSTKSGRDSRTQAILPLRGKILNVEKARLDRILNNNEIRQMITAFGTGIGGDFDLAKARYHKIVIMTDADVDGAHIRTLLLTFFYRFMRPLIEAGYVYIAQPPLYKLTQGKQKYYVYNDRELDKLKSELNPTPKWSIARYKGLGEMNADQLWETTMNPEHRALLQVKLEDAIEADQTFEMLMGDVVENRRQFIEDNAVYANLDF

gyrB

DNA gyrase subunit B

644 amino acids

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Belongs to the type II topoisomerase GyrB family.

72.512 kDa

MVTALSDVNNTDNYGAGQIQVLEGLEAARKRPGMYIGSTSERGLHHLVWEIVDNSIDEALAGYANQIEVVIEKDNWIKVTDNGRGIPVDIQEKMGRPAVEVILTVLHAGGKFGGGGYKVSGGLHGVGSSVVNALSQDLEVYVHRNETIYHQAYKKGVPQFDLKEVGTTDKTGTVIRFKADGEIFTETTVYNYETLQQRIRELAFLNKGIQITLRDERDEENVREDSYHYEGGIKSYVELLNENKEPIHDEPIYIHQSKDDIEVEIAIQYNSGYATNLLTYANNIHTYEGGTHEDGFKRALTRVLNSYGLSSKIMKEEKDRLSGEDTREGMTAIISIKHGDPQFEGQTKTKLGNSEVRQVVDKLFSEHFERFLYENPQVARTVVEKGIMAARARVAAKKAREVTRRKSALDVASLPGKLADCSSKSPEECEIFLVEGDSAGGSTKSGRDSRTQAILPLRGKILNVEKARLDRILNNNEIRQMITAFGTGIGGDFDLAKARYHKIVIMTDADVDGAHIRTLLLTFFYRFMRPLIEAGYVYIAQPPLYKLTQGKQKYYVYNDRELDKLKSELNPTPKWSIARYKGLGEMNADQLWETTMNPEHRALLQVKLEDAIEADQTFEMLMGDVVENRRQFIEDNAVYANLDF

gyrB

DNA gyrase subunit B

644 amino acids

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Belongs to the type II topoisomerase GyrB family.

72.54 kDa

MVTALSDVNNTDNYGAGQIQVLEGLEAVRKRPGMYIGSTSERGLHHLVWEIVDNSIDEALAGYANKIEVVIEKDNWIKVTDNGRGIPVDIQEKMGRPAVEVILTVLHAGGKFGGGGYKVSGGLHGVGSSVVNALSQDLEVYVHRNETIYHQAYKKGVPQFDLKEVGTTDKTGTVIRFKADGEIFTETTVYNYETLQQRIRELAFLNKGIQITLRDERDEENVREDSYHYEGGIKSYVELLNENKEPIHDEPIYIHQSKDDIEVEIAIQYNSGYATNLLTYANNIHTYEGGTHEDGFKRALTRVLNSYGLSSKIMKEEKDRLSGEDTREGMTAIISIKHGDPQFEGQTKTKLGNSEVRQVVDKLFSEHFERFLYENPQVARTVVEKGIMAARARVAAKKAREVTRRKSALDVASLPGKLADCSSKSPEECEIFLVEGDSAGGSTKSGRDSRTQAILPLRGKILNVEKARLDRILNNNEIRQMITAFGTGIGGDFDLAKARYHKIVIMTDADVDGAHIRTLLLTFFYRFMRPLIEAGYVYIAQPPLYKLTQGKQKYYVYNDRELDKLKSELNPTPKWSIARYKGLGEMNADQLWETTMNPEHRALLQVKLEDAIEADQTFEMLMGDVVENRRQFIEDNAVYANLDF

gyrB

DNA gyrase subunit B

644 amino acids

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Belongs to the type II topoisomerase GyrB family.

72.54 kDa

MVTALSDVNNTDNYGAGQIQVLEGLEAVRKRPGMYIGSTSERGLHHLVWEIVDNSIDEALAGYANKIEVVIEKDNWIKVTDNGRGIPVDIQEKMGRPAVEVILTVLHAGGKFGGGGYKVSGGLHGVGSSVVNALSQDLEVYVHRNETIYHQAYKKGVPQFDLKEVGTTDKTGTVIRFKADGEIFTETTVYNYETLQQRIRELAFLNKGIQITLRDERDEENVREDSYHYEGGIKSYVELLNENKEPIHDEPIYIHQSKDDIEVEIAIQYNSGYATNLLTYANNIHTYEGGTHEDGFKRALTRVLNSYGLSSKIMKEEKDRLSGEDTREGMTAIISIKHGDPQFEGQTKTKLGNSEVRQVVDKLFSEHFERFLYENPQVARTVVEKGIMAARARVAAKKAREVTRRKSALDVASLPGKLADCSSKSPEECEIFLVEGDSAGGSTKSGRDSRTQAILPLRGKILNVEKARLDRILNNNEIRQMITAFGTGIGGDFDLAKARYHKIVIMTDADVDGAHIRTLLLTFFYRFMRPLIEAGYVYIAQPPLYKLTQGKQKYYVYNDRELDKLKSELNPTPKWSIARYKGLGEMNADQLWETTMNPEHRALLQVKLEDAIEADQTFEMLMGDVVENRRQFIEDNAVYANLDF

gyrB

DNA gyrase subunit B

644 amino acids

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Belongs to the type II topoisomerase GyrB family.

72.526 kDa

MVTALSDVNNTDNYGAGQIQVLEGLEAVRKRPGMYIGSTSERGLHHLVWEIVDNSIDEALAGYANQIEVVIEKDNWIKVTDNGRGIPVDIQEKMGRPAVEVILTVLHAGGKFGGGGYKVSGGLHGVGSSVVNALSQDLEVYVHRNETIYHQAYKKGVPQFDLKEVGTTDKTGTVIRFKADGEIFTETTVYNYETLQQRIRELAFLNKGIQITLRDERDEENVREDSYHYEGGIKSYVELLNENKEPIHDEPIYIHQSKDDIEVEIAIQYNSGYATNLLTYANNIHTYEGGTHEDGFKRALTRVLNSYGLSSKIMKEDKDRLSGEDTREGMTAIISIKHGDPQFEGQTKTKLGNSEVRQVVDKLFSEHFERFLYENPQVARTVVEKGIMAARARVAAKKAREVTRRKSALDVASLPGKLADCSSKSPEECEIFLVEGDSAGGSTKSGRDSRTQAILPLRGKILNVEKARLDRILNNNEIRQMITAFGTGIGGDFDLAKARYHKIVIMTDADVDGAHIRTLLLTFFYRFMRPLIEAGYVYIAQPPLYKLTQGKQKYYVYNDRELDKLKSELNPTPKWSIARYKGLGEMNADQLWETTMNPEHRALLQVKLEDAIEADQTFEMLMGDVVENRRQFIEDNAVYANLDF

gyrB

DNA gyrase subunit B

644 amino acids

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Belongs to the type II topoisomerase GyrB family.

72.54 kDa

MVTALSDVNNTDNYGAGQIQVLEGLEAVRKRPGMYIGSTSERGLHHLVWEIVDNSIDEALAGYANQIEVVIEKDNWIKVTDNGRGIPVDIQEKMGRPAVEVILTVLHAGGKFGGGGYKVSGGLHGVGSSVVNALSQDLEVYVHRNETIYHQAYKKGVPQFDLKEVGTTDKTGTVIRFKADGEIFTETTVYNYETLQQRIRELAFLNKGIQITLRDERDEENVREDSYHYEGGIKSYVELLNENKEPIHDEPIYIHQSKDDIEVEIAIQYNSGYATNLLTYANNIHTYEGGTHEDGFKRALTRVLNSYGLSSKIMKEEKDRLSGEDTREGMTAIISIKHGDPQFEGQTKTKLGNSEVRQVVDKLFSEHFERFLYENPQVARTVVEKGIMAARARVAAKKAREVTRRKSALDVASLPGKLADCSSKSPEECEIFLVEGDSAGGSTKSGRDSRTQAILPLRGKILNVEKARLDRILNNNEIRQMITAFGTGIGGDFDLAKARYHKIVIMTDADVDGAHIRTLLLTFFYRFMRPLIEAGYVYIAQPPLYKLTQGKQKYYVYNDRELDKLKSELNPTPKWSIARYKGLGEMNADQLWETTMNPEHRALLQVKLEDAIEADQTFEMLMGDVVENRRQFIEDNAVYANLDF

gyrB

DNA gyrase subunit B

644 amino acids

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Belongs to the type II topoisomerase GyrB family.

72.512 kDa

MVTALSDVNNTDNYGAGQIQVLEGLEAARKRPGMYIGSTSERGLHHLVWEIVDNSIDEALAGYANQIEVVIEKDNWIKVTDNGRGIPVDIQEKMGRPAVEVILTVLHAGGKFGGGGYKVSGGLHGVGSSVVNALSQDLEVYVHRNETIYHQAYKKGVPQFDLKEVGTTDKTGTVIRFKADGEIFTETTVYNYETLQQRIRELAFLNKGIQITLRDERDEENVREDSYHYEGGIKSYVELLNENKEPIHDEPIYIHQSKDDIEVEIAIQYNSGYATNLLTYANNIHTYEGGTHEDGFKRALTRVLNSYGLSSKIMKEEKDRLSGEDTREGMTAIISIKHGDPQFEGQTKTKLGNSEVRQVVDKLFSEHFERFLYENPQVARTVVEKGIMAARARVAAKKAREVTRRKSALDVASLPGKLADCSSKSPEECEIFLVEGDSAGGSTKSGRDSRTQAILPLRGKILNVEKARLDRILNNNEIRQMITAFGTGIGGDFDLAKARYHKIVIMTDADVDGAHIRTLLLTFFYRFMRPLIEAGYVYIAQPPLYKLTQGKQKYYVYNDRELDKLKSELNPTPKWSIARYKGLGEMNADQLWETTMNPEHRALLQVKLEDAIEADQTFEMLMGDVVENRRQFIEDNAVYANLDF

gyrB

DNA gyrase subunit B

644 amino acids

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Belongs to the type II topoisomerase GyrB family.

72.54 kDa

MVTALSDVNNTDNYGAGQIQVLEGLEAVRKRPGMYIGSTSERGLHHLVWEIVDNSIDEALAGYANKIEVVIEKDNWIKVTDNGRGIPVDIQEKMGRPAVEVILTVLHAGGKFGGGGYKVSGGLHGVGSSVVNALSQDLEVYVHRNETIYHQAYKKGVPQFDLKEVGTTDKTGTVIRFKADGEIFTETTVYNYETLQQRIRELAFLNKGIQITLRDERDEENVREDSYHYEGGIKSYVELLNENKEPIHDEPIYIHQSKDDIEVEIAIQYNSGYATNLLTYANNIHTYEGGTHEDGFKRALTRVLNSYGLSSKIMKEEKDRLSGEDTREGMTAIISIKHGDPQFEGQTKTKLGNSEVRQVVDKLFSEHFERFLYENPQVARTVVEKGIMAARARVAAKKAREVTRRKSALDVASLPGKLADCSSKSPEECEIFLVEGDSAGGSTKSGRDSRTQAILPLRGKILNVEKARLDRILNNNEIRQMITAFGTGIGGDFDLAKARYHKIVIMTDADVDGAHIRTLLLTFFYRFMRPLIEAGYVYIAQPPLYKLTQGKQKYYVYNDRELDKLKSELNPTPKWSIARYKGLGEMNADQLWETTMNPEHRALLQVKLEDAIEADQTFEMLMGDVVENRRQFIEDNAVYANLDF

gyrB

DNA gyrase subunit B

644 amino acids

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Belongs to the type II topoisomerase GyrB family.

72.54 kDa

MVTALSDVNNTDNYGAGQIQVLEGLEAVRKRPGMYIGSTSERGLHHLVWEIVDNSIDEALAGYANKIEVVIEKDNWIKVTDNGRGIPVDIQEKMGRPAVEVILTVLHAGGKFGGGGYKVSGGLHGVGSSVVNALSQDLEVYVHRNETIYHQAYKKGVPQFDLKEVGTTDKTGTVIRFKADGEIFTETTVYNYETLQQRIRELAFLNKGIQITLRDERDEENVREDSYHYEGGIKSYVELLNENKEPIHDEPIYIHQSKDDIEVEIAIQYNSGYATNLLTYANNIHTYEGGTHEDGFKRALTRVLNSYGLSSKIMKEEKDRLSGEDTREGMTAIISIKHGDPQFEGQTKTKLGNSEVRQVVDKLFSEHFERFLYENPQVARTVVEKGIMAARARVAAKKAREVTRRKSALDVASLPGKLADCSSKSPEECEIFLVEGDSAGGSTKSGRDSRTQAILPLRGKILNVEKARLDRILNNNEIRQMITAFGTGIGGDFDLAKARYHKIVIMTDADVDGAHIRTLLLTFFYRFMRPLIEAGYVYIAQPPLYKLTQGKQKYYVYNDRELDKLKSELNPTPKWSIARYKGLGEMNADQLWETTMNPEHRALLQVKLEDAIEADQTFEMLMGDVVENRRQFIEDNAVYANLDF

gyrB

DNA gyrase subunit B

644 amino acids

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Belongs to the type II topoisomerase GyrB family.

72.526 kDa

MVTALSDVNNTDNYGAGQIQVLEGLEAVRKRPGMYIGSTSERGLHHLVWEIVDNSIDEALAGYANQIEVVIEKDNWIKVTDNGRGIPVDIQEKMGRPAVEVILTVLHAGGKFGGGGYKVSGGLHGVGSSVVNALSQDLEVYVHRNETIYHQAYKKGVPQFDLKEVGTTDKTGTVIRFKADGEIFTETTVYNYETLQQRIRELAFLNKGIQITLRDERDEENVREDSYHYEGGIKSYVELLNENKEPIHDEPIYIHQSKDDIEVEIAIQYNSGYATNLLTYANNIHTYEGGTHEDGFKRALTRVLNSYGLSSKIMKEDKDRLSGEDTREGMTAIISIKHGDPQFEGQTKTKLGNSEVRQVVDKLFSEHFERFLYENPQVARTVVEKGIMAARARVAAKKAREVTRRKSALDVASLPGKLADCSSKSPEECEIFLVEGDSAGGSTKSGRDSRTQAILPLRGKILNVEKARLDRILNNNEIRQMITAFGTGIGGDFDLAKARYHKIVIMTDADVDGAHIRTLLLTFFYRFMRPLIEAGYVYIAQPPLYKLTQGKQKYYVYNDRELDKLKSELNPTPKWSIARYKGLGEMNADQLWETTMNPEHRALLQVKLEDAIEADQTFEMLMGDVVENRRQFIEDNAVYANLDF

gyrB

DNA gyrase subunit B

642 amino acids

DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings.

Belongs to the type II topoisomerase family.

71.878 kDa

MRERAQEYDASQIQVLEGLEAVRKRPGMYIGSTSGEGLHHLVWEIVDNSIDEALAGFAKSIQVIIEPDDSITVIDDGRGIPVGIQAKTGRPAVETVFTVLHAGGKFGGGGYKVSGGLHGVGSSVVNALSTSLDVRVYKDGKVYYQEYRRGAVVDDLKVIEETDRHGTTVHFIPDPEIFTETTVYDFDKLATRVRELAFLNRGLHISIEDRREGQEDKKEYHYEGGIKSYVEHLNANKDVIFPEPIFIEGEQQDITVEVSMQYTDGYHSNILSFANNIHTYEGGTHESGFKTSLTRVINDYARKQKLMKENDEKLTGEDVREGLTAVVSIKHPDPQFEGQTKTKLGNSEVRTVTDRLFSEYFTKFLMENPTVGKQIVEKGMLASKARLAAKRAREVTRRKGALEISNLPGKLADCSSKDPEKCELFIVEGDSAGGSAKQGRSREFQAILPIRGKILNVEKASMDKILANEEIRSLFTAMGTGFGEDFDVSKARYHKLVIMTDADVDGAHIRTLLLTLFYRFMRPIVEAGYVYIAQPPLYGVKQGKNITYVQPGKHAEEELAKVLEELPASPKPSVQRYKGLGEMDDHQLWETTMDPEKRLMARVSVDDAIEADQIFEMLMGDRVEPRRAFIEENAHYVKNLDI

gyrB

DNA gyrase subunit B

640 amino acids

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Belongs to the type II topoisomerase GyrB family.

72.763 kDa

MGDNYNSESIQILEGLEAIRKRPGMYIGATNARGLHHLVWEIVDNSIDEVLANFANKIKIILNKDESITVIDNGRGIPIEIHPKTKVSTLETVFTILHAGGKFDSNTYKISGGLHGVGASVVNALSKYLKVEVRKNNKKYVMEFHNGGQILTPIKEVGSTSETGTTVTFLPDEKIFKETTIFSFSTIQNRIKQLVFLNKGLEISLVDLREEDEEKTVLYQFNNGIKDYVLELNKTIGTPLNDVFYVEGIEDNIVVEFGLQYNDNYSENIFSFCNNINTHEGGTHEEGARLAIVREINNYFKNQINKNNKGNEDKFTWDDIKEGMTIIISIRHPEPQYEGQTNQKLLNSEVKKIVSNIVGKGLSSYLLENPEDAKKIIEKISLSLKATIVAQRAKEITRRKIVMDSFSLPGKLSDCETKDAKIAELYIVEGDSAGGSAKSGRNRKFQAILPLRGKILNVEKAKQIKIFENNEINSIITALGAGIKDNFNDKKLRYQKVIIMTDADVDGAHIRILLLTFFYRYMKDLIENGNIYIAQPPLYKVENSNQIRYVYSDNELELYKEELLKQNKNYTIQRYKGLGEMNPEQLWETTMDPERRLLLKVSVNNAFEANLICNELMGENVEPRKKFIRENAKYVKNLDV

gyrB

DNA gyrase subunit B

640 amino acids

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Belongs to the type II topoisomerase GyrB family.

72.763 kDa

MGDNYNSESIQILEGLEAIRKRPGMYIGATNARGLHHLVWEIVDNSIDEVLANFANKIKIILNKDESITVIDNGRGIPIEIHPKTKVSTLETVFTILHAGGKFDSNTYKISGGLHGVGASVVNALSKYLKVEVRKNNKKYVMEFHNGGQILTPIKEVGSTSETGTTVTFLPDEKIFKETTIFSFSTIQNRIKQLVFLNKGLEISLVDLREEDEEKTVLYQFNNGIKDYVLELNKTIGTPLNDVFYVEGIEDNIVVEFGLQYNDNYSENIFSFCNNINTHEGGTHEEGARLAIVREINNYFKNQINKNNKGNEDKFTWDDIKEGMTIIISIRHPEPQYEGQTNQKLLNSEVKKIVSNIVGKGLSSYLLENPEDAKKIIEKISLSLKATIVAQRAKEITRRKIVMDSFSLPGKLSDCETKDAKIAELYIVEGDSAGGSAKSGRNRKFQAILPLRGKILNVEKAKQIKIFENNEINSIITALGAGIKDNFNDKKLRYQKVIIMTDADVDGAHIRILLLTFFYRYMKDLIENGNIYIAQPPLYKVENSNQIRYVYSDNELELYKEELLKQNKNYTIQRYKGLGEMNPEQLWETTMDPERRLLLKVSVNNAFEANLICNELMGENVEPRKKFIRENAKYVKNLDV

gyrB

DNA gyrase subunit B

640 amino acids

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Belongs to the type II topoisomerase GyrB family.

71.896 kDa

MEQKQMQENSYDESQIQVLEGLEAVRKRPGMYIGSTSGKGLHHLVWEIVDNSIDEALAGYCDEINVSIEEDNSIRVTDNGRGIPVGIQEKMGRPAVEVIMTVLHAGGKFGGGGYKVSGGLHGVGASVVNALSTELEVFVHREGKIHYQKYERGIPVADLKVIGDTDQTGTITRFKPDPEIFQETTVYEFDTLATRMRELAFLNRNIKLTIEDKREHKQKKEFHYEGGIKSYVEHLNRSKQPIHEEPVYVEGSKDGIQVEVSLQYNEGYTNNIYSFTNNIHTYEGGTHEVGFKTALTRVINDYGRKNSILKDADSNLTGEDVREGLTAIVSIKHPNPQFEGQTKTKLGNSEARTITESVFSEAFEKFLLENPNVARKIVEKGTMAARARVAAKKARELTRRKSALEVSSLPGKLADCSSKDPAISEIYIVEGDSAGGSAKQGRDRHFQAILPLKGKIINVEKARLDKILSNDEVRTIITAIGTNIGGDFDIEKARYHKVIIMTDADVDGAHIRTLLLTFFYRYMRQIIEHGYIYIAQPPLFKVQQGKKIQYAYNEKELEKILAELPAQPKPGIQRYKGLGEMNPTQLWETTMDPEVRSLLQVSLQDAIEADETFEILMGDKVEPRRNFIQENAKYVKNLDI

gyrB

DNA gyrase subunit B

639 amino acids

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Belongs to the type II topoisomerase GyrB family.

71.201 kDa

MSQDNEYGAGQIQVLEGLEAVRKRPAMYIGSTDSRGLHHLVYEVVDNSIDEALAGHCDAIEVALHEDGSVSVTDNGRGIPVDTHEQYDRPALEVIMTVLHAGGKFDNKSYQVSGGLHGVGVSVVNALSSELEVEVKRDGAVWTHRFEVGEPQVEEFERVRDLEPGEDTGTTIRFWPDDGIFETTEFDFKTLENRLRELAFLNSGVEISLSDERTDESSTFLFEGGIREFVEYLNETKTALHDDVIYYDDESEGIEVEIAMQATDELQGSIHAFANNINTREGGTHLTGFKTALTRVVNDYANSHDMLDDLDGDNLRGEDVREGLTAVISVKHPDPQFEGQTKTKLGNSEVRGIVESVTHQQLGTFFEENPDTATAIISKAVEAARARKAAKQAEELTRRKSALESTSLPGKLADCQSRDPSESELFIVEGDSAGGSAKQGRDRKFQAILPLKGKILNVEKHRLDRILENDEIRALITAIGGGVGDEFDIEKARYQRLILMTDADVDGAHIRTLLLTLLYRHMRPLIEAGYVYAAQPPLYRVRYRGNTYDAMDEAERDRIIEEECNGNPTQVQRFKGLGEMNPDQLWDTTMNPENRVLKRITVEDAAAADRMFNILMGDAVGPRKQFIKDHANDAEWVDI

gyrB

DNA gyrase subunit B

639 amino acids

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Belongs to the type II topoisomerase GyrB family.

71.213 kDa

MSQDNEYGAGQIQVLEGLEAVRKRPAMYIGSTDSRGLHHLVYEVVDNSIDEALAGHCDAIEVALHEDGSVSVTDNGRGIPVDTHEQYDRPALEVIMTVLHAGGKFDNKSYQVSGGLHGVGVSVVNALSSELEVEVKRDGAVWTHRFEVGEPQVEEFERVRDLEPGEDTGTTIRFWPDDGIFETTEFDFKTLENRLRELAFLNSGVEISLSDERTDESSTFLFEGGIREFVEYLNETKTALHDDVIYYDDESEGIEVEIAMQATDELQGSIHAFANNINTREGGTHLTGFKTALTRVVNDYANTHDMLDDLDGDNLRGEDVREGLTAVISIKHPDPQFEGQTKTKLGNSEVRGIVESVTHQQLGTFFEENPDTATAIISKAVEAARARKAAKQAEELTRRKSALESTSLPGKLADCQSRDPAESELFIVEGDSAGGSAKQGRDRKFQAILPLKGKILNVEKHRLDRILENDEIRALITAIGGGVGDEFDIEKARYQRLILMTDADVDGAHIRTLLLTLLYRHMRPLIEAGYVYAAQPPLYRVRYRGNTYDAMDEAERDRIIEEECNGNPTQVQRFKGLGEMNPDQLWDTTMNPENRVLKRITVEDAAAADRMFNILMGDAVGPRKQFIKDHANDAEWVDI

gyrB

DNA gyrase subunit B

638 amino acids

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Belongs to the type II topoisomerase GyrB family.

71.504 kDa

MEQQQNSYDENQIQVLEGLEAVRKRPGMYIGSTNSKGLHHLVWEIVDNSIDEALAGYCTDINIQIEKDNSITVVDNGRGIPVGIHEKMGRPAVEVIMTVLHAGGKFDGSGYKVSGGLHGVGASVVNALSTELDVTVHRDGKIHRQTYKRGVPVTDLEIIGETDHTGTTTHFVPDPEIFSETTEYDYDLLANRVRELAFLTKGVNITIEDKREGQERKNEYHYEGGIKSYVEYLNRSKEVVHEEPIYIEGEKDGITVEVALQYNDSYTSNIYSFTNNINTYEGGTHEAGFKTGLTRVINDYARKKGLIKENDPNLSGDDVREGLTAIISIKHPDPQFEGQTKTKLGNSEARTITDTLFSTAMETFMLENPDAAKKIVDKGLMAARARMAAKKARELTRRKSALEISNLPGKLADCSSKDPSISELYIVEGDSAGGSAKQGRDRHFQAILPLRGKILNVEKARLDKILSNNEVRSMITALGTGIGEDFNLEKARYHKVVIMTDADVDGAHIRTLLLTFFYRYMRQIIENGYVYIAQPPLYKVQQGKRVEYAYNDKELEELLKTLPQTPKPGLQRYKGLGEMNATQLWETTMDPSSRTLLQVTLEDAMDADETFEMLMGDKVEPRRNFIEANARYVKNLDI

gyrB

DNA gyrase subunit B

638 amino acids

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Belongs to the type II topoisomerase GyrB family.

71.662 kDa

MSKQEEISKYGAKNIQFLEGLEAVRKRPGMYIGSIGFRGLHHLIWEIVDNSVDEAMAGFATNIEVKLHPNNEIEVIDNGRGMPVDIHPTTKKSAVETILTVLYAGGKFDSTNYKVSGGLHGVGVSVVNALSDSFEVWVKRGGKFYYQKYINGGHPVKPLEVIGEVNKDETGTRIKFHPDYQIMDKVAFDFGTIIDHAKQIAYLNKGLSISCEDITKNTIRNFCFEGGIIDYVSELNRGKKVIIPDIIYAEGTFRDKTPNAQDVIVNVAIQYNETYTSNIVSYANNIQTGEGGTHEQGFYDALTRIYNKYAEDNKLFKNNNEKISREDTKDGLVAIISIKHTDPIFEGQTKGKLENKDARIATNKIISEQLERYMAENPSHAKAIIEKCLLTQRSRLAANAAREASRKKEGSEFGNLPGKLADCSSKNAEVRELFIVEGNSAGGSAKMGRDRATQAILPLRGKIINAEKQDFTSVMSNKEVSSMIHALGTGITDEFNINKLKYHKIVIMTDADVDGAHIATLLLTFFYRYMRPLIEYGFVYIAQPPLYKISTAKVTEYAYNDAQKEEILSKLEDSKNISIQRYKGLGEMDPEQLWETTMNPATRKYCKFKSMTLLAAIQSFQHWWVKKLNLVMTSFKKC

gyrB

DNA gyrase subunit B

637 amino acids

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Belongs to the type II topoisomerase GyrB family.

71.614 kDa

MSEKNEIYDESQIQVLEGLEAVRKRPGMYIGSTGTRGLHHLVYEIVDNSIDEALAGYCSHIKVFIHKDNSVTVSDDGRGMPIGIHHKMKKPTVEVIMTILHAGGKFGGGAYRVSGGLHGVGASVVNALSETCEVEVKTEGHIWKQTYHRGKVASPFEKIGDSDEHGTKIYFKPDPEIFEDTEYDYDTLSQRLRELAFLNKGIKIELTDERHDKNEIFHYEGGLKSFVSYLNRNKEVVFKEPIYVEGSIDSNYSVEIALQYNDGYNENIFSFANNIHTIEGGTHLAGFKTALTRVINDYAKKFGYLKENDKNLSGEDIREGLTAVVSVKLTEPQFEGQTKTKLGNTEVRGIVDSIISERVSTYLEENPQIGKLVIDKALVASRAREAAKKAREITRRKSVLESTSLPGKLADCSSKDAEECEIYIVEGDSAGGSAKQGRNRRFQAILPLRGKIMNVEKQRIDKILNSEEIKAMATAFGGGIGKDFDVSKLRYHKIIIMTDADVDGAHIRTLILTFFYRYMTELISEGHVFIAQPPLYKVTKTRKEYYAYSDKELEDVLQDVGGKDKNTDIQRYKGLGEMNPEQLWETTMNPEQRTLIKVNIEDAMAADEIFTILMGDKVDPRRKFIEENATKVVNLDV

gyrB

DNA gyrase subunit B

637 amino acids

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Belongs to the type II topoisomerase GyrB family.

71.233 kDa

MTREQQAYDESQIQVLEGLEAVRKRPGMYIGSTSSRGLHHLVWEIVDNSIDEAMAGFCDEIGVVIEEDNSITVTDNGRGIPVGIHEKMGRPAVEVIMTVLHAGGKFGGGGYKVSGGLHGVGASVVNALSTMLEVEVHREGKVHYQKFHRGVPAADLEVIGTTDRTGTKIHFKPDGDIFTETTVFEYDTLASRLRELAFLNKGLRIKITDMREEEKSDEFHYEGGIASFVEHLNRTRETLHETPIHIEGEKQGVYVEIAVQYNDGFTSNIYSFANNINTHEGGTHESGFKTGLTRVINDYARKHNLFKESDPNLTGEDVREGLTAIISVKIPDPQFEGQTKTKLGNSEARTITDSLFTEHFSRFLIEHPQVARKLVDKGLMASRAREAAKKARELTRRKSALEVSSLPGKLADCSSRDASISEIYIVEGDSAGGSAKQGRDRHFQAILPLRGKILNVEKARLDKILANNEIRAIITALGTGIGDDFDIEKARYHKIIIMTDADVDGAHIRTLILTFFYRYMRPLIEHGYVYIAQPPLYKVQQGKDIQYAYGDAELQEILSQLPDKAKPGIQRYKGLGEMNPSQLWETTMDPGQRTVLQVTLEDAMKADEIFEILMGDRVEPRRDFIQENARYVKNLDI

gyrB

DNA gyrase subunit B

634 amino acids

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Belongs to the type II topoisomerase GyrB family.

71.451 kDa

MNYVASNIQVLKGLEAVRKRPGMYIGSVSINGLHHLVYEVVDNSIDEALAGFCDRIDVIINLDNTITVIDNGRGIPTDIHEEEGISALELVLTKLHSGGKFNKGTYKVSGGLHGVGISVVNALSSFLEVYVNRDGKIFRQTFSKGIPTSKVEVVGESSVTGTKVTFLADSEIFETLDYNFDVLEKRLKELAFLNDKIYISIEDKRIGKEKSSKFYFEGGIKSFVDYLTNDSKAFQSEPYYIDGFINDVIVNVGLKWTESYSDNILSFVNNINTREGGTHVMGFRSGLTKAMNEAFKNSKISKKDIPNLTGDDFKEGLTAVISVKVPEPQFEGQTKSKLGNSEIRKIVEVVVYEHLLEIINLNPLEIDTILGKAIKAARAREAARKARESERKKNAFESLALPGKLADCTSKNPLEREIYIVEGDSAGGSAKMGRNRFFQAILPLWGKMLNVEKTREDKVITNDKLIPIIASLGAGVGKTFDITKLRYHKIIIMADADVDGSHIRTLLLAFFFRYMRDLIENGYIYIAMPPLYKIKYDNRIYYFYEEKEKEKFLDSIETKNRNSISLQRYKGLGEMNPTQLWETTMDPARRKMRLMNIDDAIEAEKIFVTLMGDLVEPRKEFIEQNALNVINLDV

gyrB

DNA gyrase subunit B

634 amino acids

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Belongs to the type II topoisomerase GyrB family.

70.848 kDa

MSYVASNIQVLKGLEAVRKRPGMYIGSVSINGLHHLVYEVVDNSIDEALAGFCDKIEVVINSDNSVTVNDNGRGIPTDVHEEEGISALELVLTKLHSGGKFNKGTYKVSGGLHGVGISVVNALSSFLAVIVSRDGKLFKQTYSRGIPTSEVDIIGVSSARGTKVTFLADSEIFETLEYDFETLSKRLRELAFLNDKIRISIEDRRSGKEKFLEFYFEGGIKAFVDYITNNSKNIQNEPYFIEGSCDDVIVSVGLKWTEGYSDHILSFVNNINTREGGTHVAGFKSGFLKAMSEAFRDSKISKKDVPSLTLDDFKEGLTAVISIKIPEPQFEGQTKGKLGNSYVKKIVETIVHDGLLKVIDDNLLEVDIILNKAIRAARAREAARKARESERKKSAFESLALPGKLADCASKNPAEREIYIVEGDSAGGSAKMGRDRFSQAILPLWGKMLNVEKTREDKVITNDKLIPIIASLGAGVGKTFYIEKLRYHKIIIMADADVDGSHIRTLLLTFFFRYMRELIENGHVYIAMPPLYKLKYENREHYFYDDLEKEAFLGSIETGKRDKVSLQRYKGLGEMNPTQLWETTMNPATRKMKLIKINDAIQAEKIFVTLMGDDVEPRREFIEQNALDVVNLDV

gyrB

DNA gyrase subunit B

632 amino acids

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Belongs to the type II topoisomerase GyrB family.

71.06 kDa

MSPDQTAVEYTAKDIEVLDDLEAVRKRPGMYIGGVGVRGLHHLLWEVVDNAVDEALAGYCDTIKVSLHKDGSASVEDNGRGIPTEMHELGKSALEIVMTKLHAGGKFSKKVYRVSGGLHGVGVSVVNALSEWLEVWVKRNGKIYYQKYQRGSRSPEAGHRTEVLGETKEHGTTVRFKPDREIFETTEFKYEIVAQRLKELAYLNRGLKIILFDEREGKEETFHFEDGIIGLVRSLNRNRKPLHEPIYIETTKDGVSVEVAIQFTDSDVENIQAFANNINTSEGGSHVVGFRAGLTRAVNEYGKKHLKKFEPVTGVDIREGLTAVISVKVPEPQFEGQTKTKLTNSDVKTVVESAVYSGVLRWLEENPAQAETLLNKFILNKKAREAAKRAKELVKRKNELITTLPGKLADCSSKNPEERELFIVEGESAGGSAKQARDRRFQAILPIKGKIINVEKAGMARVLKNDEIKAIISAIGAGIGKDFDITKARYRRIIIMTDADVDGAHIRTLLLTFFYRYMRPLIESGYLYIAQPPLYQIKKGKKSYYAYSDEELKRTLEQVGGGEVQRYKGLGEMNPQQLWETTMNPENRILIQVTLEDAKRADELFSILMGEDVESRRNFIMAHSKEVKNLDI

gyrB

DNA gyrase subunit B

481 amino acids

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Belongs to the type II topoisomerase GyrB family.

53.557 kDa

single

DKNTYKVSGGLHGVGVSCVNALSTVLHVTVHREGKIFEQEYHRGVPQYAVREIGATTDTGTTTHFKPDGEIFTETSYNREILAGRLRELAYLNRKIRITLTDEREKDEQGNVLSEPFYSEGGIMEFVQMLDRNGRRNSLLPAPIFIEAHDAPSNVAVEVSLQYNDSFSENIFSYVNNINTIEGGTHVAGFRRAITRVFKTYGDRNKLFEKSKIEVTGDDFREGLSAIVSVKVPEPQFEGQTKTKLGNSDVMGVVDSAVADVLNAYLEEHPKEARTVINKVVLAAQAREAARKARQLVQRKSVLTGSGLPGKLADCSENDPEKCELYLVEGDSAGGTAKQGRNRAFQAILPLRGKILNVEKAMEHKIYENEEIKNIFTALGVTIGTEEDDKALNLSKLRYHKLIIMTDADVDGSHIATLILTFVFRYMKALVEQGYVYIAQPPLYLVKKGKEQIYAWTEEQRKAAVATLAGGKEDSVTIQRY

gyrB

DNA gyrase subunit B

478 amino acids

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Belongs to the type II topoisomerase GyrB family.

53.755 kDa

single

DKDSYKVSGGLHGVGVSCVNALSTDMKVTVYSHGKVHQQEYKKGIPQYDVKEIGESEIHGTKVQFLPDDSIFTSSEYKYETIANRLRELSFLNKGIRITLQDHREVDADGKSEIETFHSEGGLREFVEYVDSTRERLIPRPLYMESDKGPIPVEVAMLYNTSYSENVFSYVNNINTVEGGTHVAGFRRALTRTLKSYADKSGMLEKLKMEVTGDDFREGLTAVISVKVQEPQFEGQTKTKLGNSDVMGAVDQVVGEMLNTYLEENPKEAKIIVQKVILAAQARNAARKAREMVQRKNVLSGSGLPGKLADCSESDPEKCEIYLVEGDSAGGSAKQGRDRKYHAILPLRGKILNVEKAQEHRIYENDEIKNMITALGVSFGTEEGEKVLNLTKLRYHKVIIMTDADIDGSHIRTLILTFFFRYMRALIDGGHVYIAQPPLYLVKRGKEEKYCWTEEQREVAVKELAKDGKEDSVGIQRY

gyrB

DNA gyrase subunit B

478 amino acids

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Belongs to the type II topoisomerase GyrB family.

53.701 kDa

single

DKDSYKVSGGLHGVGVSCVNALSTDMKVTVYSHGKVHQQEYKKGIPQYDVKEIGESDLHGTKVQFLPDDTIFTSSEYKYETIANRLRELSFLNKGIRITLQDHRQVDAEGKSEIEMFHSEGGLREFVDYLDSTREKLIPTPLYMESDKGPIPVEVAMLYNTSYSENVFSYVNNINTIEGGTHVAGFRRALTRTLKSYADKSGMLEKLKMEVTGDDFREGLTAVISVKVQEPQFEGQTKTKLGNSDVMGAVDQVVGEMLNTYLEENPKEAKIIVQKVILAAQARNAARKAREMVQRKNVLSGSGLPGKLADCSESDPEKCELYLVEGDSAGGSAKQGRDRKYHAILPLRGKILNVEKAQEHRIYENDEIKNMITALGVSFGTEEGEKVLNLTKLRYHKVIIMTDADIDGSHIRTLILTFFFRYMRALIDGGHVYIAQPPLYLVKRGKEEKYCWTEEQREAAVKELAKDGKEDSVGIQRY

gyrB

DNA gyrase subunit B

478 amino acids

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Belongs to the type II topoisomerase GyrB family.

53.456 kDa

single

DKDTYKVSGGLHGVGVSCVNALSSLLVATVHREGKVFQQKYSTGNPQGAVEVVGQSDRTGTTIYFEPDATIFATTEYKYETVSKRLRELSYLNKGIRLTLTDLRETDEQGRHLYEEFFSEGGLKEFVEHLDSTRQPLLPAPIHVEKTDGDIPVEVALIYNNSYSENVFSYVNNINTHEGGTHVSGFRRALTRTLKSYADKSGMLEKAKVEITGDDFREGLTAVISIKVAEPQFEGQTKTKLGNSDAIGAVDNAVSEILGYYLEENPREAKLIIQKVILAAQARQAARKAREMVQRKNVMGGTSLPGKLADCSDTNPERCELYLVEGDSAGGSAKQGRDRSFQAILPLRGKILNVEKAQEYKIYDNEEIKNMITAMGVTFGTEEDSKALNLTKLRYHKIIIMTDADVDGSHIRTLILTFFFRYMRELIEQGYLYVALPPLYIVKKGKEERYAWSDAERDAIIREIAPEGKEDSVGIQRY

gyrB

DNA gyrase subunit B

404 amino acids

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Belongs to the type II topoisomerase GyrB family.

44.918 kDa

single

HAGGKFDGGGYKVSGGLHGVGASVVNALSTELEVFVHREGKIHYQKYERGIPVADLKVIGDTDQTGTITRFKPDPEIFQETTVYDFDTLATRMRELAFLNRNIKLTIEDKRERKQKKEFHYEGGIKSYVEHLNRSKQPIHEEPVYVEGSKDGIQVEVSLQYNEGYTNNIYSFTNNIHTYEGGTHEVGFKTALTRVINDYGRKNSILKDADSNLTGEDVREGLTAIVSIKHPNPQFEGQTKTKLGNSEARTITESVFSEAFEKFLLENPNVARKIVEKGTMAARARVAAKKARELTRRKSALEVSSLPGKLADCSSKDPAISEIYIVEGDSAGGSAKQGRDRHFQAILPLKGKIINVEKARLDKILSNDEVRTIITAIGTNIGGDFDIEKARYHKVIIMTDADVD

gyrB

DNA gyrase subunit B

404 amino acids

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Belongs to the type II topoisomerase GyrB family.

44.896 kDa

single

HAGGKFDGGGYKVSGGLHGVGASVVNALSTELEVFVHRDGKIHYQKYERGVPAADLRVIGETDRTGTITRFKPDSEIFTETTEYEFDTLATRMRELAFLNRNIKLTIEDKREHKQKKEFHYEGGIKSYVEHLNRSKQPIHEEPVYVDGSKDGIQVEVALQYNEGYTNHIYSFTNNIHTYEGGTHEVGFKTALTRVINDYGRKNNILKDADSNLTGEDVREGLTAIVSIKHPNPQFEGQTKTKLGNSEARTITESVFSEAFEKFLLENPNVARKIIDKGTMAARARVAAKKARELTRRKSALEVSSLPGKLADCSSKDPAISEIYIVEGDSAGGSAKQGRDRHFQAILPLKGKIINVEKARLDKILSNDEVRTIITAIGTNIGGDFAIEKARYHKVIIMTDADVD

gyrB

DNA gyrase subunit B

390 amino acids

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Belongs to the type II topoisomerase GyrB family.

43.147 kDa

single

DNSYKVSGGLHGVGVSVVNALSEKLELTIHRAGKIHEQEYRHGDSQYPLKVVGDTNRTGTRVRFWPSAETFSQTIFNVDILARRLRELSFLNAGVRIVLRDERINAEHVFDYEGGLSEFVKYINEGKTHLNDIFHFTAAQADNGITVEVALQWNDSYQENVRCFTNNIPQKDGGTHLAGFRAALTRGLNNYMDSENILKKEKVAVSGDDAREGLTAIVSVKVPDPKFSSQTKEKLVSSEVKTAVEQAMNKAFSEYLLENPQAAKAIAGKIIDAARARDAARKAREMTRRKSALDIAGLPGKLADCQEKDPALSELYLVEGDSAGGSAKQGRNRKMQAILPLKGKILNVERARFDRMISSAEVGTLITALGCGIGREEYNPDKLRYHKIII

gyrB

DNA gyrase subunit B

390 amino acids

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Belongs to the type II topoisomerase GyrB family.

43.147 kDa

single

DNSYKVSGGLHGVGVSVVNALSEKLELTIHRAGKIHEQEYRHGDSQYPLKVVGDTNRTGTRVRFWPSAETFSQTIFNVDILARRLRELSFLNAGVRIVLRDERINAEHVFDYEGGLSEFVKYINEGKTHLNDIFHFTAAQADNGITVEVALQWNDSYQENVRCFTNNIPQKDGGTHLAGFRAALTRGLNNYMDSENILKKEKVAVSGDDAREGLTAIVSVKVPDPKFSSQTKEKLVSSEVKTAVEQAMNKAFSEYLLENPQAAKAIAGKIIDAARARDAARKAREMTRRKSALDIAGLPGKLADCQEKDPALSELYLVEGDSAGGSAKQGRNRKMQAILPLKGKILNVERARFDRMISSAEVGTLITALGCGIGREEYNPDKLRYHKIII

gyrB

DNA gyrase subunit B

389 amino acids

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Belongs to the type II topoisomerase GyrB family.

43.035 kDa

single

DNSYKVSGGLHGVGVSVVNALSSKLELTIHRAGHIHQQEYKHGDPVYPLKIVGDVETTGTIVRFWPSTETFSQTIFNVDILARRLRELSFLNAGVRIVLRDERVALEHVFDYEGGLSEFVKYINQGKTHLNEIFHFTTQAENGIGVEVALQWNDTYQENVRCFTNNIPQKDGGTHLAGFRAALTRGLNSYMENENLLKKEKVAVTGDDAREGLTAIVSVKVPDPKFSSQTKEKLVSSEVKPAVEQAMNKAFSEYLLENPQAAKSIAGKIIDAARARDAARKAREMTRRKSALDIAGLPGKLADCQEKDPALSELYLVEGDSAGGSAKQGRNRKMQAILPLKGKILNVERARFDKMISSQEVGTLITALGCGIGREEYNPDKLRYHKIII

gyrB

DNA gyrase subunit B

389 amino acids

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Belongs to the type II topoisomerase GyrB family.

43.033 kDa

single

DNSYKVSGGLHGVGVSVVNALSRKLELTIHRAGHIHQQEYKHGDPVYPLTVVGDTDTTGTTVRFWPSAETFSQTIFNVDILARRLRELSFLNAGVRIVLRDERIHAEHVFDYEGGLSEFVKYINQGKTHLNDIFHFTVQAENGIGVEVALQWNDTYQENVRCFTNNIPQKDGGTHLAGFRAALTRGLNSYMENENLLKKEKVAVSGDDAREGLTAIVSVKVPDPKFSSQTKEKLVSSEVKPAVEQAMNKSFSEYLLENPQAAKSIAGKIIDAARARDAARKAREMTRRKSALDIAGLPGKLADCQEKDPALSELYLVEGDSAGGSAKQGRNRKMQAILPLKGKILNVERARFDKMISSQEVGTLITALGCGIGREEYNPDKLRYHKIII

gyrB

DNA gyrase subunit B

388 amino acids

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Belongs to the type II topoisomerase GyrB family.

43.111 kDa

single

DNSYKVSGGLHGVGVSVVNALSSKLHLTIYRAGQIHEQEYHHGDPQYPLRVIGETDNTGTTVRFWPSAETFSQTIFNVEILARRLRELSFLNAGVRIVLRDERINLEHVYDYEGGLSEFVKYINEGKNHLNEIFHFTADADNGIAVEVALQWNDSYQENVRCFTNNIPQKDGGTHLAGFRAALTRGLNQYLENENILKKEKVNVTGDDAREGLTAIISVKVPDPKFSSQTKEKLVSSEVKPAVEQAMNKEFSAYLLENPQAAKSIAGKIIDAARARDAARKAREMTRRKSALDIAGLPGKLADCQEKDPALSELYLVEGDSAGGSAKQGRNRKMQAILPLKGKILNVERARFDKMISSQEVGTLITALGCGIGREEYNPDKLRYHKII

gyrB

DNA gyrase subunit B

388 amino acids

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Belongs to the type II topoisomerase GyrB family.

43.104 kDa

single

DNSYKVSGGLHGVSVSVVNALSSKLHLMISRAGQVHEQEYQHGDPQYPLRVIGETDKSGTTVRFWPSELTFTQTIFNVEILARRLRELSFLNAGVRIVLRDERINLEHVYDYEGGLSEFVKYINEGKTHLNEIFHFTADTDSGIGVEVALQWNESYQENVRCFTNNIPQKDGGSHLAGFRAALTRGLNQYLENENILKKEKVNVTGDDAREGLTAIISVKVPDPKFSSQTKEKLVSSEVKPAVEQAMNKEFSAYLLENPQAAKSIAGKIIDAARARDAARKAREMTRRKSALDIAGLPGKLADCQEKDPALSELYLVEGDSAGGSAKQGRNRKMQAILPLKGKILNVERARFDKMISSQEVGTLITALGCGIGREEYNPDKLRYHKII

gyrB

DNA gyrase subunit B

388 amino acids

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Belongs to the type II topoisomerase GyrB family.

43.065 kDa

single

DNSYKVSGGLHGVGVSVVNALSKKLHLIIHRAGQTHEQEYCHGDSQYPLKVIGETDKSGTVIRFWPSELTFSQTIFSVEILARRLRELSFLNAGVRIVLRDERVNFEHVYDYEGGLSEFVKYINEGKTHLNEIFHFTTDTDSGIAVEVALQWNESYQENVRCFTNNIPQKDGGTHLAGFRAALTRGLNQYLESENILKKEKVAVTGDDAREGLTAIISVKVPDPKFSSQTKEKLVSSEVKPAVEQAMNKEFSAYLLENPQAAKSIAGKIIDAARARDAARKAREMTRRKSALDIAGLPGKLADCQEKDPALSELYLVEGDSAGGSAKQGRNRKMQAILPLKGKILNVERARFDKMISSQEVGTLITALGCGIGREEYNPDKLRYHKII

gyrB

DNA gyrase subunit B

388 amino acids

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Belongs to the type II topoisomerase GyrB family.

43.103 kDa

single

DNSYKVSGGLHGVGVSVVNALSSKLQLTIHRAGQEHQQEYHHGDPQYPLRVIGETDRTGTIVRFWPSAETFSQTIFNVDILARRLRELSFLNAGVRIVLRDERVNLENVYDYEGGLSEFVRYINEGKTHLNEIFHFTTDADNGISVEVALQWNDSYQENVRCFTNNIPQKDGGTHLAGFRAALTRGLNSYMENENLLKKEKVVVSGDDAREGLTAIISVKVPDPKFSSQTKEKLVSSEVKPAVEQAMNKEFSAYLLENPQAAKSIAGKIIDAARARDAARKAREMTRRKSALDIAGLPGKLADCQEKDPALSELYLVEGDSAGGSAKQGRNRKMQAILPLKGKILNVERARFDKMISSQEVGTLITALGCGIGREEYNPDKLRYHKII

gyrB

DNA gyrase subunit B

388 amino acids

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Belongs to the type II topoisomerase GyrB family.

42.97 kDa

single

DNSYKVSGGLHGVGVSVVNALSKKLHLTIQRAGQIHEQEYCHGDPQYPLKVVGETDKTGTTVRFWPSELTFSQTIFSVDILARRLRELSFLNAGVRIVLRDERVNLENVYDYEGGLSEFVKYINEGKTHLNEIFHFTTDADNGIGVEVALQWNDSYQENVRCFTNNIPQKDGGTHLAGFRAALTRGLNSYMENENLLKKEKVAVSGDDAREGLTAIISVKVPDPKFSSQTKEKLVSSEVKPAVEQAMNKEFSAYLLENPQAAKSIAGKIIDAARARDAARRAREMTRRKSALDIAGLPGKLADCQEKDPALSELYLVEGDSAGGSAKQGRNRKMQAILPLKGKILNVERARFDKMISSQEVGTLITALGCGIGREEYNPDKLRYHKII

gyrB

DNA gyrase subunit B

388 amino acids

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Belongs to the type II topoisomerase GyrB family.

43.092 kDa

single

DNSYKVSGGLHGVGVSVVNALSSKLHLIINRAGQVHEQEYHHGDPQYPLRVIGETDSSGTTVRFWPSELTFSQTIFNVEILARRLRELSFLNAGVRIVLRDERINLEHVYDYEGGLSEFVKYINEGKTHLNEIFHFTADTENGIGVEVALQWNESYQENVRCFTNNIPQKDGGTHLAGFRAALTRGLNQYLENENILKKEKVNVTGDDAREGLTAIISVKVPDPKFSSQTKEKLVSSEVKPAVEQAMNKEFSAYLLENPQAAKSIAGKIIDAARARDAARKAREMTRRKSALDIAGLPGKLADCQEKDPALSELYLVEGDSAGGSAKQGRNRKMQAILPLKGKILNVERARFDKMISSQEVGTLITALGCGIGREEYNPDKLRYHKII

gyrB

DNA gyrase subunit B

216 amino acids

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Belongs to the type II topoisomerase GyrB family.

23.775 kDa

multiple

SYKVSGGLHGVGVSVVNALSSKLELTIHRAGHIHQQEYKHGDPVYPLKVIGDIETTGTTVRFWPSAETFSQTIFNVDILARRLRELSFLNAGVRIVLRDERVALEHIFDLEVGLSEKSALDIAGLPGKLADCQEKDPALSELYLVEGDSAGGSAKQGRNRKMQAILPLKGKILNVERARFDKMISSQEVGTLITALGCGIGREEYNPDKLRYHKII

gyrB

DNA gyrase subunit B

216 amino acids

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Belongs to the type II topoisomerase GyrB family.

23.742 kDa

multiple

SHKVSGGLHGVGVSVVNALSSKLQLTIHRAGQIHEQEYQHGDPQYPLKVVGETSTTGTTVRFWPSGDTFSQTIFNVDILARRLRELSFLNAGVKIVLRDERVNFEHIYAYEGGLSEKSALDIAGLPGKLADCQEKDPALSELYLVEGDSPGGSAKQGRNRKMQAILPLKGKILNVERARFDKMISSQEVGTLITALGCGIGREEYNPDKLRYHKII

gyrB

DNA gyrase subunit B

216 amino acids

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Belongs to the type II topoisomerase GyrB family.

23.767 kDa

multiple

SHKVSGGLHGVGVSVVNALSSKLELTVQRAGQIHEQEYQHGVPQYPLRVVGQTERTGTKVRFWPSAETFSQTIFNVDILARRLRELSFLNAGVRIVLCDERINLEHVFDYEGGLSEKSALDIAGLPGKLADCQEKDPALSELFLVEGDSAGGSAKQGRNRKMQAILPLKGKILNVERARFDRMISSAEVGTLITALGCGIGREEYNPDKLRYHKIV

gyrB

DNA gyrase subunit B

216 amino acids

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Belongs to the type II topoisomerase GyrB family.

24.02 kDa

multiple

SYKVSGGLLRVGVSVVNALSKKLHLTIHRAGQIHEQEYAHGDPQYPLKVVGETDTSGTTVRFWPSEWTFSQTIFSVDILARRLRELSFLNAGVRIVLRDERVNLEHIYDYEVGLSEKSALDIAGLPGKLADCQEKDPALSELYLVEGDSAGGSAKQGRNRKMQAILPLKGKILNVERARFDKMISSQEVGTLITALGCGIGREEYNPDKLRYHKII

gyrB

DNA gyrase subunit B

216 amino acids

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Belongs to the type II topoisomerase GyrB family.

23.872 kDa

multiple

SYKVSGGLHGVGVSVVNALSKKLHLTIHRAGQIHEQEYAHGDPQYPLKVVGETDTSGTTVRFWPSELTFSQTIFSVDILARRLRELSFLNAGVRIVLRDERVNLEHIYDYEVGLSEKSALDIAGLPGKLADCQEKDPALSELYLVEGDSAGGSAKQGRNRKMQAILPLKGKILNVERARFDKMISSQEVGTLITALGCGIGREEYNPDKLRYHKII

gyrB

DNA gyrase subunit B

182 amino acids

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Belongs to the type II topoisomerase GyrB family.

19.78 kDa

single

MSNTYDSSSIKVLKGLDAVRKRPGMYIGDTDDGTGLHHMVFEVVDNAIDEALAGYCDEIIVTIHSDNSVSVRDDGRGIPTGIHEEEGVSAAEVIMTVLHAGGKFDDNSYKVSGGLHGVGVSVVNALSEKLELTIHRDGKIHQQIYRSGVPDDRLKVIGETDKSGTFVRFWPSLDTFKGETEF

gyrB

DNA gyrase subunit B

182 amino acids

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Belongs to the type II topoisomerase GyrB family.

19.78 kDa

single

MSNTYDSSSIKVLKGLDAVRKRPGMYIGDTDDGTGLHHMVFEVVDNAIDEALAGYCDEIIVTIHSDNSVSVRDDGRGIPTGIHEEEGVSAAEVIMTVLHAGGKFDDNSYKVSGGLHGVGVSVVNALSEKLELTIHRDGKIHQQIYRSGVPDDRLKVIGETDKSGTFVRFWPSLDTFKGETEF

gyrB

DNA gyrase subunit B

134 amino acids

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Belongs to the type II topoisomerase GyrB family.

14.961 kDa

single

EFVKYLDRSKTAVMPDPIYMVGEVRGIGVEVAMWWNDSYHETVLPFTNNIPQRDGGTHLAGFRGALTRTITKYAQDSGIAKREKIDFTGDDAREGLTCVLSVKVPDPKFSSQTKDKLVSSEVRPAVENLVNEKL

gyrB

DNA gyrase subunit B

134 amino acids

A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.

Belongs to the type II topoisomerase GyrB family.

14.961 kDa

single

EFVKYLDRSKTAVMPDPIYMVGEVRGIGVEVAMWWNDSYHETVLPFTNNIPQRDGGTHLAGFRGALTRTITKYAQDSGIAKREKIDFTGDDAREGLTCVLSVKVPDPKFSSQTKDKLVSSEVRPAVENLVNEKL