gua1

GMP synthase [glutamine-hydrolyzing]

557 amino acids

61.432 kDa

MAEEQNPSATFDTILTLDFGSQYTHLITRRLREIGVYSEMLPCTQKLADLPFKPKGIILSGGPYSVYEDGAPHADPAVFELGVPVLGICYGLQEIAYRLGKDNVVAGTAREYGHADLNAQRLDNQGHVDKLFAGLEEHVKVWMSHGDKLVKLPEGFHTIATTANSEYAGIAHETKPVYGIQFHPEVTHTPDGAKLLRNFAVDICGANPNWTMSKFVDQEILRIRKLVGETDHVLGAVSGGVDSTVAAKLMKEAIGDRFHAVLVNNGCMRLNECETVAETLNKHLGINLTVVDASKRFLDGLKGVTDPEKKRMFIGATFIDVFEEEAEKIEALAENSGAKVKWFLQGTLYPDVIESISFKGPSATIKTHHNVGALPKRMIEGQGMKLIEPLRELFKDEVRQLGRELGIAHELVMRHPFPGPGIAIRVLGEVTPERVDIARKADHIFISMIREAGLYDKISQAYAALDPSKAVGVMGDKRVYAEIIILRAVETTDCKLTLGIDGDFVLRYIISVMTARAFPFDNEFLSKCATRIINEVHGVSRVLYDISSKPPATIEME

GUA1

GMP synthase [glutamine-hydrolyzing]

545 amino acids

59.691 kDa

MSDAFETAAPPHATYDTVLVLDMGSQTSHLILRRLRSLGVYSEMLPCTQKIKDLGWKPVGVILSGGPSSVYADDAPGVDPLVFELGVPVLGVCYGNQLIAWRANPKSVAPGVNREYGETQMAIHKIGTHGDRLFEGLGDSLNVVMSHFDKVVQLPDGFQTIATTKNSEFAGIAHETQPIFGIQFHPEISHTEKGTDIIANFATKICGARPDWKMDDFSAREIKRIRELVGDKAQVIGAVSGGVDSTVAAKLMKEAIGDRFHAILVDQGLMRLNECEQVKETLDKHLGINLTVVDGSELFLGRLAGVTEPEAKRKIIGGTFIDLFEIEALRIEKEAENTDRAGKVEWFLQGTLYADIVESLSFKGAASSTIKSHHNAGGLPARMQNGEAQLKLLEPLRELFKDEVRAFGRQLGIHEELIGRHPFPGPGLGIRIIGEVTPERVEIVRKADHIFISMIREAGIYDEVTQAYAALDSSRAVGVQGDARVYGYICILRAVTSLDMMSAEPYEFTWSLMKAISRRIVNEVDGIARVVYDTTSKPPGTIELE

GUA1

GMP synthase [glutamine-hydrolyzing]

543 amino acids

60.291 kDa

MTEAIHSQYDSILILDFGSQYSHLITRRCRELNVYCEMLPCTQKIKDLDWKPKGIILSGSPYSVYDEVAPRVDPDVFTAGVPVLGICYGLQEIAWNHGGKVDPHDKREYGHAMVEVVKHGVPHLDALFKNWEGSVQVWMSHGDQLSKAPEDFVVIAKTPTAPFAAMAHKSKPIYGVQFHPEVTHSLRGVELFDSFVDICACRRDWTMETFIDKEIKRIREIVGPKGQVLGAISGGVDSSVAAKLMHEAIGDRFHAVMVDNGVLRTNEAAQVYEMLSKDLGVNLTVVDASEQFLSRLKDVEDPEQKRKIIGNTFIHVFEAEVAKLEKQAEDEEAAALAAGKPQEAKGKFEYLLQGTLYPDVIESISFKGPSATIKTHHNVGGLLEDMKLKLIEPLRELFKDEVRALGKLLGIPAHLVGRHPFPGPGLAIRILGPVTREQVKILQHADSIYIDEIRAAGLYDQISQAFAVLLPVRAVGVQGDKRTYDQVIALRAAATTDFMTATWYPFPAEFLSKVSNRITNEVQGVNRVVLDISSKPPATIEWL

GUA1

GMP synthase [glutamine-hydrolyzing]

541 amino acids

59.923 kDa

MATDGSDPIPPHKTFDTILVLDFGSQYTHLITRRLRELNVYSEMLPCNTKLADLPFTPKGIILSGGPYSVYEEGAPHVDHAVFDLGVPILGICYGLQEMAWHFGKNAGVAAGEKREYGHANLKVESHGGHMDELFKDVGNELEVWMSHGDKLSNMPENFTTVATTTNAPFAGIAHKEKKYYGIQFHPEVTHTKMGKTVLKNFAVDICQSTTDWTMGKFVDQEITRIRKLVGEKGQVIGAVSGGVDSTVAAKLMKEAIGDRFHAVMVDNGVLRLNEAKQVKETLEKGLGINLTVIDASDMFLDRLKGITDNPEQKRKVIGNTFIEIFQEKAKEIAAAAKNSSNAGEIEWLLQGTLYPDVIESLSFKGPSQTIKTHHNVGGLPANMNLKLIEPLRELFKDEVRALGVELGIPEDLVWRHPFPGPGIAIRILGEVTREQVRIAREADYIFIEEIKAAGLYRNISQAFAALLPVKAVGVMGDKRVHDQVIALRAVETTDFMTADWYPFDGEFLKRVSRRIVNEVNGVCRVVYDITSKPPGTIEME

gua1

GMP synthase [glutamine-hydrolyzing]

541 amino acids

59.794 kDa

MAETPELEPHNAFDTILTLDFGSQYTHLITRRLRELNVYSEMLPCTQKLADLKFKPAGVILSGGPYSVYEEGAPHVDPAYFDLGVPILGICYGLQEIAYRLDSTNVIAGTSREYGLAQLKAKKVGGHVDHLFDGLEDEFNVWMSHGDKLGKLPEGFHTIATTPNSEYAGIAHETKPIYGLQLHPEVTHTQNGTKLLKNFAVNICGCKQNWTMARFVDQEIARIRKLVGPTGQVLGAVSGGVDSTVAAKLMKEAIGDRFHAVLVDTGFMRLNECEQVKQTLAEHLGINLIVADASQVFMEGLKGISDPEQKRKFIGNKFIDVFEEEAKKIEDAAAHSETAGKIGFFLQGTLYPDVIESISFKGPSATIKTHHNVGGLPKRMTEGQGLKLIEPLRELFKDEVRDLGRQLGIAHEMVMRHPFPGPGIAIRILGEITPERVEMARKADHIFISMIREAGLYDKIGQAFAALDPSRAVGVMGDKRVYENIVLLRAVETTDFMTAIAYPFEHEFLTRVSTRIVNEVSGVCRVAYDYTSKPPGTIELE

gua1

GMP synthase [glutamine-hydrolyzing]

539 amino acids

60.044 kDa

MSSTEVPGEVSTSVSSYFDTILILDFGSQYSHLIARRLREIHVYAELLPCTQKIEALPFKPIGVILSGGPYSVYDDIAPHVDPAVFELGVPVLGICYGMQEIAWLNGRCVEPGIEREYGPATVSMEPEIKTEVFKSFFNSMPKEFEVWMSHGDRLSALPNGYETIGRTKNSPFAVIAHVTKPIIGLQFHPEVTHTPLGLQLIKNFAIEICHAKPNWSMENFVDKEILRIRKMIGPSDHVIGAVSGGVDSTVASKVLKEAIGDRFHAIMVDNGLLRLNEAEIVRETLNKHLGIQLTVVDASEEFIGKLKGVTDPEKKRKIIGNTFIHVFEREAERIVKETNGKVEYLLQGTLYPDVIESISFKGPSQTIKTHHNVGGLLKDMKLKLIEPLRELFKDEVRALGELLGIEHSLVWRHPFPGPGLGIRILGEVNAAQLEIARKADHIFITEIRNHGYYDKISQAFAALLPVKAVGVMGDKRTHEQVIALRAITTSDFMTADWYDGFSIKFLKLVSSRICNEVSGVNRVLYDISSKPPATVEME

GUA1

GMP synthase [glutamine-hydrolyzing]

530 amino acids

58.813 kDa

MSANIDDVPIEVSKVFDTILVLDFGSQYSHLITRRLREFNVYAEMLPCTQKIAELSWKPKGIILSGGPYSVYAEDAPHVDHDIFKLGVPILGICYGMQELAWINGKGVARGDKREYGPATLNVEDPECALFKGVDHSQVWMSHGDKLHALPTGFKVVATSDNSPFCGISNESEHIYGIQFHPEVTHTVQGKKLLKNFAVDICQAKTNWSMENFIDTEIARIKKLVGPTAEVIGAVSGGVDSTVGAKIMKEAIGDRFHAIYVDNGVMRKNETESVKKTLDEGLGINLTVVDAGDLFLGRLKGVTDPEKKRKIIGNTFIHVFEEEAAKIKPRDGSEIEYLLQGTLYPDVIESISFKGPSQTIKTHHNVGGLLEDMKLKLIEPLRELFKDEVRHLGELLGVPEDLVWRHPFPGPGLAIRVLGEVTKEQVKIAREADAIFIEEIKKAGLYRQISQAFAALLPVKSVGVMGDQRTYEQVIALRAIETLDFMTADWFIFEAAFLKKVASRIVNEVDGVARVTYDITSKPPATVEWE

GUA1

Inosine-5'-monophosphate dehydrogenase

529 amino acids

Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.

Belongs to the IMPDH/GMPR family.

58.066 kDa

MGEDSYLCLSEEIKKKLEEYSEKDGYDLDSLICSRRHGGLTYNDIIILPGYIDFEVNSVSLESHITKKIVLKTPFMSSPMDTVTESDMAINLALLGGIGVIHHNCTIEEQTEMVRKVKKFENGFITSPIVLSLNHRVRDVRRIKEELGFSGIPITDTGQLNGKLLGIVTSRDIQFHNNDESFLSEVMTKDLVTGSEGIRLEEANEILRSCKKGKLPIVDKEGNLTALLSRSDLMKNLHFPLASKLPDSKQLICAAAVGTRPDDRIRLKHLVEAGLDIVVLDSSQGNSIYQINMIKWIKKEFPNLEVIAGNVVTREQAANLISAGADALRVGMGSGSICITQEIMAVGRPQATAVYAVSEFASKFGVPTIADGGIENIGHITKALALGASAVMMGNLLAGTTESPGQYYYRDGQRLKSYRGMGSIDAMEHLSGKNKGDNAASSRYFGEADTIRVAQGVSGSVIDKGSLHVYVPYLRTGLQHSLQDIGVQNLTELRKQVKEKNIRFEFRTVASQLEGNVHGLDSYQKKLWS

GUA1

GMP synthase [glutamine-hydrolyzing]

529 amino acids

58.792 kDa

MVNPADVPIEVSKVFDTILVLDFGSQYSHLITRRLREFNVYAEMLPCTQKISELTWKPKGIILSGGPYSVYEDGSPHVDHDIFKLNVPILGICYGMQELAWINGKGVARGDKREYGPATLNVEDSSCSLFKGVDHSQVWMSHGDKLHALPTGFKVVATSDNSPFAAISNEKENIFGIQFHPEVTHTKQGKVLLRNFAIDICQASNNWTMENFIDTEIARIQKLVGPTAEVIGAVSGGVDSTVGAKIMKEAIGDRFHAIYVDNGLMRLNETEQVYKTLTEGLGINLTVVDATDLFLGKLQGVTDPEKKRKIIGNNFIHVFEAEAAKIKPASGQEIEYLLQGTLYPDVIESISFKGPSQTIKTHHNVGGLLEDMKLKLIEPLRELFKDEVRHLGEIMGVPHDLVWRHPFPGPGLAIRVLGEVTREQLKIAREADNIFIEEIRKAGLYKDISQAFAALLPVKSVGVMGDQRTYEQVIALRAIETTDFMTADWFVFEAAFLKKTASRIVNEVDGVARVTYDITSKPPATVEWE

GUA1

GMP synthase [glutamine-hydrolyzing]

527 amino acids

58.35 kDa

MPAPVNIPSMFDTILVLDFGSQYSHLITRRLREFNVYAEMLPCTQKIAELPWKPKGVILSGGPYSVYAEGSPHVDHAVFDLGVPILGICYGMQELAWINGKGVHAGEKKEFGHATIHVEKPSDPLFHGIDNFQVWMSHGDKLNALPTGYEVVATSDNSPYAGIAHTSEKIWGIQFHPEVTHTTKGKQLLQNFAVDICGAAQKWSMENFVDTEIQRIRDLVGPHAEVIGAVSGGVDSTVGAKLMKEAIGDRFHAILVDNGVMRLNECENVKKTLGEGLGINLNVVDAADLFLGKLKGVTDPEKKRKIIGNTFIEVFEEEAAKIQPTHPEAGEIEFLLQGTLYPDVIESISFKGPSQTIKTHHNVGGLLDNMKLKLIEPLRELFKDEVRKLGEIMGIPHDLVWRHPFPGPGIAIRVLGEVTPSQVEIARKADFIYIEEIKKAGIYEEISQAFACLLPVKSVGVMGDQRTYEQVIALRAIETVDFMTADWYIFDANFLKTVARRIVNEVPGVARVVYDITSKPPATVEWE

GUA1

GMP synthase [glutamine-hydrolyzing]

525 amino acids

58.482 kDa

MAAGEQVSNMFDTILVLDFGSQYSHLITRRLREFNIYAEMLPCTQKISELGWTPKGVILSGGPYSVYAEDAPHVDHAIFDLNVPILGICYGMQELAWINGKQVGRGDKREYGPATLKVIDDSNSLFKGMNDSTVWMSHGDKLHGLPTGYKTIATSDNSPYCGIVHETKPIYGIQFHPEVTHSTQGKTLLKNFAVDLCHAKQNWTMENFIDTEINRIRKLVGPTAEVIGAVSGGVDSTVASKLMTEAIGDRFHAILVDNGVLRLNEAANVKKTLVEGLGINLMVVDASEEFLSKLKGVTDPEKKRKIIGNTFIHVFEREAEKIKPKDGKEIQFLLQGTLYPDVIESISFKGPSQTIKTHHNVGGLLENMKLKLIEPLRELFKDEVRHLGELLGIPHDLVWRHPFPGPGIAIRVLGEVTKEQVEIARKADNIYIEEIKKAGLYNQISQAFACLLPVKSVGVMGDQRTYDQVIALRAIETTDFMTADWFPFEHSFLKKVASRIVNEVDGVARVTYDITSKPPATVEWE

GUA1

GMP synthase [glutamine-hydrolyzing]

525 amino acids

58.202 kDa

MAAVEQVSSVFDTILVLDFGSQYSHLITRRLREFNVYAEMLPCTQKISELGWKPKGVILSGGPYSVYAADAPHVDRAVFELGVPILGICYGLQELAWIAGAEVGRGEKREYGRATLHVEDSACPLFNNVDSSTVWMSHGDKLHALPADFHVTATTENSPFCGIAHDSKPIFGIQFHPEVTHSSQGKTLLKNFAVEICQAAQTWTMENFIDTEIQRIRTLVGPTAEVIGAVSGGVDSTVAAKLMTEAIGDRFHAILVDNGVLRLNEAANVKKILGEGLGINLTVVDASEEFLTKLKGVTDPEKKRKIIGNTFIHVFEREAARIQPKNGEEIEFLLQGTLYPDVIESISFKGPSQTIKTHHNVGGLLDNMKLKLIEPLRELFKDEVRHLGELLGISHELVWRHPFPGPGIAIRVLGEVTKEQVEIARKADHIYIEEIRKAGLYNKISQAFACLLPVKSVGVMGDQRTYDQVIALRAIETTDFMTADWYPFEHEFLKHVASRIVNEVEGVARVTYDITSKPPATVEWE

GUA1

GMP synthase [glutamine-hydrolyzing]

525 amino acids

58.584 kDa

MSSIEQVNEVFDTILVLDFGSQYSHLITRRLREFNIYAEMLPCTQKIADLHFKPKGVIMSGGPYSVYAEDAPHVDHAIFDLGVPILGICYGMQELAWINGKQVARGEKREYGPATLNVLDKEDALFKNVDHSTVWMSHGDKLHGLPTGFKVIATSDNSPYCGIVHESKQIYGIQFHPEVTHSSNGKTLLKNFAVDLCHAKQNWTMKNFIGTEVQRIRDLVGPTAEVIGAVSGGVDSTVASKLMTEAIGDRFHAILVDNGVLRLNEAATVKKTLVDGLGINLTVVDAADEFLDNLKGVTDPEKKRKIIGNTFIHVFEREAEKIKPKDGKAIEFLLQGTLYPDVIESISFKGPSQTIKTHHNVGGLLENMKLKLIEPLRELFKDEVRELGELLGISHELVWRHPFPGPGIAIRVLGEVTREQVEIARKADHIYIEEIRKAGLYDKISQAFACLLPVKSVGVMGDQRTYEQVIALRAIETTDFMTADWYPFEHSFLRKVASRIVNEVDGVARVTYDITSKPPATVEWE

gua1

Inosine-5'-monophosphate dehydrogenase

524 amino acids

Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.

Belongs to the IMPDH/GMPR family.

57.026 kDa

MSAFKPYTEALEVLKKYEKKDGLSIDDLIRHNFQGGLTFNDFLILPGYIDFVPNNVSLETRISRNIVLKTPFMSSPMDTVTEDQMAIYMALLGGIGVIHHNCTPEEQAAMVRKVKKYENGFILDPVVFSPQHTVGDVLKIKETKGFSGIPITENGKLRGKLVGIVTSRDVQFHKDTNTPVTEVMTPREELITTAEGISLERANEMLRKSKKGKLPVVDKDDNLVALLSLTDLMKNLHFPLASKTSDTKQLMVAAAIGTRDDDRTRLALLAEAGLDAVVIDSSQGNSCFQIEMIKWIKKTYPKIDVIAGNVVTREQTASLIAAGADGLRVGMGSGSACITQEVMACGRPQATAIAQVAEFASQFGIGVIADGGIQNVGHMVKSLSLGATAVMMGGLLAGTTESPGEYYVREGQRYKSYRGMGSIAAMEGTGVNKNASTGRYFSENDAVRVAQGVSGLVVDKGSLLRFLPYLYTGLQHALQDIGTKSLDELHEAVDKHEVRFELRSSAAIREGDIQGFATYEKRLY

GUA1

GMP synthase [glutamine-hydrolyzing]

524 amino acids

58.555 kDa

MSPVEVSNVFDTILVLDFGSQYSHLITRRLREFNVYAEMLPCTQKIADLHWKPKGVILSGGPYSVYEKDAPHVDKAIFDLGVPILGICYGLQEIAWINNTEVGRGEKREYGPATLRVEDKSCPLFANVDHSTVWMSHHDKVHNLPAGFKITATSENSPFCGIANEDKQIYGIQFHPEVTHSTQGKTLLRNFAVDICKASQSWNMENFIDTEINRIRELVGPDAEVIGAVSGGVDSTVAAKLMDRAIGDRFHAIMVDNGVLRLNEAATVKKTLGEGLGINLTVVDASDEFLDKLKGVTDPEKKRKIIGNTFIHVFEREAAKIQPKNGKEIEFLLQGTLYPDVIESISFKGPSQTIKTHHNVGGLLENMKLKLIEPLRELFKDEVRELGELLGISHELVWRHPFPGPGIAIRVLGEVTREQVAIARKADYIYIEEIRKAGLYNNISQAFACLLPVKSVGVMGDQRTYEQVIALRAIETTDFMTADWYPFEHSFLKKVASRIVNEVDGVARVTYDITSKPPATVEWE