Protein
S-methyl-5'-thioadenosine phosphorylase
Organism
Tuber melanosporum (strain Mel28)
Function
Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.
Similarity
Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.
Sequence
MPLPDTFSESVRIAVIGGTGISALEAEGFTAVASLDIQTPYGAPGSPLTILKTPQNTPIAFLSRHGLHHELTPTEIPNRANIAALRSIGVRSIIAFSAVGSLQEHIRPRDFVVPSQIIDRTKGLRASTFFEGGLVGHVGFADPFDSELSKVVFDIGSDGVLNGEGVKMHKDALLICMEGPQFSTRAESNLYRSWGGDVINMSALPEAKLAKEAEIAYVMVCMSTDYDCWKTNEAAVTVETVMGNMHANGANAKHLAAAILKELAKEEHQDLVGAKHLEGLSKWACCTAPAGRKAEVVKKIEFMLPGYFS