GRS1

Gene

GRS1

Protein

Glycine--tRNA ligase 1, mitochondrial

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c)

Length

690 amino acids

Function

Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP) (PubMed:23816885). Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis (By similarity).

Similarity

Belongs to the class-II aminoacyl-tRNA synthetase family.

Mass

78.184 kDa

Sequence

MSFFNISRRFYSQIVKKSVKIKRMSVEDIKKARAAVPFNREQLESVLRGRFFYAPAFDLYGGVSGLYDYGPPGCAFQNNIIDAWRKHFILEEDMLEVDCTMLTPYEVLKTSGHVDKFSDWMCRDLKTGEIFRADHLVEEVLEARLKGDQEARGLVEDANAAAKDDAEKKKRKKKVKQIKAVKLDDDVVKEYEEILAKIDGYSGPELGELMEKYDIGNPVTGETLESPRAFNLMFETAIGPSGQLKGYLRPETAQGQFLNFNKLLEFNNSKTPFASASIGKSFRNEISPRAGLLRVREFLMAEIEHFVDPLDKSHPKFNEIKDIKLSFLPRDVQEAGSTEPIVKTVGEAVASRMVDNETLGYFIARIYQFLMKIGVDESKLRFRQHMANEMAHYAADCWDGELKTSYGWIECVGCADRSAYDLTVHSKKTKEKLVVRQKLDNPIEVTKWEIDLTKKLFGPKFRKDAPKVESHLLNMSQDDLASKAELLKANGKFTIKVDGVDGEVELDDKLVKIEQRTKVEHVREYVPSVIEPSFGIGRIIYSVFEHSFWNRPEDNARSVLSFPPLVAPTKVLLVPLSNHKDLVPVTTEVAKILRKSQIPFKIDDSGVSIGKRYARNDELGTPFGVTIDFESAKDHSVTLRERDSTKQVRGSVENVIKAIRDITYNGASWEEGTKDLTPFIAQAEAEAETD

Protein

Glycine--tRNA ligase 1, mitochondrial: GRS1

Gene

grs1

Protein

Putative glycine--tRNA ligase

Organism

Schizosaccharomyces pombe (strain 972 / ATCC 24843)

Length

652 amino acids

Function

Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP). Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis.

Similarity

Belongs to the class-II aminoacyl-tRNA synthetase family.

Mass

74.005 kDa

Sequence

MTEVSKAAAFDRTQFEELMKKRFFFSPSFQIYGGISGLYDYGPPGSALQSNLVDIWRKHFVIEESMLEVDCSMLTPHEVLKTSGHVDKFADWMCKDPATGEIFRADHLVEEVLEARLKGDKEARGQNSNDQPEESDDKKKRKKKVKEIRATRLDDKTVEEYEFILAQIDNYDGDQLGELMKKYDIRNPATNGELETPRQFNLMFETQIGPSGGLKGYLRPETAQGQFLNFSRLLEFNNGKVPFASAMVGKAFRNEISPRSGLLRVREFLMAEVEHFVDPKNKEHDRFDEVSHMPLRLLPRGVQLEGKTDILEMPIGDAVKKGIVDNTTLGYFMARISLFLEKIGIDMNRVRFRQHMSNEMAHYACDCWDAEIQCSYGWIECVGCADRSAYDLSVHSKATKTPLVVQEALPEPVVVEQFEVEVNRKKFGPRFKRDAKAVEEAMISWPESEKVEKSAQLVAEGKIIVNVNGVEHTVESDLVTIEKRKHTEHIRTYTPNVIEPSFGLGRILYVLMEHAYWTRPEDVNRGVLSFPASIAPIKALIVPLSRNAEFAPFVKKLSAKLRNLGISNKIDDSNANIGRRYARNDELGTPFGLTVDFETLQNETITLRERDSTKQVRGSQDEVIAALVSMVEGKSSFEDALAKFGEFKSTQE

Protein

Putative glycine--tRNA ligase: grs1