Protein
G-protein coupled bile acid receptor 1
Organism
Oryctolagus cuniculus
Function
Receptor for bile acid. Bile-acid binding induces its internalization, activation of extracellular signal-regulated kinase and intracellular cAMP production. May be involved in the suppression of macrophage functions by bile acids. Involved in bile acid promoted GLP1R secretion (By similarity).
Similarity
Belongs to the G-protein coupled receptor 1 family.
Sequence
MTPNSTGEVPGPIPRGALELSLALASLIIAANLLLALGIACDRRLRSPPAGCFFLSLLLAGLLTGLALPTLPGLWRQSHRGYWSCLLVYLAPNFSFLSLLANLLLVHGERYVAVLRPLQPPGSIRLALLLTWTGPLLFASLPALGWNHWGPEANCSSQTIFPAPYLYLEVYGLLLPAVGAAALLSAHVLLAAHRQLQDIRRLERAVCRDAPSALARALTWRQARAQAGATLLFGLCWGPYVATLFLSVLAYEQRPPLGPGTLLSLLSLGSASAAAVPVAMGLGDHRYTAPWRAAARRWLRGLRGRGSQASPGPSTAYHTSSQSSVDVDLN