GON4L

Gene

Gon4l

Protein

GON-4-like protein

Organism

Mus musculus

Length

2260 amino acids

Function

Has transcriptional repressor activity, probably as part of a complex with YY1, SIN3A AND HDAC1 (PubMed:21454521). Required for B cell lymphopoiesis (PubMed:20530203).

Mass

248.742 kDa

Sequence

MLPCKKRRLSVTESSQQQDDQEGDDLDLEAAVKPDTDQLPDSASESLSWGQSQDSAVCPEGLSMQDGDDQLRAEGLSLNSKMLAQHVNLAVLEAVDVAVSQEIPLPSLESSHSLPVHVDKGRLQVSASKKGKRVVFTPGQVTREDRGDHPVPEEPPSGEPAEEAKTEGGELELRSDGEVPLLSSSSQSAKPGAQPRKSVQPDGSAFPQDKPLGPLVRQAEEEMEDGGLFIPTEEQDSEESDKKKKTKKGTKRKRDGKGPEQGTMVYDPKLDDMLDRTLEDGAKQHNLTAVNVRNILHEVITNEHVVAMMKAAISETEDMPLFEPKMTRSKLKEVVEKGVVIPTWNISPIKKASEIKQPPQFVDIHLEEDDSSDEEYSPDEEEEDETAEESLLESDVESTASSPRGVKRSRLRLSSEVAETDEESGMLSEVEKAATPALRHISAEVVPMGPPPPPKPKQSRDSVFMEKLDAVDEELASSPVCMDSFQPMEDSLIAFRTRSKMPLKDVPLGQLEAELQAPDITPDMYDPNTADDEDWKQWLGGLINDDVENEDEADDDDDPEYNFLEDLDEPDTEDFRTDRAVRITKKEVNGLMEELFETVQSVVPSKFQDEMGFSNMEDDGPEEEERATESRPSFNTPQALRFEEPLANLLNERHRTVKELLEQLKMKKPSVRQQPEVEKLKPQEEAAHQTLVLDPAQRSRLQQQMQQHVQLLTQIYLLTTSNPNLSSEASTTRIFLKELGTFAENSIALHQQFNPRFQTLFQPCNWMGAMRLIEDFTQVSIDCSPHKTAKKTASEFPCLPKQVAWILATNKVFMYPELLPICSLKANNPRDKTIFTKAEDNLLALGLKHFEGTEFPKPLISKYLVTCKTAHQLTVRIKNLNLNRAPNNVIKFYKKTKQLPVLVRCCEEIQPHQWKPPFEKEEHRLPFWLKASLQSIQDELRNISEGATEGGSVTTATESSTDQHLQKASPALGDEPQYPLLLPKGVVLKLKPGSKRFSRKAWRQKRPLVQKPLLIQPSPSVQPVFNPGKMATWPTQSEVPPSNTVVQIPHLIQPAAVLQTLPGFPSVGVRGEDGFESPTALPAMPCGSEARTTFPLSETQSAPPSCSAPKLMLPSLAPSKFRKPYVRRKPTRRKGAKVSPCVKPAPIIHPTPVIFTVPATTVKVVSIGGGCNMIQPVSAAVAPSPQTIPITTLLVNPTTFPCSLNQPLVASSISPLIVSSNPLTLPVTSIPEDKAQVKLDVAEGKNAPQNPESKLKPQELTPLCTTVFSKEEPKSWHSSADTGSQEAFSESSACSWAVVKTESQEGSSEKSACGWTVVKTEDGGHAVEPLPQNLQDSLSSSSKDLLNMVKMEAQDCMVEISSNFPKQDIGEEVKEECSMELDSESPQEKPSSASEMSKQTVLQREDMQAAKSPSVPQDAAAEGRTSSHASRGLPKSTLSSMGQGGGLSGPPGKLEDSANADGQSVGTPAGPDTGGEKDGPEEEEEEDFDDLTQDEEDELSSASEESVLSVPELQETMEKLTWLASERRMSQEGESEEENSQEENSEPEEEEEEEAEGMETLQKEDEVNDEAVGDAAKKPPSTLASPQTAPEIETSIAPAGESIKAAGKGRSSHRARNKRGSRARASKDTSKLLLLYDEDILDRDPLREQKDLAFAQAYLTRVREALQHTPGKYEDFLQIIYEFESSTQMHSAVDLFKSLQTLLQDWPQLLKDFAAFLLPEQALSCGLFEEQQAFEKSRKFLRQLEICFAENPSHHQKIIKVLQGCADCLPQDIAELKTQMWQLLRGHDHLQDEFSIFFDHLRPAASRMGDFEEINWTEEKEYEFDGFEEVILPDVEEDEEPAKVSTASKSKRRKEIGVQHQDKDTEWPEAAKDCSCSCHEGGPESKLKKSKRRNCHCSSKVCDSKPYKSKEPPELVGSGPLHEASTVPGSKEAGQGKDMLEEEILEEQENMEVTQSKTARTTRKGEAPAPGSTIGSTLLCPAEVTPMELLLEGPALCSAETPRLPPQTGAVVCSVRRNQAGPEVVSCLSTSSLPPEEGEDQRAAANSETIAPHREASETERLPETVEHSAPLPSPVSTRTRDTGRRHICGKAGSQSWLIESRAEAEAAHVAAPICEKSSGARASEAAPKTAREVLAEDSGTQGMGPEGALPKASEATVCANNSKVSSTGEKVVLWTREADRVILTMCQEQGAQPHTFSVISQQLGNKTPVEVSHRFRELMQLFHTACEASSEDEDDATSTSNADQLSDHGDLLSEEELDE

Gene

Gon4l

Protein

GON-4-like protein

Organism

Rattus norvegicus

Length

2256 amino acids

Function

Has transcriptional repressor activity, probably as part of a complex with YY1, SIN3A AND HDAC1. Required for B cell lymphopoiesis.

Mass

247.903 kDa

Sequence

MLPCKKRSGVTESAQQQDDQEGEDLHLEAAVKPDTDQLPDCTSESLSWGQSHDSAGCPEVHSMQDVGSQLSVEGTPLSSKMLTQRVNLAVSEAVDVPVSQEIPVPSLESSHSLPVHMGKGRLQSTASRKGKKIAFMPGQVTREDGGDHTVPEEPPSGEHAEEVKAEGGELEMHSEGDLPSLSSGSQSAKPRAQPRKSFQPDGSAFPQEKSLGPLVRQAEEDMEDGGLFIPTEEQDGEESDKRKKTKKGTKRKRDGRGQEQGTMTYDPKVDDMLDRTLEDGAKQHNLTAVNVRNILHEVITNEHVVAMMKAAISETEDMPLFEPKMTRSKLKEVVEKGVVIPTWNISPIKKASETKQPPQFVDIHLEDDDSSDEEYQPDEEEEDETAEESLLESDVESAASSPRGVKRSRLRLSSEAAEADEESGVLSEVEKVATPALRHISAEVVPMGPPPPPKPKQTRDSTFMEKLNAVDEELAASPVCMDSFQPMEDSLIAFRTRSKMPLKDVPLGQLEAELQAPDITPDMYDPNTADDEDWKLWLGGLLNDDVENEDEADDDDDPEYNFLEDLDEPDTEDFRTDRAVRITKKEVNGLMEELFETVQSVVPSKFQDEMGFSNMEDDGPEEEERVTESRPSFNTPQALRFEEPLANLLNERHRTVKELLEQLKMKKSSVRQQPEVEKLKPQTEKVHQTLVLDPAQRSRLQQQMQQHVQLLTQIYLLTTSNPNLSSEASTTRVFLKELGTFAENSTALHQQFNPRFQTLFQPCNWVGAMQLIEDFTHISIDCSPHKTVKKTASEFPCLPKQVAWILATNKVFMYPELLPICSLKANNPRDKTIFTKAEDNLLALGLKHFEGTEFPKPLISKYLVTCKTAHQLTVRIKNLNLNRAPNNVIKFYKKTKQLPVLVRCCEEIQPHQWKPPIEKEEHRLPFWLKASLQSIQEELRNLAGGATAGGSVTAATETSTDQHLQKTSPVVGGDTQYPLLLPKGVVLKLKPGSKRFSRKAWRQKRPLVQKPLLIQPSPSVQPVFNPGKMATWPTQSEVPPSNTVVQIPHLIQPAAVLQTLPGFPSVGVCGEDSFESPAALPAMPSGSEARTSFPWSESQSAPPSSSAPKLMLPSLGPSKFRKPYVRRKPTRRKGAKASPCVKPAPIIHPTPVIFTVPATTVKVVSLGGGCNMIQPVTAAVAPSPQTIPITTLLVNPTSFPCSLNQPLVASSISPLLVSSNPLALPVTSLPEEKAHVSLDIAEGKNAPQNPEPKIKPQEPTPQCATVFSKEEPRSWHPSADTGNQEAVSESSACSWAAVKTEGQEGSSEKSVCGWTVVKTEDGGHAVQPLPQDPQDSLNSPSKDLLNMVKLEAEDCMEEISSDFPKQDIGEEVKEECCMELDRDSPQEKASSVSEMSKQTATPREETQAAKSPTVSQDAPDAIRDASKGLPQSTLSSMDQGTVLNSPPGKPEDSANADGQSVGTPAGTDTGAEKDGAEEEEEEDFDDLTQDEEDELSSASEESVLSVPELQETMEKLTWLASERRMSQEGESEEENSQEENSEPEEEEEEEAEGMETLQKEDEATDEAGGGAAEKPPSTLASPHTAPEVETSITPAGESIKAAGKGRSSHRARSRRGSRARASKDASKLLLLYDEDILDRDPLREQKDLAFAQAYLTRVREALQHIPGKYEDFLQIIYEFESNAQMHSAVDLFKSLQTLLHDWPQLLKDFAAFLLPEQALSCGLFEEQQAFEKSRKFLRQLEICFAENPSHHQKIIKVLQGCADCLPQDITELKTQMWQLLRGHDHLQDEFSIFFDHLRPAANRMGDFEEINWTEEKEYEFDGFEEVILPEVEEEEEPAKVSTASKSKRRKEIGVQHQDKESEWPEAAKDGSCPCHEGGPESKLKKSKRRNCHCSSKVCDSKSYKSKEPLELVGSGPLQEASTVPGTKEAGQGKDMSEEETMEGQENVEVSQNKTGRTTRKGEAPIPGSTVRTALLCSAEVTPIELSLEGPTCCSPETPRLPPQTGAVVCSVRRNQAGPEVVSCLGTSSIPPKEGEDQKAVANSETIAPLPETSETERLPGTVELPAPLPSPVSLSTRDTGRRHIYGKAGTQSWLLDNRAEAKAAHMVAPIRGTSSGASASEAAPTASREGLAEDSETQGKGPEAVLPKASEATVCANNSKVSSTGEKVVLWTREADRVILTMCQEQGAQPHTFSVISQQLGNKTPVEVSHRFRELMQLFHTACEASSEDEDDATSTSNADQLSDHGDLLSEEELDE

Gene

GON4L

Protein

GON-4-like protein

Organism

Homo sapiens

Length

2241 amino acids

Function

Has transcriptional repressor activity, probably as part of a complex with YY1, SIN3A AND HDAC1. Required for B cell lymphopoiesis.

Mass

248.62 kDa

Sequence

MLPCKKRRTTVTESLQHKGNQEENNVDLESAVKPESDQVKDLSSVSLSWDPSHGRVAGFEVQSLQDAGNQLGMEDTSLSSGMLTQNTNVPILEGVDVAISQGITLPSLESFHPLNIHIGKGKLHATGSKRGKKMTLRPGPVTQEDRCDHLTLKEPFSGEPSEEVKEEGGKPQMNSEGEIPSLPSGSQSAKPVSQPRKSTQPDVCASPQEKPLRTLFHQPEEEIEDGGLFIPMEEQDNEESEKRRKKKKGTKRKRDGRGQEGTLAYDLKLDDMLDRTLEDGAKQHNLTAVNVRNILHEVITNEHVVAMMKAAISETEDMPMFEPKMTRSKLKEVVEKGVVIPTWNISPIKKANEIKPPQFVDIHLEEDDSSDEEYQPDDEEEDETAEESLLESDVESTASSPRGAKKSRLRQSSEMTETDEESGILSEAEKVTTPAIRHISAEVVPMGPPPPPKPKQTRDSTFMEKLHAVDEELASSPVCMDSFQPMDDSLIAFRTRSKMPLKDVPLGQLEAELQAPDITPDMYDPNTADDEDWKMWLGGLMNDDVGNEDEADDDDDPEYNFLEDLDEPDTEDFRTDRAVRITKKEVNELMEELFETFQDEMGFSNMEDDGPEEEECVAEPRPNFNTPQALRFEEPLANLLNEQHRTVKELFEQLKMKKSSAKQLQEVEKVKPQSEKVHQTLILDPAQRKRLQQQMQQHVQLLTQIHLLATCNPNLNPEATTTRIFLKELGTFAQSSIALHHQYNPKFQTLFQPCNLMGAMQLIEDFSTHVSIDCSPHKTVKKTANEFPCLPKQVAWILATSKVFMYPELLPVCSLKAKNPQDKIVFTKAEDNLLALGLKHFEGTEFPNPLISKYLLTCKTAHQLTVRIKNLNMNRAPDNIIKFYKKTKQLPVLGKCCEEIQPHQWKPPIEREEHRLPFWLKASLPSIQEELRHMADGAREVGNMTGTTEINSDRSLEKDNLELGSESRYPLLLPKGVVLKLKPVATRFPRKAWRQKRSSVLKPLLIQPSPSLQPSFNPGKTPARSTHSEAPPSKMVLRIPHPIQPATVLQTVPGVPPLGVSGGESFESPAALPAVPPEARTSFPLSESQTLLSSAPVPKVMLPSLAPSKFRKPYVRRRPSKRRGVKASPCMKPAPVIHHPASVIFTVPATTVKIVSLGGGCNMIQPVNAAVAQSPQTIPITTLLVNPTSFPCPLNQSLVASSVSPLIVSGNSVNLPIPSTPEDKAHVNVDIACAVADGENAFQGLEPKLEPQELSPLSATVFPKVEHSPGPPLADAECQEGLSENSACRWTVVKTEEGRQALEPLPQGIQESLNNPTPGDLEEIVKMEPEEAREEISGSPERDICDDIKVEHAVELDTGAPSEELSSAGEVTKQTVLQKEEERSQPTKTPSSSQEPPDEGTSGTDVNKGSSKNALSSMDPEVRLSSPPGKPEDSSSVDGQSVGTPVGPETGGEKNGPEEEEEEDFDDLTQDEEDEMSSASEESVLSVPELQETMEKLTWLASERRMSQEGESEEENSQEENSEPEEEEEEEAEGMESLQKEDEMTDEAVGDSAEKPPTFASPETAPEVETSRTPPGESIKAAGKGRNNHRARNKRGSRARASKDTSKLLLLYDEDILERDPLREQKDLAFAQAYLTRVREALQHIPGKYEDFLQVIYEFESSTQRRTAVDLYKSLQILLQDWPQLLKDFAAFLLPEQALACGLFEEQQAFEKSRKFLRQLEICFAENPSHHQKIIKVLQGCADCLPQEITELKTQMWQLLKGHDHLQDEFSIFFDHLRPAASRMGDFEEINWTEEKEYEFDGFEEVALPDVEEEEEPPKIPTASKNKRKKEIGVQNHDKETEWPDGAKDCACSCHEGGPDSKLKKSKRRSCSHCSSKVCDSKSYKSKEPHELVGSSPHREASPMPGAKEAGQGKDMMEEEAPEERESTEATQSRTVRTTRKGEMPVSAGLAVGSTLPSPREVTVTERLLLDGPPPHSPETPQFPPTTGAVLYTVKRNQVGPEVRSCPKASPRLQKEREGQKAVSESEALMLVWDASETEKLPGTVEPPASFLSPVSSKTRDAGRRHVSGKPDTQERWLPSSRARVKTRDRTCPVHESPSGIDTSETSPKAPRGGLAKDSGTQAKGPEGEQQPKAAEATVCANNSKVSSTGEKVVLWTREADRVILTMCQEQGAQPQTFNIISQQLGNKTPAEVSHRFRELMQLFHTACEASSEDEDDATSTSNADQLSDHGDLLSEEELDE