Protein
Gonadotropin-releasing hormone receptor
Function
Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This receptor mediates its action by association with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Ligand interaction triggers steroidogenesis in spermatozoa and follicles. Appears to be involved in contraction of the radula retractor muscle.
Similarity
Belongs to the G-protein coupled receptor 1 family.
Sequence
MDYLNDSMFNNMTYNITSTPLPDAPRFDNVYVSKLCVLGTVFVISFFGNTLVIIQIFRIRGSRSTIQSLILNLAIADLMVSFFNILMDIIWSATVEWLAGNTMCKIMKYLTVFGLHLSTYITVSIALDRCFAILSPMSRSKAPLRVRIMITMAWVLSAIFSIPQAVIFQEQRKMFRQGMFHQCRDSYNALWQKQLYSASSLILLFVIPLIIMVTSYLLILKTIVKTSRQFHDTPISPTSMSCYSVNHGQIRTHLFERARKRSSRMSAVIVAAFILCWTPYYIIFLGFAFFQWDNSRTVIYFFTLGTSNCMLNPLIYGAFTIYKVHRGRSGSANSPSGTRLMIMVNKRGRSTTTTTNRMSGSGRRQLTTGQTITQCASLTNPHQPVRPSPGINSTTSPNGKMPTKPPG