GNL2

ARF guanine-nucleotide exchange factor GNL2

1375 amino acids

Activates the ARF proteins by exchanging bound GDP for free GTP. Plays a role in vesicular protein sorting. Essential for pollen germination.

156.243 kDa

MDRIAVRAKRKELGISCMLNTEVGAVLAVIRRPLSESYLSPQETDHCDSSVQQSLKSLRALIFNPQQDWRTIDPSVYLSPFLEVIQSDEIPASATAVALSSILKILKIEIFDEKTPGAKDAMNSIVSGITSCRLEKTDLVSEDAVMMRILQVLTGIMKHPSSELLEDQAVCTIVNTCFQVVQQSTGRGDLLQRNGRYTMHELIQIIFSRLPDFEVRGDEGGEDSESDTDEIDMSGGYGIRCCIDIFHFLCSLLNVVEVVENLEGTNVHTADEDVQIFALVLINSAIELSGDAIGQHPKLLRMVQDDLFHHLIHYGASSSPLVLSMICSCILNIYHFLRKFMRLQLEAFFSFVLLRVTAFTGFLPLQEVALEGLINFCRQPAFIVEAYVNYDCDPMCRNIFEETGKVLCRHTFPTSGPLTSIQIQAFEGLVILIHNIADNMDREEDEGNEEDDNNSNVIKPSPVEIHEYIPFWIDKPKEDFETWVDHIRVRKAQKRKLAIAANHFNRDEKKGLEYLKYNYLVSDPLDPMALASFFRFTPGLDKTMIGDYLGDPDELHLSVLRSFTHTFEFTGMNLDTALRTFLESFRLPGESQKIERMIEAFSERFYDQQSSDIFASKDTVHILCYSLIMLNTDQHNPQVRRKMTEDEFIRNNRAINAGNDLPKEYLSELFQSIATNAFALSTHSGPVEMNPNRWIELMNRTKTTQPFSLCQFDRRIGRDMFATIAGPSIAAVSAFFEHSDDDEVLHECVDAMISIARVAQYGLEDILDELIASFCKFTTLLNPYTTPEETLFAFSHDMKPRMATLAVFTLANTFGDSIRGGWRNIVDCLLKLRKLQLLPQSVIEFEINEENGGSESDMNNVSSQDTKFNRRQGSSLMGRFSHFLALDNVEESVALGMSEFEQNLKVIKQCRIGQIFSKSSVLPDVAVLNLGRSLIYAAAGKGQKFSTAIEEEETVKFCWDLIITIALSNVHRFNMFWPSYHEYLLNVANFPLFSPIPFVEKGLPGLFRVCIKILASNLQDHLPEELIFRSLTIMWKIDKEIIETCYDTITEFVSKIIIDYSANLHTNIGWKSVLQLLSLCGRHPETKEQAVDALIGLMSFNASHLSQSSYAYCIDCAFSFVALRNSSVEKNLKILDLMADSVTMLVKWYKTASTDTANSYSPASNTSSSSSMEENNLRGVNFVHHLFLKLSEAFRKTTLARREEIRNRAVTSLEKSFTMGHEDLGFTPSGCIYCIDHVIFPTIDDLHEKLLDYSRRENAEREMRSMEGTLKIAMKVLMNVFLVYLEQIVESAEFRTFWLGVLRRMDTCMKADLGEYGDNKLQEVVPELLTTMIGTMKEKEILVQKEDDDLWEITYIQIQWIAPALKDELFPDEEI

GNL2

Nucleolar GTP-binding protein 2

731 amino acids

GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation (By similarity). May promote cell proliferation possibly by increasing p53/TP53 protein levels, and consequently those of its downstream product CDKN1A/p21, and decreasing RPL23A protein levels (PubMed:26203195).

Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.

83.655 kDa

MVKPKYKGRSTINPSKASTNPDRVQGAGGQNMRDRATIRRLNMYRQKERRNSRGKIIKPLQYQSTVASGTVARVEPNIKWFGNTRVIKQSSLQKFQEEMDTVMKDPYKVVMKQSKLPMSLLHDRIRPHNLKVHILDTESFETTFGPKSQRKRPNLFASDMQSLIENAEMSTESYDQGKDRDLVTEDTGVRNEAQEEIYKKGQSKRIWGELYKVIDSSDVVVQVLDARDPMGTRSPHIETYLKKEKPWKHLIFVLNKCDLVPTWATKRWVAVLSQDYPTLAFHASLTNPFGKGAFIQLLRQFGKLHTDKKQISVGFIGYPNVGKSSVINTLRSKKVCNVAPIAGETKVWQYITLMRRIFLIDCPGVVYPSEDSETDIVLKGVVQVEKIKSPEDHIGAVLERAKPEYISKTYKIDSWENAEDFLEKLAFRTGKLLKGGEPDLQTVGKMVLNDWQRGRIPFFVKPPNAEPLVAPQLLPSSSLEVVPEAAQNNPGEEVTETAGEGSESIIKEETEENSHCDANTEMQQILTRVRQNFGKINVVPQFSGDDLVPVEVSDLEEELESFSDEEEEEQEQQRDDAEESSSEPEEENVGNDTKAVIKALDEKIAKYQKFLDKAKAKKFSAVRISKGLSEKIFAKPEEQRKTLEEDVDDRAPSKKGKKRKAQREEEQEHSNKAPRALTSKERRRAVRQQRPKKVGVRYYETHNVKNRNRNKKKTNDSEGQKHKRKKFRQKQ

Gnl2

Nucleolar GTP-binding protein 2

728 amino acids

GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation (By similarity). May promote cell proliferation possibly by increasing p53/TP53 protein levels, and consequently those of its downstream product CDKN1A/p21, and decreasing RPL23A protein levels (By similarity).

Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.

83.345 kDa

MVKPKYKGRSTINRSAASTNPDRVQGAGGQNMRDRGTIRRLNMYRQKERRNSRGKVIKPLQYQSTVASGTVARVEPNIKWFGNTRVIKQASLQKFQEEMDKVMKDPYKVVMKQSKLPMSLLHDRIQPHNAKVHILDTESFESTFGPKSQRKRPNLFASDMQSLLENAEMSTESYDQGKDRDLVMEDTGVRNEAQEEIYKKGQSKRIWGELYKVIDSSDVVVQVLDARDPMGTRSPHIEAYLKKEKPWKHLIFVLNKCDLVPTWATKRWVAVLSQDYPTLAFHASLTNPFGKGAFIQLLRQFGKLHTDKKQISVGFIGYPNVGKSSVINTLRSKKVCNVAPIAGETKVWQYITLMRRIFLIDCPGVVYPSEDSETDIVLKGVVQVEKIKAPQDHIGAVLERAKPEYISKTYKIESWENAEDFLEKLALRTGKLLKGGEPDMLTVSKMVLNDWQRGRIPFFVKPPNAELPTDSQLPPSSPLEVPTETTQNNPEEETTETEVERSDSITEKEPEGDCSQDRNSEMQQILARVRQNFGKINVGPQFSADDLVPVEMSDLEDLESSGEEEEQEQEQPGEDAEEERSPDTQEEPVGNDTKAVLRALDEKIAKYQRFLNKAKAKKFSAVRISKDLSEKVFAKYKEEKKTSAEDSDAAPTKKARKWDAQMEEEPSNKTQRMLTCKERRRAARQQQSKKVGVRYYETHNVKNRNRNKKKTSDSEGQKHRRNKFRQKQ