Function
Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway. Converts GlcNAcMan(5)GlcNAc(2) (Man5Gn) into GlcNAcMan(3)GlcNAc(2) (MGn) by sequential removal of two alpha1,6- and alpha1,3-linked mannose residues from the alpha1,6-mannose branch of the substrate. To a lesser extent, also able to cleave beta1,2-xylosylated Man5Gn-glycopeptide (Man5GnX-GP) and pyridylaminated substrates Man5Gn-PA and Man5GnX-PA, but not active toward Man5-glycopeptide (PubMed:16460512, PubMed:21478158). Required for resistance to salt stress (PubMed:18408158).
Sequence
MPFSSYIGNSRRSSTGGGTGGWGQSLLPTALSKSKLAINRKPRKRTLVVNFIFANFFVIALTVSLLFFLLTLFHFGVPGPISSRFLTSRSNRIVKPRKNINRRPLNDSNSGAVVDITTKDLYDRIEFLDTDGGPWKQGWRVTYKDDEWEKEKLKIFVVPHSHNDPGWKLTVEEYYQRQSRHILDTIVETLSKDSRRKFIWEEMSYLERWWRDASPNKQEALTKLVKDGQLEIVGGGWVMNDEANSHYFAIIEQIAEGNMWLNDTIGVIPKNSWAIDPFGYSSTMAYLLRRMGFENMLIQRTHYELKKDLAQHKNLEYIWRQSWDAMETTDIFVHMMPFYSYDIPHTCGPEPAICCQFDFARMRGFKYELCPWGKHPVETTLENVQERALKLLDQYRKKSTLYRTNTLLIPLGDDFRYISIDEAEAQFRNYQMLFDHINSNPSLNAEAKFGTLEDYFRTVREEADRVNYSRPGEVGSGQVVGFPSLSGDFFTYADRQQDYWSGYYVSRPFFKAVDRVLEHTLRGAEIMMSFLLGYCHRIQCEKFPTSFTYKLTAARRNLALFQHHDGVTGTAKDYVVQDYGTRMHTSLQDLQIFMSKAIEVLLGIRHEKEKSDQSPSFFEAEQMRSKYDARPVHKPIAAREGNSHTVILFNPSEQTREEVVTVVVNRAEISVLDSNWTCVPSQISPEVQHDDTKLFTGRHRLYWKASIPALGLRTYFIANGNVECEKATPSKLKYASEFDPFPCPPPYSCSKLDNDVTEIRNEHQTLVFDVKNGSLRKIVHRNGSETVVGEEIGMYSSPESGAYLFKPDGEAQPIVQPDGHVVTSEGLLVQEVFSYPKTKWEKSPLSQKTRLYTGGNTLQDQVVEIEYHVELLGNDFDDRELIVRYKTDVDNKKVFYSDLNGFQMSRRETYDKIPLQGNYYPMPSLAFIQGSNGQRFSVHSRQSLGVASLKEGWLEIMLDRRLVRDDGRGLGQGVMDNRAMTVVFHLLAESNISQADPASNTNPRNPSLLSHLIGAHLNYPINTFIAKKPQDISVRVPQYGSFAPLAKPLPCDLHIVNFKVPRPSKYSQQLEEDKPRFALILNRRAWDSAYCHKGRQVNCTSMANEPVNFSDMFKDLAASKVKPTSLNLLQEDMEILGYDDQELPRDSSQPREGRVSISPMEIRAYKLELRPHK