Protein
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase
Organism
Giardia intestinalis (strain ATCC 50803 / WB clone C6)
Function
Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in cytoplasmic and nuclear proteins resulting in their modification with a beta-linked N-acetylglucosamine (O-GlcNAc).
Similarity
Belongs to the glycosyltransferase 41 family. O-GlcNAc transferase subfamily.
Sequence
MVALMDKIAQLFRNKQYSDLIQLIDKQLHAKNEPEALIFLYAIQGEISFKQKDWIQAFAAYEKAVAESKQKGLPTQVYAQIVQRQMIILLRLQMLDTAFGLFSENQSVSVDNVQVLAQLALLYLMCERYSEAEKLLSSIVESSTSNTITLSKQFKEDIGPFKELFGVLDTYDTFLATILNNLAICNSKLGNHTLAFDQFQQALDIIKDPEKITRPPLSPITVLFDNCVSTVDEDKEKALKVEHHMLTINESKENQEDDTVLSLLRDGCTLIPSSTLGTHLPLIIELHSTICYNIGKLELTLGNLDRSVNHFKKSIEYQPSFARYVALGLVYRDMRNFYDAAEMLTKAVDSCVGISNLCLGEVVYNLGILVSEELKMPYKSLQFFDEATVLFIRGEFSAGAILSRIMKANSLTTITTATAVSSDWEFIMAFLNTLYLDLCAFSKDQGFNVEAAFTGTNAISFNLPITEPQEKESPKSDKIASEKPLVESNPGRSRTPSSMNDVYMLSAENLSFSLLESSFAQKETITSRLFPTFQAETKRYLAILYTNLGLIYYRIGIPTYYKQARRCFEVAIWFDNDCVFAINYLSVLLLKENSKTLAIEGLLKCTRLFPEYYEPFYNLGNILKADEENKKALQYYSRAIELNPRFLDGYLARGVLYAELHRFETAYLDFSKCIELDPDNRHAFCNYIHMKQILGIFHNDTLDMRKISKIIDDYIHEYLTVQNAINKGVVLPSHPLPPIMPYHCYLYRLSSSQLRFICQRYSEQNVNWVKQNIDMMSTPLLDLSIHQRPMPPSIGLINSVSSSSQLQLSMLPLNQSAADSMVPLAMLTPGPTLCTAIGFQSIKSVIRDSQHITHGPIFSYDRALITLARSKHSSKCPISYIDIVNLKSPLRLGVLCDDINSIPIGCILESWLRNIDPKVASLSIYSTVASDKSALRTSLEAHCSNFIDFTNYKYQNNPFLCAQRINGDGICIMISMCQHNCGLEGRILAMRPAPIQISYWTHGGTTNSNYLDYILADQYCIPPGYAHLYSEHVITMPGCFICPSHSMHYSNAILLEEHADILKVTVEEVRSLIQDSKPDIDVNHHSAAGENILSLDGSDATSSSVDSGIGSRTHSEAPIGGGDKDEGAHSSKILELELELAEIAKMKGETKNGVSTNSASEGRDELLMNDRILITGDNVFFQVQPIRNGRLVGGRDRSMIKKMEPLLKAIYPLQRIASEAAVPASMEKSENNSDLTSHRVCLELPLYRKNIRALYGIPANCFLFCTFNQVYKFDMGTLGIIAALLRSVPNAYYALLKFPPASQLHIEAFFRHKAPDILDRVIFLSMLPMKVEHIRRYLAVDVFVDTLKCNGSTIVLDALWSGVPVVGFVGEYILSRKTLSFLSVLECKDLICASQGEAVLLCTRLAVDSGYYFSVRKRILKNRSNLFNISRWCDNFVLTMMLAYKNWIFGGKPTSFSTERVIANVKSQGFSWPLKSTGAQ