GIT3

Major glycerophosphoinositol permease GIT3

535 amino acids

Glycerophosphodiester transporter that mediates uptake of glycerophosphocholine (GroPCho) with GIT4 (PubMed:24114876). GIT3 acts as the major GroPCho permease (PubMed:24114876). Does not possess detectable glycerophosphoinositol (GroPIns) transport activity (PubMed:24114876). The expanded ability to utilize GroPIns and GroPCho results from the organism's pathogenic nature and its need to occupy a variety of environments within its host organism (PubMed:24114876). This possibility is buttressed by the fact that GroPIns and GroPCho are present and abundant in human fluids (PubMed:24114876).

Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.

59.4 kDa

MSTRDLPHSFSELSYGWVKRIRAEFTVGKSKEQLLAEDYHSTTDEDSEVVTSVKANSLWPAFASGAGLFSDGYVNNSISTVLFCLKKIYPDEITKSNAINNIASIAFVGTVVGQLGFGYISDRIARKGGMMAANVMLIFFTLMCAVGSWGVTVQGFFACLTVWRFFLGVAIGAEYPTSSVIASEFANQLPPGKRNRYFSWFTNAMIDSGFVVSAFVPFVLIWIFTEKHLRALWRVAIGLGVIPPLSLFFMRLKMKNSSSFQKLHMKNVKYRDYPWWLIVKFYWFRLTIVSLIWFIYDFSAYSFGNFNTIIIGEIIPEAPIWKQWGWSIVFNLFYIPGAFLGAISADYIGPRLTLALGVGIQGVIGIAMSACLNSLKKHIAGFVVVFGIFTTFGEFGPGDNIGLLASKTSATAIRGQYYGIAAAIGKIGAFVGTWVFPAIQSKYANNANPDLQLQVPFYISSALCLFSACLAIFFCPQVGQDAIYKEDHDFVQYLSNNGFDINMLGEGGDVREVCRESDSLEKGKRDDFQVDNNSL

git3

Glucose receptor protein git3

466 amino acids

Activates gpa2 when triggered by glucose and then activates adenylate cyclase.

Belongs to the G-protein coupled receptor GPR1/git3 family.

53.86 kDa

MLHLDYTFNVSDATSTSSIIIVSRRELANLRIMVIIASAISIVFSLIAIFWRWSRRRTIREQFHIALFSVLFIRSIVQMIHPCLALSDPFFWAPKHRCFTIGFFLLVLVRMTDYWIFINILHNALLVLFPHVDTERRGLYRFRHTVFTLSFVIPLTIGGLAFTNKRNTFVNLQTRCYLPYTPVRFMFGLNWSFDYALSIAIIALQTCMFISIRRKIKRFKKYSHQQTNVFDTLNVIDSYPTAPDQVALPPFPDTNSTLTYTPSNSQSIYSSQSQPSPYSRPLLSSVHPNLPPGSQSTPANLNQSGIHFEQDFRDSPNRTNGLEDHTSFKLSSPLTSDEDGASSVLAAYGNDMQDDPLLKQRKRILSQSKFLFAYPAIFIFMWILPQIQIIVILAQPLHCSGSCKRFAFVAVFADNFVAIFIALSDFIWICYRGYTYLKERDSSKSYWDQIKELTLKWWRGKFGEEK