gigyf2

GRB10-interacting GYF protein 2

1329 amino acids

Key component of the 4EHP-GYF2 complex, a multiprotein complex that acts as a repressor of translation initiation.

Belongs to the GIGYF family.

152.268 kDa

MAETQTLNFGPEWLRALAGGVGSSIVASPPLSPALPKYKLADYRYGREEMLALYVKDNMIPVDLHDKEFLPILQEEPLPPLALVPFTEEEQRNFSMSVNSAAVLRLTGRGGGTVAGAPRGRSSSRGRGRGRGDGFYQRSFDDVEGGFGRGGREMHRSQSWEERGDRRFEKPGRKDPDGAPAHFPLNHIRANYEDPAAVNARKFIHAECDNWRTTRDELNGEEDDNGWRLAGARRENERWCPPSPDGPRSAGWREHPDQRRRFGFGDEERSGYRRPRSGSGSAEEERDSLPEWCLEDAEEETGTFDSSGAFLSLKVRALEKAPKEPILEEAELDFRPLEENDEYAEKDDSETEQTKDTDTNTRHESDRNEENCKSEEPSPVAVPFSAVVTPPKATTPAPIQPVHLEKAEDKERPSERTTLPEIRHELSKAPLHTALSNSIVEAISIPHVANKLPDLPVPAPSVLPVKSVPPQSQQVKPIEMPVSVPPALLRSTGSVGPISRPSALPSDLDEDEGLKHFEQEAEKMVAYLQDGGVDDERLASKIGPKPSALPITNEAAFKWFYKDPQGEIQGPFNNQEMSEWFQAGYFTMTLQVKRGCDEMFQPLGEMIKLWGRVPFTPGPTLPPILGDADQERMKRQQEINALNMYQLQQMQYQYLLRQQYALQQKVLNSAPPPPPPPQQQLNLLLHQALKIRTPEPQQSLLPPVTRSMSVPDSGSVWEMQNPSTQASCSPNMQPAAPSTWEGSSVWDLPLDNMPQASSIEQLQLEKAKALKLEMERREAELRAKREEEERKRLEEALRARQEEERKRLEEEELARRKQEEALKRQREQEEAQRRKKEEEERLAQEEALRRLEERRREEEERRQREEFLRKQQEEERRKQEELEAQRRREEEKRLEEEAAAAAAALLRQQQEEQKKREQEAQRQQELQRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSKWGQQSTTANSLSQSQNALSLAEIQKLEEERERQTREEQRRQQQELQRVQQQQPQTKLPGWGSVAKQPMATKSLLEIQREEAQQMKQRKDQQQQQQQQQQPPPQPQPQQHSTNTQQNRTQNRAAINTSVWGSVNNVSSNWMMDSSVWGDTQNSNIGFWDEAVKEAAPPQTTRKSHTPKNKGNANLSNSSSGKASKKVEEEEKLLKLFQGANKNQDGFMQWCEQTLHTLNTANNLDVPTFASFLKEVDSPYEVHDYVRAYLGDTPQAKDFAKQFLERRAKQNDNQQKPQQGQQQKQQESVWGIREVPQSVLLQQQQQQQLQQQQQQRFETVTSGKKKKKQKMVRADPSLLGFSVNASSERLNMGEIETVEDF

GIGYF2

GRB10-interacting GYF protein 2

1299 amino acids

Key component of the 4EHP-GYF2 complex, a multiprotein complex that acts as a repressor of translation initiation (PubMed:22751931). In 4EHP-GYF2 the complex, acts as a factor that bridges EIF4E2 to ZFP36/TTP, linking translation repression with mRNA decay (By similarity). May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling, including IGF1 and insulin receptors (PubMed:12771153).

Belongs to the GIGYF family.

150.07 kDa

MAAETQTLNFGPEWLRALSSGGSITSPPLSPALPKYKLADYRYGREEMLALFLKDNKIPSDLLDKEFLPILQEEPLPPLALVPFTEEEQRNFSMSVNSAAVLRLTGRGGGGTVVGAPRGRSSSRGRGRGRGECGFYQRSFDEVEGVFGRGGGREMHRSQSWEERGDRRFEKPGRKDVGRPNFEEGGPTSVGRKHEFIRSESENWRIFREEQNGEDEDGGWRLAGSRRDGERWRPHSPDGPRSAGWREHMERRRRFEFDFRDRDDERGYRRVRSGSGSIDDDRDSLPEWCLEDAEEEMGTFDSSGAFLSLKKVQKEPIPEEQEMDFRPVDEGEECSDSEGSHNEEAKEPDKTNKKEGEKTDRVGVEASEETPQTSSSSARPGTPSDHQSQEASQFERKDEPKTEQTEKAEEETRMENSLPAKVPSRGDEMVADVQQPLSQIPSDTASPLLILPPPVPNPSPTLRPVETPVVGAPGMGSVSTEPDDEEGLKHLEQQAEKMVAYLQDSALDDERLASKLQEHRAKGVSIPLMHEAMQKWYYKDPQGEIQGPFNNQEMAEWFQAGYFTMSLLVKRACDESFQPLGDIMKMWGRVPFSPGPAPPPHMGELDQERLTRQQELTALYQMQHLQYQQFLIQQQYAQVLAQQQKAALSSQQQQQLALLLQQFQTLKMRISDQNIIPSVTRSVSVPDTGSIWELQPTASQPTVWEGGSVWDLPLDTTTPGPALEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQQEEARQMQKQQQQQQQHQQPNRARNNTHSNLHTSIGNSVWGSINTGPPNQWASDLVSSIWSNADTKNSNMGFWDDAVKEVGPRNSTNKNKNNASLSKSVGVSNRQNKKVEEEEKLLKLFQGVNKAQDGFTQWCEQMLHALNTANNLDVPTFVSFLKEVESPYEVHDYIRAYLGDTSEAKEFAKQFLERRAKQKANQQRQQQQLPQQQQQQPPQQPPQQPQQQDSVWGMNHSTLHSVFQTNQSNNQQSNFEAVQSGKKKKKQKMVRADPSLLGFSVNASSERLNMGEIETLDDY

Gigyf2

GRB10-interacting GYF protein 2

1291 amino acids

Key component of the 4EHP-GYF2 complex, a multiprotein complex that acts as a repressor of translation initiation (PubMed:26763119). In 4EHP-GYF2 the complex, acts as a factor that bridges EIF4E2 to ZFP36/TTP, linking translation repression with mRNA decay (PubMed:26763119). May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling, including IGF1 and insulin receptors (PubMed:12771153).

Belongs to the GIGYF family.

149.193 kDa

MAAETQTLNFGPEWLRALSSGGSITSPPLSPALPKYKLADYRYGREEMLALFLKDYKIPFDLLEKEFLPILQEEPLPPLALVPFTEEEQRNFSMSVNSAAVLRLTGRGGGGGTVVGAPRGRSSSRGRGRGRGECGFYQRSFDEVEGVFGRGGGREMHRSQSWEERGDRRFEKPGRKDVGRPNFEESGPTSVGRKHEFIRSESENWRIFREEQNGEDEDGGWRLAGSRRDGERWRPHSPDGPRSTGWREHMERRRRFEFDFRDRDDERGYRRVRSGSGSIDDDRDSLPEWCLEDAEEEMGTFDSSGAFLSLKKVQKEPIPEEQEMDFRPVEEGEERSDSDSSHNEEAKEPDKTNRREGEKTDRAGAEASEEVPQTSLSSARPGTPSDHQPQEATQFERKDEPKAEQVEKAEEENRSENSLSAKVPSRGDETVPASQQPSTPLPPDTASPLLILSPPVPTPSSASRPVETAAVEAPGMSSVSTEPDDEEGLKHLEQQAEKMVAYLQDSALDDERLTSKLQEHRAKGVSIPLMHEAMQKWYYKDPQGEIQGPFNNQEMAEWFQAGYFTMSLLVKRACDESFQPLGDIMKMWGRVPFSPGPAPPPHMGELDQERLTRQQELTALYQMQHLQYQQFLIQQQYAQVLAQQQKAALSSQQQQQLALLLQQFQALKMRMSDQNIIPSVTRSVSVPDTGSIWELQPAASQPAVWEGGSVWDLPLDTTAPGPSLEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELELQRQKDLMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTATCQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQQKLSGWGNVSKPAGTTKSLLEIQQEEARQMQKQQQQQQQQQQQHQQSNRARNSTHSNLHTSLGNSVWGSINTGPSNQWASELVSSIWSNADTKNSNMGFWDDAVKEVGPRNSTNKNKNNASLSKSVGVSNRQNKKVEEEEKLLKLFQGVNKAQDGFTQWCEQMLHALNTANNLDVPTFVSFLKEVESPYEVHDYTRAYLGDTSEAKEFAKQFLERRAKQKVNQQRQQQQQQQQQQDSVWGMNHSTLHSVFQTNQSNNQQSNFEAVQSGKKKKKQKMVRADPSLLGFSVNASSERLNMGEIETLDDY

gigyf2

GRB10-interacting GYF protein 2

1239 amino acids

Key component of the 4EHP-GYF2 complex, a multiprotein complex that acts as a repressor of translation initiation.

Belongs to the GIGYF family.

141.636 kDa

MTAETQTLNFGPEWLRALSSGGSVISPPLSPALPKYKLADFRYGREEMLALYVKDNKVPSDLLDKEFLPILNDEPLLPLALVSFTEEEQRNFSMSVNSAAVLRLTNRGSSGGGGTVVGVPRGRSSSRGRGRGRGESGFYQRSFDEVESGFGRGAREMHRSQSWEERGDRRFEKPARKEPDGVRGSAWREIPDRRRRFDYDLRESKDERGYRRPRSGSGIAEDERDSLPEWCLDDAEDETGTFDSSGAFLSSKPSKKVQKEPIPEEQEIDFHPSVDGAEVSDSDGSQTEEAKETDPVQSQNQDDDLSRNDHTVQAAPSPDHKTSSPVRRTDMTLDTAHQKAVSPHLSCKMDAKSQSPSSPPTPSKHKEDAASASHQGTREKAGPCLPHPQSPALSQRSPARQPDPHIVPAMSSVPVPQLDTPTVPIHSSVCAAPGMEPVPPEPDEDGLEHLEQQAQQMVAYLQDGTLDDDHLLTKVLDQRVKGPSLDNQQKWYYKDPQGEIQGPFSNREMAEWYQAGYFPMTLLLRRVCDETFQPLGDIFKKWGRVPFSTPPTPRLGDLDPERLSRQQEITALYQMRHLHYQQLLFQQQYAVLAQQQKVALSSQQQQLPLPLQPLSMRIPEHTVIPPVVRALSVPESTSLWELPPAPTQPAVWEGSSVWDLPVEPTTQGTTREQLAQMDKVKAAKMEQERREAELRAKQEEEEQHRRKEAEEERKRREEEELARRKQEEALQRQKELALQKQMEEEERQRKKELQLLEERMRQEEERKRLEEERRRQEEERRKQLEERKRAEEERRRREEEKKREEDERRQLEEIQRKQEEAARWAREEEEAVRLLLEEARLKAEEEERNKREEAQRQKELQRQRQQQQEALRRLQLQQQQQQLAQMKLPSSSTWGQQVTPSAASQSALSLAEIQKLEEERERQKLQEQRHQQQELKALQQQQQQQQQKIPGWGTMSKPTGTTKSLLEIQQEEAGQMQKNHQQPGRNRPANISLPVAPVVNNHISSPTVGNSGSSVWGSLNNNLSPQWSSDSMSSIWGSTDVKGSSVGFWDDAVKEVAPRNATSKNKNNASKSAGSNSRQSKKVEQEEKLLRLFQGANKCQDDFTQWCEKTMHAINTAHSLDVPTFVSFLREVESPYEVHDYVCAYLGDTPEAKDFSKQFIERRTKQKTSQHRPQQDVAWVTCQTSQANSQPITLEAVQCAGRKKKKQKMVRADPSLLGFSVNASSERLNMGEIETAEDY