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GH12079

Gene
GH12079
Protein
Ubiquitin-conjugating enzyme E2 S
Organism
Drosophila grimshawi
Length
208 amino acids
Function
Catalyzes the covalent attachment of ubiquitin to other proteins. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating polyubiquitin chains initiated by the E2 enzyme vih/UbcH10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit.
Similarity
Belongs to the ubiquitin-conjugating enzyme family.
Mass
23.26 kDa
Sequence
MSSQYSNVENLSPQTIRQVMKELQDMESTPPEGIKVLINESDVTDIQALIDGPAGTPYAVGIFRVKLTLSKDFPQTPPKAYFLTKIFHPNVASNGEICVNTLKKDWKPDLGIKHILLTIKCLLIVPNPESALNEEAGKMLLERYDDYSQRARMMTEIHAQPAKCGAGASDAKDDDGPSTKKHAGVDKKLQDKKKEKLLKEKKRMLKRL