About Products Protein Database Contact

GEMIN8

Gene
GEMIN8
Protein
Gem-associated protein 8
Organism
Homo sapiens
Length
242 amino acids
Function
The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus.
Mass
28.637 kDa
Sequence
MAAVKASTSKATRPWYSHPVYARYWQHYHQAMAWMQSHHNAYRKAVESCFNLPWYLPSALLPQSSYDNEAAYPQSFYDHHVAWQDYPCSSSHFRRSGQHPRYSSRIQASTKEDQALSKEEEMETESDAEVECDLSNMEITEELRQYFAETERHREERRRQQQLDAERLDSYVNADHDLYCNTRRSVEAPTERPGERRQAEMKRLYGDSAAKIQAMEAAVQLSFDKHCDRKQPKYWPVIPLKF

Gene
Gemin8
Protein
Gem-associated protein 8
Organism
Mus musculus
Length
238 amino acids
Function
The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus (By similarity).
Mass
28.396 kDa
Sequence
MASNWRASASWYSHPVYARYWQHYHHAMLWMQGHQNAYRKFRDSYFTSPWLFPHGALPWNSPAYEAGHPWDSQGQHMAQQESPYRVSHPKSPGQPLRNSSRTQASTRGNEARCEEEELESDSDDEVECDLSNMEITEELRQYFAQTERHREERRRQQQLDAERLNDYVNADHGLYFNHRRSLEPPSEKPWERRQAEMKRLYGNSAPKILAMETAVQLSFDKHCDRKQPKYWPVIPLKF

Gene
GEMIN8
Protein
Gem-associated protein 8
Organism
Bos taurus
Length
234 amino acids
Function
The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus (By similarity).
Mass
26.744 kDa
Sequence
MEAKSESTQASESWSSHPVYARYWQHYHQAMAWMRSHQSAYQKAVESVVTSPWYYPATDLAQSPAAKGGTSPKSRSKSPSASGDACRRRSRPGKPGPQRRSTEKPARFAEDNDSESDDCGIVCDLSNMVITDELRQYFAETEQHREELRRQHQLDAARLKDYVNADHGLYCDKRGRSTLPPTERPGERRQAEMKRLYGASAAKIQAMETAMQLSFDKHCDRKQPKYWPVIPLKF