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GDF10

Gene
GDF10
Protein
Growth/differentiation factor 10
Organism
Bos taurus
Length
478 amino acids
Function
Growth factor involved in osteogenesis and adipogenesis. Plays an inhibitory role in the process of osteoblast differentiation via SMAD2/3 pathway. Plays an inhibitory role in the process of adipogenesis.
Similarity
Belongs to the TGF-beta family.
Mass
52.626 kDa
Sequence
MARGPARTSLGPGSQQLPLLSLLLLLLLRDADGSHTAAARPPPPAAADGLAGDKNPQRSPGDVAAAQSPGAQDMVAVHMLRLYEKYSRRGARPGGGNTVRSFRARLEVVNQKAVYFFNLTSMQDSEMILTATFHFYSEPQWPPAREVPCKQRAKNASCRLLPPGPPARQHLLFRSLSQNTATQGLLRGAMALPPPPRGLWQAKDISLIVKAARRDGELLLSAQLDSGEKDTGVPRLGPHAPYILIYANDLAISEPNSVAVTLQRYDPFQAGDPEPGAAPNSSADPRVRRATQATGPLQNNELPGLDERPAQAPHAQHYHKHELWPNPLRALKPRPGRKDRRKKGQDVFMASSQVLDFDEKTMQKARKKQWDEPRVCSRRYLKVDFADIGWNEWIISPKSFDAYYCSGACEFPMPKMVRPSNHATIQSIVRAVGIVPGIPEPCCVPDKMSSLGVLFLDENRNVVLKVYPNMSVETCACR
Protein
Growth/differentiation factor 10: GDF10

Gene
GDF10
Protein
Growth/differentiation factor 10
Organism
Homo sapiens
Length
478 amino acids
Function
Growth factor involved in osteogenesis and adipogenesis. Plays an inhibitory role in the process of osteoblast differentiation via SMAD2/3 pathway. Plays an inhibitory role in the process of adipogenesis.
Similarity
Belongs to the TGF-beta family.
Mass
53.122 kDa
Sequence
MAHVPARTSPGPGPQLLLLLLPLFLLLLRDVAGSHRAPAWSALPAAADGLQGDRDLQRHPGDAAATLGPSAQDMVAVHMHRLYEKYSRQGARPGGGNTVRSFRARLEVVDQKAVYFFNLTSMQDSEMILTATFHFYSEPPRWPRALEVLCKPRAKNASGRPLPLGPPTRQHLLFRSLSQNTATQGLLRGAMALAPPPRGLWQAKDISPIVKAARRDGELLLSAQLDSEERDPGVPRPSPYAPYILVYANDLAISEPNSVAVTLQRYDPFPAGDPEPRAAPNNSADPRVRRAAQATGPLQDNELPGLDERPPRAHAQHFHKHQLWPSPFRALKPRPGRKDRRKKGQEVFMAASQVLDFDEKTMQKARRKQWDEPRVCSRRYLKVDFADIGWNEWIISPKSFDAYYCAGACEFPMPKIVRPSNHATIQSIVRAVGIIPGIPEPCCVPDKMNSLGVLFLDENRNVVLKVYPNMSVDTCACR
Protein
Growth/differentiation factor 10: GDF10

Gene
Gdf10
Protein
Growth/differentiation factor 10
Organism
Mus musculus
Length
476 amino acids
Function
Growth factor involved in osteogenesis and adipogenesis. Plays an inhibitory role in the process of osteoblast differentiation via SMAD2/3 pathway (PubMed:22155034). Plays an inhibitory role in the process of adipogenesis (PubMed:21712809).
Similarity
Belongs to the TGF-beta family.
Mass
52.575 kDa
Sequence
MAPGPARISLGSQLLPMVPLLLLLRGAGCGHRGPSWSSLPSAAAGLQGDRDSQQSPGDAAAALGPGAQDMVAIHMLRLYEKYNRRGAPPGGGNTVRSFRARLEMIDQKPVYFFNLTSMQDSEMILTAAFHFYSEPPRWPRAREVFCKPRAKNASCRLLTPGLPARLHLIFRSLSQNTATQGLLRGAMALTPPPRGLWQAKDISSIIKAARRDGELLLSAQLDTGEKDPGVPRPSSHMPYILVYANDLAISEPNSVAVSLQRYDPFPAGDFEPGAAPNSSADPRVRRAAQVSKPLQDNELPGLDERPAPALHAQNFHKHEFWSSPFRALKPRTGRKDRKKKDQDTFTAASSQVLDFDEKTMQKARRRQWDEPRVCSRRYLKVDFADIGWNEWIISPKSFDAYYCAGACEFPMPKIVRPSNHATIQSIVRAVGIVPGIPEPCCVPDKMNSLGVLFLDENRNAVLKVYPNMSVETCACR
Protein
Growth/differentiation factor 10: Gdf10

Gene
Gdf10
Protein
Growth/differentiation factor 10
Organism
Rattus norvegicus
Length
476 amino acids
Function
Growth factor involved in osteogenesis and adipogenesis. Plays an inhibitory role in the process of osteoblast differentiation via SMAD2/3 pathway. Plays an inhibitory role in the process of adipogenesis.
Similarity
Belongs to the TGF-beta family.
Mass
52.961 kDa
Sequence
MAPGLARISLRSQLLPLVPLLLLLRGAGCGHRVPSWSSLPSAADSVQRDRDLQQSPGDAAAALGPGAQDIVAVHMLRLYEKYNRRGAPPGGGNTVRSFRARLDVIDQKPVYFFNLTSMQDSEMILTATFHFYSEPPRWPRAREVFCKPRAKNASCRLLTPGLPARLHLIFRSLSQNTATQGLLRGAMALTPPPRGLWQAKDISSIIKAARRDGELLLSAQLDSGEKDLGVPRPSSHMPYILVYANDLAISEPNSVAVTLQRYDPFPAGDFEPGAAPNSSADPRVRRAAQVSKPLQDNELPGLDERPAPALHAQHFHKHEFWSSPFRALKPRTGRKDRKKKDQDTFTPSSSQVLDFDEKTMQKARRRQWDEPRVCSRRYLKVDFADIGWNEWIISPKSFDAYYCAGACEFPMPKIVRPSNHATIQSIVRAVGIVPGIPEPCCVPDKMNSLGVLFLDENRNVVLKVYPNMSVETCACR
Protein
Growth/differentiation factor 10: Gdf10

Gene
gdf10
Protein
Growth/differentiation factor 10
Organism
Xenopus laevis
Length
443 amino acids
Function
Dorsalizing factor. Antagonizes mesoderm formation by nodal-like proteins and ventralizing BMPs. Cooperates with cer1 to promote embryonic head formation.
Similarity
Belongs to the TGF-beta family.
Mass
50.657 kDa
Sequence
MQFSLVMSYYCLACFLVMFALGRAIKAHTSKLPPEGVGTIRLQSDPLSLHMAKLYEKYSREGSRLQDGNTVRSFRAQPDSQFGSPLYRFNLSSLQQTEEVLAATLHFAPVKGSRSSRDSYCKRSKKSSCRLLLPTQHQKISLVFKSVIQNKTLGSEKWNTTNIFHKRAAWHVKDITNIIKDAQHERDLFISMEISFGEKFATVFENNPSELPYILVFADDRAISDPNSIALTLQRYDPFQPNGGNSKQAPNTFPESRVKRDTSDLASSHDNELPDIKYMRYSKEDLWESTYKSLKHKSPRKEKKKKGQENEETLPKSPVLHFDERTMKKARRRQWDEPRVCSRRYLKVDFADIGWSEWIISPKSFDAYYCSGACEFPMAKVVRPSNHATIQSIVKAVGIIPGVPEPCCTPDMMNSLSVLFLDEGRNMVLKVYPNMSVESCSCR
Protein
Growth/differentiation factor 10: gdf10