Protein
Cytoplasmic tRNA 2-thiolation protein 2
Organism
Drosophila simulans
Function
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6/CTU1 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position.
Similarity
Belongs to the CTU2/NCS2 family.
Sequence
MCSIGEDDFGDDGAAHAMAVESLPLGIVLSPGNCSKCDVNSDELYKLNFRTAECRECFLAYARHKFRAALGAAKILPRNAEVLLVLDGSAESLVLLDMLHFAQTQNTFKRLHCNARVVYVEEQQVQGRDPVHLEALQNLSTQYAPFDFYVIELGALPSSMQRIKDYSPSLNANNELIHKLQKLRSLTARQDYLQQQRKNLICSVAQCLRCTHVFESNISVDLATQLLTAIALGRGGSAALDVALLDDRLSGDVKLLRPLKDLNEQEIQFYIHAQRLKPLFQKGSRYGREHGQTASLQNLTSAFVANLQQNYASTVSTVFRTGDKIAANSNPEQSSCVHCRSTLDTELSDTLLAIEYSRSVSEAGVSLYKSGQDLEDLAKKRLENKDGLCHACRAIQAELDSGNLL