About Products Protein Database Contact

GCKR

Gene
Gckr
Protein
Glucokinase regulatory protein
Organism
Rattus norvegicus
Length
627 amino acids
Function
Inhibits glucokinase (GCK) by forming an inactive complex with this enzyme. The affinity of GCKR for GCK is modulated by fructose metabolites: GCKR with bound fructose 6-phosphate has increased affinity for GCK, while GCKR with bound fructose 1-phosphate has strongly decreased affinity for GCK and does not inhibit GCK activity.
Similarity
Belongs to the GCKR family.
Mass
68.917 kDa
Sequence
MPGTKRYQHVIETPEPGEWELSGYEAAVPITEKSNPLTRNLDKADAEKIVKLLGQCDAEIFQEEGQIVPTYQRLYSESVLTTMLQVAGKVQEVLKEPDGGLVVLSGGGTSGRMAFLMSVSFNQLMKGLGQKPLYTYLIAGGDRSVVASREQTEDSALHGIEELKKVAAGKKRVVVIGISVGLSAPFVAGQMDYCMDNTAVFLPVLVGFNPVSMARNDPIEDWRSTFRQVAERMQKMQEKQEAFVLNPAIGPEGLSGSSRMKGGGATKILLETLLLAAHKTVDQGVVSSQRCLLEILRTFERAHQVTYSQSSKIATLMKQVGISLEKKGRVHLVGWQTLGIIAIMDGVECIHTFGADFQDIRGFLIGDHSDMFNQKDELTNQGPQFTFSQDDFLTSILPSLTETDTVVFIFTLDDNLTEVQALAERVREKCQNIQALVHSTVGQSLPAPLKKLFPSLISITWPLLFFDYEGTYVQKFQRELSTKWVLNTVSTGAHVLLGKILQNHMLDLRIANSKLFWRALAMLQRFSGQSKARCIESLLQAIHFPQPLSDDVRAAPISCHVQVAHEKEKVIPTALLSLLLRCSISEAKARLSAASSVCEVVRSALSGPGQKRSTQALEDPPACGTLN
Protein
Glucokinase regulatory protein: Gckr

Gene
GCKR
Protein
Glucokinase regulatory protein
Organism
Homo sapiens
Length
625 amino acids
Function
Inhibits glucokinase (GCK) by forming an inactive complex with this enzyme. The affinity of GCKR for GCK is modulated by fructose metabolites: GCKR with bound fructose 6-phosphate has increased affinity for GCK, while GCKR with bound fructose 1-phosphate has strongly decreased affinity for GCK and does not inhibit GCK activity.
Similarity
Belongs to the GCKR family.
Mass
68.685 kDa
Sequence
MPGTKRFQHVIETPEPGKWELSGYEAAVPITEKSNPLTQDLDKADAENIVRLLGQCDAEIFQEEGQALSTYQRLYSESILTTMVQVAGKVQEVLKEPDGGLVVLSGGGTSGRMAFLMSVSFNQLMKGLGQKPLYTYLIAGGDRSVVASREGTEDSALHGIEELKKVAAGKKRVIVIGISVGLSAPFVAGQMDCCMNNTAVFLPVLVGFNPVSMARNDPIEDWSSTFRQVAERMQKMQEKQKAFVLNPAIGPEGLSGSSRMKGGSATKILLETLLLAAHKTVDQGIAASQRCLLEILRTFERAHQVTYSQSPKIATLMKSVSTSLEKKGHVYLVGWQTLGIIAIMDGVECIHTFGADFRDVRGFLIGDHSDMFNQKAELTNQGPQFTFSQEDFLTSILPSLTEIDTVVFIFTLDDNLTEVQTIVEQVKEKTNHIQALAHSTVGQTLPIPLKKLFPSIISITWPLLFFEYEGNFIQKFQRELSTKWVLNTVSTGAHVLLGKILQNHMLDLRISNSKLFWRALAMLQRFSGQSKARCIESLLRAIHFPQPLSDDIRAAPISCHVQVAHEKEQVIPIALLSLLFRCSITEAQAHLAAAPSVCEAVRSALAGPGQKRTADPLEILEPDVQ
Protein
Glucokinase regulatory protein: GCKR

Gene
gckr
Protein
Glucokinase regulatory protein
Organism
Xenopus laevis
Length
619 amino acids
Function
Inhibits glucokinase (gck) by forming an inactive complex with this enzyme. The affinity of gckr for gck is modulated by fructose metabolites: gckr with bound fructose 6-phosphate has increased affinity for gck, while gckr with bound fructose 1-phosphate has strongly decreased affinity for gck and does not inhibit gck activity.
Similarity
Belongs to the GCKR family.
Mass
68.739 kDa
Sequence
MRGTRKYQHVIETPDPGKWELAGYEESLPISEKSNPMTRELDKADPSQLVQLLRDCDAEIFQEEDENLIHYHRLYSESVLKTMGDVAKRVQEVLKNPDDSLVVLSGCGTSGRLALLLANSFNGLLKGLHKTPCYCYIMSGGDRSIVTSQESSEDNPQLGAQELEKVCEGKKNVLFIGISCGLSAPFIAGQLDFCMRHLDVYLPVLVGFNPVSMARNERIEGWHSSFRQVAERLQTLHDSQKGFILNPAVGPEGVSGSSRMKGGSATKILLETLLLVAHKAESNVPVTEKCLLEILRTYERAHKVTYSQSKKIAALMKQTATSLQKKGHLYILGWGTLGLVGIMDAVECVPTYQADWRDVRGFITGGYHSIENKEGDLSSLGPQFSISHEDFVKNVLPSVSETDTVLLIFTLDDDLNQIEKLVALVKEKTSNIQVICHATAGQYLPNSLKKTIPSIIGLTWPILFLEYEGAFIQKFQRELSTKWILDTVTSGAYTLRGKIFRNFMVDFKINNSKLFHRATSVLQRLTGQSHQRCTEVLLQSIYGEQTLSEQIRNTTIAGHVEAAASQDKVLPVAIVSLLRSCTIQDSRSRINSSLSIRSAIESSMNVPGRKRGAEDSESR
Protein
Glucokinase regulatory protein: gckr

Gene
Gckr
Protein
Glucokinase regulatory protein
Organism
Mus musculus
Length
587 amino acids
Function
Inhibits glucokinase (GCK) by forming an inactive complex with this enzyme. The affinity of GCKR for GCK is modulated by fructose metabolites: GCKR with bound fructose 6-phosphate has increased affinity for GCK, while GCKR with bound fructose 1-phosphate has strongly decreased affinity for GCK and does not inhibit GCK activity (By similarity).
Similarity
Belongs to the GCKR family.
Mass
64.679 kDa
Sequence
MPSTKRYQHVIETPEPGEWELSGYEAAVPITEKSNPLTRNLDKADAEKIVQLLGQCDAEIFQEEGQIMPTYQRLYSESVLTTMLQVAGKVQEVLKEPDGGLVVLSGGGTSGRMAFLMSVSFNQLMKGLGQKPLYTYLIAGGDRSVVASRERTEDSALHGIEELKKVAAGKKRVVVIGISVGLSAPFVAGQMDYCMDNTAVFLPVLVGFNPVSMARNDPIEDWRSTFRQVAERMQKMQEKQEAFVLNPAIGPEGLSGSSRMKGGSATKILLETLLLAAHKTVDQGVVSSQRCLLEILRTFERAHQVTYSQSSKIATLTKQVGISLEKKGHVHLVGWQTLGIIAIMDGVECIHTFGADFRDIRGFLIGDHNDMFNQKDELSNQGPQFTFSQDDFLTSVLPSLTEIDTVVFIFTLDDNLAEVQALAERVREKSWNIQALVHSTVGQSLPAPLKKLFPSLISITWPLLFFDYEGSYVQKFQRELSTKWVLNTRFSGQSKARCIESLLQVIHFPQPLSNDVRAAPISCHVQVAHEKEKVIPTALLSLLLRCSITEAKERLAAASSVCEVVRSALSGPGQKRSIQAFGDPVVP
Protein
Glucokinase regulatory protein: Gckr