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GBU1

Gene
GBU1
Protein
Guanidinobutyrase
Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
Length
410 amino acids
Function
Catalyzes the hydrolysis of 4-guanidinobutanoate to gamma-aminobutyrate (GABA) and urea. Involved in an alternative, arginase-independent arginine degradation pathway via GABA.
Similarity
Belongs to the arginase family. Agmatinase subfamily.
Mass
45.55 kDa
Sequence
MKVAGFILGALIQFSLTEGHVEQNENANLTEMWGEDWPFSGIQTFAHLPHHKCLIDMEKKFDIGVIGVPFDTAVSFRGGARFGPQAIRKASQRQTSMRGFNFRADINPYQDWASVVDCGDVPVTPMDNCLALKMMTAAYENLLSHESQTSDNNLPPRFVTLGGDHSIILPALRALRKTYGRLAVIHFDSHLDTWAPSKYPSFWHSDTSEFTHGSMLWIAHNEGLLTENNNIHAGLRTRLSGSSFEDYDDDDKVGFHRIEADEIMDGGIKSIVEKIKSKIPSDVPVYISVDIDVLDPSAAPGTGTMEVGGWMTRELIRIIRELEDLNLVGADIVEVSPPFDPTEITSLAGAQIAYELITNMVKKGPIDPELIKHNLELSDKLTQGQQLLGFSSPTDELNDKIQKEQFVLQA