Protein
Polypeptide N-acetylgalactosaminyltransferase 5
Organism
Rattus norvegicus
Function
Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward EA2 peptide substrate, but has a weak activity toward Muc2, Muc1b, rMuc-2 or mG-Muc substrates.
Similarity
Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
Sequence
MNKIRKFFRGSGRVLAFIFVASVIWLLFDMAALRLSFSEINTGILKEDIMRREQTGFRVEADQMTILSPSSRGMRPPRNGAGGKESFRKAENRVLKVEENVDQVQRKGKMQFLLGRGKAVSLWHRTHVQTLPVTLPMQKTQGRDSKPEVSSLHMMSKQTTVLGSEKDSFTVSRGVPLNKTAEHTETLDKKQEAPENYNLSSDTSKQASQRALNVTISVRTDRSKQQSQTVTKSSIQFASLPILKPEEVTVTKKTEAQGKDLKYEAHKARPLLKFTADVGHLKKQSTNETGLGVLPEADGAKVAPGKKLNFSESQIVIITKEEGQKTDTKEVPNSKIQTVFPKLLGESQGKHIPRSQSQTLSSPLAPKRAVSQSKPTLAEELHTARSNLTAKATTVGHQQSHANISENPGKHHVLRIDVTLSPRDLNAPGQFGRPVVVPPGKKKEAEQRWKEGNFNVYLSDLIPVDRAIEDTRPAGCAEQLVHNDLPTTSIIMCFVDEVWSALLRSVHSVLNRSPPHLIKEILLVDDFSTKDYLKANLDKYMSQFPKVRILRLKERHGLIRARLAGAQNATGDVLTFLDSHVECNVGWLEPLLERVYLNRKKVACPVIEVINDKDMSYMTVDNFQRGVFTWPMNFGWRTIPPDVIAKNGIKETDIIRCPVMAGGLFSIDKSYFYELGTYDPGLDVWGGENMELSFKVWMCGGEIEIIPCSRVGHIFRNDNPYSFPKDRMKTVERNLVRVAEVWLDEYKELFYGHGDHLIDQGLDVGNLTQQRELRKKLKCQSFKWYLDNVFPDLKAPVVRASGVFINLALGKCVSIKNITVVLEDCDGSSELQQFNYTWVRLIKHGEWCVAPIPDKGSLTLYPCDNRNNRLKWLHRSASAFHPELVDHIVFESYQQLLCMEGNFSQKTLKLAACNPTEPQQKWKFEKYYDV