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GALNT12

Gene
GALNT12
Protein
Polypeptide N-acetylgalactosaminyltransferase 12
Organism
Homo sapiens
Length
581 amino acids
Function
Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward non-glycosylated peptides such as Muc5AC, Muc1a and EA2, and no detectable activity with Muc2 and Muc7. Displays enzymatic activity toward the Gal-NAc-Muc5AC glycopeptide, but no detectable activity to mono-GalNAc-glycosylated Muc1a, Muc2, Muc7 and EA2. May play an important role in the initial step of mucin-type oligosaccharide biosynthesis in digestive organs.
Similarity
Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
Mass
66.938 kDa
Sequence
MWGRTARRRCPRELRRGREALLVLLALLALAGLGSVLRAQRGAGAGAAEPGPPRTPRPGRREPVMPRPPVPANALGARGEAVRLQLQGEELRLQEESVRLHQINIYLSDRISLHRRLPERWNPLCKEKKYDYDNLPRTSVIIAFYNEAWSTLLRTVYSVLETSPDILLEEVILVDDYSDREHLKERLANELSGLPKVRLIRANKREGLVRARLLGASAARGDVLTFLDCHCECHEGWLEPLLQRIHEEESAVVCPVIDVIDWNTFEYLGNSGEPQIGGFDWRLVFTWHTVPERERIRMQSPVDVIRSPTMAGGLFAVSKKYFEYLGSYDTGMEVWGGENLEFSFRIWQCGGVLETHPCSHVGHVFPKQAPYSRNKALANSVRAAEVWMDEFKELYYHRNPRARLEPFGDVTERKQLRDKLQCKDFKWFLETVYPELHVPEDRPGFFGMLQNKGLTDYCFDYNPPDENQIVGHQVILYLCHGMGQNQFFEYTSQKEIRYNTHQPEGCIAVEAGMDTLIMHLCEETAPENQKFILQEDGSLFHEQSKKCVQAARKESSDSFVPLLRDCTNSDHQKWFFKERML

Gene
Galnt12
Protein
Polypeptide N-acetylgalactosaminyltransferase 12
Organism
Mus musculus
Length
576 amino acids
Function
Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward non-glycosylated peptides such as Muc5AC, Muc1a and EA2, and no detectable activity with Muc2 and Muc7. Displays enzymatic activity toward the Gal-NAc-Muc5AC glycopeptide, but no detectable activity to mono-GalNAc-glycosylated Muc1a, Muc2, Muc7 and EA2. May play an important role in the initial step of mucin-type oligosaccharide biosynthesis in digestive organs (By similarity).
Similarity
Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.
Mass
66.541 kDa
Sequence
MWGRAVRRRCPRGLRRGREALLALLALAGLGALLRARSRSGTVDPGPPRTPLPGRHEPVLPRPPLPADALGAHGEAVRLQLQGEELRLQEESVKQHQINIYLSDRISLHRRLPERWNPLCREVKYDYDNLPKTSVVIAFYNEAWSTLLRTVYSVLETSPDILLEEVILVDDYSDREHLKERLANELSQLPKVRLIRASRREGLVRARLLGASAARGEVLTFLDCHCECHEGWLEPLLQRIHEKESAVVCPVIDVIDWNTFEYLGNSGEPQIGGFDWRLVFTWHVVPQRERQSMRSPIDVIRSPTMAGGLFAVSKRYFDYLGSYDTGMEVWGGENLEFSFRIWQCGGTLETHPCSHVGHVFPKQAPYSRSKALANSVRAAEVWMDEFKELYYHRNPQARLEPFGDVTERKKLRAKLQCKDFKWFLDTVYPELHVPEDRPGFFGMLQNRGLRGYCLDYNPPNENHVEGHQVLLYLCHGMGQNQFFEYTTRKEIRYNTRQPEACITVEDGKDTLVMDLCRETVPENQEFILQEDGTLVHKHSRKCVEATEKVLDNGFAPYLRDCTNSDNQRWFFKERMS