GALNT11

Polypeptide N-acetylgalactosaminyltransferase 11

608 amino acids

Polypeptide N-acetylgalactosaminyltransferase that catalyzes the initiation of protein O-linked glycosylation and is involved in left/right asymmetry by mediating O-glycosylation of NOTCH1. O-glycosylation of NOTCH1 promotes activation of NOTCH1, modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO). Polypeptide N-acetylgalactosaminyltransferases catalyze the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Displays the same enzyme activity toward MUC1, MUC4, and EA2 than GALNT1. Not involved in glycosylation of erythropoietin (EPO).

Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.

68.919 kDa

MGSVTVRYFCYGCLFTSATWTVLLFVYFNFSEVTQPLKNVPVKGSGPHGPSPKKFYPRFTRGPSRVLEPQFKANKIDDVIDSRVEDPEEGHLKFSSELGMIFNERDQELRDLGYQKHAFNMLISDRLGYHRDVPDTRNAACKEKFYPPDLPAASVVICFYNEAFSALLRTVHSVIDRTPAHLLHEIILVDDDSDFDDLKGELDEYVQKYLPGKIKVIRNTKREGLIRGRMIGAAHATGEVLVFLDSHCEVNVMWLQPLLAAIREDRHTVVCPVIDIISADTLAYSSSPVVRGGFNWGLHFKWDLVPLSELGRAEGATAPIKSPTMAGGLFAMNRQYFHELGQYDSGMDIWGGENLEISFRIWMCGGKLFIIPCSRVGHIFRKRRPYGSPEGQDTMTHNSLRLAHVWLDEYKEQYFSLRPDLKTKSYGNISERVELRKKLGCKSFKWYLDNVYPEMQISGSHAKPQQPIFVNRGPKRPKVLQRGRLYHLQTNKCLVAQGRPSQKGGLVVLKACDYSDPNQIWIYNEEHELVLNSLLCLDMSETRSSDPPRLMKCHGSGGSQQWTFGKNNRLYQVSVGQCLRAVDPLGQKGSVAMAICDGSSSQQWHLEG

Galnt11

Polypeptide N-acetylgalactosaminyltransferase 11

608 amino acids

Polypeptide N-acetylgalactosaminyltransferase that catalyzes the initiation of protein O-linked glycosylation and is involved in left/right asymmetry by mediating O-glycosylation of NOTCH1. O-glycosylation of NOTCH1 promotes activation of NOTCH1, modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO). Polypeptide N-acetylgalactosaminyltransferases catalyze the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Displays the same enzyme activity toward MUC1, MUC4, and EA2 than GALNT1. Not involved in glycosylation of erythropoietin (EPO) (By similarity).

Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.

69.201 kDa

MGSITVRYFCYGCLFTSATWTVLLFIYFNFSEVTQPLRNVPIKGSGPHGPFPKKFYPRFTRGPGRVLDPQFKANRIDRLMNNHIEDPDKGLSKSSSELGMIFNERDQELRDLGYQKHAFNMLISNRLGYHRDVPDTRNAECRRKSYPTDLPTASIVICFYNEAFSALLRTVHSVVDRTPAHLLHEIILVDDSSDFDDLKGELDEYIQRYLPAKVKVIRNMKREGLIRGRMIGAAHATGEVLVFLDSHCEVNVMWLQPLLAIILEDPHTVVCPVIDIISADTLAYSSSPVVRGGFNWGLHFKWDLVPVSELGGPDGATAPIRSPTMAGGLFAMNRQYFNDLGQYDSGMDIWGGENLEISFRIWMCGGKLFILPCSRVGHIFRKRRPYGSPEGQDTMTHNSLRLAHVWLDEYKEQYFSLRPDLKNKSFGNISERVELRKKLGCQSFKWYLDNIYPEMQIPGPNAKPQQPVLINRGPKRPRVLQRGRLYHLQTNKCLVAQGRSSQKGGLVLLKTCDYGDPTQVWIYNEDHELILNNLLCLDMSETRSSDPPRLMKCHGSGGSQQWTFGKNNRLYQVSVGQCLRVMDLMDQKGYVGMAICDGSSSQQWRLEG

Galnt11

Polypeptide N-acetylgalactosaminyltransferase 11

608 amino acids

Polypeptide N-acetylgalactosaminyltransferase that catalyzes the initiation of protein O-linked glycosylation and is involved in left/right asymmetry by mediating O-glycosylation of NOTCH1. O-glycosylation of NOTCH1 promotes activation of NOTCH1, modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO). Polypeptide N-acetylgalactosaminyltransferases catalyze the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Displays the same enzyme activity toward MUC1, MUC4, and EA2 than GALNT1. Not involved in glycosylation of erythropoietin (EPO) (By similarity).

Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.

69.039 kDa

MGSVTIRYFCYGCLFTSATWTVLLFIYFNFSEVTQPLRNVPIKGSGPHGPFPKKFYPRFTRGPGRVLEPQFKANRMDDLMNNNIEDPDKGLSKSSSELGMIFNERDQELRDLGYQKHAFNMLISNRLGYHRDVPDTRNAECRGKSYPTDLPTASVVICFYNEAFSALLRTVHSVVDRTPAHLLHEIILVDDSSDFDDLKGELDEYIQRYLPAKVKVIRNMKREGLIRGRMIGAAHATGEVLVFLDSHCEVNVMWLQPLLAIILEDPHTVVCPVIDIISADTLAYSSSPVVRGGFNWGLHFKWDLVPVSDLGGADSATAPIRSPTMAGGLFAMNRQYFNDLGQYDSGMDIWGGENLEISFRIWMCGGKLFIIPCSRVGHIFRKRRPYGSPEGQDTMTHNSLRLAHVWLDEYKEQYFSLRPDLKTKSFGNISERVELRKKLGCQSFKWYLDNVYPEMQVSGPKARLQQPVFINRGPKRPRVLLRGRLYHLQTNKCLVAQGRSSQKGGLVLLKACDYGDPTQVWIYNEEHELILNNLLCLDMSETRSSDPPRLMKCHGSGGSQQWTFGKNNRLYQVSVGQCLRVVDQMDQKGYVGMAICDGSSSQQWRLEG

galnt11

Polypeptide N-acetylgalactosaminyltransferase 11

601 amino acids

Polypeptide N-acetylgalactosaminyltransferase that catalyzes the initiation of protein O-linked glycosylation and is involved in left/right asymmetry by mediating O-glycosylation of NOTCH1. O-glycosylation of NOTCH1 promotes activation of NOTCH1, modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO). Polypeptide N-acetylgalactosaminyltransferases catalyze the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor.

Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.

68.383 kDa

MGSAALRCFCYGCLFTSVTWTLLLFIYFNFSEESQGFRHVPVKGLEPYKPLPKKIYPRFSRDSMGQHSDPRKGHNGNQLETEANADLSPELGMIFNEQDQDVRDVGYQKHAFNLLISNRLGYHRDVPDTRDSKCAKKTYPPDLPMASIVICFYNEAFSALLRTVHSVLDRTPAQLLHEIILVDDNSELDDLKKDLDGYMQENLSKKVKLVRNKQREGLIRGRMVGASHATGDVLVFLDSHCEVNEMWLQPLLAPIKENPRTVVCPVIDIISADTLIYSSSPVVRGGFNWGLHFKWDPVPLAELGGPEGFSAPFRSPTMAGGLFAMDREYFNMLGQYDSGMDIWGGENLEISFRIWMCGGSLLIVPCSRVGHIFRKRRPYGSPGGHDTMAHNSLRLAHVWMDEYKDQYFALRPELRNRDFGDIRERLALRRRLNCKSFKWYLDNIYPEMQVSGPNAKPQPPVFMNKGQKRPKILQRGRLINMQTNRCLVAQGHPSQKGGLVVAKECDYNDSEQVWSYNEEHELILSNLLCLDMSETRSSDPPRLMKCHGSGGSQQWVFGKSNRLYQVSVGQCLKLVDPMSRKGYVSMAICDGSPSQQWHLEN