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Flacc

Gene
Flacc
Protein
Fl(2)d-associated complex component
Organism
Drosophila melanogaster
Length
1150 amino acids
Function
Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of mRNAs, a modification that plays a role in the efficiency of mRNA splicing and is required for sex determination (PubMed:29535189, PubMed:29555755). In the WMM complex, acts as a key regulator of m6A methylation by bridging fl(2)d to the RNA-binding component nito (PubMed:29535189). Required for sex determination and dosage compensation via Sxl alternative splicing: m6A methylation acts as a key regulator of Sxl pre-mRNA and promotes female-specific alternative splicing of Sxl, which determines female physiognomy (PubMed:29535189, PubMed:29555755).
Similarity
Belongs to the ZC3H13 family.
Mass
128.975 kDa
Sequence
MEKKAKESLRRYKKAARHSATHSSSSDSTSDSDSGSSSYSSTDSEQGVGGVGVGVGVPGGAGGPGGSGSVHGHPHTHGHGHHPRSAERHHRKKKSSRRGGSSSGDEPSSSRRKRDKRDHVQKKLVAKRNHIKRKLKEARLKKRAAAALSGHVHRSLSPTTRAKLKKLAERKRLRAASKEQRERDKLRVVQRDRERDHHRLGSSRSPPSSSTTTTTKIRIHQDIVGKRQKSPGLGSGLGGGSSSSSSRMHHQLMSREKIIIQTRARGRTPSLERERERERERERERERERHDLSLRERDRRDRERERAEREAARDKERAEALARCQERQRERERLAREKLRRQEEEEGGKRGGPGRDLDLPPYGSRERSLDTVERERERERSGRHVRDKRELDPYEREQEYLEERHGHGLIDEMRRYRRRDLSPMPEHYAPRLRDPRELYSEEERERAYKRAYLDARYSSREREAWLEARELRERELQGREYRDLETEDTLYPDERERLIRDRERDRERERDRERERNIGPRGDFRPEWEREWEEEGAGGGPGGPSGTPGRPGGFVGGPKRGKPPAHAGGGPPSQQQHHSASEPDWDADERERERERERDRERERDREDRPDTGGGGAGGDRPSIKNEPAWLEHDQREKPRGWQQQSSNSGGDWRDNDDAPPAPSHPHPASPHHHVHPRGERGSGRGFRRGGHGHGDHGERPGYRSHPPPLMTLPVQPPGGYSRGFPHKRLPYGSGRDGAALGARDGGLPGSSTFLKKHTHAPLVSPTQTPLLNPLLNAAKPNAAAQASAVAAATTAVAAAKAAAQSAANATTNPGILAQVSKLNTVCIKQEDASEDSAGTPELGAQDSPTQSLNLNQSLSSEGNPVKQELIRTSAVEGELSEISDSDDDILNKTDKVRPKNELPTETEQEMDTNADEVKSEALHIVAGHPIKGEEGDEVLDFEEISDGELEEDARHKGIGDALGVDWQGLIAETRQQASDAQAAQQGVDRGTSAKQRWQPYRVLLDLGISFGMAGEGYARCVMEEARQQLLQEKEQGQQRELDGDEEPPAKIPSPLLDYREFLASQQQLEPLACVQMGLRSAAVERQRLVGNVCGPGSRALSARQDLRLRRQLCGLPARECEFPRSVPIVGEGLRNLAMQMFQRRLLDVK