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FXYD3

Gene
Fxyd3
Protein
FXYD domain-containing ion transport regulator 3
Organism
Mus musculus
Length
88 amino acids
Function
Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na(+) out of the cell and K(+) into the cell (PubMed:15743908). Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus reversing glutathionylation-mediated inhibition of ATP1B1 (By similarity). Induces a hyperpolarization-activated chloride current when expressed in Xenopus oocytes (By similarity).
Similarity
Belongs to the FXYD family.
Mass
9.526 kDa
Sequence
MQEVVLSLLVLLAGLPTLDANDPENKNDPFYYDWYSLRVGGLICAGILCALGIIVLMSGKCKCKFRQKPSHRPGEGPPLITPGSAHNC

Gene
FXYD3
Protein
FXYD domain-containing ion transport regulator 3
Organism
Sus scrofa
Length
88 amino acids
Function
Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na(+) out of the cell and K(+) into the cell. Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus reversing glutathionylation-mediated inhibition of ATP1B1. Induces a hyperpolarization-activated chloride current when expressed in Xenopus oocytes.
Similarity
Belongs to the FXYD family.
Mass
9.314 kDa
Sequence
MHEVALSVLILLAGLSALDANDPEDKNSPFYYDWHSLRVGGLICAGTPCALGIIILLSGKCKCKFSQKPSHRPGDAPPLITPGSAHDC

Gene
Fxyd3
Protein
FXYD domain-containing ion transport regulator 3
Organism
Rattus norvegicus
Length
88 amino acids
Function
Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na(+) out of the cell and K(+) into the cell. Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus reversing glutathionylation-mediated inhibition of ATP1B1. Induces a hyperpolarization-activated chloride current when expressed in Xenopus oocytes.
Similarity
Belongs to the FXYD family.
Mass
9.411 kDa
Sequence
MQEFALSLLVLLAGLPTLDANDPEDKDSPFYYDWHSLRVGGLICAGILCALGIIVLMSGKCKCKFSQKPSHRPGDGPPLITPGSAHNC

Gene
FXYD3
Protein
FXYD domain-containing ion transport regulator 3
Organism
Homo sapiens
Length
87 amino acids
Function
Isoform 2: Decreases the apparent K+ affinity of the sodium/potassium-transporting ATPase only at slightly negative and positive membrane potentials and increases the apparent Na+ affinity over a large range of membrane potentials.
Similarity
Belongs to the FXYD family.
Mass
9.263 kDa
Sequence
MQKVTLGLLVFLAGFPVLDANDLEDKNSPFYYDWHSLQVGGLICAGVLCAMGIIIVMSAKCKCKFGQKSGHHPGETPPLITPGSAQS