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FPGS

Gene
FPGS
Protein
Folylpolyglutamate synthase, mitochondrial
Organism
Cricetulus griseus
Length
587 amino acids
Function
Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis.
Similarity
Belongs to the folylpolyglutamate synthase family.
Mass
65.093 kDa
Sequence
MSWARTHLRSALSLAAVSARGATTEGAARRWLSAWPAPQEPGMEYQDAVRMLNTLQTNASYLEQVKRQRSDPQAQLEAMEVYLARSGLQVEDLNQLNIIHVTGTKGKGSTCAFTERILRSYGLKTGFFSSPHLVQVRERIRINGKPISPELFTKHFWRLYHQLEEFKDDSHVAMPAYFRFLTLMAFHVFLQEKVDLAVVEVGIGGAYDCTNIIRKPVVCGVSSLGMDHTSLLGDTVEKIAWQKGGIFKPGVPAFTVLQPEGPLAVLRDRAQQTSCPLYLCPPLEALEDGGLPLTLGLEGEHQRSNAALALQLAHCWLEQQDHQDIRELKVSRPSMRWQLPLAPVFHPTSHMRHGLRDTEWPGRTQVLRRGPLTWYLDGAHTTSSVQACVRWYCQSLQRSKHPSGGPEVYVLLFNSTGDRDSAALLKLLQPCQFDYAVFCPNLTEVSSTENADQQNFTVTLDQVLLRCLQHQQHWSCLSEKQASPDFLSSPSPEPGRPGSLQPALRPPHSTGTNSLVFSCISHALQWISQGRDPIFQAPSPPRSLLSHPTASSGASILREAGAIHVLVTGSLHLVGGVLKLLEPSLSQ

Gene
FPGS
Protein
Folylpolyglutamate synthase, mitochondrial
Organism
Homo sapiens
Length
587 amino acids
Function
Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis. Unsubstituted reduced folates are the preferred substrates. Metabolizes methotrexate (MTX) to polyglutamates.
Similarity
Belongs to the folylpolyglutamate synthase family.
Mass
64.609 kDa
Sequence
MSRARSHLRAALFLAAASARGITTQVAARRGLSAWPVPQEPSMEYQDAVRMLNTLQTNAGYLEQVKRQRGDPQTQLEAMELYLARSGLQVEDLDRLNIIHVTGTKGKGSTCAFTECILRSYGLKTGFFSSPHLVQVRERIRINGQPISPELFTKYFWRLYHRLEETKDGSCVSMPPYFRFLTLMAFHVFLQEKVDLAVVEVGIGGAYDCTNIIRKPVVCGVSSLGIDHTSLLGDTVEKIAWQKGGIFKQGVPAFTVLQPEGPLAVLRDRAQQISCPLYLCPMLEALEEGGPPLTLGLEGEHQRSNAALALQLAHCWLQRQDRHGAGEPKASRPGLLWQLPLAPVFQPTSHMRLGLRNTEWPGRTQVLRRGPLTWYLDGAHTASSAQACVRWFRQALQGRERPSGGPEVRVLLFNATGDRDPAALLKLLQPCQFDYAVFCPNLTEVSSTGNADQQNFTVTLDQVLLRCLEHQQHWNHLDEEQASPDLWSAPSPEPGGSASLLLAPHPPHTCSASSLVFSCISHALQWISQGRDPIFQPPSPPKGLLTHPVAHSGASILREAAAIHVLVTGSLHLVGGVLKLLEPALSQ

Gene
Fpgs
Protein
Folylpolyglutamate synthase, mitochondrial
Organism
Mus musculus
Length
587 amino acids
Function
Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis. Dihydrofolate, tetrahydrofolate, 5,10-methylenetetrahydrofolate, 10-formyltetrahydrofolate and 5-formyltetrahydrofolate are the best substrates. Folic acid and 5-methyltetrahydrofolate can also act as substrates.
Similarity
Belongs to the folylpolyglutamate synthase family.
Mass
64.955 kDa
Sequence
MSWARSRLCSTLSLAAVSARGATTEGAARRGMSAWPAPQEPGMEYQDAVRTLNTLQTNASYLEQVKRQRSDPQAQLEAMEMYLARSGLQVEDLNRLNIIHVTGTKGKGSTCAFTERILRNYGLKTGFFSSPHMVQVRERIRINGKPISPELFTKHFWCLYNQLEEFKDDSHVSMPSYFRFLTLMAFHVFLQEKVDLAVVEVGIGGAFDCTNIIRKPVVCGVSSLGIDHTSLLGDTVEKIAWQKGGIFKPGVPAFTVVQPEGPLAVLRDRAQQIGCPLYLCPPLEALEEVGLPLSLGLEGAHQRSNAALALQLAHCWLERQDHQDIQELKVSRPSIRWQLPLAPVFRPTPHMRRGLRDTVWPGRTQILQRGPLTWYLDGAHTTSSVQACVHWYRQSLERSKRTDGGSEVHILLFNSTGDRDSAALLKLLQPCQFDYAVFCPNVTEVSSIGNADQQNFTVTLDQVLLRCLQHQQHWNGLAEKQASSNLWSSCGPDPAGPGSLLLAPHPPQPTRTSSLVFSCISHALLWISQGRDPIFQPQSLPRNLLNHPTANSGASILREAAAIHVLVTGSLHLVGGVLKLLDPSMSQ

Gene
FPGS
Protein
Folylpolyglutamate synthase, mitochondrial
Organism
Bos taurus
Length
585 amino acids
Function
Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis.
Similarity
Belongs to the folylpolyglutamate synthase family.
Mass
64.9 kDa
Sequence
MSRARCHALFLAAVSPRGATTRVAVRRGLSAWPVLQEPDMEYQDAVRTLNTLQTNANYLEMVKRKRGDPQTQLEAMKLYLARSGLQVEDLDQLNIIHITGTKGKGSTCAFTERILRSYGLKTGFFSSPHLVQVRERIRINGQPISSELFTKHFWRLYHRLEETKDDSSCVSMPGYFRFLTLMAFHVFLQEKVDLAVLEVGIGGAYDCTNIIRKPVVCGITSLGIDHTGLLGDTMEKIAWQKGGIFKSGVPAFTVLQPDEPLAVLRDRAQQISCPLYLCPPLQALEEGGPPLTLGLEGEHQRSNAALALQVARCWLQQKGYQDAGELKASRPSLPGQLPLAPVFQPTPRMQQGLRHTEWPGRTQLLRRGPLTWYLDGAHTTSSMQACVRWFRQALHRCERPDSGSEVRVLLFNSTGDRDSAALLKLLQPCQFDYAIFCPNLAEMASTDNADQQNFTVTLDQVLLRCLAHQQHWSRLHEEQVSPDPWSTPGQEQDGPASLLLAPHPPHTHSASSLVFSCISHALQWITQGRDPLFQPPSPPRGLLAHPVADSGATVLQEAADIHVLVTGSLHLVGGVLKLLEPSLSQ

Gene
fpgS
Protein
Folylpolyglutamate synthase
Organism
Lactobacillus casei
Length
428 amino acids
Function
Involved in the conversion of folates to polyglutamate derivatives, and likely functions in the retention of cellular folate pools. Catalyzes successive MgATP-dependent additions of glutamate to a pteroylmonoglutamate substrate, with a high preference for 5,10-methylenetetrahydrofolate (mTHF). Thus, metabolizes mTHF to the tetraglutamate derivative, but longer glutamate chain length products are not observed. Tetrahydrofolate (H4PteGlu) and 10-formyl-H4PteGlu are poorer folate substrates. In contrast to E.coli FolC, this enzyme does not display dihydrofolate synthase activity.
Similarity
Belongs to the folylpolyglutamate synthase family.
Mass
46.589 kDa
Sequence
MNYTETVAYIHSFPRLAKTGDHRRILTLLHALGNPQQQGRYIHVTGTNGKGSAANAIAHVLEASGLTVGLYTSPFIMRFNERIMIDHEPIPDAALVNAVAFVRAALERLQQQQADFNVTEFEFITALGYWYFRQRQVDVAVIEVGIGGDTDSTNVITPVVSVLTEVALDHQKLLGHTITAIAKHKAGIIKRGIPVVTGNLVPDAAAVVAAKVATTGSQWLRFDRDFSVPKAKLHGWGQRFTYEDQDGRISDLEVPLVGDYQQRNMAIAIQTAKVYAKQTEWPLTPQNIRQGLAASHWPARLEKISDTPLIVIDGAHNPDGINGLITALKQLFSQPITVIAGILADKDYAAMADRLTAAFSTVYLVPVPGTPRALPEAGYEALHEGRLKDSWQEALAASLNDVPDQPIVITGSLYLASAVRQTLLGGKS