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FOXI1

Gene
FOXI1
Protein
Forkhead box protein I1
Organism
Homo sapiens
Length
378 amino acids
Function
Transcriptional activator required for the development of normal hearing, sense of balance and kidney function. Required for the expression of SLC26A4/PDS, JAG1 and COCH in a subset of epithelial cells and the development of the endolymphatic system in the inner ear. Also required for the expression of SLC4A1/AE1, SLC4A9/AE4, ATP6V1B1 and the differentiation of intercalated cells in the epithelium of distal renal tubules (By similarity).
Mass
40.973 kDa
Sequence
MSSFDLPAPSPPRCSPQFPSIGQEPPEMNLYYENFFHPQGVPSPQRPSFEGGGEYGATPNPYLWFNGPTMTPPPYLPGPNASPFLPQAYGVQRPLLPSVSGLGGSDLGWLPIPSQEELMKLVRPPYSYSALIAMAIHGAPDKRLTLSQIYQYVADNFPFYNKSKAGWQNSIRHNLSLNDCFKKVPRDEDDPGKGNYWTLDPNCEKMFDNGNFRRKRKRKSDVSSSTASLALEKTESSLPVDSPKTTEPQDILDGASPGGTTSSPEKRPSPPPSGAPCLNSFLSSMTAYVSGGSPTSHPLVTPGLSPEPSDKTGQNSLTFNSFSPLTNLSNHSGGGDWANPMPTNMLSYGGSVLSQFSPHFYNSVNTSGVLYPREGTEV

Gene
Foxi1
Protein
Forkhead box protein I1
Organism
Mus musculus
Length
372 amino acids
Function
Transcriptional activator required for the development of normal hearing, sense of balance and kidney function. Required for the expression of SLC26A4/PDS, JAG1 and COCH in a subset of epithelial cells and the development of the endolymphatic system in the inner ear. Also required for the expression of SLC4A1/AE1, SLC4A9/AE4, ATP6V1B1 and the differentiation of intercalated cells in the epithelium of distal renal tubules.
Mass
40.798 kDa
Sequence
MSSFDLPAPSPPRCSPQFPSIGQEPPEMNLYYENFFHPQGMPSPQRPTSFEGGGEYGTTPNPYLWLNGPAMTPPPYLPGTNASPFLPQAYGMQRQLLPSDLGWLPIPSQEELMKLVRPPYSYSALIAMAIHGAPDQRLTLSQIYQYVADNFPFYNKSKAGWQNSIRHNLSLNDCFKKVPRDEDDPGKGNYWTLDPNCEKMFDNGNFRRKRKRKSDSSSSTSSLASEKTENGLLASSPKPTEPQEVLDTASPDTTTSSPEKRSSPAPSGTPCLNNFLSTMTAYVSGTNPISRSVATPGLSSEPIDKMGQNSLNFNSYTPLTNLSSHGNGGEWANPVATNALGYGGSVFNQFSPHFYNSINTNGILFPREGTEV

Gene
foxi1
Protein
Forkhead box protein I1
Organism
Xenopus tropicalis
Length
363 amino acids
Function
Transcription factor. Essential for ventral specification of the early cephalic (head) ectoderm during gastrulation, playing a role in the 'non-neural' versus 'neural' cell fate choice. Binds to DNA via the target sequence 5'-[AG]TAAA[CT]A-3', with 5'-ATAAACA-3' being the preferred binding site (By similarity).
Mass
40.236 kDa
Sequence
MNPVQQPAQQRSPASSLPHPKRAQEAPDMALYCDNFMYPQQSLHPSQRGPNFAIGEYTSPANPYLWLGGHGVNNAPNYSPSPAPYMPPSFGAPQRQFLPNSPAFGGTELSWMSAASQEELLKMVRPPYSYSALIAMAIQHASDRRLTLSQIYQYVAENFPFYKKSKAGWQNSIRHNLSLNDCFKKVPRDENDPGKGNYWTLDPNCEKMFDNGNFRRKRKPKSDANSAKIAKIGEDHLNPKGKESPPMITPSSPEEPSPTGHSKSPSPPAVTYTPCLTNFIGSMTAVDAATANRQGPLGLLNELSQRNISSLSSFISGSAVDQSAEHPDTSLFYNRSPYYSSFPTTAQKQPQFLQQPPLYQGRY