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FOXE1

Gene
foxe1
Protein
Forkhead box protein E1
Organism
Xenopus laevis
Length
379 amino acids
Function
Transcription factor that binds consensus sites on a variety of gene promoters and activate their transcription.
Mass
41.708 kDa
Sequence
MTAESQQSPTRATAAGAGLQQTSGFTMPVVKVEKDPAPEASMSNGGSEVDDTHKGRRRKRPLQKGKPPYSYIALIAMSIANSADRKLTLGGIYKFITERFPFYRDNSKKWQNSIRHNLTLNDCFIKIPREPGRPGKGNYWALDPNAEDMFDSGSFLRRRKRFKRTDLTTYPAYIHDTSMFSPLQVARATYPNTVYPNMTMSPNYSQQIAPHSSVYYPSSSPAFSSAQPRVFSINTLIGHSGSEHAQPPNRSISPEVNSTSSSSCNYGGSAYSSQAGSGTMLPRSTNPVPYSYSVPNSHLQMNQSTYTHSNAQLFGSASRLPMPTSPPMNSDTVDFYGRMSPGQYTSLATYNSNGQLGGTNAYLRHATYSGNMERFVPAV

Gene
FOXE1
Protein
Forkhead box protein E1
Organism
Homo sapiens
Length
373 amino acids
Function
Transcription factor that binds consensus sites on a variety of gene promoters and activate their transcription. Involved in proper palate formation, most probably through the expression of MSX1 and TGFB3 genes which are direct targets of this transcription factor. Also implicated in thyroid gland morphogenesis. May indirectly play a role in cell growth and migration through the regulation of WNT5A expression.
Mass
38.076 kDa
Sequence
MTAESGPPPPQPEVLATVKEERGETAAGAGVPGEATGRGAGGRRRKRPLQRGKPPYSYIALIAMAIAHAPERRLTLGGIYKFITERFPFYRDNPKKWQNSIRHNLTLNDCFLKIPREAGRPGKGNYWALDPNAEDMFESGSFLRRRKRFKRSDLSTYPAYMHDAAAAAAAAAAAAAAAAIFPGAVPAARPPYPGAVYAGYAPPSLAAPPPVYYPAASPGPCRVFGLVPERPLSPELGPAPSGPGGSCAFASAGAPATTTGYQPAGCTGARPANPSAYAAAYAGPDGAYPQGAGSAIFAAAGRLAGPASPPAGGSSGGVETTVDFYGRTSPGQFGALGACYNPGGQLGGASAGAYHARHAAAYPGGIDRFVSAM

Gene
Foxe1
Protein
Forkhead box protein E1
Organism
Mus musculus
Length
371 amino acids
Function
Transcription factor that binds consensus sites on a variety of gene promoters and activate their transcription. Involved in proper palate formation, most probably through the expression of MSX1 and TGFB3 genes which are direct targets of this transcription factor (PubMed:21177256). Also implicated in thyroid gland morphogenesis (PubMed:9697704). May indirectly play a role in cell growth and migration through the regulation of WNT5A expression (By similarity).
Mass
37.768 kDa
Sequence
MTAESAPPPPPQPETLAAVKEERGEAAAAGAGVPAEAAGRGAGGRRRKRPLQRGKPPYSYIALIAMAIAHAPERRLTLGGIYKFITERFPFYRDNPKKWQNSIRHNLTLNDCFLKIPREAGRPGKGNYWALDPNAEDMFESGSFLRRRKRFKRSDLSTYPAYMHDAAAAAAAAAAAIFPGAVPAARPAYPGAVYAGYAPPLAAPPPVYYPAASPGPCRVFGLVPERPLSPDLGPAPSAAGGSCAFAAAAGAAGTGSFQPAVCTGARPVNPAAYAAAYAGPDGAYPQGASSALFAAAAGRLAGPASPPAGGGSGGVEATVDFYGRTSPGQFGAALGPCYNPGGQLGAGGGGAYHSRHATAYPGAVDRFVSAM