FNBP1L

Formin-binding protein 1-like

605 amino acids

Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. May bind to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promote membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by activating the WASL/N-WASP-WASPIP/WIP complex, the predominant form of WASL/N-WASP in cells. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Essential for autophagy of intracellular bacterial pathogens.

Belongs to the FNBP1 family.

70.065 kDa

MSWGTELWDQFDSLDKHTQWGIDFLERYAKFVKERIEIEQNYAKQLRNLVKKYCPKRSSKDEEPRFTSCVAFFNILNELNDYAGQREVVAEEMAHRVYGELMRYAHDLKTERKMHLQEGRKAQQYLDMCWKQMDNSKKKFERECREAEKAQQSYERLDNDTNATKADVEKAKQQLNLRTHMADENKNEYAAQLQNFNGEQHKHFYVVIPQIYKQLQEMDERRTIKLSECYRGFADSERKVIPIISKCLEGMILAAKSVDERRDSQMVVDSFKSGFEPPGDFPFEDYSQHIYRTISDGTISASKQESGKMDAKTTVGKAKGKLWLFGKKPKPQSPPLTPTSLFTSSTPNGSQFLTFSIEPVHYCMNEIKTGKPRIPSFRSLKRGWSVKMGPALEDFSHLPPEQRRKKLQQRIDELNRELQKESDQKDALNKMKDVYEKNPQMGDPGSLQPKLAETMNNIDRLRMEIHKNEAWLSEVEGKTGGRGDRRHSSDINHLVTQGRESPEGSYTDDANQEVRGPPQQHGHHNEFDDEFEDDDPLPAIGHCKAIYPFDGHNEGTLAMKEGEVLYIIEEDKGDGWTRARRQNGEEGYVPTSYIDVTLEKNSKGS

Fnbp1l

Formin-binding protein 1-like

605 amino acids

Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. May bind to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promote membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by activating the WASL-WASPIP complex, the predominant form of WASL/N-WASP in cells. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Essential for autophagy of intracellular bacterial pathogens (By similarity).

Belongs to the FNBP1 family.

69.885 kDa

MSWGTELWDQFDSLDKHTQWGIDFLERYAKFVKERIEIEQNYAKQLRNLVKKYCPKRSSKDEEPRFTSCIAFFNILNELNDYAGQREVVAEEMAHRVYGELMRYAHDLKTERKMHLQEGRKAQQYLDMCWKQMDNSKKKFERECREAEKAQQSYERLDNDTNATKADVEKAKQQLNLRTHMADENKNEYAAQLQNFNGEQHKHFYVVIPQIYKQLQEMDERRTIKLSECYRGFADSERKVIPIISKCLEGMILAAKSVDERRDSQMVVDSFKSGFEPPGDFPFEDYSQHIYRTISDGTISAAKQESGKMDSKSTVGKAKGKLWLFGKKPKPQSPPLTPTSLFTSSTPNGSQFLTLSIEPVHYCMNEIKTGKPRIPSFRSLKRGVSLIMGPALEDFSHLPPEQRRKKLQQRIDELNRGLQKEADQKEALNKMKDVYEKNPQMGDPGSLQPKLAETMNNIDRLRMEIHKNEAWLSEVEGKTGIRGDRRHSSDINHLVTQGRESPEGSYTDDANQEVRGPPQQHGHHSEFDDEFEDDDPLPAIGHCKAIYPFDGHNEGTLAMKEGEVLYIIEEDKGDGWTRARRQNGEEGYVPTTYIDVTLEKSSKGS

Fnbp1l

Formin-binding protein 1-like

605 amino acids

Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. May bind to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promote membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by activating the WASL-WASPIP complex, the predominant form of WASL/N-WASP in cells. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Essential for autophagy of intracellular bacterial pathogens (By similarity). May negatively regulate neurite extension and axon branching in developing neurons.

Belongs to the FNBP1 family.

69.974 kDa

MSWGTELWDQFDSLDKHTQWGIDFLERYAKFVKERIEIEQNYAKQLRNLVKKYCPKRSSKDEEPRFTSCIAFFNILNELNDYAGQREVVAEEMAHRVYGELMRYAHDLKTERKMHLQEGRKAQQYLDMCWKQMDNSKKKFERECREAEKAQQSYERLDNDTNATKADVEKAKQQLNLRTHMADENKNEYAAQLQNFNGEQHKHFYVVIPQIYKQLQEMDERRTIKLSECYRGFADSERKVIPIISKCLEGMILAAKSVDERRDSQMVVDSFKSGFEPPGDFPFEDYSQHIYRTVSDGTISASKQEGGKMDSKSTAGKAKGKLWLFGKKPKPQSPPLTPTSLFTSSPPNGSQFLTLSIEPVHYCMNEIKTGKPRIPSFRSLKRGWSMKMGPALEDFSHLPPEQRRKKLQQRIDELNRGLQKESDQKEALNKMKDVYEKNPQMGDPGSLQPKLAETMNNIDRLRMEIHKNEAWLSEVEGKTGVRGDRRHSSDINHLVTQGRESPEGSYTDDANQEVRGPPQQHGHHSEFDDEFEDDDPLPAIGHCKAIYPFDGHNEGTLAMKEGEVLYIIEEDKGDGWTRARRQNGEEGYVPTTYIDVTLEKNSKGS

fnbp1l

Formin-binding protein 1-like

550 amino acids

Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Promotes cdc42-induced actin polymerization by activating the wasl-waspip complex, the predominant form of wasl/n-wasp in cells. Essential for autophagy of intracellular bacterial pathogens (By similarity).

Belongs to the FNBP1 family.

64.01 kDa

MSWGTELWDQFDNLEKHTQWGIDFLDKYAKFVKERLEIEQNYAKQLRNLVKKYCPKRSAKDEEPRFTSCLSFYNILNELNDYAGQREVVAEEMGHRVYAEIMRYSNDIKGERKSHLQEGRKAQQYLDMCLKQMDNSKRKFERECREAEKAQQTYERLDNDSNATKSDVEKAKQQLHLRTHMADESKNEYAAQLQNYNAEQHKHFYIVIPQVYKHLQEMDERRTVKLSECYKGFADAERKVIPIISKCLEGMVQAAKSVDERRDSQIVVDCFKSGFEPNGDYPFEDYSQHIYRTVSDGTISTPKQESLKPDPRVTVGKAKGKLWLFGKKPKGPALEDFSHLPPEQRRKRLQQRIDELSRELQKEMDQKDALNKMKDVYEKNPQMGDPSSLHPKIAETTSNIERLRMEIHKNEAWLSEVEGKVSQRSERRHSAEANHLVAQGRESPEGSYTEDANQEGRVQPQPHAHPEFDDEFDDDEPLPAIGHCKSLYPFDGNNEGTLAMKEGEVLYIIEEDKGDGWTRARKQNGEEGYVPTSYIDITLEKNSKGAVTYI

fnbp1l

Formin-binding protein 1-like

543 amino acids

Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Essential for autophagy of intracellular bacterial pathogens (By similarity). Promotes cdc42-induced actin polymerization by activating the wasl-waspip complex, the predominant form of wasl/n-wasp in cells.

Belongs to the FNBP1 family.

63.33 kDa

MSWGTELWDQFDNLEKHTQWGIDFLDKYAKFVKERLEIEQNYAKQLRNLVKKFCPKRSAKDEEPRFTSCLSFYNILNELNDYAGQREVVAEEIGHRVYAEIMRYSNDIKGERKSHLHEGRKAQQYLDMCLKQMDNSKRKFERECREAEKAQQSYERLDNDTNATKSDVEKAKQQLHLRTHMADESKNEYAAQLQNYNAEQHKHFYIVIPQVYKHLQEMDERRTIKLSECYKGFADAERKVIPIISKCLEGMVQAAKSVDERRDSQIVVDCFKSGFEPPGDFPFEDYSQHIYRTVSDGTISTPKQESLKPDPRMTVGKAKGKLWLFGKKPKGPALEDFSHLPPEQRRKRLQQRIDELSRELQKEMDQKDALNKMKDVYEKNPQMGDPGSLHPKIAETTSNIERLRMEIHKNEGWLSEVEGKVSQRSERRHSAEANHLVAQGRESPEGSYTEDANQEGRVQPQHHAHPEFDDEFDDDEPLPAIGHCKSLYPFDGNNEGTLAMKEGEVLYIIEEDKGDGWTRARKQNGEEGYVPTSYIEITLEKKQ