Function
Heme transporter that exports cytoplasmic heme. It can also export coproporphyrin and protoporphyrin IX, which are both intermediate products in the heme biosynthetic pathway. Does not export bilirubin. Heme export depends on the presence of HPX and is required to maintain intracellular free heme balance, protecting cells from heme toxicity. Heme export provides protection from heme or ferrous iron toxicities in liver, brain, sensory neurons and during erythtopoiesis, a process in which heme synthesis intensifies (By similarity). Confers susceptibility to Feline leukemia virus subgroup C (FeLV-C) infection, which is associated with fatal erythroid aplasia, also known as aplastic anemia (PubMed:10648427).
Sequence
MVKLNDEEGAAMAPGHQPTNGYLLVPGGEPPGKVSAELQNGPKAVCLTLNGVSRDSLAAAAEALCRPQTPLAPEEETQTRLLPTGPGEETPGTEGSPAPQTALSARRFVVLLIFSLYSLVNAFQWIQYSVISNVFEGFYGVSSLHIDWLSMVYMLAYVPLIFPATWLLDTRGLRLTALLGSGLNCLGAWVKCASVQQHLFWVTMLGQCLCSVAQVFILGLPSRIASVWFGPKEVSTACATAVLGNQLGAAIGFLLPPVLVPNTQNNTDLLACNISTMFYGTSSVATFLCFLTIIAFKEKPQYPPSQAQAALQNSPPAKYSYKKSIRNLFRNVPFVLLLITYGIITGAFYSVSTLLNQMILTYYKGEEVSAGKIGLTLVVAGMVGSILCGFWLDYTKIYKQTTLIVYILSFLGMVIFTFTLDLGYGIVVFVTGGVLGFFMTGYLPLGFEFAVEITYPESEGTSSGLLNAAAQIFGILFTLAQGKLTTDYSPKAGNIFLCVWLFLGIILTALIKSDLRRHNINIGIANGDIKAVPVEDTVEDSPTDKESKTIVMSKQSESAI