fgfr4

Fibroblast growth factor receptor 4

922 amino acids

Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway (By similarity).

Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.

103.465 kDa

MLSILKVFIAICFMELVCSRSITSGEPRAKDIRVSRHILTPGYPENATVLVGGHVKLVCKLHQPASTRLQWFKKDSNRLGPDGSPVLTALTPLLENLSKVNIFPLVNISLEDAGEYVCKAENSAGQATRSAWVEVLSEVSEEPTEEPSEHLLLELGDVLKLRCDTNRPGAVQWFKSGVRVQHNARIQIRAAVMEIADVTYEDSGVYVCMLRGTKEALRNFTITVADAVGSGDDDDEDNGLDDIGPETENDQVYISRAPYWTHTQRMEKKLYAVPAGNTVKFRCPATGSPLPTIRWLKNGREFRGEHRIGGIKLRHQHWSLVMESVVPSDRGNYSCVVENKYGSIAHTYLLDVLERSPHRPILQAGLPKNTTAIVGGDAQFLCKVYSDAQPHIQWLKHIEMNGSRYGPDGIPYVKIVKTGSLNMSEVEVLYLTNISMEDAGEYSCLAGNSIGFSHQSAWLTVLSEEDVAKEVDLMEAKYTDIIIYASGFLALVMAIVIVVLCRMQVHPSREPFDTLPVQKLSKFPLRRQYSVESNSSGKSSASLMRVARLSSSCSPMLAGVMEFELPYDPDWEFPRENLTLGKPLGEGCFGQVVRAEAYGINKENQDHMATVAVKMLKDDATDKDLADLISEMELMKVMDKHKNIINLLGVCTQDGPLYVLVEYASKGSLREYLRARRPPGMDYTFDVTKVPEEQLTFKDLVSCAYQVARGMEYLASKRCIHRDLAARNVLVTEDNVMKIADFGLARGVHQIDYYKKTTNGRMPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPSNCTHELYMKMRECWHAVPTQRPTFKQLVEELDRVLVSISDEYLDLSTPFEQYSPSCEDTSSSCSSDNDSVFTHDALSTEPCLLGYHDVHSRMDLKTTMR

fgfr4

Fibroblast growth factor receptor 4

828 amino acids

Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway (By similarity).

Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.

93.417 kDa

MSGSIRRSYTAMQNFPRFLLGVLFVATLSSCRPRLSEDEANWKGQTETSEVEEHLLLDPGNALRLFCDTNQSSSINWYREQERLLSGGKIRMVGTVLEVSDVTYEDSGLYICVVRGTGKILRRFSISVVDSLASGDEEEEEEDDDDEDGRREDTTADINEEPVYFFQAPYWTQPSRMDKKLHAVPAGNTVKFRCPAGGSPLPTIRWSLKNGREFRGEHRIGGIQIRHQHWSLVMESVVPSDRGNYTCVVENRVGSLTYTYFLDVLERSSHRPILQAGLPANTTARVGSDVEFYCKVYSDAQPHIQWLKHIEVNGSHFGPDDFPYVQVLKTADINPSDVEVLHLRNITMEDAGEYTCLAGNSIGLSHQSAWLTVLPNEDFLEQAEPAESRYMDIIIYTSGFLAVAMAIMIVILCRMQTPHSKQTLQTPTVHKLAKFPLIRQFSLESSSSGKSSAPLIRITRLSSSCAPMLPGVMEVELPLDAKWEFPRDRLVLGKPLGEGCFGQVVRAEGYGIEKDRPEKPVTVAVKMLKDNGTDKDLSDLISEMELMKVIGKHKNIINLLGVCTQEGPLFVIVEYASKGNLREFLRARRPPTPEDAFDITKVPEELLSFKDLVSCAYQVARGMEYLESKRCIHRDLAARNVLVAEDNVMKIADFGLARGVHDIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDIWSFGVLTWEIFTLGGSPYPVIPYEELFKLLREGHRMDKPSNCTHELYMLMRECWHAVPTQRPTFKQLEHLDRILTAVSEEYLDLSMPFEQYSPSCEDSASTCSSSDDSVFAPDPVPSSPCVFNYHNIHSQLGT

fgfr4

Fibroblast growth factor receptor 4

828 amino acids

Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway (By similarity).

Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.

93.417 kDa

MSGSIRRSYTAMQNFPRFLLGVLFVATLSSCRPRLSEDEANWKGQTETSEVEEHLLLDPGNALRLFCDTNQSSSINWYREQERLLSGGKIRMVGTVLEVSDVTYEDSGLYICVVRGTGKILRRFSISVVDSLASGDEEEEEEDDDDEDGRREDTTADINEEPVYFFQAPYWTQPSRMDKKLHAVPAGNTVKFRCPAGGSPLPTIRWSLKNGREFRGEHRIGGIQIRHQHWSLVMESVVPSDRGNYTCVVENRVGSLTYTYFLDVLERSSHRPILQAGLPANTTARVGSDVEFYCKVYSDAQPHIQWLKHIEVNGSHFGPDDFPYVQVLKTADINPSDVEVLHLRNITMEDAGEYTCLAGNSIGLSHQSAWLTVLPNEDFLEQAEPAESRYMDIIIYTSGFLAVAMAIMIVILCRMQTPHSKQTLQTPTVHKLAKFPLIRQFSLESSSSGKSSAPLIRITRLSSSCAPMLPGVMEVELPLDAKWEFPRDRLVLGKPLGEGCFGQVVRAEGYGIEKDRPEKPVTVAVKMLKDNGTDKDLSDLISEMELMKVIGKHKNIINLLGVCTQEGPLFVIVEYASKGNLREFLRARRPPTPEDAFDITKVPEELLSFKDLVSCAYQVARGMEYLESKRCIHRDLAARNVLVAEDNVMKIADFGLARGVHDIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDIWSFGVLTWEIFTLGGSPYPVIPYEELFKLLREGHRMDKPSNCTHELYMLMRECWHAVPTQRPTFKQLEHLDRILTAVSEEYLDLSMPFEQYSPSCEDSASTCSSSDDSVFAPDPVPSSPCVFNYHNIHSQLGT

FGFR4

Fibroblast growth factor receptor 4

822 amino acids

Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway (By similarity).

Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.

92.069 kDa

MGVQKDSRDIRWNRTTRPLALLLCGLLAFSALSCARTLPEGRKANLAELVSEEEEHFLLDPGNALRLFCDTNQTTIVNWYTESTRLQHGGRIRLTDTVLEIADVTYEDSGLYLCVVPGTGHILRNFTISVVDSLASGDDDDEDHGREDSAGDMGEDPPYSTSYRAPFWSQPQRMDKKLYAVPAGNTVKFRCPSAGNPTPGIRWLKNGREFGGEHRIGGIRLRHQHWSLVMESVVPSDRGNYTCLVENKFGSISYSYLLDVLERSPHRPILQAGLPANTTAMLGSDVQFFCKVYSDAQPHIQWLKHIEVNGSRYGPDGVPFVQVLKTADINSSEVEVLYLHNVSFEDAGEYTCLAGNSIGLSYQSAWLTVLPEEDFAKEAEGPETRYTDIIIYTSGSLALLMAAVIVVLCRMQLPPTKTHLEPATVHKLSRFPLMRQFSLESSSSGKSSTSLVRVTRLSSSCTPMLPGVLEFDLPLDSKWEFPRERLVLGKPLGEGCFGQVVRAEAYGINKDQPDKAITVAIKIVKDKGTDKELSDLISEMELMKLMGKHKNIINLLGVCTQDGPLYMIVEYASKGNLREFLRARRPPSPDYTFDMTKVPEEQLSFQDLVSCSYQVARGMAYLESKRCIHRDLAARNVLVTGENVMKIADFGLARGVHDIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLTWEIFTLGGSPYPGIPVEELFKLLREGHRMDKPSNCTHELYMLMRECWHAAPSQRPTFKQLVETLDRILATVAEEYLDLSMPFEQYSPACEDTTSTCSSDDSVFTHEPDVPSLFTHHTTTSMVGT

FGFR4

Fibroblast growth factor receptor 4

822 amino acids

Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway (By similarity).

Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.

92.069 kDa

MGVQKDSRDIRWNRTTRPLALLLCGLLAFSALSCARTLPEGRKANLAELVSEEEEHFLLDPGNALRLFCDTNQTTIVNWYTESTRLQHGGRIRLTDTVLEIADVTYEDSGLYLCVVPGTGHILRNFTISVVDSLASGDDDDEDHGREDSAGDMGEDPPYSTSYRAPFWSQPQRMDKKLYAVPAGNTVKFRCPSAGNPTPGIRWLKNGREFGGEHRIGGIRLRHQHWSLVMESVVPSDRGNYTCLVENKFGSISYSYLLDVLERSPHRPILQAGLPANTTAMLGSDVQFFCKVYSDAQPHIQWLKHIEVNGSRYGPDGVPFVQVLKTADINSSEVEVLYLHNVSFEDAGEYTCLAGNSIGLSYQSAWLTVLPEEDFAKEAEGPETRYTDIIIYTSGSLALLMAAVIVVLCRMQLPPTKTHLEPATVHKLSRFPLMRQFSLESSSSGKSSTSLVRVTRLSSSCTPMLPGVLEFDLPLDSKWEFPRERLVLGKPLGEGCFGQVVRAEAYGINKDQPDKAITVAIKIVKDKGTDKELSDLISEMELMKLMGKHKNIINLLGVCTQDGPLYMIVEYASKGNLREFLRARRPPSPDYTFDMTKVPEEQLSFQDLVSCSYQVARGMAYLESKRCIHRDLAARNVLVTGENVMKIADFGLARGVHDIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLTWEIFTLGGSPYPGIPVEELFKLLREGHRMDKPSNCTHELYMLMRECWHAAPSQRPTFKQLVETLDRILATVAEEYLDLSMPFEQYSPACEDTTSTCSSDDSVFTHEPDVPSLFTHHTTTSMVGT

FGFR4

Fibroblast growth factor receptor 4

802 amino acids

Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes SRC-dependent phosphorylation of the matrix protease MMP14 and its lysosomal degradation. FGFR4 signaling is down-regulated by receptor internalization and degradation; MMP14 promotes internalization and degradation of FGFR4. Mutations that lead to constitutive kinase activation or impair normal FGFR4 inactivation lead to aberrant signaling.

Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.

87.954 kDa

MRLLLALLGVLLSVPGPPVLSLEASEEVELEPCLAPSLEQQEQELTVALGQPVRLCCGRAERGGHWYKEGSRLAPAGRVRGWRGRLEIASFLPEDAGRYLCLARGSMIVLQNLTLITGDSLTSSNDDEDPKSHRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFPYVQVLKTADINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPEEDPTWTAAAPEARYTDIILYASGSLALAVLLLLAGLYRGQALHGRHPRPPATVQKLSRFPLARQFSLESGSSGKSSSSLVRGVRLSSSGPALLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAVSEEYLDLRLTFGPYSPSGGDASSTCSSSDSVFSHDPLPLGSSSFPFGSGVQT

Fgfr4

Fibroblast growth factor receptor 4

800 amino acids

Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes SRC-dependent phosphorylation of the matrix protease MMP14 and its lysosomal degradation. FGFR4 signaling is down-regulated by receptor internalization and degradation; MMP14 promotes internalization and degradation of FGFR4 (By similarity).

Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.

88.708 kDa

MWLLLALLSIFQETPAFSLEASEEMEQEPCPAPISEQQEQVLTVALGQPVRLCCGRTERGRHWYKEGSRLASAGRVRGWRGRLEIASFLPEDAGRYLCLARGSMTVVHNLTLIMDDSLPSINNEDPKTLSSSSSGHSYLQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPMPTIHWLKNGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENSLGSIRYSYLLDVLERSPHRPILQAGLPANTTAVVGSNVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFPYVQVLKTTDINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPAEEEDLAWTTATSEARYTDIILYVSGSLALVLLLLLAGVYHRQAIHGHHSRQPVTVQKLSRFPLARQFSLESRSSGKSSLSLVRGVRLSSSGPPLLTGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEALGMDSSRPDQTSTVAVKMLKDNASDKDLADLISEMEMMKLIGRHKNIINLLGVCTQEGPLYVIVEYAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPALVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDDVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMERPPNCPSELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAVSEEYLDLRLTFGPYSPNNGDASSTCSSSDSVFSHDPLPLEPSPFPFPEAQTT

Fgfr4

Fibroblast growth factor receptor 4

800 amino acids

Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes SRC-dependent phosphorylation of the matrix protease MMP14 and its lysosomal degradation. FGFR4 signaling is down-regulated by receptor internalization and degradation; MMP14 promotes internalization and degradation of FGFR4 (By similarity).

Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.

88.708 kDa

MWLLLALLSIFQETPAFSLEASEEMEQEPCPAPISEQQEQVLTVALGQPVRLCCGRTERGRHWYKEGSRLASAGRVRGWRGRLEIASFLPEDAGRYLCLARGSMTVVHNLTLIMDDSLPSINNEDPKTLSSSSSGHSYLQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPMPTIHWLKNGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENSLGSIRYSYLLDVLERSPHRPILQAGLPANTTAVVGSNVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFPYVQVLKTTDINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPAEEEDLAWTTATSEARYTDIILYVSGSLALVLLLLLAGVYHRQAIHGHHSRQPVTVQKLSRFPLARQFSLESRSSGKSSLSLVRGVRLSSSGPPLLTGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEALGMDSSRPDQTSTVAVKMLKDNASDKDLADLISEMEMMKLIGRHKNIINLLGVCTQEGPLYVIVEYAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPALVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDDVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMERPPNCPSELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAVSEEYLDLRLTFGPYSPNNGDASSTCSSSDSVFSHDPLPLEPSPFPFPEAQTT

Fgfr4

Fibroblast growth factor receptor 4

799 amino acids

Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes SRC-dependent phosphorylation of the matrix protease MMP14 and its lysosomal degradation. FGFR4 signaling is down-regulated by receptor internalization and degradation; MMP14 promotes internalization and degradation of FGFR4. Plays a role in postnatal lung development. May be involved in the development of skeletal muscle cell lineages.

Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.

88.661 kDa

MWLLLALLSIFQGTPALSLEASEEMEQEPCLAPILEQQEQVLTVALGQPVRLCCGRTERGRHWYKEGSRLASAGRVRGWRGRLEIASFLPEDAGRYLCLARGSMTVVHNLTLLMDDSLTSISNDEDPKTLSSSSSGHVYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPMPTIHWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENSLGSIRYSYLLDVLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHVVINGSSFGADGFPYVQVLKTTDINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPEEDLTWTTATPEARYTDIILYVSGSLVLLVLLLLAGVYHRQVIRGHYSRQPVTIQKLSRFPLARQFSLESRSSGKSSLSLVRGVRLSSSGPPLLTGLVNLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPSRPDQTSTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPALVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDDVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFEILLWEIFTLGGSPYPGIPVEELFSLLREGHRMERPPNCPSELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAVSEEYLDLRLTFGPFSPSNGDASSTCSSSDSVFSHDPLPLEPSPFPFSDSQTT

FGFR4

Fibroblast growth factor receptor 4

713 amino acids

Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes SRC-dependent phosphorylation of the matrix protease MMP14 and its lysosomal degradation. FGFR4 signaling is down-regulated by receptor internalization and degradation; MMP14 promotes internalization and degradation of FGFR4 (By similarity).

Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.

80.17 kDa

MLPLWLVLAGLLLAVGPAASHRGEMEPDSLASGDDDEDSDGDGPHGDRSEEPVYMHRAPYWTHPHRMDKKLYAVPAGNTVKFRCPASGSPSPSIRWFKNGREFRGEHRIGGIRLRHQHWSLVMESVVPSDRGNYTCLVENRFGRIRYSYLLDVLERSPHRPILQAGLPANTTALVGSDVEFFCKVYSDAQPHLQWLKHIEVNGSSYGPDGVPYVQVLKTADINSSEVEVLYLRNVTMEDAGEYTCLAGNSIGLSYQSAWLTVLPEEELVHEAETSEAKYTDIIIYTSGSLAVAMALIIVVLCRMQTQSSKQPLEPMAVHKLSKFPLIRQFSLDSSSSGKSSTSLMRVTRLSSSCAPMLAGVVEMDLPLDSKWEFPREKLVLGKPLGEGCFGQVVRAEAYGIDRQWPDRAVTVAVKMLKDNATDKDLADLISEMEMMKLMDKHKNIINLLGVCTQDGPLYVIVEFAAKGNLREYLRARRPPTPDYTFDITELHEEQLCFKDLVSCVYQVARGMEYLESRRCIHRDLAARNVLVTAENVMKIADFGLARDVHDIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFGILMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDCPSNCTHELYMLMRECWHAVPLQRPTFKQLVEGLDKILAAISEEYLDLSMPFEQYSPSCEDTTSTCSSDDSVFTHDPMPLAPCLFSCPSGRT