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FGF2

Gene
FGF2
Protein
Fibroblast growth factor 2
Organism
Pan troglodytes
Length
288 amino acids
Function
Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis.
Similarity
Belongs to the heparin-binding growth factors family.
Mass
30.736 kDa
Sequence
MVGVGGGDVEDVTPRPGGCQISGRGARGCNGIPGAAAWEAALPRRRPRRHPSVNPRSRAAGSPRTRGRRTKERPSGSRLGDHGRGRALPGGRVGGRGRGRAPERVGGRGRGRGTAAPRAAPAARGSRPGPAGTMAAGSITTLPALPEDGGSGAFPPGHFKDPKRLYCKNGGFFLRIHPDGRVDGVREKSDPHIKLQLQAEERGVVSIKGVCANRYLAMKEDGRLLASKCVTDECFFFERLESNNYNTYRSRKYTSWYVALKRTGQYKLGSKTGPGQKAILFLPMSAKS
Protein
Fibroblast growth factor 2: FGF2

Gene
FGF2
Protein
Fibroblast growth factor 2
Organism
Homo sapiens
Length
288 amino acids
Function
Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4 (PubMed:8663044). Also acts as an integrin ligand which is required for FGF2 signaling (PubMed:28302677). Binds to integrin ITGAV:ITGB3 (PubMed:28302677). Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration (PubMed:8663044, PubMed:28302677). Functions as a potent mitogen in vitro (PubMed:3732516, PubMed:3964259). Can induce angiogenesis (PubMed:23469107, PubMed:28302677).
Similarity
Belongs to the heparin-binding growth factors family.
Mass
30.77 kDa
Sequence
MVGVGGGDVEDVTPRPGGCQISGRGARGCNGIPGAAAWEAALPRRRPRRHPSVNPRSRAAGSPRTRGRRTEERPSGSRLGDRGRGRALPGGRLGGRGRGRAPERVGGRGRGRGTAAPRAAPAARGSRPGPAGTMAAGSITTLPALPEDGGSGAFPPGHFKDPKRLYCKNGGFFLRIHPDGRVDGVREKSDPHIKLQLQAEERGVVSIKGVCANRYLAMKEDGRLLASKCVTDECFFFERLESNNYNTYRSRKYTSWYVALKRTGQYKLGSKTGPGQKAILFLPMSAKS
Protein
Fibroblast growth factor 2: FGF2

Gene
FGF2
Protein
Fibroblast growth factor 2
Organism
Cavia porcellus
Length
170 amino acids
Function
Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis.
Similarity
Belongs to the heparin-binding growth factors family.
Mass
18.354 kDa
Fragment
multiple
Sequence
VGGRGRGRGTAAAARREPGGAMAAGSITTLPALPEGGDGGAFAPGHFKDPNGGFFLRIHPDGRVDGVREKTDPHIKLQLQAEDRGVVSIKGVCANRYLAMKEDGRLLASKCVTDECFFFERLESNNYNTYRSRKYSSWYVALKRTGQYKLGSKTGPGQKAILFLPMSAKS
Protein
Fibroblast growth factor 2: FGF2

Gene
FGF2
Protein
Fibroblast growth factor 2
Organism
Gallus gallus
Length
158 amino acids
Function
Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis.
Similarity
Belongs to the heparin-binding growth factors family.
Mass
17.374 kDa
Sequence
MAAGAAGSITTLPALPDDGGGGAFPPGHFKDPKRLYCKNGGFFLRINPDGRVDGVREKSDPHIKLQLQAEERGVVSIKGVSANRFLAMKEDGRLLALKCATEECFFFERLESNNYNTYRSRKYSDWYVALKRTGQYKPGPKTGPGQKAILFLPMSAKS
Protein
Fibroblast growth factor 2: FGF2

Gene
FGF2
Protein
Fibroblast growth factor 2
Organism
Monodelphis domestica
Length
156 amino acids
Function
Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis.
Similarity
Belongs to the heparin-binding growth factors family.
Mass
17.303 kDa
Sequence
MAAGSITTLPALSGDGGGGGAFPPGHFKDPKRLYCKNGGFFLRIHPDGRVDGIREKSDPNIKLQLQAEERGVVSIKGVCANRYLAMKEDGRLLALKYVTEECFFFERLESNNYNTYRSRKYSNWYVALKRTGQYKLGSKTGPGQKAILFLPMSAKS
Protein
Fibroblast growth factor 2: FGF2

Gene
FGF2
Protein
Fibroblast growth factor 2
Organism
Ovis aries
Length
155 amino acids
Function
Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis.
Similarity
Belongs to the heparin-binding growth factors family.
Mass
17.28 kDa
Sequence
MAAGSITTLPALPEDGGSSAFPPGHFKDPKRLYCKNGGFFLRIHPDGRVDGVREKSDPHIKLQLQAEERGVVSIKGVCANRYLAMKEDGRLLASKCVTDECFFFERLESNNYNTYRSRKYSSWYVALKRTGQYKLGPKTGPGQKAILFLPMSAKS
Protein
Fibroblast growth factor 2: FGF2

Gene
fgf2
Protein
Fibroblast growth factor 2
Organism
Xenopus laevis
Length
155 amino acids
Function
Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis.
Similarity
Belongs to the heparin-binding growth factors family.
Mass
17.241 kDa
Sequence
MAAGSITTLPTESEDGGNTPFSPGSFKDPKRLYCKNGGFFLRINSDGRVDGSRDKSDSHIKLQLQAVERGVVSIKGITANRYLAMKEDGRLTSLRCITDECFFFERLEANNYNTYRSRKYSSWYVALKRTGQYKNGSSTGPGQKAILFLPMSAKS
Protein
Fibroblast growth factor 2: fgf2

Gene
FGF2
Protein
Fibroblast growth factor 2
Organism
Bos taurus
Length
155 amino acids
Function
Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis.
Similarity
Belongs to the heparin-binding growth factors family.
Mass
17.25 kDa
Sequence
MAAGSITTLPALPEDGGSGAFPPGHFKDPKRLYCKNGGFFLRIHPDGRVDGVREKSDPHIKLQLQAEERGVVSIKGVCANRYLAMKEDGRLLASKCVTDECFFFERLESNNYNTYRSRKYSSWYVALKRTGQYKLGPKTGPGQKAILFLPMSAKS
Protein
Fibroblast growth factor 2: FGF2

Gene
Fgf2
Protein
Fibroblast growth factor 2
Organism
Rattus norvegicus
Length
154 amino acids
Function
Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis.
Similarity
Belongs to the heparin-binding growth factors family.
Mass
17.139 kDa
Sequence
MAAGSITSLPALPEDGGGAFPPGHFKDPKRLYCKNGGFFLRIHPDGRVDGVREKSDPHVKLQLQAEERGVVSIKGVCANRYLAMKEDGRLLASKCVTEECFFFERLESNNYNTYRSRKYSSWYVALKRTGQYKLGSKTGPGQKAILFLPMSAKS
Protein
Fibroblast growth factor 2: Fgf2

Gene
Fgf2
Protein
Fibroblast growth factor 2
Organism
Mus musculus
Length
154 amino acids
Function
Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis.
Similarity
Belongs to the heparin-binding growth factors family.
Mass
17.153 kDa
Sequence
MAASGITSLPALPEDGGAAFPPGHFKDPKRLYCKNGGFFLRIHPDGRVDGVREKSDPHVKLQLQAEERGVVSIKGVCANRYLAMKEDGRLLASKCVTEECFFFERLESNNYNTYRSRKYSSWYVALKRTGQYKLGSKTGPGQKAILFLPMSAKS
Protein
Fibroblast growth factor 2: Fgf2

Gene
FGF2
Protein
Fibroblast growth factor 2
Organism
Oryctolagus cuniculus
Length
137 amino acids
Function
Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis.
Similarity
Belongs to the heparin-binding growth factors family.
Mass
15.419 kDa
Fragment
single
Sequence
PALPEDGGSGAFPPGHFKDPKRLYCKNGGFFLRIHPDGRVDGVREKSDPHIKLQLQAEERGVVSIKGVCANRYLAMKEDGRLLASKCVTDECFFFERLESNNYNTYRSRKYSSWYVALKRTGQYKLGSKTGPGQKAI
Protein
Fibroblast growth factor 2: FGF2