FGD5

FYVE, RhoGEF and PH domain-containing protein 5

1462 amino acids

Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape.

159.891 kDa

MFRGPKPPIAPKPRLTAPNEWRASVYLNDSLNKCSNGRLPCVDRGLDEGPRSIPKCSESETDEDYIVVPRVPLREDEPKDEGSVGNKALVSPESSAEEEEEREEGGEACGLEGTGAGEDSVAPAAPGAGALSREGEEGTDLALEDEGEGCADEPGTLEQVSRSEEEEKLVQPHRECSLEDSGPWAGEGVFQSDLLLPHIHGEDQEPPDTPGEAEEDDEEGCASTDPAGADEGSGPDRPTEDMGQDAEDTSEEPPEKEELAGVQEAETATDCPEVLEEGCEEATGVTGGEQVDLSEPPDHEKKTNQEVAAATLEDHAQDESAEESCQIVPFENDCMEDFVTSLTGSPYEFFPTESTSFCSESCSPLSESAKGLESEQAPKLGLRAEENPMVGALCGQCGSLQGGAAEGPAAPDVVVVLEEEALDDALANPYVMGVGLPGQAAPGEGGQAASDALGGYGSKEELNCEAEGGLVPADRKNTSTRVRPHSGKVAGYVPETVPEETGPEAGSSAPGIGGAAEEVGKTLLSLEGKPLEASRALPAKPRAFTLYPRSFSVEGREIPVSVYQEPEGSGLDDHRIKRKEDNLSLSCVIGSSGSFSQRNHLPSSGTSTPSSMVDIPPPFDLACITKKPITKSSPSLLIESDSPDKYKKKKSSFKRFLALTFKKKTENKLHVDVNVSSSRSSSESSYHGPSRILEVDRRSLSNSPQLKSRTGKLRASESPSSLIFYRDGKRKGVPFSRTVSRVESFEDRSRPPFLPLPLTKPRSISFPSADTSDYENIPAMNSDYENIQIPPRRPARAGAFTKLFEDQSRALSTANENDGYVDMSSFNAFESKQQSADQDAESAYTEPYKVCPISSAAPKEDLTSDEEQRSSEEEDSASRDPSVTHKVEGQSRALVIAQELLSSEKAYVEMLQHLNLDFHGAVMRALDDMDHEGRDTLAREELRQGLSELPAIHDLHQGILEELEERLSNWESQQKVADVFLAREQGFDHHATHILQFDRYLGLLSENCLHSPRLAAAVREFEQSVQGGSQTAKHRLLRVVQRLFQYQVLLTDYLNNLCPDSAEYDNTQGALSLISKVTDRANDSMEQGENLQKLVHIEHSVRGQGDLLQPGREFLKEGTLMKVTGKNRRPRHLFLMNDVLLYTYPQKDGKYRLKNTLAVANMKVSRPVMEKVPYALKIETSESCLMLSASSCAERDEWYGCLSRALPEDYKAQALAAFHHSVEIRERLGVSLGERPPTLVPVTHVMMCMNCGCDFSLTLRRHHCHACGKIVCRNCSRNKYPLKYLKDRMAKVCDGCFGELKKRGRAVPGLMRERPVSMSFPLSSPRFSGSAFSSVFQSINPSTFKKQKKVPSALTEVAASGEGSAISGYLSRCKRGKRHWKKLWFVIKGKVLYTYMASEDKVALESMPLLGFTIAPEKEEGSSEVGPIFHLYHKKTLFYSFKAEDTNSAQRWIEAMEDASVL

Fgd5

FYVE, RhoGEF and PH domain-containing protein 5

1219 amino acids

Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape (By similarity).

134.719 kDa

MGSPESEVSPDVQEQEAATDNPEVFEEDSADAAEGEDQIEQEEPPNCDEEAYNRDAAAATMQVGEDLGEEGDHVQEDPAEESCQIIPFESDSVEEDFSPTLTENPYEIFPTESTSFCNNTYSLDESANGHEPVCEICVEEVPGVGPPLNQHDSLPDGSGEDSPVVPDVVVVPENEGPVDDALSSPYVMGVGLLSLGEGAQSDTQAASGTLSGYSTWEEGDSEGGQVPVDRKNIATRARPHSGKVAGHVPETVLEETGPETCSSGMGIRDTSDEVRKIGILPEGKPPECVRALPAKPRAFTLYPRSFSVEGRESPLSMFREPEGAGLDSHRVRRKEDNLSLPGAIGSSGSFSQRSHLPSSGTSTPSSVVDIPPPFDLACITKKPITKSSPSLLIDGDTLEKASKKKKSSFKRFLELTFRKKTESKVHVDMNLSSSRSSSESSYHGPARVLELDRRSLSNSPQLKCRTGKLRASDSPAALIFYRDSKRKGVPFSRTVSRVESFEDRSRPPFLPLPLTKPRSISFPNADTSDYENIPAMNSDYENIQIPPRRPVRTGTFTKLFEEQSRALSTANENDGYVDMSSFNAFESKQQSSEQEAESAYTEPYKVCPISAAPREDLTSDEEQGSSEEEDSASRDPSLSHKGEGQSRALVIAQELLSSEKAYVQMLQHLSLDFHGAVLRALENVEQEGREPLAQEELRQGLRELPAICDLHQGILESLEQRLGDCGEGQPQVADIFLAREQEFEHHAAHILQFDRYLGLLAESCLLSPRLATTVREFEQSSQGGGQSMKHRMLRVVQRLFQYQVLLTDYLNNLCPDSAEYDNTQSALTLISKVTDRANESMEQGENLQKLVHIEYSVRGQGDLLQPGREFLKEGTLMRVRGKSRHPRHLFLMNDTLLYTHPQKDGKYRLKSSLPVANMKVSRPVMDKVPYALKIETPESCLTLSASSCAERDEWHYCLSRALPEDYKTQALAAFHHSVEIRERLGISLGERLPTLVPVTHAMMCMNCGCDFSLTVRRHHCHACGKIVCRNCSRNKYPLKCLKNRMAKVCDGCFRELKLRNGPVPGSMRERPVSMSFPLSSSRFSSGSALSSVFQSISPSTFKKQKKVPSALSEVAASGEGSAISGYLSRCKSGKRRWKKLWLVIKGKVLYTYLASEDKVAMESIPLLGFTIAPEKEEGSSEVGPVFHLYHKKTLFYSFKAEDSNSAQRWMEAMEDASVL