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FEN1

Gene
FEN1
Protein
Flap endonuclease 1
Organism
Plasmodium falciparum (isolate 3D7)
Length
672 amino acids
Function
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Similarity
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
Mass
76.681 kDa
Sequence
MGIKGLTKFIADAAPNAIKEIKIESLMGRIIAIDASMSLYQFIIAIRDSEQYGNLTNESGETTSHISGLMSRSIRLMENGLKPIYVFDGAPPELKGSELEKRGEKRQKAEELLKKAKEEGNLEEIKKQSGRTVRVTRKQNEEAKKLLTLMGIPIIEAPCEAESQCAFLTKYNLAHATATEDADALVFGTKILIRNLNANATSNQNKNKNNSKRGYILTEINLEQVLKGLNLTMDEFIDFCILCGCDYCDTIKGIGSKTAYNLIKEYNCIEKIIENIDQNKYQVPSNFRFQEARKSFINPNVLPKEDIKIDWNEPQIEELKHFLIKDYNFNELRVTNYINRLLKARKVTTQRRLDNFFTACTKKSTKLIVEETKKEQTLPARKGKKRPTAGDKNKQKAVKRKIEQANANGHHKMKEENKSVDNEKNEDGIKSVDNEKNEDGIKSVDDEKNLDDEKNLDDEKNKDDEKNKDDEKNKDDEKNKDDEKNKDDEKKSLDNFSSNLFDSDKESESGNIIKNEKQNMDDEKINDNLPSLFGDHSRIRHTENKDNISDINNNNNNNNSSSNNNNISNNHFNSVSSNSTFNSSTKLKSEDTLKSNSPLKEDSPNSYNNIKNNNHTININSQINNHKEPISNNNLNNINNSTEIKKKNTLFLLPFCPKDVTNVKKKKYTQRC

Gene
FEN1
Protein
Flap endonuclease 1
Organism
Babesia bovis
Length
672 amino acids
Function
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Similarity
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
Mass
74.767 kDa
Sequence
MGIKGLIGFLSDAAPGCISEVTLESLSGTSIAIDASTALYQFTIAIREGSYLSSLTNSKGESTSHIAGLLNRCIRLLELGIRPVFVFDSTPPEAKSQTLAKRKLLREEAESSLEKAIEEDDKEAIRKYVGRTVRITQKENESAKKLLRLVGVPVIEAAEEAEAQCAYLCQRGFVTAVGSEDADALVFRCGVLLKNLTASNKPVVRVDLAKALELLELTHEQFTDFCILCGCDYCGTLKGVGPKTAYNLIKKHGSISRILEVRSETLEGYEAAQEYFRDPKVRDITTIDRCEANIDGLREFLISENDFSEERVDKLIERLQKARSKKTQLSLKSFFGYPPRAANITRNYTVPIKGVSPPAVVESAVDSTSDDGKDEVPSDDKVPSVNEVPTVDKVPSVNEVPTVEEAPPADAVPTVEDTSEPPSEEPDAKKRNKRVPIEVDDSLVPDNLKRFICVQHYDPRVTIKRTGASELGSDSVDSLVSHICGVYGIQSGTPDNDLSVVGEGILWPNPILQRFRSVTKDLPNSRLHELWRCSSSHGISWDALDKLYINFREARDSSVEEWDKYAPEIVDFASKVARDKITQWLDGSTSCPPRLLRRWTHLLYSRWRERYLHVYGPRMLSRYLKGEVTDRVLVREINECLPAGVECSELPLDTEPSEHNPHFVRRVPKSGS

Gene
FEN1
Protein
Flap endonuclease 1
Organism
Plasmodium falciparum
Length
650 amino acids
Function
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Similarity
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
Mass
73.99 kDa
Sequence
MGIKGLTKFIADAAPNAIKEIKIESLMGRIIAIDASMSLYQFIIAIRDSEQYGNLTNESGETTSHISGLMSRSIRLMENGLKPIYVFDGAPPELKGSELEKRGEKRQKAEELLKKAKEEGNLEEIKKQSGRTVRVTRKQNEEAKKLLTLMGIPIIEAPCEAESQCAFLTKYNLAHATATEDADALVFGTKILIRNLNANATSNQNKNKNNSKRGYILTEINLEQVLKGLNLTMDEFIDFCILCGCDYCDTIKGIGSKTAYNLIKEYNCIEKIIENIDQNKYQVPSNFRFQEARKSFINPNVLPKEDIKIDWNEPQIEELKHFLIKDYNFNELRVTNYINRLLKARKVTTQRRLDNFFTACTKKSTKLIVEETKKEQTLPARKGKKRPTAGDKNKQKAVKRKIEQANANGHHKMKEENKSVDNEKNEDGIKSVDNEKNEDGIKSVDDEKNLDDEKNLDDEKNKDDEKKSLDNFSSNLFDSDKESESGNIIKNEKQNMDDEKINDNLPSLFGDHSRIRHTENKDNISDINNNNNNNNNNSSSNNNNISNNHFNSVSSNSTFNSSTKLKSEDTLKSNSPLKEDSPNSYNNIKNNNHTININSQINNHKEPISNNNLNNINNSTEIKKKNTLFLLPFCPKDVTNVKKKKYTQRC

Gene
FEN1
Protein
Flap endonuclease 1
Organism
Plasmodium vivax (strain Salvador I)
Length
623 amino acids
Function
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Similarity
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
Mass
69.212 kDa
Sequence
MGIKGLTKFIADAAPNAIKEIKIENLMGRVVAIDASMSLYQFIIAIRDSEQYGNLTNESGETTSHISGLMSRSIKLMENGLKPIYVFDGAPPELKGSELEKRGEKRQKAEELLKKAKEEGNLEEIKKQSGRTVRVTRKQNEEAKKLLTLMGIPVVEAPCEAESQCAFLTKYNLAHATATEDADALVFGTKILIRNLNANASSANQNKNKNSSKRGYILTEINLEQVLKGLNLSMNEFIDFCILCGCDYCDTIKGIGSKTAYNLIKEYNSIEKIIENIDKNKYQVPSNFRFVEARDSFINPKVLPKEEVKIDWCEPKIEELKNFLIKDYNFNEVRVTNYINRLLKARKVTTQRRLDNFFTACTKKSTKLVIEESQSQSKTQKEAKSKRKGKKRDAPNDGAAKLNSKQSKKTKVEKEPKREKKDEEAPNGEAHNGDNNEDEETPGMGARDPFDTDDEEDNPSPNFFHQKSDSESGNVKKEKTEQEGNATTAGDVYNYPNGKDTAGSNTHLSSNSTLHSCNNVGSEKAPNEGMHTVGSSAPEAGTNHVGINHVGTNHVGINHVGTNHVGTNHVGSGDLFPPNVADCANNNADKAQPEMKKKNMLFLLPYCPKNVTNVKKRKSVQRC

Gene
FEN1
Protein
Flap endonuclease 1
Organism
Plasmodium knowlesi (strain H)
Length
595 amino acids
Function
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Similarity
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
Mass
66.308 kDa
Sequence
MGIKGLTKFIADAAPNAIKEIKIENLMGRVVAIDASMSLYQFIIAIRDSEQYGNLTNESGETTSHISGLMSRSIKLMENGLKPIYVFDGAPPELKGSELEKRGEKRQKAEELLKKAKEEGNLEEIKKQSGRTVRVTKKQNEEAKKLLTLMGIPVVEAPCEAESQCAFLTKYNLAHATATEDADALVFGTKILIRNLNANASSTSQNKNKNSSKRGYILTEINLEQVLKGLNLNMNEFIDFCILCGCDYCDTIKGIGSKTAYNLIKEYNSIEKIIENIDKNKYQIPSNFRFVEARDSFINPKVLSKEEIKIDWGEPKIEELKNFLIKDYNFNEVRVTNYINRLLKARKVTTQRRLDNFFTACTKKSTKLVNEESQIKKEVKPKRKGKKRDAPNDSSTKLNSKQNKKPKGEKESKTEKDDGDTHNGNDNEEEGGEGETADMGAKDPFDTEEDEDNPSVNFFHHKSDSESGNVKKESTEQEANATPTGDVYSFPNGKDASGSNIHLSSNSTLHSCNNLNGDKAINESMHVVGSSAPEAGNNEIGNGDLFTSNAADCVNNNTDKTQAEIEMKKKNISFLLPYCPKNVTSVKKRKSVQRC

Gene
FEN1
Protein
Flap endonuclease 1
Organism
Theileria annulata
Length
506 amino acids
Function
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Similarity
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
Mass
57.281 kDa
Sequence
MGIKGLIPFLSEKVPSSISELSLECLSGESLAIDASAALYQFTIAIRDSSYFSSLVNSKGESTSHIYGLMNRCSKLLEYGIKPVFVFDSKPPELKSKTLDKRRQKREEAKTDFKKAISEGDKESAKKLVGRTVKVTKDMNDSAKKLLRLMGIPVIEALEEAEAQCAYLVTKNLCHFVASEDTDTLVFGGWFLLRNVTSSANKKIVKVDLQKVLDGLEFNFDQFVDFCILCGCDYCDTLEGVGPKTAYSLVKKYQSLEEIVRFKGGDYDEFKEAKDYFLSPKVNEYDENSVKMGTIDPEGLTEFLVQENNFSKERVEKFIEKLLKFKTKKIQTSLLSFLTNPQPTNKSKSLDEGPKQSSTEDYKVNTNPSTKGSNVYTTDTNSTKDTKGIECTATTTNNNLENKVKIENEENDTGRRDSIDDLFKEFEDETNLFEQDEFEPKSKEYNLEKQHELELNVHNRNVILIDDDDDEVLTTANSEKMNCEIGKVKEEPNKKGKFSLISIYIF

Gene
FEN1
Protein
Flap endonuclease 1
Organism
Theileria parva
Length
494 amino acids
Function
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Similarity
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
Mass
55.913 kDa
Sequence
MGIKGLIPFLSEKVPSSISELSLESLSGESLAIDASAALYQFTIAIRDSSYFSSLVNSKGESTSHIYGLMNRCSKFLEYGIKPVFVFDSKPPELKTKTLEKRRQQREEANASLKKAISEGDKESVKKLVGRTVKVSKEMNESAKKLLRLMGVPVIEALEEAEAQCAYLVTKNLCRFVASEDTDTLVFGGAFLLRNVASSSSKKILKVDLQKVLDGLEFNFDQFIDFCILCGCDYCDTLEGVGPKTAYSLVKKYQNLEEIVNFKGGDYDDFKEAKEYFLSPKVNEYDENSVKLGTIDPEGLTEFLVQENNFSKERVEKFIEKLLKFKTKKIQTSLLSFLTAPQHNNKAKSSNKRPREPKALDCKPNTYGSGKGTNVVKKESSTIKKDEIDLTAEDLFCEPSNSDNEEDDRGRVDKNEDLFKKSENETNEIKQNQFKSKSDEKKKQEEHHTIEFNFNHRKVILIDDDDDEVVTTANSEKMNCGKCLIYYFLQKLIK

Gene
FEN1
Protein
Flap endonuclease 1
Organism
Cryptosporidium parvum (strain Iowa II)
Length
490 amino acids
Function
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Similarity
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
Mass
54.994 kDa
Sequence
MGIKGLTKFLADNAPKSIQQQGIGSLLGKRVAIDASMWIYQFLAAIREGSQWGNLTNSSGESTSHINGMLSRTTRLLEAGIKPVFVFDGAPPEMKKDELTKRDERREKALAELEKAQEIGDEELIKKQSVRTIHVTKKQVEDVKKLLGFLGMPCIDAPSEAEAQCAELCKDGLVYGVVTEDADSLTFGTPIQIKQLNFSESSNKITDKSPSKQKNGMQIIKLSLILSELDINMDQFIDLCILSGCDYCGTIRGIGTSTAYKLLKKYHNIESILKNIDQTKNPIPGNFDFSKVRELFKNPLVSKNNQIKDLIKWSNPKYEELMEWLIKEQNFNEARVNSYCERIKKSKNKTSQTCLDGFFKTASNERKNTHETPSRPPLSEKQKSETRKEVDSSLSCDKKKVKIEETKIISEWGAPVSKNLSSQAEKDLAENSSEAPNQSSEIKVNKIEENKDSESSTVENTPSLQTKSPEPTMRPVKRKLNRLISESDED

Gene
FEN1
Protein
Flap endonuclease 1
Organism
Plasmodium yoelii yoelii
Length
480 amino acids
Function
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Similarity
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
Mass
54.468 kDa
Sequence
MGIKGLTKFIADTAPNAIKEIKIENLMGRVVAIDASMSLYQFIIAIRDGDQYGNLMNESGETTSHISGLMSRTIKLMENGLKPIYVFDGAPPELKGSELEKRGEKRQKAEELLIKAKAEGNLEEIKKQSGRTVRVTKKQNEEAKKLLTLMGIPVIESPCEAEAQCAFLTKYEMAHATATEDADALVFGTKILIRNLNANASSNKNKNKNSSKRGYILTEINLEQVLKGLKLTMDEFIDFCILCGCDYCDTIKGIGSKTAYNLIKEYNCIENIIKNIDQNKYQVPANFKYVEARQSFINPKVLEKSEVKIDWCEPKIEELKTFLIKEHNFNEVRVTNYITRLLKARKVTTQRRLDTFFTTCTKKSTKLIIEESQKEVLKTKGKGKKREINNDSSTKLNAKKKKTNVKDEKKNNEKVDELKNKSDENLVKDEEDDQDDYDQNIFDEKTNSESGNIKNENVKEDVSSNDITMDIPKCTNDIVC

Gene
FEN1
Protein
Flap endonuclease 1
Organism
Plasmodium chabaudi
Length
479 amino acids
Function
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Similarity
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
Mass
54.503 kDa
Sequence
MGIKGLTKFIADTAPNAIKEIKIENLMGRVVAIDASMSLYQFIIAIRDGDQYGNLMNEAGETTSHISGLMSRTIKLMENGLKPIYVFDGAPPELKGSELEKRGEKRQKAEELLLKAKEEGNLEEIKKQSGRTVRVTKKQNEEAKKLLTLMGIPVIESPCEAEAQCAFLTKYDMAHATATEDADALVFGTKILIRNLNANASSNKNKNKNSSKRGYILTEINLEQVLKGLKLTMDEFIDFCILCGCDYCDTIKGIGSKTAYNLIKEYNCIENIIKNIDQNKYQVPDNFKYVEARQSFINPKVLEKSEVKIDWCEPKIEELKTFLIKEHNFNEVRVTNYITRLLKARKVTTQRRLDTFFTTCTKKSTKLIIEESQKELLKAKGKGKKRELNDNSTKLNAKKKKTNIKDEKKNTDKMDELKNKSDENFVKDEENDQDDYDQNLFDEKTNSDSGNIKNENIKEDISSNDITMDIPKCTNDIVC

Gene
FEN1
Protein
Flap endonuclease 1
Organism
Plasmodium berghei (strain Anka)
Length
478 amino acids
Function
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Similarity
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
Mass
54.486 kDa
Sequence
MGIKGLTKFIADTAPNAIKEIKIENLMGRVVAIDASMSLYQFIIAIRDGDQYGNLMNESGETTSHISGLMSRTIKLMENGLKPIYVFDGAPPELKGSELEKRGEKRQKAEELLIKAKEENLEEIKKQSGRTVRVTKKQNEEAKKLLTLMGIPVIESPCEAEAQCAFLTKYEMAHATATEDADALVFGTKILIRNLNANASSNKNKNKNSSKRGYILTEINLEQVLKGLKLTMDEFIDFCILCGCDYCDTIKGIGSKTAYNLIKEYNCIENIIKNIDQNKYQVPANFKYVEARQSFIKPKVLEKSEVKIDWCEPKIEELKKFLIKEHNFNEVRVTNYITRLLKARKVTTQRRLDTFFTTCTKKSTKLIIEENQKEVLKTKSKGKKREINNDNSTKLNAKKKKTNVKDEKKNNEKVDEPKNKPNENLVKDEDDQDDYDQNIFDERTNSESGNIKNENVKEDISSSDITMDIPKCINDIVC

Gene
FEN1
Protein
Flap endonuclease 1
Organism
Cryptosporidium muris (strain RN66)
Length
472 amino acids
Function
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Similarity
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
Mass
53.823 kDa
Sequence
MGIKGLARFLVDNAPKSIQQQSIDSLIGRIIAIDASMWMYQFLAAIREGSQWGNLTNEAGESTSHISGMLSRTIRLLEAGIKPVFVFDGEPPELKMEELMKRKERREKAQQELEKAQEEGDTETIRKQLIRTIKITKEQSDDVKYMLKLLGIPVIEATSEAEAQCAELCKEGLVYGVATEDADSLTFGTPLVIRHLNFSDGKFSDSKGNSKNSLQVIKLSTVLSDLGLSMQQFVDLCILCGCDYCGTIRGIGALTAYKLLKKHKDIETIINELDKNKHPLPMSFDYIKVRELFTNPNVIKAKEFRDKLKWTNPNLEGLSEWLIKQQNFSEVRVANYCTRIKKSKGKTAQTSLDSFFTLTPKKTSENKNKEKEITKVQEVKETISNINKDTRKDSVSEWGEIKTKIIETKEDKLDFERRNKIIQEDKLNSKKEFDYNEKLQCNSTAENTPIIDNKAKVLSIKKRRINRVNYDE

Gene
FEN1
Protein
Flap endonuclease 1
Organism
Coprinopsis cinerea (strain Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003)
Length
458 amino acids
Function
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Similarity
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
Mass
50.783 kDa
Sequence
MGIKGLTGLLNEHAPNSIKEHDIKTLFGRKVAIDASMSIYQFLIAVRQRDGEMLTNDAGETTSHLMGFFYRTIRIVENGIKPAYVFDGKPPELKKGVLSKRFEKREEAKEEGEEAKEIGTAEDVDRFSRRTVKVTKQHNEECQKLLRLMGVPCVIAPSEAEAQCAELARGGKVYAAGSEDMDTLTFNAPILFRHLTFSEAKKQPISEINLEAALKGLDMDMSQFVDLCILLGCDYLEPIKGVGPKSALKLIREFGGLKEVVEHLREKAAARKAEAEEEDEEEAEEPAPTSDVEMPDDEDGEKDSDDEEEAERRKKAEAAKKKKAQEKAKSAKKGKGKGKGGIQIPDEWPWEEAKQIFLKPDVIPADQVELEWKNPDVEGLVQFLVTEKGFSEERVRKGAEKLTKFLNAKQQGRLDGFFTVKPKQAPPPAAKGKGAASKGTKRKGEDKAEGSGKKAKKK

Gene
FEN1
Protein
Flap endonuclease 1
Organism
Coprinopsis cinerea
Length
458 amino acids
Function
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Similarity
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
Mass
50.813 kDa
Sequence
MGIKGLTGLLNEHAPNSIKEHDIKTLFGRKVAIDASMSIYQFLIAVRQRDGEMLTNDAGETTSHLMGFFYRTIRIVENGIKPAYVFDGKPPELKKGVLSKRFEKREEAKEEGEEAKEIGTAEDVDRFSRRTVKVTKQHNEECQKLLRLMSVPCVIAPSEAEAQCAELARGGKVYAAGSEDMDTLTFNAPILFRHLTFSEAKKQPISEINLEAALKGLDMDMSQFVDLCILLGCDYLEPIKGVGPKSALKLIREFGGLKEVVEHLREKAAARKAEAEEEDEEEAEEPAPTSDVEMPDDEDGEKDSDDEEEAERRKKAEAAKKKKAQEKAKSAKKGKGKGKGGIQIPDEWPWEEAKQIFLKPDVIPADQVELEWKNPDVEGLVQFLVTEKGFSEERVRKGAEKLTKFLNAKQQGRLDGFFTVKPKQAPPPAAKGKGAASKGTKRKGEDKAEGSGKKAKKK

Gene
FEN1
Protein
Flap endonuclease 1
Organism
Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)
Length
453 amino acids
Function
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Similarity
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
Mass
50.154 kDa
Sequence
MGIKGLTGLLSENAPKCMKDHEMKTLFGRKVAIDASMSIYQFLIAVRQQDGQMLMNESGDVTSHLMGFFYRTIRMVDHGIKPCYIFDGKPPELKGSVLAKRFARREEAKEGEEEAKETGTAEDVDKLARRQVRVTREHNEECKKLLSLMGIPVVTAPGEAEAQCAELARAGKVYAAGSEDMDTLTFNSPILLRHLTFSEAKKMPISEIHLDVALRDLEMSMDQFIELCILLGCDYLEPCKGIGPKTALKLMREHGTLGKVVEHIRGKMAEKAEEIKAAADEEAEAEAEAEKYDSDPESEEGGETMINSDGEEVPAPSKLKSPKKKAPAKKKKVASSGMQIPEFWPWEEAKQLFMKPDVVNGDDLVLEWKQPDTEGLVEFLCRDKGFNEDRVRAGAAKLSKMLAAKQQGRLDGFFTVKPKEPAAKDTGKGKGKATKGEKRKAEEKGSAKKKSKN

Gene
FEN1
Protein
Flap endonuclease 1
Organism
Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)
Length
453 amino acids
Function
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Similarity
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
Mass
50.154 kDa
Sequence
MGIKGLTGLLSENAPKCMKDHEMKTLFGRKVAIDASMSIYQFLIAVRQQDGQMLMNESGDVTSHLMGFFYRTIRMVDHGIKPCYIFDGKPPELKGSVLAKRFARREEAKEGEEEAKETGTAEDVDKLARRQVRVTREHNEECKKLLSLMGIPVVTAPGEAEAQCAELARAGKVYAAGSEDMDTLTFNSPILLRHLTFSEAKKMPISEIHLDVALRDLEMSMDQFIELCILLGCDYLEPCKGIGPKTALKLMREHGTLGKVVEHIRGKMAEKAEEIKAAADEEAEAEAEAEKYDSDPESEEGGETMINSDGEEVPAPSKLKSPKKKAPAKKKKVASSGMQIPEFWPWEEAKQLFMKPDVVNGDDLVLEWKQPDTEGLVEFLCRDKGFNEDRVRAGAAKLSKMLAAKQQGRLDGFFTVKPKEPAAKDTGKGKGKATKGEKRKAEEKGSAKKKSKN

Gene
FEN1
Protein
Flap endonuclease 1
Organism
Chlamydomonas reinhardtii
Length
396 amino acids
Function
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Similarity
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
Mass
43.588 kDa
Sequence
MGIHGLTKLLGDNAPGCIKETKFENLFGRKVAVDASMHIYQFMVVVGRQGDQLLTNEAGEITSHLQGMFFRTAKMLEAGIKPVYVFDGKPPQLKQDQLAQRTERRADANEALEKAKEAGDQEAIEKYSKRSVRVTREHNDECKRLLRLMGVPVVEAPTEAEAQCAEMAKSGLVYGLATEDMDALTFGAPRVIRHLMAPSSQNVPVQEFDREVALRELELTDDQFIDLCILMGCDYCGTIRGIGAVRALQMIKKHGSIEGMLKELDPAKYPVPEPFPHKESHEFFKNPEVTPSAEIPPLKWTAPDEEGLVQFLVNEKQFNEQRVRNAVGRIKANKTKANQGRLESFFTSLPKPATADKAKPKEDDKKRKAGAAAGGKDAKGGAAAKKGKFGVGGGKK

Gene
FEN1
Protein
Flap endonuclease 1
Organism
Uncinocarpus reesii (strain UAMH 1704)
Length
395 amino acids
Function
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Similarity
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
Mass
44.634 kDa
Sequence
MGIKHLYQIISENAPDAVKSGEIKNQFGRKVAIDASMSIYSFLIAVRSDGQQLMNESGETTSHLMGLFYRTLRMVDNGIKPLYVFDGAPPKLKSGELAKRIARKQEAAEQHEEAKETGTTEDVEKFSRRTVRVTREHNEECKKLLKLMGIPYINAPTEAEAQCAVLARAGKVYAAASEDMDTLCFDSPILLRHLTFSEQRKEPILEIHLDRVLEGLGMDRKTFVDLCILLGCDYLDPIPKVGPNTALKLIRDHGSLEKVVEAMKNDPKQKYTIPDDWPYEQARDLFFEPDVRPADHPECDFKWEAPDVEGLVKFLVEGKGFSEDRVRSGAARLQKNMKTAQQSRLEGFFKPVAKTDEEKASLKRKHEEKLEAAKKKKKEDAKAKREAKSRPKGTA

Gene
fen1
Protein
Flap endonuclease 1
Organism
Pyrenophora tritici-repentis (strain Pt-1C-BFP)
Length
395 amino acids
Function
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Similarity
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
Mass
44.732 kDa
Sequence
MGIKHLYQLIEEHTPEAVKKGEIKNQFGRKVAIDASMSIYSFLIAVRSDGQQLMSETGETTSHLMGLFYRTMRMVDNGIKPLYVFDGAPPKLKSGELAKRFQRKTEAHAAAEEAKETGTAEDVEKFSRRTVRVTREHNEECQRLLKLMGIPYIVAPTEAEAQCAALARGGKVYAAASEDMDTLTFDTPILLRHLTFSEQRKEPILEIHLDKVLEGLQMERKQFIDLCILLGCDYLDPIKGIGPSTALKLIREHNDLEGVVEHIKSQSSKKLTIPDDWPFADARLLFLEPDVRPADDPECDFKWEAPDVEGLVKFLVEEKHFNEDRVRNGAAKLQKNMKTAQQSRLEGFFKPIEKTAEQKATLKRKADEKLEEKKKKQKVDAKAKKQAKAKPRTAG

Gene
fen1
Protein
Flap endonuclease 1
Organism
Talaromyces marneffei (strain ATCC 18224 / CBS 334.59 / QM 7333)
Length
395 amino acids
Function
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Similarity
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
Mass
44.574 kDa
Sequence
MGIKHLYQVISENAPDAVKTGEIKNHFGRKVAIDASMSIYSFLIAVRSDGQQLMSEAGETTSHLMGMFYRTLRIVDNGIKPLYVFDGAPPKMKGGELAKRSARKREAHEAHEEAKETGTAEDMEKFSRRTVRVTREHNEECKKLLKLMGVPYIDAPTEAEAQCAVLARAGKVYAAASEDMDTLCFEAPILLRHLTFSEQRKEPILEIHLDKALEGLGMDMAQFIDLCILLGCDYLEPIPKVGPNTALKLIREHGSLEKVVEAIENDPKKKYVIPDDWPYQEARELFFNPDVRKADDPQCDFKWESPDVEGLVKFLVTDKGFSEDRVRNGAARLAKNLKTAQQSRLEGFFKPVAKTDAEKASMKRKHDEKIEEQKKRKKEDAKAKKEAKARPRGAV

Gene
fen1
Protein
Flap endonuclease 1
Organism
Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)
Length
395 amino acids
Function
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Similarity
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
Mass
44.666 kDa
Sequence
MGIKHLYQVISENAPDAVKTGEIKNHFGRKVAIDASMSIYSFLIAVRSDGQQLMSDAGETTSHLMGMFYRTLRIVDNGIKPLYVFDGAPPKLKGGELAKRSARKREAHEAHEEAKETGTAEDMEKFSRRTVRVTREHNEECKKLLKLMGVPYIDAPTEAEAQCAVLARAGKVYAAASEDMDTLCFEAPILLRHLTFSEQRKEPIQEIHLDKALEGLGMDRKQFIDLCILLGCDYLEPIPKVGPNTALKLIREHGSLEKVVEAIESDPKKKYVIPDDWPYKEARELFFNPDVRKADDPQCDFKWESPDVEGLIQFLVTEKGFSEDRVRNGAARLAKNLKSAQQSRLEGFFKPVTKTEAEKASLKRKHDEKIEEQKKRKKEEAKAKKEAKARPRGAV

Gene
FEN1
Protein
Flap endonuclease 1
Organism
Ajellomyces capsulatus (strain H143)
Length
395 amino acids
Function
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Similarity
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
Mass
44.899 kDa
Sequence
MGIKHLYQIIQENAPDAVKAGEIKNHFGRKVAIDASMSIYSFLIAVRSDGQQLTSETGETTSHLMGMFYRTLRIVDNGIKPVYVFDGAPPKLKSGELAKRFMRKSEAAEAHEEAKEVGTAEEVEKFSRRTVRVTREHNEECKKLLKLMGVPYIDAPTEAEAQCAVLARAGKVYAAASEDMDTLCFDSPILLRHLTFSEQRKEPILEIHLDRVLEGLDMDRKQFVDLCILLGCDYLDPIPKVGPNTALKLIRDHGSLEQVVEAIKSDPKKKYTIPEDWPYKEARELFFDPDVRNADHPDCDFKWEAPDVEGLVKFLVEEKAFSEDRVRNAAARLQKNLKTAQQSRLEGFFKPIAKTEQEKAVLKRKHEEKLELQKKKKKEDSKAKKEAKSKPRGTT

Gene
FEN1
Protein
Flap endonuclease 1
Organism
Ajellomyces capsulatus (strain NAm1 / WU24)
Length
395 amino acids
Function
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Similarity
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
Mass
44.897 kDa
Sequence
MGIKHLYQIIQENAPDAVKAGEIKNHFGRKVAIDASMSIYSFLIAVRSDGQQLTSETGETTSHLMGMFYRTLRIVDNGIKPVYVFDGAPPKLKSGELAKRFMRKSEAAEAHEEAKEVGTAEEVEKFSRRTVRVTREHNEECKKLLKLMGVPYIDAPTEAEAQCAVLARAGKVYAAASEDMDTLCFDSPILLRHLTFSEQRKEPILEIHLDRVLEGLDMDRKQFVDLCILLGCDYLDPIPKVGPNTALKLIRDHGSLEQVVEAIKSDPKKKYTIPEDWPYKEARELFFDPDVRKADHPDCDFKWEAPDVEGLVKFLVEEKAFSEDRVRNAAARLQKNLKTAQQSRLEGFFKPIAKTEQEKAVLKRKHEEKLELQKKKKKEDAKAKKEAKSKPRGTT

Gene
FEN1
Protein
Flap endonuclease 1
Organism
Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586)
Length
395 amino acids
Function
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Similarity
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
Mass
44.853 kDa
Sequence
MGIKHLYQVIQENAPDAVKAGEIKNHFGRKVAIDASMSIYSFLVAVRSDGQQLMSETGETTSHLMGMFYRTLRIVENGIKPVYVFDGAPPKLKSGELAKRFMRKSEAAEAHEEAKEVGTAEDVEKFSRRTVRVTREHNEECKKLLKLMGVPYINAPTEAEAQCAVLARAGKVYAAASEDMDTLCFDSPILLRHLTFSEQRKEPILEIHLDRVLEGLDMDRKQFVDLCILLGCDYLDPIPKVGPNTALKLIRDHGSLEKVVEAIQSDPKKKYTIPEDWPYKDARELFFDPDVRKADHPDCNFKWEAPDVEGLVKFLVEEKAFSEDRVRNGAARLQKNLKTAQQSRLEGFFKPIAKTEQEKATLKRKHEEKLELQKKKKKEEAKAKKEAKSKPRGAV

Gene
fen1
Protein
Flap endonuclease 1
Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)
Length
395 amino acids
Function
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Similarity
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
Mass
44.641 kDa
Sequence
MGIKHLYQVIAENAPDAIKAGDIKNHFGRKVAIDASMSIYSFLIAVRSEGQQLMSDTGETTSHLMGMFYRTLRMVDNGIKPLYVFDGAPPKLKSGELAKRSARKHEATEAHEEAKETGTAEDVEKFSRRTVRVTREHNAECKKLLKLMGIPYIDAPTEAEAQCAVLARAGKVYAAASEDMDTLCFEAPILLRHLTFSEQRKEPIQEIHLNRALEGLGMDRNQFIDLCILLGCDYLEPIPKVGPNTALKLIRDHGTLEKVVESIEKDPKQKYVIPESWPYQDARELFLNPDVRDANDPECDFKWEAPDIEGLVDFLVKDKGFNEDRVRNGAARLQKNLKTAQQSRLEGFFKPVAKTDAEKATLKRKHDEKIQEQKKRKKEEAKAKKEAKARPRAAV

Gene
FEN1
Protein
Flap endonuclease 1
Organism
Leishmania braziliensis
Length
395 amino acids
Function
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Similarity
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
Mass
44.144 kDa
Sequence
MGILGLSKLLYDKSPNAIRERELKSFFGRRIAIDASMSIYQFIIAMKGFQDGQGMELTNEQGDVTSHLNGLFARTLRMIDEGIKPIYVFDGKPPKLKADELETRRQKAAEAEREFEKAKDAGDDEMMEKMSKRTVRVSREQIEESKKLLQLMGVPVIQAPSEAEAQCAELVKKGKAWAVGTEDMDALTFGSTVMLRHLNISDAKKRPIAEIHLDEVLQATGLSMDQFVDLCILLGCDYVPKVPGIGPQRAWEGIQRYGNIESFLESLDAAKHMVPPDFCYREARAFFLNPEVTRAEEIDIRFSEPDEAGLIQFLVKEKLFNPDRVNKGIARLRAALTKKTQGRLDNFFTIVKAPPQAAAPRAPLAGRKRSHDGKCVHVSGTLQKATGGHKKAVRK

Gene
FEN1
Protein
Flap endonuclease 1
Organism
Leishmania infantum
Length
395 amino acids
Function
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Similarity
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
Mass
44.201 kDa
Sequence
MGILGLSKLLYDKSPNAIREQELKNFFGRRIAIDASMSIYQFIIAMKGFQDGQGLELTNEKGDVTSHLNGLFARTLRMIDEGIKPIYVFDGKPPKLKADELEMRRQKAAEAEREFEKAKDAGDDEMMEKMSKRTVRVSRDQIDESKKLLRLMGIPVIQAPSEAEAQCAELVKKGKAWAVGTEDMDALTFGSTVMLRHLNISDAKKRPIAEIHLDEVLQITGLSMGQFVDLCILLGCDYVPKVPGIGPQKAWEGIQRYGSIESFLESLDTTKHPVPADFYYKEARAFFQNPEVTPAEEINIQFSEPDEVGLIQFLVKEKLFNPDRVNKGIARLRAALTRKTQGRLDSFFTVTKVPQQTAAARAPLAGTKRPRDGKYVHVSGTLRKATSGHKKAVKK

Gene
FEN1
Protein
Flap endonuclease 1
Organism
Leishmania major
Length
395 amino acids
Function
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Similarity
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
Mass
44.339 kDa
Sequence
MGILGLSKLLYDKSPNAIREQELKNFFGRRIAVDASMSIYQFIIAMKGFQDGQGLELTNEKGDVTSHLNGLFARTLRMIDEGIKPIYVFDGKPPKLKADELEMRRQKAAEAERAFEKAKDAGDDEMMEKMSKRTVRVSRDQIDESKKLLRLMGIPVIQAPSEAEAQCAELVKKGKAWAVGTEDMDALTFGSTVMLRHLNISDAKKRPIVEIHLDEVLQTTGLSMDQFVDLCILLGCDYVPKVPGIGPQKAWEGIQRYGSIESFLESLDTTKHPVPADFYYKEARAFFQNPEVTRAEEIDIQFSEPDEVGLIQFLVKEKLFNPDRVNKGIARLRAAFTRKTQGRLDSFFTITKVPQQTAAARAPLVGTKRPRDGKYVHVSGTLRKATSGHKKAVKK

Gene
fen1
Protein
Flap endonuclease 1
Organism
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)
Length
395 amino acids
Function
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Similarity
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
Mass
44.65 kDa
Sequence
MGIKHLFQVIQENAPDAVKSGDIKNHFGRKVAIDASMSIYSFLIAVRSEGQQLMSESGETTSHLMGMFYRTLRMVDNGIKPLYVFDGAPPKLKSGELAKRTARKAEATEAHEEAKETGTAEEIEKFSRRTVRVTREHNAECKKLLKLMGVPYIDAPTEAEAQCAVLARAGKVYAAASEDMDTLCFEAPILLRHLTFSEQRKEPIQEIHLNRVLEGLDMDRSQFIDMCILLGCDYLEPIPKVGPNTALKLIREHGSLEKVVEAIESDPKKKYVIPEDWPYQDARELFHHPDVRAADHPECDFKWEAPDIEALVDFLVKDKGFNEDRVRNGAARLQKNLKTAQQSRLEGFFKPVAKTDAEKASLKRKHDEKLQEQKKRKKEEAKAKKEAKAKPRGAA

Gene
fen1
Protein
Flap endonuclease 1
Organism
Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163)
Length
395 amino acids
Function
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Similarity
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
Mass
44.766 kDa
Sequence
MGIKHLFQVIQENAPDAIKAGDIKNHFGRKVAIDASMSIYSFLIAVRSEGQQLMSESGETTSHLMGMFYRTLRMVDNGIKPLYVFDGAPPKLKSGELAKRTARKAEATEAHEEAKETGTAEDVEKFSRRTVRVTREHNAECKKLLKLMGIPYIDAPTEAEAQCAVLARAGKVYAAASEDMDTLCFEAPILLRHLTFSEQRKEPIQEIHLNRALEGLGMDRKQFIDLCILLGCDYLEPIPKVGPNTALKLIREHGSLEKVVEAIENDPKKKYVIPEYWPYQDARELFLHPDVREADHPECDFKWEAPDVEALVEFLVKDKGFNEDRVRNGAARLQKNLKTAQQSRLEGFFKPVARTDEEKASLKRKHDEKLQEQKKRKKEEAKAKKEAKAKPRGAA

Gene
fen1
Protein
Flap endonuclease 1
Organism
Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167)
Length
395 amino acids
Function
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Similarity
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
Mass
44.722 kDa
Sequence
MGIKHLYQVIAENAPDAIKAGDIKNHFGRKVAIDASMSIYSFLIAVRSEGQQLMSDTGETTSHLMGMFYRTLRMVDNGIKPLYVFDGAPPKLKSGELAKRTARKAEATEAHEEAKETGTAEDVEKFSRRTVRVTRDHNAECKKLLKLMGIPYIDAPTEAEAQCAVLARAGKVYAAASEDMDTLCFEAPILLRHLTFSEQRKEPILEIHLSRALEGLDMDRKQFIDLCILLGCDYLEPIPKVGPNTALKLIREFGSLEKVVEHMESDPKKKYVIPEDWPYQDARELFLNPDVREASHPDCDFKWEAPDIEGLVEFLVKDKGFNEDRVRNGAARLQKNLKTAQQSRLEGFFKPVARTDEEKANLKRKHDEKLQEQKKRKKEEAKAKKEAKARPRGAG

Gene
fen1
Protein
Flap endonuclease 1
Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)
Length
395 amino acids
Function
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Similarity
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
Mass
44.796 kDa
Sequence
MGIKHLFQVIQENAPDAIKAGDIKNHFGRKVAIDASMSIYSFLIAVRSEGQQLMSESGETTSHLMGMFYRTLRMVDNGIKPLYVFDGAPPKLKSGELAKRTARKAEATEAHEEAKETGTAEDVEKFSRRTVRVTREHNAECKKLLKLMGIPYIDAPTEAEAQCAVLARAGKVYAAASEDMDTLCFEAPILLRHLTFSEQRKEPIQEIHLNRALEGLGMDRKQFIDLCILLGCDYLEPIPKVGPNTALKLIREHGSLEKVVEAIENDPKKKYVIPEYWPYQDARELFLHPDVREADHPECDFKWEAPDVEALVEFLVKDKGFNEDRVRNGATRLQKNLKTAQQSRLEGFFKPVARTDEEKASLKRKHDEKLQEQKKRKKEEAKAKKEAKAKPRGAA

Gene
fen1
Protein
Flap endonuclease 1
Organism
Aspergillus niger (strain CBS 513.88 / FGSC A1513)
Length
395 amino acids
Function
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Similarity
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
Mass
44.681 kDa
Sequence
MGIKQLYQVISENAPDAIKAGDIKNHFGRKVAIDASMSIYSFLIAVRSEGQQLMSDTGETTSHLMGMFYRTLRMVDNGIKPLYVFDGAPPKLKSGELAKRFARKSEATEAHEEAKETGTAEDVEKFSRRTVRVTREHNAECKKLLKLMGIPYIDAPTEAEAQCAVLARAGKVYAAASEDMDTLCFETPILLRHLTFSEQRKEPIQEIHLNRALEGLGMDRKQFIDLCILLGCDYLEPIPKVGPNTALKLIRDHGSLEKVLEFMENDPKKKFVVPEDWPYEDARELFLNPDVRDANDPECDFKWEAPDVPGLVDFLVKDKGFNEDRVKNGAARLQKNLKSAQQSRLEGFFKPVARTDEEKASLKRKHDEKIQEQKKKKKEEAKAKKEAKSRPRGAG

Gene
fen1
Protein
Flap endonuclease 1
Organism
Aspergillus terreus (strain NIH 2624 / FGSC A1156)
Length
395 amino acids
Function
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Similarity
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
Mass
44.742 kDa
Sequence
MGIKQLYQVISENAPDAIKAGDIKNHFGRKVAIDASMSIYSFLIAVRSEGQQLMSDTGETTSHLMGMFYRTLRMVDNGIKPLYVFDGAPPKLKSGELAKRTARKTEATEAHEEAKETGTAEDVEKFSRRTVRVTREHNAECKKLLKLMGIPYIDAPTEAEAQCAVLARAGKVYAAASEDMDTLCFEAPILLRHLTFSEQRKEPIQEIHLSRALEGLDMDRAKFIDLCILLGCDYLEPIPKVGPNTALKLIRDHGSLEKVVEYIQNDPKKKYVIPEDWPYQDARELFLHPDVRDANDPECDFKWEAPDIEGLVEFLVKDKGFNEDRVRNGAARLQKNLKTAQQSRLEGFFKPVARSDEEKATLKRKHDEKLQEQKKRKKEEAKAKKEAKARPRGAG

Gene
FEN1
Protein
Flap endonuclease 1
Organism
Blastomyces gilchristii (strain SLH14081)
Length
395 amino acids
Function
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Similarity
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
Mass
44.853 kDa
Sequence
MGIKHLYQVIQENAPDAVKAGEIKNHFGRKVAIDASMSIYSFLVAVRSDGQQLMSETGETTSHLMGMFYRTLRIVENGIKPVYVFDGAPPKLKSGELAKRFMRKSEAAEAHEEAKEVGTAEDVEKFSRRTVRVTREHNEECKKLLKLMGVPYINAPTEAEAQCAVLARAGKVYAAASEDMDTLCFDSPILLRHLTFSEQRKEPILEIHLDRVLEGLDMDRKQFVDLCILLGCDYLDPIPKVGPNTALKLIRDHGSLEKVVEAIQSDPKKKYTIPEDWPYKDARELFFDPDVRKADHPDCNFKWEAPDVEGLVKFLVEEKAFSEDRVRNGAARLQKNLKTAQQSRLEGFFKPIAKTEQEKATLKRKHEEKLELQKKKKKEEAKAKKEAKSKPRGAV

Gene
FEN1
Protein
Flap endonuclease 1
Organism
Sordaria macrospora (strain ATCC MYA-333 / DSM 997 / K(L3346) / K-hell)
Length
394 amino acids
Function
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Similarity
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
Mass
44.836 kDa
Sequence
MGIKQLFSIIKDEAPAAIKEGDIKNQFGRKVAIDASMSIYSFLIAVRSDGQQLMNEAGETTSHLMGMFYRTLRMVDNGIKPLYVFDGAPPKLKSGELAKRFQRKQEATEGLEEAKETGTAEDVEKFSRRTVRVTREHNAECQKLLKLMGIPYIVAPTEAEAQCAVLARAGKVYAAASEDMDTLCFHTPILLRHLTFSEQRKEPIQEIHTDKVLEGLGMDRKQFVDLCILLGCDYLDPIPKVGPSTALKLIREHGTLEEVVEWMKADPKGRYQIPEDWPFEDARALFFEPDVRPADDPLCDFKWEKPDIEGLVQFLAHEKGFSEDRVRSASIKLQKNMQTSQQARIEGFFKVLPKTEEEKKAHKRKLEEQAEQKRKKVKEEKKEKAKLKAKPRGA

Gene
FEN1
Protein
Flap endonuclease 1
Organism
Arthroderma otae (strain ATCC MYA-4605 / CBS 113480)
Length
394 amino acids
Function
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Similarity
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
Mass
44.213 kDa
Sequence
MGIKSLYQIISENAPDAIKAGEIKNQFGRKVAIDAYVKTAQRYRASTDEEQLTNESGETTSHLMGMFYRTLRMVDNGIKPLYVFDGAPPKLKSGELAKRTMRKAEAQEAAEEAKETGTAEDVEKFSRRTVRVTREHNAECKRLLKLMGIPYIDAPTEAEAQCAVLAKEGKVFGAASEDMDTLCFAAPVLLRHLTFSEQRKEPILEIHLDKVLEGLGMEMTQFVDLCILLGCDYLDPIPKVGPNTALKMIRDHGTLEKVVETIESDPKKKYVIPDDWPYLQARDLFFNPDVRPADAPECDFKWTAPDVEGLVRFLVEEKGFSEDRVRNGAARLTKNLKSAQQSRLEGFFKPVAKTEQQKATAKRKAEEKAELAKKKKKEDAKAKRAMGAKPRGAR

Gene
FEN1
Protein
Flap endonuclease 1
Organism
Trypanosoma brucei brucei (strain 927/4 GUTat10.1)
Length
393 amino acids
Function
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Similarity
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
Mass
44.363 kDa
Sequence
MGVLGLSKLLYDRTPGAIKEQELKVYFGRRIAIDASMAVYQFVIAMKGFQEGQSVELTNEAGDVTSHLSGIFFRTLRMIDEGLRPIYVFDGKPPTLKASELESRRQRAEDAKHEFEKAKEEGDDEAMEKMSKRMVRVGRDQMEEVKTLLRLMGIPVVQAPSEAEAQCAELVKKNKAWAVGTEDMDALAFGSRVMLRHLTYGEAKKRPIAEYHLDEILEASGFSMQQFIDLCILLGCDYVPRISGIGPHKAWEGIKKYGSLEAFIESLDGTRYVVPEEFNYKDARNFFLEPEVTPGEEIDIQFREPDEEGLIKFLVDEKLFSKERVLKGIQRLRDALTKKTQGRLDQFFTITKPQKQVNSEASTAGTKRNRGAVALPGVLQRKSSSGHKKAVKK

Gene
FEN1
Protein
Flap endonuclease 1
Organism
Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)
Length
393 amino acids
Function
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Similarity
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
Mass
44.363 kDa
Sequence
MGVLGLSKLLYDRTPGAIKEQELKVYFGRRIAIDASMAVYQFVIAMKGFQEGQSVELTNEAGDVTSHLSGIFFRTLRMIDEGLRPIYVFDGKPPTLKASELESRRQRAEDAKHEFEKAKEEGDDEAMEKMSKRMVRVGRDQMEEVKTLLRLMGIPVVQAPSEAEAQCAELVKKNKAWAVGTEDMDALAFGSRVMLRHLTYGEAKKRPIAEYHLDEILEASGFSMQQFIDLCILLGCDYVPRISGIGPHKAWEGIKKYGSLEAFIESLDGTRYVVPEEFNYKDARNFFLEPEVTPGEEIDIQFREPDEEGLIKFLVDEKLFSKERVLKGIQRLRDALTKKTQGRLDQFFTITKPQKQVNSEASTAGTKRNRGAVALPGVLQRKSSSGHKKAVKK

Gene
FEN1
Protein
Flap endonuclease 1
Organism
Trypanosoma cruzi (strain CL Brener)
Length
393 amino acids
Function
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Similarity
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
Mass
44.266 kDa
Sequence
MGILGLSKLLYDRSPAAIRERELKNYFGRRIAIDASMTIYQFIIAMKGFQDGQGMELTNEAGEVTSHLNGLFARTLRMVDEGLRPIYVFDGKPPTLKASELQERRQRAEEAQQLFDTAKEEGNDELMEKMSKRTVRVSREQLEEAKKLLQLMGIPVVQAPSEAEAQCAELVKKKKAWAVATEDMDALTFGAPVMLRHLTYSEAKKRPIAEFHLDEILGITGLTMTQFIDLCILLGCDYVPKIPGIGPQKAWEGIKKHGDIETLLQSLDAGRHSVPEGFHYEEARQFFLKPEVTPAEEIEIQFREPDEEGLVKFLVEEKLFNKDRVLKGIQRLRNALTRKTQGRLDQFFTITRPVTKPNTCDAKAGVKRGHSAIALSGTLQQKGSSGHKKVVKK

Gene
FEN1
Protein
Flap endonuclease 1
Organism
Thalassiosira pseudonana
Length
390 amino acids
Function
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Similarity
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
Mass
43.324 kDa
Sequence
MGIKGLAKLLSDEAPLSLKEVPLSHLHGRKLAIDASMAIYQFLIAVRSGGPGGQNAAMMLTNADGETTSHIQGIFNRTIRFISEGIRPVYVFDGKPPQFKSGELLKRREKRLKAEQALKAAEESGNIEEQDKQSKRLVRAGTKENEDCIKLLTLMGVPVIRAPCEAEAQAAALARSGKVYAAATEDMDALTFRSPVMVRKMTFANASKSDVQQIFYDKAIEGLEITHDQFVDLCILLGCDYCDTIKGIGPKTALKLIREHKNIETILKHLNREKYVVPDIYVEARRLFNHHEVLPDNEIELKWTECQPEPLKSFLVDEMGFNPDRVQASIEKLQKAFKASAKPQSRMDSFFKVKANPEGDKKKAEKRKAELAASRGKGKKGKGGGGFKKK

Gene
FEN1
Protein
Flap endonuclease 1
Organism
Yarrowia lipolytica (strain CLIB 122 / E 150)
Length
389 amino acids
Function
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Similarity
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
Mass
43.446 kDa
Sequence
MGIKGLNKLLMEHCPAALRSSEIKNFGGRKVAIDASMSLYQFVIAVRQADGQQLTNENGETTSHLMGMFYRTLRMVDNGIKPVYVFDGKPPVLKSGELAKRKERREEALKKIEELKQQVEDGEEGEETKEAQEDVTRFEKRTVRVTPEQNDEAKKLLTLMGIPIVEAPCEAEAQCAKLAEAGKVYAAASEDMDTLCFGSPVLLRHLTFSEAKKMPISEINFAKILEGLEMTHAQFIDLCILLGCDYADTIRGVGPQTALKLMKEHGSLEKIVEHIEKNPSGKLKVPENWPYQEVRALLQAPDVLDSSSCDIKWNNPDVEGLVDFLVRDKGFSEDRVRAGAARLMKQVKVKPQARLDGFFKVMPKEGGEKRKADDKKTKGKKPATKKAKK

Gene
Fen1
Protein
Flap endonuclease 1
Organism
Drosophila ananassae
Length
388 amino acids
Function
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Similarity
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
Mass
43.176 kDa
Sequence
MGILGLSKLIADLAPQAIRESEIKNFFGRKVAIDASMCLYQFLIAVRSEGAQLATVNGDPTSHLMGMFYRTIRLLDNGIKPVYVFDGKPPDLKSGELAKRAERREEAEKALKAATEAGDDAEIEKFNRRLVRVTKEHAREAKELLKLMGVPYVEAPCEAEAQCAALVKAGKVYATATEDMDALTFGSTKLLRYLTYSEARKMPVKEFSYEKLLDGLGVNNREFIDLCILLGCDYCESIKGIGPKRAIELINNYRDIETILDNLDTSKYTVPENWNYKIARELFIEPEVANADAIELKWTEPDEEGLVKFLCGDRQFNEDRVRSGAKKLLKSKQSQTQVRLDSFFKTLPSTPSATNAAKRKAEEAKKSANNKKAKTSGGGGGGRGRRPK

Gene
Fen1
Protein
Flap endonuclease 1
Organism
Drosophila grimshawi
Length
388 amino acids
Function
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Similarity
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
Mass
43.17 kDa
Sequence
MGILGLSKLIADLAPLAIRESEIKNFFGRKVAIDASMCLYQFLIAVRSEGAQLAAVNGDPTSHLMGMFYRTIRLLDNGIKPVYVFDGAPPDMKSGELAKRAERRDEAEKALKAATEAGDEAQIEKFNRRLVRVTKEHSREAKELLKLMGVPYVDAPCEAEAQCAALVKAGKVYATATEDMDALTFGSCKLLRYLTYSEARKMPVKEFSYDKVLQGLELTSKEFIDLCILMGCDYCESIRGVGPKRAIELIKSYRDIETILENIDTNKYAVPENWNYKRARELFIEPDVTDASTIDLKWTDPDEDGLVQFLCGDRQFNEERVRNGAKKLLKSKQAQTQVRLDSFFKTLPSSPNAIAAAKRKAEESKKSANSKKAKIGGGSGAGRGRRPK

Gene
Fen1
Protein
Flap endonuclease 1
Organism
Drosophila mojavensis
Length
388 amino acids
Function
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Similarity
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
Mass
43.254 kDa
Sequence
MGILGLSKLIADLAPLAIRESEIKNFFGRKVAIDASMCLYQFLIAVRSEGAQLATVNGDPTSHLMGMFYRTIRLLDNGIKPVYVFDGKPPDLKAGELAKRAERREEAEKALKVATDAGDEAEIEKFNRRLVRVTKEHSNEAKELLKLMGVPYVDAPCEAEAQCAALVKAGKVYATATEDMDALTFGSCKLLRYLTYSEARKMPVKEFSYDKVLQGLELTSKEFIDLCILMGCDYCDSIKGIGPKRAIELIKTYRDIETILENIDTSKYIVPENWNYQRARELFVEPEVTDASTIDLKWTAPDEDGLVQFLCGDRQFNEERVRNGARKLLKSKQSQTQVRLDSFFKALPSSPNATAAAKRKAEEIKKSANNKKAKTSGGSGAARGRRPK

Gene
Fen1
Protein
Flap endonuclease 1
Organism
Drosophila willistoni
Length
388 amino acids
Function
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Similarity
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
Mass
43.126 kDa
Sequence
MGILGLSKLIADLAPQAIRESEIKNFFGRKVAIDASMCLYQFLIAVRSEGAQLATVNGDPTSHLMGMFYRTIRLLDNGIKPVYVFDGKPPDLKSGELAKRAERREEAEKALKAATEAGDEAEIEKFNRRLVRVTKEHAREAKELLKLMGVPYVDAPCEAEAQCAALVKAGKVYATATEDMDALTFGSSKLLRYLTYSEARKMPVKEFTYEKLLQGLELNQREFIDLCILLGCDYCESIKGIGPKRAIELINSYRDIETILDNLDTSKYTVPENWNYKVARELFIEPEVADASAIDLKWTEPDEEGLVKFLCGERQFSEERVRGGAKKLLKSKKAQTQVRLDSFFQTLPSSPNAVAAAKRKAEEAKKSANNKKAKIGGGGGAGRGRRPK

Gene
Fen1
Protein
Flap endonuclease 1
Organism
Drosophila erecta
Length
387 amino acids
Function
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Similarity
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
Mass
43.093 kDa
Sequence
MGILGLSKLIADLAPQAIRESEMKHFFGRKVAIDASMCLYQFLIAVRSEGAQLATVNGDPTSHLMGMFYRTIRLLDNGIKPVYVFDGKPPDLKSGELAKRAERREEAEKALKAATDAGDDAGIEKFNRRLVRVTKEHAKEAKELLTLMGVPYVDAPCEAEAQCAALVKAGKVYATATEDMDALTFGSTKLLRYLTYSEARKMPVKEFSYDKLLEGLSINSREFIDLCILLGCDYCESIKGIGPKRAIELINNYRDIETILDNLDSSKYTVPENWNYKVARELFIEPEVANAESIDLKWVEPDEEGLVKFLCGDRQFSEERVRNGAKKLMKSKQAQTQVRLDSFFKTLPSTPNATNAAKRKAEEAKKSANNKKAKTSGGVGGRGRRPK

Gene
Fen1
Protein
Flap endonuclease 1
Organism
Drosophila yakuba
Length
387 amino acids
Function
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Similarity
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
Mass
43.022 kDa
Sequence
MGILGLSKLIADLAPQAIRESEIKNFFGRKVAIDASMCLYQFLIAVRSEGAQLATVNGDPTSHLMGMFYRTIRLLDNGIKPVYVFDGKPPDLKSGELAKRAERREEAEKALKAATDAGDDAGIEKFNRRLVRVTKEHANEAKELLTLMGVPYVDAPCEAEAQCAALVKAGKVYATATEDMDALTFGSTKLLRYLTYSEARKMPVKEFSYEKLLEGLSINSREFIDLCILLGCDYCESIKGIGPKRAIELINNYRDIETILDNLDSSKYTVPENWNYKVARELFIEPEVANADNIDLKWVEPDEEGLVKFLCGDRQFSEERVRNGAKKLMKSKQAQTQVRLDSFFKTLPSTPNATNAAKRKAEEAKKSANNKKAKTSGGGGGRGRRPK

Gene
Fen1
Protein
Flap endonuclease 1
Organism
Drosophila persimilis
Length
386 amino acids
Function
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Similarity
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
Mass
43.134 kDa
Sequence
MGILGLSKLIADLAPQAIRESEMKHFFGRKVAIDASMCLYQFLIAVRSEGAQLATVNGDPTSHLMGMFYRTIRLLDNGIKPVYVFDGKPPDLKSGELAKRAERREEAEKALKAATDAGDDAEIEKFNRRLVRVTKEHAREAKELLSLMGVPYVDAPCEAEAQCAALVKAGKVYATATEDMDALTFGSTKLLRYLTYSEARKMPVKEFSYDKLLEGLEVNNREFIDLCILLGCDYCESIKGIGPKRAIELINNYRDIETILDNLDTSKYTVPENWNYKVARELFIEPEVADASAIDLKWTEPDEEGLVKFLCGDRQFSEERVRNGAKKLLKSKHAQTQVRLDSFFKTLPSTPNAVHAAKRKAEEAKKSANNKKAKTSGGAARGRRPK

Gene
Fen1
Protein
Flap endonuclease 1
Organism
Drosophila pseudoobscura pseudoobscura
Length
386 amino acids
Function
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Similarity
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
Mass
43.145 kDa
Sequence
MGILGLSKLIADLAPQAIRESEMKHFFGRKVAIDASMCLYQFLIAVRSEGAQLATVNGDPTSHLMGMFYRTIRLLDNGIKPVYVFDGKPPDLKSGELAKRAERREEAEKALKAATDAGDDAEIEKFNRRLVRVTKEHAREAKELLSLMGVPYVDAPCEAEAQCAALVKAGKVYATATEDMDALTFGSTKLLRYLTYSEARKMPVKEFSYDKLLEGLEVNNREFIDLCILLGCDYCESIKGIGPKRAIELINNYRDIETILDNLDTSKYTVPENWNYKVARELFIEPEVADASAIDLKWTEPDEEGLVKFLCGDRQFSEERVRNGAKKLFKSKHAQTQVRLDSFFKTLPSTPNAVNAAKRKAEEAKKSANNKKAKTSGGAARGRRPK

Gene
Fen1
Protein
Flap endonuclease 1
Organism
Drosophila virilis
Length
386 amino acids
Function
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Similarity
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
Mass
43.115 kDa
Sequence
MGILGLSKLIADLAPQAIRESEIKNFFGRKVAIDASMCLYQFLIAVRSEGAQLATVNGDPTSHLMGMFYRTIRLLDNGIKPVYVFDGQPPDLKSGELAKRAERREEAEKALKAATEAGDEAEIDKFNRRLVRVTKEHSREAKELLKLMGVPYVDAPCEAEAQCAALVKAGKVYATATEDMDALTFGSCKLLRYLTYSEARKMPVKEFSYDKVLQGLELTSKEFIDLCILMGCDYCESIKGVGPKRAIELIKSYRDIETILENIDTSKYPVPENWNYKRARELFIEPDVADASAIDLKWTEPDEDGLVQFLCGDRQFNEERVRNGAKKLLKSKQAQTQVRLDSFFTTLPSTPNASTSAAKRKAEEAKKSANNKKAKTSSAGRGRRPK

Gene
Fen1
Protein
Flap endonuclease 1
Organism
Drosophila melanogaster
Length
385 amino acids
Function
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Similarity
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
Mass
42.948 kDa
Sequence
MGILGLSKLIADLAPQAIRESEMKHFFGRKVAIDASMCLYQFLIAVRSEGAQLATVNGDPTSHLMGMFYRTIRLLDNGIKPVYVFDGKPPDLKSGELAKRAERREEAEKALKAATDAGDDAGIEKFNRRLVRVTKEHAKEAKELLTLMGVPYVDAPCEAEAQCAALVKAGKVYATATEDMDALTFGSTKLLRYLTYSEARKMPVKEFSYDKLLEGLAINNREFIDLCILLGCDYCESIKGIGPKRAIELINTYRDIETILDNLDSSKYTVPENWNYKVARELFIEPEVADADSIDLKWVEPDEEGLVKFLCGDRQFNEERVRNGAKKLMKSKQAQTQVRLDSFFKTLPSTPNATNAAKRKAEEAKKSANNKKAKTSGGGRGRRPK

Gene
Fen1
Protein
Flap endonuclease 1
Organism
Drosophila sechellia
Length
385 amino acids
Function
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Similarity
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
Mass
42.933 kDa
Sequence
MGILGLSKLIADLAPQAIRESEMKHFFGRKVAIDASMCLYQFLIAVRSEGAQLATVNGDPTSHLMGMFYRTIRLLDNGIKPVYVFDGKPPDLKSGELAKRAERREEAEKALKAATDAGDDAGIEKFNRRLVRVTKEHAKEAKELLTLMGVPYVDAPCEAEAQCAALVKAGKVYATATEDMDALTFGSTKLLRYLTYSEARKMPVKEFSYDKLLEGLAINNREFIDLCILLGCDYCESIKGIGPKRAIELINTYRDIETILDNLDSSKYTVPENWNYKVARELFIEPEVANADSIDLKWVEPDEEGLVKFLCGDRQFNEERVRNGAKKLMKSKQAQTQVRLDSFFKTLPSTPNATNAAKRKADEAKKSANNKKAKTSGGGRGRRPK

Gene
Fen1
Protein
Flap endonuclease 1
Organism
Drosophila simulans
Length
385 amino acids
Function
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Similarity
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
Mass
42.947 kDa
Sequence
MGILGLSKLIADLAPQAIRESEMKHFFGRKVAIDASMCLYQFLIAVRSEGAQLATVNGDPTSHLMGMFYRTIRLLDNGIKPVYVFDGKPPDLKSGELAKRAERREEAEKALKAATDAGDDAGIEKFNRRLVRVTKEHAKEAKELLTLMGVPYVDAPCEAEAQCAALVKAGKVYATATEDMDALTFGSTKLLRYLTYSEARKMPVKEFSYDKLLEGLAINNREFIDLCILLGCDYCESIKGIGPKRAIELINTYRDIETILDNLDSSKYTVPENWNYKVARELFIEPEVANADSIDLKWVEPDEEGLVKFLCGDRQFNEERVRNGAKKLMKSKQAQTQVRLDSFFKTLPSTPNATNAAKRKAEEAKKSANNKKAKTSGGGRGRRPK

Gene
FEN1
Protein
Flap endonuclease 1
Organism
Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284)
Length
385 amino acids
Function
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Similarity
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
Mass
43.294 kDa
Sequence
MGIKGLNAIISEHVPSAVRKSEIKNFFGRKVAIDASMSLYQFLIAVRQQDGVQLASESGETTSHLMGIFYRTLRMIDNGIKPCYVFDGKPPVLKSHELSKRSARRATTEEKLKEAVEEAEKLKHERRLVKVTPEHNEEAKKLLRLMGLPYVEAPCEAEAQCAELAKAGKVYAAASEDMDTLCYRTPFLLRHLTFSEAKKEPIHEINTEILLQGLELSIEQFIDLGIMLGCDYCDSIRGVGPVTALKLIKEHKTLENIVEYIESGQANNKWKVPENWPFKEARQLFLDPDVVKGSEVDLKWSEPQEQELVDFMCKEKGFNEERIRSGIKRLQKGLKTGVQGRLDGFFKVKPKNKEQLAAANAKAKSTKAGKQATKGKVGKPGRPRK

Gene
FEN1
Protein
Flap endonuclease 1
Organism
Tetrahymena thermophila (strain SB210)
Length
384 amino acids
Function
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Similarity
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
Mass
43.111 kDa
Sequence
MGIHKLMDLLKEKAPGCIKTSDLKFYAGRMIACDASMAMYQFLATTSSASDFQIQNLTDKDGNKTGHLVGLLNRTVMLIENGLKPVWVFDGKPPQFKSGELARRQKAKDEAAEKQKTAIETGDMQEALKQEQRNLHITKEMKADAIKLLQLVGVPVILAPCEAEAQCAALAKAKKVFATVTEDMDALTFATPFLLRNLNSKKEPITEINYEKMLQELKLSHNEFVDLCILCGCDYLGRIEGVGPVNAFKLITEHKSLEKVLEHMEEVNKQSTKKQKYTVPSSYDYVSARDLFINPEVTDPETIQLEWKKPDVEELKKFLVEEKGFSEQRVTSQMEKVLNAKEHKGSQTRLNDFFKVQPKDTSSTSKASKKPTNTKSANKKGGKK

Gene
FEN1
Protein
Flap endonuclease 1
Organism
Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239)
Length
384 amino acids
Function
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Similarity
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
Mass
43.647 kDa
Sequence
MGVKGLNQLIKEHSPHAYKEFELKNLFGRKVAIDASMCLYQFLIAVRQSDGQQLTNDEGETTSHLSGIFYRTIRMVENNIKPVYVFDGKPPVLKGGELEKRLLKREEAQKQIDNLKDDASVSDMTKYQKRLVRVSRDQNDEAKKLLELMGIPYVNAPCEAEAQCAELARGGKVFAAASEDMDTLCYEPPQLLRHLTFAEARKMPIDQITYKEAIQGLDMTKEQFIDLCILLGCDYCETIKGVGPVTAYKLIKEHGSLDNIVKYLQENPDKTKYKVPENWPYNEARQLFMKPEVLPALEVELKWKEPDLDGLIEYMVKNKGFSEDRIRSGAEKLKKGLKAGIQGRLDGFFTVVPKYSNTSPLGKDDKKRKTNDKKGAAAKKTKRR

Gene
Fen1
Protein
Flap endonuclease 1
Organism
Anopheles gambiae
Length
383 amino acids
Function
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Similarity
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
Mass
42.958 kDa
Sequence
MGIKGLSQLIADIAPFAVKEGEIKQFFGRKVAIDASMCLYQFLIAVRAEGAQLTSVDGETTSHLMGTFYRTIRLLENGIKPVYVFDGKPPDLKSGELNKRAERREEAQKALDKATEAGATEDIEKFNRRLVKVTKHHANEAKELLRLMGVPYVEAPCEAEAQCAALVRAGKVYATATEDMDALTFGSNILLRHLTFSEARKMPVQEFAYEKVLKGFELTQDEFIDLCILLGCDYCDTIRGIGPKKAIELINKHRSIEKILEHLDRQKYIVPEGWNYEQARKLFKEPEVQDADTIELKWSEPDEEGLVKFLCGDRQFNEDRIRSGAKKILKTKNTATQGRLDSFFKVLPSTGTPKRKVDEKKPLAGSSAKKAKTGGATRGRKPK

Gene
FEN1
Protein
Flap endonuclease 1
Organism
Arabidopsis thaliana
Length
383 amino acids
Function
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Similarity
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
Mass
42.797 kDa
Sequence
MGIKGLTKLLADNAPSCMKEQKFESYFGRKIAVDASMSIYQFLIVVGRTGTEMLTNEAGEVTSHLQGMFNRTIRLLEAGIKPVYVFDGKPPELKRQELAKRYSKRADATADLTGAIEAGNKEDIEKYSKRTVKVTKQHNDDCKRLLRLMGVPVVEATSEAEAQCAALCKSGKVYGVASEDMDSLTFGAPKFLRHLMDPSSRKIPVMEFEVAKILEELQLTMDQFIDLCILSGCDYCDSIRGIGGQTALKLIRQHGSIETILENLNKERYQIPEEWPYNEARKLFKEPDVITDEEQLDIKWTSPDEEGIVQFLVNENGFNIDRVTKAIEKIKTAKNKSSQGRLESFFKPVANSSVPAKRKEIPESTTKGAANKKTKGAGGRKKK

Gene
fen1
Protein
Flap endonuclease 1
Organism
Xenopus tropicalis
Length
382 amino acids
Function
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Similarity
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
Mass
42.782 kDa
Sequence
MGIHGLAKLIADVAPAAIKEHDIKSYFGRKVAVDASMCIYQFLIAVRQDGNMLQNEDGETTSHLMGMFYRTIRMIEHGIKPVYVFDGKPPQMKSGELAKRSERRAEAEKLLEAAEEAGEVENIEKFNKRLVKVTKQHNEECKKLLTLMGVPYVDAPCEAEATCAALVKAGKVYAAATEDMDALTFGTPVLLRHLTASEAKKLPIQEFHLNRVMQDMGVSHEQFVDLCILLGSDYCETIRGIGPKRAIDLIRQHKSIEEIVDNIDLKKYPIPENWLHKEARQLFLEPEVVDTESTELKWIEPDEEGLVAFMCAEKQFSEDRIRNGAKKLAKNRQGSTQGRLDDFFKVTGSISSTKRKEVESKGSAKKKAKTAGTPAGKFKRGK

Gene
FEN1
Protein
Flap endonuclease 1
Organism
Glycine max
Length
382 amino acids
Function
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Similarity
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
Mass
42.914 kDa
Sequence
MGIKGLTKLLADNAPKSMKENKFESYFGRKIAIDASMSIYQFLIVVGRSGTEMLTNEAGEVTSHLQGMFSRTIRLLEAGIKPVYVFDGKPPDLKKQELAKRYSKRAEATEDLSEALETANKEDIEKFSKRTVKVTKQHNDDCKRLLRLMGVPVVEAPSEAEAQCAALCKAGKVYGVVSEDMDSLTFGAPKFLRHLMDPSSKKIPVMEFEVAKILEELNMTMDQFIDLCILSGCDYCDSIRGIGGLTALKLIRQHGSIENIPENLNKERYQIPDNWPYQEARRLFKEPLVITDEKELDIKWSSPDEEGLITFLVNENGFNRDRVTKAIEKIKVAKNKSSQGRLESFFKPTANPSVPIKRKETPVNNAKETNKKTKAGGGKKKK

Gene
Fen1
Protein
Flap endonuclease 1
Organism
Glossina morsitans morsitans
Length
382 amino acids
Function
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Similarity
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
Mass
42.698 kDa
Sequence
MGILGLSKLIADICPQAIKESDIKNYFGRKVAIDASMCLYQFLIAVRAEGAQLTNVDGETTSHLMGMFYRTIRLLENGIKPVYVFDGKPPISKSGELAKRAERREDAQKALEKATEAGNEADMDKFNRRLVKVTKEHANEAKELLKLMGVPYVEAPCEAEAQCAALVKAGKVYATATEDMDALTFGSGILLRHLTFSEARKMPVKEFSYAKVLDGFGLTSQEFIDLCILLGCDYCDGIRGIGPKRATELMNSYKDIETILEKIDRKKYTVPEDWNYQIARELFVNPEVADPSSLELKWFDPDEDGLVRFFCGDRQFNEDRVRSGAKKILKCKSSQTQGRLDSFFKVIPAACGTTPKRKADDKNNVQQKKSKTAGNTKGKRPK

Gene
FEN1
Protein
Flap endonuclease 1
Organism
Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)
Length
381 amino acids
Function
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Similarity
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
Mass
43.067 kDa
Sequence
MGIKGLNSIITEHVPSAIRKSDIKAFFGRKVAIDASMSLYQFLIAVRQQDGGQLSTETGETTSHLMGMFYRTLRMIDNGIKPCYVFDGKPPVLKSHELDKRTSRREETEKKLAEATEEAEKMKHERRLVKVSKEHNDEAKKLLELMGIPYVNAPGEAEAQCAELAKKGKVYAAASEDMDTLCYRTPYLLRHLTFSEARKEPIHEINTEIVLQGLELTIDQFIDLGIMLGCDYCDSIKGVGPVTALKLMKEHGSLEKIVEYIESGEANNKWKVPENWPYKEARELFVKPDVIDANEIDLKWTPPKEDELIQYLCHEKKFSEERVRSGIKRLQKGLKSGVQGRLDGFFKVVPKTKEQLEAAAAKAKLAKKNAKGAKGKVTKRR

Gene
FEN1
Protein
Flap endonuclease 1
Organism
Gallus gallus
Length
381 amino acids
Function
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Similarity
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
Mass
42.983 kDa
Sequence
MGIHGLAKLIADVAPSAIRENDIKSYFGRKVAIDASMSIYQFLIAVRQGAEVLQNEEGETTSHLMGMFYRTIRMVENGIKPVYVFDGKPPQLKSGELAKRTERRSEAEKHLQEAQEAGEEANIEKFSKRLVKVTQQHTDECKKLLMLMGIPYVEAPGEAEASCATLVKAGKVYAAATEDMDCLTFGSPVLMRHLTASEAKKLPIQEFHLNRVLQDLGLTWEQFVDLCILLGCDYCESIRGIGPKRAVELIKQHKTIEEIIQHIDTKKYPLPENWLHKEAQKLFLEPDVINPDDVELKWTEPNEEELVQFMCGEKQFNEERIRNGVKRLSKSRQGSTQGRLDDFFKVTGSITSAKRKEPETKGSAKKKAKTNSATAKFKKGK

Gene
FEN1
Protein
Flap endonuclease 1
Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)
Length
381 amino acids
Function
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Similarity
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
Mass
43.183 kDa
Sequence
MGIKNLATLISEQVPNAIKSRDIKYFHGRKVAIDASMSLYQFLIAVRQQDGVQLAGEDGETTSHLMGMFYRTLRMIDHGIKPCYVFDGSPPELKKYELDKRKVRREDTEAKLKEATEQAEIIKHERRLVKVLPWHNEEAQKLLSLMGIPYVVAPAEAEAQCAELAKSGKVFAAASEDMDTLCYQTPVLLRHLTFSEARKLPIQEFDTDVIYNTLDLTQTQFIDLGIILGCDYCEGIKGVGPVNALKLIKEHGSLEAIVEKFENGDISSGRWKIPEGWQFKEARDLFMQPDVIPSEEVTLKWEEPKAEELIEFMVKEKGFNEDRIKSGIERLRKGLKVGVQKRLDSFFKIQPKTKEELATAAKKAKDAKKKAAAKGKIAKRR

Gene
fen1
Protein
Flap endonuclease 1
Organism
Xiphophorus maculatus
Length
380 amino acids
Function
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Similarity
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
Mass
42.652 kDa
Sequence
MGIHGLAKLIADHAPGAIKEQDIKNYFGRKIAIDASMCIYQFLIAVRQDGNVLQSEDGETTSHLMGMFYRTIRMLENGIKPVYVFDGKPPQLKSAELEKRGERRAEAEKMLAKAQELGEQENIDKFSKRLVKVTKQHNDDCKKLLTLMGVPYIEAPCEAEASCAALVKEGKVFATATEDMDGLTFGTNVLLRHLTASEAKKLPVQEFHFNRILQDIGLTSEQFIDLCILLGCDYCGTIKGIGPKRAIDLIRQHGSIEEILENIDTSKHPAPEDWLYKEARNLFLKPEVVDSSTVDLKWREPDEEALIQFMCSEKQFSEDRIRNGCKKMMKSRQGSTQGRLDSFFSVTGSLSSKRKEPETKGSAKKKQKTGATPGKFRKGK

Gene
Fen1
Protein
Flap endonuclease 1
Organism
Rattus norvegicus
Length
380 amino acids
Function
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Similarity
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
Mass
42.609 kDa
Sequence
MGIQGLAKLIADVAPSAIRENDIKSYFGRKVAIDASMSIYQFLIAVRQGGDVLQNEEGETTSHLMGMFYRTIRMMENGIKPVYIFDGKPPQLKSGELAKRSERRAEAEKQLQQAQEAGAEEEVEKFTKRLVKVTKQHNDECKHLLSLMGIPYLDAPSEAEASCAALAKAGKVYAAATEDMDCLTFGSPVLMRHLTASEAKKLPIQEFHLSRVLQELGLNQEQFVDLCILLGSDYCESVRGIGPKRAVDLIQKHKSIEEIVRRLDPSKYPVPENWLHKEARQLFLEPEVLDPESVELKWSEPNEEELVKFMCGEKQFSEERIRSGVKRLNKSRQGSTQGRLDDFFKVTGSLSSAKRKEPEPKGPAKKKAKTGGAGKFRRGK

Gene
fen1
Protein
Flap endonuclease 1
Organism
Salmo salar
Length
380 amino acids
Function
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Similarity
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
Mass
42.475 kDa
Sequence
MGIHGLAKLIADQAPSAIKEQDIKNYFGRKIAIDASMCMYQFLVAVRQDGNVLQNENGETTSHLMGMFYRTIRMLEHGIKPVYVFDGKPPQLKSGELEKRGERRAEAEKLLAQAQEAGEQENIDKFSKRLVKVTQQHNDECKKLLTLMGVPYIEAPCEAEASCAALVKAGKVFATATEDMDGLTFGTGVLLRHLTASEAKKLPIQEFQFTRLLQDINLTHEQFIDLCILLGCDYCGTIKGIGPKRAIDLIRQHGSIEEILENIDSSKHPAPEDWLYKEARGLFLQPDVVDCSTVDLKWSEPDEDALIQFMCAEKQFSEDRIKNGCKKILKSRQGSTQGRLDTFFTITGSLSSKRKEPETKGSNKKKQKTGATPGKFKKGK

Gene
FEN1
Protein
Flap endonuclease 1
Organism
Ovis aries
Length
380 amino acids
Function
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Similarity
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
Mass
42.676 kDa
Sequence
MGIQGLAKLIADVAPSAIRENDIKSYFGRKVAIDASMSIYQFLIAVRQGGDVLQNEEGETTSHLMGMFYRTIRMMENGIKPVYVFDGKPPQLKSGELAKRSERRAEAEKQLQQAQAAGAETEVEKFTKRLVKVTKQHNDECKHLLSLMGIPYLDAPSEAEASCAALVKAGKVYAAATEDMDCLTFGSPVLMRHLTASEAKKLPIQEFHLSRILQELGLNQEQFVDLCILLGSDYCESIRGIGPKRAVDLIQKHKSIEEIVRRLDPNKYPVPENWLHKEAQQLFLEPEVLDPESVELKWSEPNEEELVRFMCGEKQFSEERIRSGVRRLSKSRQGSTQGRLDDFFKVTGSLSSAKRKEPEPKGAAKKKQRLGPAGKFKRGK

Gene
fen1
Protein
Flap endonuclease 1
Organism
Danio rerio
Length
380 amino acids
Function
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Similarity
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
Mass
42.536 kDa
Sequence
MGIHGLAKLIADHAPSAIKEHEIKSYFGRKIAIDASMCIYQFLIAVRQDGNVLQNEDGETTSHLMGMFYRTIRMLESGIKPVYVFDGKPPQLKSGELEKRVERRAEAEKLLAQAQEAGEQENIDKFSKRLVKVTKQHNEECKKLLSLMGVPYIEAPCEAEASCAALVKAGKVYATATEDMDGLTFGTTVLLRHLTASEAKKLPIQEFHFSRILQDMELTHQQFIDLCILLGCDYCGTIKGIGPKRAIDLIKQHGSIEEILENIDPNKHPAPEDWLYKEARGLFLEPEVVDGTSVDLKWNEPDEDGLIQFMCAEKQFSEDRIRNGCKKITKSRQGSTQGRLDTFFTVTGSISSKRKEPETKGSAKKKQKTSATPGKFKKGK

Gene
Fen1
Protein
Flap endonuclease 1
Organism
Aedes aegypti
Length
380 amino acids
Function
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Similarity
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
Mass
42.574 kDa
Sequence
MGIKGLSQLIADLAPFAVKEGEIKNFFGRKVAIDASMCLYQFLIAVRAEGAQLTSVDGETTSHLMGTFYRTIRLLENGIKPVYVFDGKPPDLKSGELTKRAEKREEAQKALDKATEAGVTEDIDKFNRRLVKVTKQHSNEAKELLKLMGVPYVDAPCEAEAQCAALVKGGKVYATATEDMDALTFGSNILLRHLTFSEARKMPVQEFNYDKILQGLELTRDEFIDLCILLGCDYCDSIRGIGPKKAVELINKHRTIEKILENLDTKKYVVPENWNYQQARVLFKEPEVANPEEVELKWGEPDEEGLVKYLCGDRQFNEDRIRAGAKKILKTKSTATQGRLDSFFKVLPSTPNPKRKIEDKKTPASKKAKTTGGKPGRKPK

Gene
fen1
Protein
Flap endonuclease 1
Organism
Anoplopoma fimbria
Length
380 amino acids
Function
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Similarity
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
Mass
42.46 kDa
Sequence
MGIHGLTKLIADQAPGAIKEQDIKNYFGRKIAIDASMCLYQFLIAVRQDGNVLQNEDGETTSHLMGMFYRTIRMLEHGIKPVYVFDGKPPQLKSAELEKRGEKRAEAEKMLAQAQELGEQENIDKFSKRLVKVTKQHNDECKKLLTLMGVPYIEAPCEAEATCAALVKAGKVFATATEDMDGLTFGTNVLLRHLTASEAKKLPIQELHYSRILQDIGLTNEQFIDLCIPLGCDYCGTIKGIGPKRAIDLIKQHGSIEEILENIDSSKHPAPEDWLYKEARGLFLKAEVVDCSTVDLKWSEPDEEGLIQFMCNEKQFSEDRMRNGCKKILKSRQGSTQGRLDSFFSITGSLSSKRKEPELKGSAKKKQKTGATPGKFKKGK

Gene
FEN1
Protein
Flap endonuclease 1
Organism
Homo sapiens
Length
380 amino acids
Function
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Similarity
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
Mass
42.593 kDa
Sequence
MGIQGLAKLIADVAPSAIRENDIKSYFGRKVAIDASMSIYQFLIAVRQGGDVLQNEEGETTSHLMGMFYRTIRMMENGIKPVYVFDGKPPQLKSGELAKRSERRAEAEKQLQQAQAAGAEQEVEKFTKRLVKVTKQHNDECKHLLSLMGIPYLDAPSEAEASCAALVKAGKVYAAATEDMDCLTFGSPVLMRHLTASEAKKLPIQEFHLSRILQELGLNQEQFVDLCILLGSDYCESIRGIGPKRAVDLIQKHKSIEEIVRRLDPNKYPVPENWLHKEAHQLFLEPEVLDPESVELKWSEPNEEELIKFMCGEKQFSEERIRSGVKRLSKSRQGSTQGRLDDFFKVTGSLSSAKRKEPEPKGSTKKKAKTGAAGKFKRGK

Gene
FEN1
Protein
Flap endonuclease 1
Organism
Bos taurus
Length
380 amino acids
Function
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Similarity
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
Mass
42.51 kDa
Sequence
MGIQGLAKLIADVAPSAIRENDIKSYFGRKVAIDASMSIYQFLIAVRQGGDVLQNEEGETTSHLMGMFYRTIRMMENGIKPVYVFDGKPPQLKSGELAKRSERRAEAEKQLQEAQAAGAEAEVEKFTKRLVKVTKQHNDECKHLLSLMGIPYLDAPSEAEASCAALVKAGKVYAAATEDMDCLTFGSPVLMRHLTASEAKKLPIQEFHLSRILQELGLNQEQFVDLCILLGSDYCESIRGIGPKRAVDLIQKHKSIEEIVRRLDPNKYPVPENWLHKEAQQLFLEPEVLDPESVELKWSEPNEEELIKFMCGEKQFSEERIRSGVRRLSKSRQGSTQGRLDDFFKVTGSLSSAKRKEPEPKGAAKKKAKTGAAGKFKRGK

Gene
FEN1
Protein
Flap endonuclease 1
Organism
Branchiostoma floridae
Length
380 amino acids
Function
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Similarity
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
Mass
42.875 kDa
Sequence
MGIQGLAKLIGDHAPGAMKENEIKNYFGRKVAIDASMSIYQFLIAVRQDGNMLTNDAGEATSHLMGMFYRTIRMVDNGIKPVYVFDGKPPNMKSGELAKRAERREEAQKALEKAEEAGEAEDVNKFQKRLVKVTKEHNAECKKLLTLMGIPYVDAPCEAEAQCAELAKKGKVYAAGTEDMDVLTFGTNIMLRHLTFSEARKMPIKEYYYDRLLAELDLTQDQFIDLCILLGCDYCDSIRGIGPKRAIELIRQYKSIEEILKHIDTKKFPVPEDWPYDQARKLFKEPEVTPADQVELKWVDPDEEGLVQYMSNEKGFSEDRIKNGAKKLKNARHTSTQGRLDSFFKVMSSPSVKRKEPPKGAKGSASKKAKMSGGKFKKPK

Gene
FEN1
Protein
Flap endonuclease 1
Organism
Zygosaccharomyces rouxii (strain ATCC 2623 / CBS 732 / NBRC 1130 / NCYC 568 / NRRL Y-229)
Length
379 amino acids
Function
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Similarity
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
Mass
42.791 kDa
Sequence
MGIKGLNAIISEHVPSAVRKSDIKAFFGRKVAIDASMSLYQFLIAVRQQDGAQLSTESGETTSHLMGMFYRTLRMIDNGIKPCYVFDGKPPILKSFELKKRSDKRVDTEKKLEEAVDQAEKLKQERRLVKVSPEHNDEAKYLLKLMGIPYIVAPCEAEAQCAQLAKDGKVYAAASEDMDTLCYKTPYLLRHLTFSEAKKEPIHEIDTELVLQGLELTQEQFVDLGIMLGCDYCESIRGIGPVTALKLIKEHGSLEKIVEFIESGQANNKWKVPEDWPYNEARQLFLNPDVVNSQDINLKWNPPDEEKLIEFLCHEKKFNEERVKSGIKRLQKGLKSGVQVRLDGFFQKVPKTKEQLAAATAKAKAAKKTKGKTGKVSKR

Gene
FEN1
Protein
Flap endonuclease 1
Organism
Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968)
Length
379 amino acids
Function
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Similarity
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
Mass
43.238 kDa
Sequence
MGVKGLNQLIKEHAPEAFKEFQLKNLFGRKIAIDASMCLYQFLIAVRQAEGQQLTNDEGETTSHLSGMFYRTIRLVENSIKPVYVFDGKPPVLKGGELEKRLLRREEAIKQRENIKDEGTIEDMVRYEKRTVRVTREQNDEAKKLLELMGVPYVNAPCEAEAQCAELARGGKVFAAASEDMDTICYQPPFLLRHLTFSEARKMPIDQIQYEKVLEALEMDRETFIDLCILLGCDYCETIRGVGPVTAFKLIKEHGSLDKIVEYLTNNPDKTNFKVPEDWPYDEARKLFINPDTIDASEVNLKWKEPDVEGLIQYMVKEKGFSEDRIRSGAEKLKKGLKGGVQGRLDGFFQSVPKPKDSADKKRKNDTKSAKSKKAKTRK

Gene
FEN1
Protein
Flap endonuclease 1
Organism
Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
Length
378 amino acids
Function
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Similarity
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
Mass
42.508 kDa
Sequence
MGIKGLNSIIQQQVPSAIRPREMKQFFGRRVAIDASMSLYQFLIAVRQADGVQLASADGETTSHLMGMFYRTLRMVDHGLKPCYVFDGKPPVLKAHELDKRTERRKETEQKLAELTEQAEIMKHERRLVKVEQWHVAEAKKLLGLMGIPYVDAPGEAEAQCAELAKKGKVFAAASEDMDTLCYRTPYLLRHLTFSEARKEPIHEIDTELVLQGLGLSQEQLVDLGIMLGCDYCESIKGVGPVTALKLIKEHGSLENIVEFISSGGNAKWKVPENWPYKEARALFLQPDVLDAEGVSLKWEEPKEEELIAFMCKEKGFNEDRIKSGIQKLRKGLKGGVQGRLDSFFKVKPKTTEQLAASARKAQAAKKTNQKGKVLKRR

Gene
FEN1
Protein
Flap endonuclease 1
Organism
Brugia malayi
Length
378 amino acids
Function
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Similarity
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
Mass
42.844 kDa
Sequence
MGVKDLSKVIGDHSPNSIRLKEFKGYFGRKVAVDASMCLYQFLIAVRQDGSQLQTESGETTSHLLGMFYRTIRMIDNGIKPVYVFDGKPPQMKTSELEKRTERRTEAEKQRNDAVELGDETSVNKFEKRLVKVTKEQSEEAKRLVTLMGIPVLDAPCEAEAQCAALAKAGKVFATVSEDMDALTFGSPILLRQMIASEAKKLPVKEMNLNQVLKDFGMNMGQFVDLCILLGCDYVSTIRGIGPKKAFELIKKYECIENVLETINQTKYPIPQDWQYKEARRLFLEPDVMNCENLELVWKEPDVEGIVQFLCVEKSFNEDRVRGSLTRMQKGRQAAQQARIDSFFSVSKVVTSETTKRKNEEKNNLKKRGPSLGKKAKK

Gene
FEN1
Protein
Flap endonuclease 1
Organism
Trichoplax adhaerens
Length
377 amino acids
Function
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Similarity
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
Mass
42.466 kDa
Sequence
MGIHGLAKLIADHAPSAIKENEIKNYFGRKVAIDASMSIYQFLIAVRSDGNVLTNEAGETTSHLMGLFYRTIRMMENGIKPVYVFDGKPPRLKSGELARRQERREEAQKQASEAEKEGDADNIDKFTRRTVRMTPEHCEEGKKLLKLMGVPVVQAPCEAESQCAALVKAGKVYATGTEDMDALTFGSNVMLRHLTFSEARKMPIQEFHLKNALQELNFSMEQFIDLCILLGCDYCDSIKGVGPKRAVGLIEKYKSIEDIVKNISSEKFTVPENWPYKDARMLFLNPDVEKCEDMELKWTEPDADELVKFLVEEKGFSEDRIRRGVEKISKARGTSTQGRLDSFFTITPGAIKRKTDAKKDAGKKKAKPGPAGRFKRR

Gene
FEN1
Protein
Flap endonuclease 1
Organism
Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294)
Length
377 amino acids
Function
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Similarity
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
Mass
42.468 kDa
Sequence
MGIKGLNAIISEHVPSAVRKSDIKTFFGRKVAIDASMSLYQFLIAVRQQDGGQLTNEAGETTSHLMGMFYRTLRMIDNGIKPCYVFDGKPPVLKSHELSKRTARREETEKKLQEATDQAEKMKQERRLVKVSKEHNDEAKQLLELMGIPYITAPCEAESQCAELAKCGKVYAAASEDMDTLCYRTPYLLRHLTFSEAKKEPIHEIDTELVLKGLDLTLEQFVDLGIMLGCDYCDSIKGVGPVTALKLIKEYGSLEKIIEYIESDSSNSKWKIPNDWPYKDARELFLKPDVINGNEVELKWQPPNEKGLIDFLCGEKKFSEERVKSGIERLKKGLKSGVQGRLDGFFQVVPKTKEQLAKAAAKAKAAKKSGKVTKKRR

Gene
FEN1
Protein
Flap endonuclease 1
Organism
Clavispora lusitaniae (strain ATCC 42720)
Length
376 amino acids
Function
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Similarity
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
Mass
42.525 kDa
Sequence
MGVKGLNQLIKEHAPDAFKEYQLKNLFGRKVAIDASMCLYQYLIAVRQQDGQQLTSEDGETTSHLSGMFYRTIRLVESGLKPMYVFDGKPPVLKGGELEKRLLKRQDALKQIEDLKETGTVEELMKYEKRTVRASREQNDEAKKLLELMGIPYIVAPSEAEAQCAELARAGKVFAAASEDMDTLCYEPKYLLRHLTVAEARKMPIDQIDYEAMLKGLDMDRSTFVDLCILLGCDYCETIKGVGPVTAFKLIKEHGSLDNIVKWIQENPEKTKYKVPENWPYDEAKQLFMNPEITKGDEVDVKWNEPNVDGLVEFMVKQKGFSEERIRSGAEKLKKALKGGVQGRLDGFFTVVKSSPAKRKPDAKDAKGKGKKKAKR

Gene
FEN1
Protein
Flap endonuclease 1
Organism
Entamoeba dispar (strain ATCC PRA-260 / SAW760)
Length
376 amino acids
Function
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Similarity
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
Mass
42.484 kDa
Sequence
MGIKGLSKLLARYAPKSMKEGKIDQYSGRVIAIDASILVYQFISAVRDTTGATMVDEFGETTSHIIGTFYRTIKLIESGIKPVYVFDGKPPEMKDGELNKRKENAQKAQEQLDKALEEGDKEQAKKLMKRTARMTKEQSDEVKKLLQLMGIPCVEANCEAEGTCAALVKAGKCYATATEDMDALTLGSEYVVRKFSASDNKKEPIREYSLSSILEETGFSMEQFIDLCILLGCDYCDTIKGVGPITAFELIQQYKSIENVLKHLSDKYKVPENWKYKEARELFLHPDVADFSDYKLEWNKLDEEGIKQYLVTEKHFNEERVTKGIEKLKNVKSKKAQGRLDSFFSVKKVPLSKSEAASGVKRKKPTTKAKESRKKK

Gene
FEN1
Protein
Flap endonuclease 1
Organism
Entamoeba histolytica
Length
376 amino acids
Function
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Similarity
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
Mass
42.577 kDa
Sequence
MGIKGLSKLLARYAPKSMKEGKIDQYSGRVIAIDASILVYQFISAVRDTTGATMVDEFGETTSHIIGTFYRTIKLIESGIKPIYVFDGKPPEMKDGELHKRKENAQKAQEQLDKALEEGDKEQAKKLMKRTARMTKEQSDEVKKLLQLMGIPCIEANCEAEGTCAALVKAGKCYATATEDMDALTLGSEHVVRKFSANDNKKDPIREYSLSSILEETGFTMEQFIDLCILLGCDYCETIKGVGPITAFELIQQYKSIENILQHLSDKYKVPENWKYKEARELFLHPDVADFSDYKLEWNKIDEEGIKKYLVTEKHFNEERVSKGIEKLKNVKSKKAQGRLDSFFNVKKVPLSKSEAASGVKRKKPTTKAKESRKKK

Gene
FEN1
Protein
Flap endonuclease 1
Organism
Ustilago maydis (strain 521 / FGSC 9021)
Length
374 amino acids
Function
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Similarity
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
Mass
42.304 kDa
Sequence
MGIKGLTALISDEAPGAIKEMEIKTYFGRKVAIDASMSLYQFLIAVRQNDGQQLMTESGETTSHLLGFFYRTLRMIDYGIKPMYVFDGTPPDLKKELLQKRFGRREEAREQEEEQKDVADAEKMDQLARRQVRPTRQHNEEVRHLLKLMGIPCVIAPSEAEAQCAELARAGKVYAAGSEDMDTLTFGTPILLKHLTASEQKKLPVHQVDLAKALEGLQMTMAQFIDLCILLGCDYLDPIKGIGPKTALKLIREHKTLENVVHHLKEDGKKSVQIPDHWPFQEARKIFESPDVQKGVDLDLKWEAPDVEAMVKFLCQDKGFSEDRVRKGCEKLQKSLSQKQQGRLDGFFTVKPGSAPPKRKAEDDKKNVKKKGKK

Gene
FEN1
Protein
Flap endonuclease 1
Organism
Komagataella phaffii (strain GS115 / ATCC 20864)
Length
373 amino acids
Function
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Similarity
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
Mass
42.592 kDa
Sequence
MGIKGLNALINEHSPKAFRNGEMKTFFGRKVAIDASMCLYQFLIAVRQQDGQQLANEEGETTSHLMGFFYRTIRMVGYGIKPCYVFDGKPPVLKGGELEKRLKRREEAEKQRLDMKETGTLADIAKFERRTVRVTREQNDQAKKLLELMGIPYVDAPCEAEAQCAELAKGGKVYAAASEDMDTLCYETPYLLRHMTTAEARKLPVTEIDYAKVMEGLEMELPQFIDLCILLGCDYCETIKGVGPVTAFKLIKEHGSIEKVVEAIENNPKSKQKIPENWPYNEARELFLHPEVIPASECELEWKEPDEEALVDYMVRQHGFSEQRIRDGASKLRKSLKTGTQGRLDKFFVVKKRPAEEKKGKNTKEEKPKKKRK

Gene
FEN1
Protein
Flap endonuclease 1
Organism
Giardia intestinalis (strain ATCC 50803 / WB clone C6)
Length
361 amino acids
Function
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Similarity
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
Mass
40.03 kDa
Sequence
MGIRGLAKLIEEVAPAAVSKRLIQHYCNKVIAIDASVMLYQFITTITSGDGTALANSSGEVTSHLVGLLAKVIRLAEAGIKPIFVFDGKPPEDKQGELEKRRQAREAAELEQQKAEEEGNLERAKQLSRRTVKVTQQHCKQAERLLDTLGIPYVVAAGEAEAQCVAMAKERVCEGVASSDLDVLAFGSPCLIRNLAQGGDREIVEINLNTVLKELGFSYDEFLDLCILCGCDYANSLEGIGPKTAYKLIVKHRSIEEVLAADQGKLAEKALNWPYVRARELFKNPAVIDPKEIKKTLKWKPVNRGEAMQFLVEEMEFDRETTEKKLDKLVAARKKPKQCTIDSFFSPRSSNPEVTKTKVKQ

Gene
FEN1
Protein
Flap endonuclease 1
Organism
Enterocytozoon bieneusi (strain H348)
Length
358 amino acids
Function
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Similarity
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
Mass
41.15 kDa
Sequence
MGIKRLSKLIKTYCSEGVQNRELKYYSGYKIAIDASMCIYQFLVAVRAEGQSLSWGDSTTSHISGIFYRSIRWIENGIIPVFVFDGIPPEEKIHEFEKRTKRRQDINAKLQDAIEQQDQVLVSKYDRMNVKMEKSHIEECQKTLRLLNIPYVIAPSEAEAYCAWLCKSKFVDAVATEDMDSLCFGSPLLLRNFNTALSQKLPVEEYNLHKILEGLQFTMEQFVDLCILLGCDYSATIRGVGMKRAFEYIKKYKSIDNLIGIVDFPDDFKYKEARTIFFTLGTDTSNNFTNENPINTNIATWDLIAVDSASINIEAVIDFLCNEKGFDKGRIETGIKKLQKQKKVNKQTRIDSFFKKKL

Gene
FEN1
Protein
Flap endonuclease 1
Organism
Encephalitozoon cuniculi (strain GB-M1)
Length
345 amino acids
Function
Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
Similarity
Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.
Mass
38.943 kDa
Sequence
MGIKQLSKLLRENSKRGIRERPLVYYSSKKVAIDASMSMYQFLIAVRSGGATLGNEDSPTSHLVGFFYRTIRMVELGITPVYVFDGVPPEIKMKELEKRKERRAAADREYREASEVGDKELMEMYDKRKTKVTGVHVDECKRLLGLMGIPFETAPSEAEAYCALLCKKKAVYGVATEDMDALTFGSPVVLRNFNGTQSKRLPVMEHNLPQILEDLSLDHSEFIDLCILLGCDYCSTLKGIGPKKALGLIKKHRSIGNILKNEDLEVPGDWRYSDAQKIFGSLAEIGEIRDFNISWDSIDRNGIVNFLVEEKGFDLERVNKGIDKLINSRKKGTQGRLDCFITRSK