Protein
NADPH:adrenodoxin oxidoreductase, mitochondrial
Organism
Salvelinus fontinalis
Function
Serves as the first electron transfer protein in all the mitochondrial P450 systems including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver.
Similarity
Belongs to the ferredoxin--NADP reductase type 1 family.
Sequence
MSTHKAALCKVQILKLFLISARCVRITRFYGVCGLSTSTPASSPKVCIVGGGPAGFYTAQHLVKTRTDVQVDIYERLPVPFGLVRFGVAPDHPEVKNVINTFTQTARHARCSFHGNVRVGKDVTVEELQEAYHAVVLSYGAEGNRTMGVPGEDLAGVYSAKDFVGWYNGLPRNRELRPDLSCETAVILGQGNVALDVARMLLSPVDILKKTDITQHALDALAESSVRRVLIVGRRGPLQVACTIKELREMVNLPGTRPEMEASEFEGIAETLKSLARPRKRLTELLLKAAIETPGEEELEKRNKAERAWGFRFLRRPLEVLPSTDLIRAAGIRLAVNRLEGDGEGVRAVATGEVEDVECGLVISSIGYKSLPIDPAVPFDGRKAIIPNTMGRVQQTAGLYCSGWVKRGPTGVIATTMNDSFDTARTLLQDIGKGTLDVSSVKPGSQGVSALLEKRGVKPVSFSDWEKIDSEETRRGETRGKPREKMLDVGEMLQVARA