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FDM1

Gene
FDM1
Protein
Factor of DNA methylation 1
Organism
Arabidopsis thaliana
Length
634 amino acids
Function
Forms a complex with IDN2 and FDM2/IDNL2 that is required for RNA-directed DNA methylation (RdDM) and that functions at a downstream step of the RdDM pathway (PubMed:22302148, PubMed:22757778, PubMed:22570638, PubMed:22592791). Required for de novo DNA methylation and 24 nucleotide small interfering RNA (siRNA) accumulation (PubMed:22570638). Binds unmethylated but not methylated DNAs through its coiled-coil domain (PubMed:22757778). May bind double-stranded RNAs (dsRNAs) with 5'-overhangs through its XS domain (PubMed:22302148, PubMed:22757778). However, according to (PubMed:22570638), FMD1 does not bind dsRNAs.
Mass
72.635 kDa
Sequence
MSISDEEAEISESEIEDYSETPYRLLRDGTYKVKVNGQLRCPFCAGKKKQDYKYKELYAHATGVSKGSATRSALQKANHLALAMFLENELAGYAEPVPRPPVVPPQLDETEPNPHNVYVWPWMGIVVNPLKEADDKELLLDSAYWLQTLSKFKPIEVNAFWVEQDSIVGVIAKFNGDWSGFAGATELEKEFETQGSSKKEWTERSGDSESKAYGWCARADDFESQGPIGEYLSKEGQLRTVSDISQKNVQDRNTVLEELSDMIAMTNEDLNKVQYSYNRTAMSLQRVLDEKKNLHQAFADETKKMQQMSLRHIQKILYDKEKLSNELDRKMRDLESRAKQLEKHEALTELDRQKLDEDKRKSDAMNKSLQLASREQKKADESVLRLVEEHQRQKEDALNKILLLEKQLDTKQTLEMEIQELKGKLQVMKHLGDDDDEAVQKKMKEMNDELDDKKAELEGLESMNSVLMTKERQSNDEIQAARKKLIAGLTGLLGAETDIGVKRMGELDEKPFLDVCKLRYSANEAAVEAATLCSTWQENLKNPSWQPFKHEGTGDGAEEVVDEDDEQLKKLKREWGKEVHNAVKTALVEMNEYNASGRYTTPELWNFKEGRKATLKEVITFISNDIKILKRKRT