FBXO9

F-box only protein 9

447 amino acids

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of TTI1 and TELO2 in a CK2-dependent manner, thereby directly regulating mTOR signaling. SCF(FBXO9) recognizes and binds mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, the SCF(FBXO9) does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTORC1 is inactivated to restrain cell growth and protein translation, while mTORC2 is activated due to the relief of feedback inhibition by mTORC1.

52.329 kDa

MPDIIWVFPPQAEAEEDCHSDTVRADDDEENESPAETDLQAQLQMFRAQWMFELAPGVSSSNLENRPCRAARGSLQKTSADTKGKQEQAKEEKARELFLKAVEEEQNGALYEAIKFYRRAMQLVPDIEFKITYTRSPDGDGVGNSYIEDNDDDSKMADLLSYFQQQLTFQESVLKLCQPELESSQIHISVLPMEVLMYIFRWVVSSDLDLRSLEQLSLVCRGFYICARDPEIWRLACLKVWGRSCIKLVPYTSWREMFLERPRVRFDGVYISKTTYIRQGEQSLDGFYRAWHQVEYYRYIRFFPDGHVMMLTTPEEPQSIVPRLRTRNTRTDAILLGHYRLSQDTDNQTKVFAVITKKKEEKPLDYKYRYFRRVPVQEADQSFHVGLQLCSSGHQRFNKLIWIHHSCHITYKSTGETAVSAFEIDKMYTPLFFARVRSYTAFSERPL

Fbxo9

F-box only protein 9

437 amino acids

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of TTI1 and TELO2 in a CK2-dependent manner, thereby directly regulating mTOR signaling. SCF(FBXO9) recognizes and binds mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, the SCF(FBXO9) does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTORC1 is inactivated to restrain cell growth and protein translation, while mTORC2 is activated due to the relief of feedback inhibition by mTORC1 (By similarity).

50.76 kDa

MSAEAEEDCHSDADRVGDEGNESPAERDLQAQLQMFRAQWMFELTPGVGSSHGETRPCRAGRSSMLKAAADTKGRQELAKEEKARELFLQAVEEEQNGALYEAIKFYRRAMQLVPDIEFKITYTRSPDGDGVGSGYIEENEDASKMADLLSYFQQQLTLQESVLKLCQPELETSQTHISVLPMEVLMYIFRWVVSSDLDLRSLEQLSLVCRGFYICARDPEIWRLACLKVWGRSCMKLVPYASWREMFLERPRVRFDGVYISKTTYIRQGEQSLDGFYRAWHQVEYYRYMRFFPDGHVMMLTTPEEPPSIVPRLRTRNTRTDAILLGHYRLSQDADNQTKVFAVITKKKEEKPLDHKYRYFRRVPVQEADHSFHVGLQLCSSGHQRFNKLIWIHHSCHITYKATGETAVSAFEIDKMYTPLLFARVRSYTAFSERPL

FBXO9

F-box only protein 9

437 amino acids

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of TTI1 and TELO2 in a CK2-dependent manner, thereby directly regulating mTOR signaling. SCF(FBXO9) recognizes and binds mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, the SCF(FBXO9) does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTORC1 is inactivated to restrain cell growth and protein translation, while mTORC2 is activated due to the relief of feedback inhibition by mTORC1 (By similarity).

50.817 kDa

MAEAEEDCHSEAVREGDDDDENESPAETDLQAQLQRFRAQWMFELAPGGGSGNLESRPCRAARGSLLRAADTRGKQELAKEEKARELFLKAVEEEQNGALYEAIKFYRRAMQLVPDIEFKITYTRSPDGDGVGNSYIEDTDDDSKMADLLSYFQQQLTFQESVLKLCQPELESSQTHISALPMEVLMYVFRWVVSSDLDLRSLEQLSQVCRGFYICARDPEIWRLACLKVWGRSCIKLVPYTSWREMFLERPRVRFDGVYISKTTYIRQGEQSLDGFYRAWHQVEYYRYVRFFPDGHVMMLTTPEEPQSIVPRLRTRNTRTDAILLGHYRLSQDTDNQTKVFAVITKKKEEKALDHKYRYFRRAPVQEADQNFHVGLQLCSSGHQSFNKLIWIHHSCHITYKSTGETAVTAFEIDKMYTPLLFARVRSYTAFSERPL

Fbxo9

F-box only protein 9

435 amino acids

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of TTI1 and TELO2 in a CK2-dependent manner, thereby directly regulating mTOR signaling. SCF(FBXO9) recognizes and binds mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, the SCF(FBXO9) does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTORC1 is inactivated to restrain cell growth and protein translation, while mTORC2 is activated due to the relief of feedback inhibition by mTORC1 (By similarity).

50.689 kDa

MAEAEEDCHSDAVRVGDEGHESPAERDLQAQLQMFRAQWMFELTPGVGSSNVESRPCRAGRSSILKAAADKGRQELAKEEKARELFLKAVEEEQNGALYEAIKFYRRAMQLVPDIEFKITYTRSPDGDGVGSSYIEDNEDASKMADLLSYFQQQLTFQESVLKLCQPELETSQTHISVLPMEVLMYIFRWVVSSDLDLRSLEQLSLVCRGFYICARDPEIWRLACLKVWGRSCMKLVPFSSWREMFLERPRVRFDGVYISKTTYIRQGEQSLDGFYRAWHQVEYYRYIRFFPDGHVMMLTTPEEPPSIVPRLRTRNTRTDAILLGHYRLSQDADNQTKVFAVITKKKEEKPLDHKYRYFRRVPVQEADHNFHVGLQLCSSGHQRFNKLIWIHHSCHITYRSTGETAVSAFDIDKMYTPLFFARVRSYTAFSERPL

fbxo9

F-box only protein 9

431 amino acids

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins and acts as a regulator of mTOR signaling.

50.249 kDa

MAEGDEDSYTDSLMSNENGRPGETNLQEELQMFRARWMSELTPGLSSGGLENRPCNAAARGPVGKVSETKAKQELAKEAKARELFLKAAEEEQNGALYEAIKFYRQAMQLVPDIEFKINYTWSPDGDTKNFLDDANNDSKMADLLSYFQQQLTFQQSKLCQPDIDVTQTHISVLPMEVLMYIFRWVVSSDLDLRALEQLSLVCKGFYICARDPEIWRLACLKVWGRNCVKIVPYTTWRQMFLERPRVRFDGVYISKTTYIRQGEQSLDGFYRAWHQVEYYRYLRFFPDGHVMMLTTPEDPQTIVPRLRTKNARTDAMLLGHYRLSQDTDNQTKVFAVITNKKEEKPSDYQKYRYFRRPQVQETERSFHVGLQLCSSGRHKFNKLVWIHHSCHITYKSTGETAVTAFDIDKMYTPMFFVRVKSFTAVSERPL

fbxo9

F-box only protein 9

421 amino acids

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins and acts as a regulator of mTOR signaling.

49.371 kDa

MAESNQNTDGAVEEGEDENTGDSNLQMELSAFRAKWMSELQPSSGGQRSFSRNAELRRRQETAKEEKARELFLKAVEEEQNGAVYEAIKYYKSAMQLVPDIEFKINYSRTPDPERGGSYLESSENNREIDDLLTYFQHQLTLGNDAMKLCEHETETSQVHISALPFEVLMYIFRWVVSCDLDLRALEQLSLVCRGFYICARDPEIWRSACLRVWGRSCTKMLPYSSWREMFLERPRVRFDGVYISKTSYIRQGEESLDGFYRAWHQVEYYRYLRFFPDGQVMMLTTPEDPLVTVPRLRSKNSRMDSIMFGHYRLSQDTDNQTKVYVVVSKRKEEKVSEYQRSRFCRRNPVPEAERSFHVGLQLSSGGRQRFNKLVWIHHSCHITYRSTGETVVTAFDVDKMYTPLFFARVKSYTAFSERPL