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FBXO7

Gene
Fbxo7
Protein
F-box only protein 7
Organism
Mus musculus
Length
523 amino acids
Function
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes BIRC2 and DLGAP5. Plays a role downstream of PINK1 in the clearance of damaged mitochondria via selective autophagy (mitophagy) by targeting PRKN to dysfunctional depolarized mitochondria. Promotes MFN1 ubiquitination (By similarity).
Mass
57.649 kDa
Sequence
MKLRVRLQKRTQPLEVPESEPTLGQLRAHLSQVLLPTLGFSSDTRFAITLNNKDALTGDEETLASYGIVSGDLICLVLEDDMPAPNLPSSTDTEHSSLQDNDQPSLAATPSQTNIPDEQGTDSSQGQATPFDAWTDDSMEGPSQNVEAESIQDAMSMEEVSGFHPLEPMLCNETEDGQVPHSLETLYQSAGCSNISDALIVLVHLLMLESGYIPQGTETKAVTMPEKWKSSGVYKLQYTHPLCEGGFAVLTCVPLGNLIIINATIKVNGGIKNVKSVQLQPGSYVAAGVEPGESAAKVYKDLKKLSRLFKDQLVYPLLAFTRQVLNLPDVFGLVVLPLELKLRIFRLLDVHSVLALSAVCHDLLIASNDPLLWRCLYLRDFRDGTVRGPDTDWKELYRKKHIQRKEAQRMRHAMFLPSAHPIPFCPIPVYPRAYLPTSLLPPGIIGGEYDERPILPSVGDPVTSLIPRPGELPGQFRPLRPRFDPVDPLPGPHSLLPGRAIPNNRFPFRPGRGRSADSRLPFL
Protein
F-box only protein 7: Fbxo7

Gene
FBXO7
Protein
F-box only protein 7
Organism
Bos taurus
Length
522 amino acids
Function
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes BIRC2 and DLGAP5. Plays a role downstream of PINK1 in the clearance of damaged mitochondria via selective autophagy (mitophagy) by targeting PRKN to dysfunctional depolarized mitochondria. Promotes MFN1 ubiquitination (By similarity).
Mass
57.965 kDa
Sequence
MKLRVRLQKRTWPLDMPEVEPTLGQLRAYLSQALPTWGYSSDARFAITLNNKDALTGDEETLASYGIVSGDLLCLILEDAIAAPNLPSSTVSEHSSVQNNDQPSLATSSSQSNIQDAQLHDSLQGQATQSEVWNDDSVSGPGQHFEAEAVPDVVDVEEGTGYYLAEPMLCSESVEGQVPHSLEILYQSADCLNPCDALIVSIHLLMLESGYIPQGTEAKAVSMPQNWRLGGVYKLQYTHPLCEGGSAALTCVPLGNLIVINATLKINSEVRSVKRLQLLPESFICKEESGENVAMIYKDLQKLSRLFKDQLVYPLLAFTRQALNLPDVFGLVVLPLELKLRIFRLLDVRSVLSLSAVCRDLCITSNDQLLWRCLYLRDFRDGSIRGRDTDWKELYKKRYKQRKEAQRGRHVMFLPSSPHPIPFYPSPLHPRPFPPSSLHPPGIIGGEYDQRLTLPYVGDPINSLIPGPGETPSQFPPLRPRFDPVGPLPGPNPILPGRGGPSDRFPLRPSRGWPTDSRLPFM
Protein
F-box only protein 7: FBXO7

Gene
FBXO7
Protein
F-box only protein 7
Organism
Homo sapiens
Length
522 amino acids
Function
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes BIRC2 and DLGAP5. Plays a role downstream of PINK1 in the clearance of damaged mitochondria via selective autophagy (mitophagy) by targeting PRKN to dysfunctional depolarized mitochondria. Promotes MFN1 ubiquitination.
Mass
58.503 kDa
Sequence
MRLRVRLLKRTWPLEVPETEPTLGHLRSHLRQSLLCTWGYSSNTRFTITLNYKDPLTGDEETLASYGIVSGDLICLILQDDIPAPNIPSSTDSEHSSLQNNEQPSLATSSNQTSMQDEQPSDSFQGQAAQSGVWNDDSMLGPSQNFEAESIQDNAHMAEGTGFYPSEPMLCSESVEGQVPHSLETLYQSADCSDANDALIVLIHLLMLESGYIPQGTEAKALSMPEKWKLSGVYKLQYMHPLCEGSSATLTCVPLGNLIVVNATLKINNEIRSVKRLQLLPESFICKEKLGENVANIYKDLQKLSRLFKDQLVYPLLAFTRQALNLPDVFGLVVLPLELKLRIFRLLDVRSVLSLSAVCRDLFTASNDPLLWRFLYLRDFRDNTVRVQDTDWKELYRKRHIQRKESPKGRFVMLLPSSTHTIPFYPNPLHPRPFPSSRLPPGIIGGEYDQRPTLPYVGDPISSLIPGPGETPSQFPPLRPRFDPVGPLPGPNPILPGRGGPNDRFPFRPSRGRPTDGRLSFM
Protein
F-box only protein 7: FBXO7

Gene
Fbxo7
Protein
F-box only protein 7
Organism
Rattus norvegicus
Length
522 amino acids
Function
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes BIRC2 and DLGAP5. Plays a role downstream of PINK1 in the clearance of damaged mitochondria via selective autophagy (mitophagy) by targeting PRKN to dysfunctional depolarized mitochondria. Promotes MFN1 ubiquitination (By similarity).
Mass
57.561 kDa
Sequence
MKLRVRLQKRTQPLEVPESEPTLGQLRAHLIQDLLPTLGFSSDTRFAITLNNKDALTGDEETLASYGIVSGDLICLVLEDEMPAPNLPSSTDSEHSSLQNNDQPPLAATSSQANIPDEQGSDSSHGQVTQYDAWTDDSMEGPSHSAEAVSIQDAMSVEEASGFHPLEPMLCSETEDGQVPHSLEALYQSAGCSTVSDALIVLVHLLMLESGYIPQGTEAKAASMPEKWKSSGVYKLQYTHPLCEGGSAVLTCVPLGKLIMINATIKVNGGIKNVKSVQLKPGAYVRRAEPGESAAKVYKDLKKLSRLFKDQLVYPLLAFTRQVLNLPDVFGLVVLPLELKLRIFRLLDVHSVLALSAVCHDLLIASNDPLLWRCLYLRDFRDSTIRGPDTDWKELYRKKHIQRKEAQRMRHVMYLPSVHPIPFCPIPVYPRPYLPTTLLPPGIIGGEYDERPILPSVGDPVTSLIPRPGEPPSQFRPVRPRFDPVGPLPGSNSLLPGRASPNNRFPFRPGRGRSADNRLPYL
Protein
F-box only protein 7: Fbxo7