fbxo31

F-box only protein 31

551 amino acids

Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. Specifically recognizes phosphorylated cyclin-D1 (ccnd1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest (By similarity).

Belongs to the FBXO31 family.

63.238 kDa

MAVCARLCGVGQSGGCRRRQQRKGAGNGPELEDEEEEDEVRIEAEVIGGQAAEAPRRPRSLLHLPPEILVEIFSSLPGTELPSLAQVCRKFRQILTTDTIWKRRCKQEYGVCENLRKLEVTGVSCRDVYVKRINPRVKSGRFMKILPDYEHMEYRDIYTCLLHQYRHILGLWQPDIGPYGGLLNVVVDGLFIIGWMYLPPHDPHVDEAMRLKPVFRIHLMERNDATVECMYGHKGPHNGQIQIVKKDEFSTKCIQTDYHRMSGGRQEEFRTWLREDLGRTLEDIFHEHMQELILMKFIYICQYDNCLTYRRIYHPPSRPDDLLNPGFFKGTYGSHGLEIVMLSFHGTIAKVTKITGDPNVPAGQQTLEVDLTRPVQLPDVEHLRNFDEMSRLILDVQAQIHREQRQTGNEEDDGRGAGPDKAEHSQQPAPVLRPANEDANKVDGGDGEEQKPPNVQSFVLPTGVMARNEEYPRSCKMCFYGTGLIAGHGFSSPERTPGLFILFDEDRFGFIWLELKSFSLYSRMRDRFQQSEAPSVEAFEEMLQNMQSWTT

FBXO31

F-box only protein 31

539 amino acids

Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. Specifically recognizes phosphorylated cyclin-D1 (CCND1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest. May act as a tumor suppressor.

Belongs to the FBXO31 family.

60.664 kDa

MAVCARLCGVGPSRGCRRRQQRRGPAETAAADSEPDTDPEEERIEASAGVGGGLCAGPSPPPPRCSLLELPPELLVEIFASLPGTDLPSLAQVCTKFRRILHTDTIWRRRCREEYGVCENLRKLEITGVSCRDVYAKLLHRYRHILGLWQPDIGPYGGLLNVVVDGLFIIGWMYLPPHDPHVDDPMRFKPLFRIHLMERKAATVECMYGHKGPHHGHIQIVKKDEFSTKCNQTDHHRMSGGRQEEFRTWLREEWGRTLEDIFHEHMQELILMKFIYTSQYDNCLTYRRIYLPPSRPDDLIKPGLFKGTYGSHGLEIVMLSFHGRRARGTKITGDPNIPAGQQTVEIDLRHRIQLPDLENQRNFNELSRIVLEVRERVRQEQQEGGHEAGEGRGRQGPRESQPSPAQPRAEAPSKGPDGTPGEDGGEPGDAVAAAEQPAQCGQGQPFVLPVGVSSRNEDYPRTCRMCFYGTGLIAGHGFTSPERTPGVFILFDEDRFGFVWLELKSFSLYSRVQATFRNADAPSPQAFDEMLKNIQSLTS

Fbxo31

F-box only protein 31

507 amino acids

Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. Specifically recognizes phosphorylated cyclin-D1 (CCND1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest (By similarity).

Belongs to the FBXO31 family.

57.191 kDa

MAVCARLCGVGPARGCRRRQQRRGPAETAAADSEADTDPEEERIEAGPARCSLLELPPELLVEIFASLPGTDLPSLAQVCSRFRRILHTDTIWRRRCREEYGVCENLRKLEITGVSCRDVYAKLLHRYRHILGLWQPDIGPYGGLLNVVVDGLFIIGWMYLPPHDPHVGDPMRFKPLFRIHLMERKSATVECMYGHKGPHNGHIQIVKRDEFSTKCNQTDHHRMSGGRQEEFRTWLREEWGRTLEDIFHEHMQELILMKFIYTSQYDNCLTYRRIYLPPSHPDDLIKPGLFKGTYGSHGLEIVMLSFHGSRARGTKITGDPNIPAGQQTVEIDLQRRIQLPDVENLRNFNELSRIVLEVREQVRQEQEAGEGAAPPREPSAKAADGPPAKDGKEPGGGAEAAEQSASSGQGQPFVLPVGVSSRNEDYPRTCRLCFYGTGLIAGHGFTSPERTPGVFVLFDEDRFGFLWLELKSFSLYSRVQATFQNAAAPSPQAFDEMLRNIQSLTS

Fbxo31

F-box only protein 31

507 amino acids

Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. Specifically recognizes phosphorylated cyclin-D1 (CCND1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest (By similarity).

Belongs to the FBXO31 family.

57.399 kDa

MAVCARLCGVGPARGCRRRQQRRGPAETAAADSEADTDPEEERIEAGPARCSLLELPPELLVEIFASLPGTDLPSLAQVCSRFRRILHTDTIWRRRCREEYGVCENLRKLEITGVSCRDVYAKLLHRYRHILGLWQPDIGPYGGLLNVVVDGLFIIGWMYLPPHDPHVGDPMRFKPLFRIHLMERKSATVECMYGHKGPHNGHIQIVKRDEFSTKCNQTDHHRMSGGRQEEFRTWLREEWGRTLEDIFHEHMQELILMKFIYTSQYDNCLTYRRIYLPPSHPDDLIKPGLFKGTYGSHGLEIVMLSFHGSRARGTKITGDPNIPAGQQTVEIDLQRRIQLPDVENLRNFNELSRIVLEVREQVRQEQEAGEGPAPHREPAVKDPEGPPAKASKEAGPGAEAAEQSSTSGQGQPFVLPAGVSSRNEDYPRTCRLCFYGTGLIAGHGFTSPERTPGVFVLFDEDRFGFLWLELKSFSLYSRVQATFQNADAPSPQAFDEMLRNIQSLTS