Fbln1

Fibulin-1

705 amino acids

Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes.

Belongs to the fibulin family.

78.033 kDa

MERPVPSRLVPLPLLLLSSLSLLAARANADISMEACCTDGNQMANQHRDCSLPYTSESKECRMVQEQCCHNQLEELHCATGINLASEPEGCASLHSYNSSLETIFIKRCCHCCMLGKASLARDQTCEPIVMISYQCGLVFRACCVKARENSDFVQGNGADLQDPAKIPDEEDQEDPYLNDRCRGGGPCKQQCRDTGDEVICSCFVGYQLQSDGVSCEDINECITGSHNCRLGESCINTVGSFRCQRDSSCGTGYELTEDNNCKDIDECETGIHNCPPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCIDINECLSISAPCPVGQTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECSPPAEPCGKGHHCLNSPGSFRCECKAGFYFDGISRTCVDINECQRYPGRLCGHKCENTPGSFHCSCSAGFRLSVDGRSCEDVNECLNSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGSFRCLSFECPENYRRSADTFRQEKTDTVRCIKSCRPNDEACVRDPVHTVSHTVISLPTFREFTRPEEIIFLRAVTPLYPANQADIIFDITEGNLRDSFDIIKRYEDGMTVGVVRQVRPIVGPFYAVLKLEMNYVLGGVVSHRNVVNVHIFVSEYWF

FBLN1

Fibulin-1

704 amino acids

Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes.

Belongs to the fibulin family.

78.138 kDa

MDKLRGARPLRLLLLLLALLPALRGQDLSMEECCDKGVEWANKNRICTSLPLISESRECSMTQVQCCRSKLEEHYCSDGIEFASVHEECDSHNGENSTCEAEYFKKCCYCCLLGKTAQVQGQSCEPNLKIGYQCGIVFRACCVKGQEGTDVSISDDAPKKEQVEISKEELDQEDPYLHDGCRGGGPCSQQCRDTGSSYVCSCFVGYQLQPDGVNCEDINECITGTHSCGIGQTCVNTLGSFRCQRDTSCGTGYELTDDSRCKDIDECETGTHNCPPDFICQNTPGSFRCRPKLQCMNGFIQDALGNCIDINECLSTNMPCPAGQICINTDGSYTCQRISPSCGRGYHLNEDGTRCVDVDECSSSDQPCGEGHVCINGPGNYRCECKSGYSFDVISRTCIDINECRRYPGRLCAHKCENTPGSYYCTCTMGFKLSSDGRSCEDLNECESSPCSQECANVYGSYQCYCRRGFQLSDIDGISCEDIDECALPTGGHICSFRCINIPGSFQCTCPSTGYRLAPNARNCQDIDECVAETHNCSFNETCFNIQGGFRCLSLECPENYRKSGDTVRLEKTDTIRCIKSCRPNDVNCVLDPVHTISHTVISLPTFREFTRPEEIIFLRAITPTYPANQADIIFDITEGNLRESFDIIKRYMDGMTVGVVRQVRPIVGPFHAILKLEMNYVMGGVVSHRNIVNVHIFVSEYWF

FBLN1

Fibulin-1

703 amino acids

Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. Has been implicated in a role in cellular transformation and tumor invasion, it appears to be a tumor suppressor. May play a role in haemostasis and thrombosis owing to its ability to bind fibrinogen and incorporate into clots. Could play a significant role in modulating the neurotrophic activities of APP, particularly soluble APP.

Belongs to the fibulin family.

77.214 kDa

MERAAPSRRVPLPLLLLGGLALLAAGVDADVLLEACCADGHRMATHQKDCSLPYATESKECRMVQEQCCHSQLEELHCATGISLANEQDRCATPHGDNASLEATFVKRCCHCCLLGRAAQAQGQSCEYSLMVGYQCGQVFQACCVKSQETGDLDVGGLQETDKIIEVEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDECESGIHNCLPDFICQNTLGSFRCRPKLQCKSGFIQDALGNCIDINECLSISAPCPIGHTCINTEGSYTCQKNVPNCGRGYHLNEEGTRCVDVDECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYLCSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPSSGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENYRRSAATLQQEKTDTVRCIKSCRPNDVTCVFDPVHTISHTVISLPTFREFTRPEEIIFLRAITPPHPASQANIIFDITEGNLRDSFDIIKRYMDGMTVGVVRQVRPIVGPFHAVLKLEMNYVVGGVVSHRNVVNVHIFVSEYWF

fbln1

Fibulin-1

681 amino acids

Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes.

Belongs to the fibulin family.

74.46 kDa

MDLYMIVLLSLCGLLRAQETTDTISLDNCCEDGKKRGLESQDCSSLPLISESTTCRVVQEQCCSAVLEDSICTSGINMAKDQSSCDALLSGSSTCETKTTKMCCECCLLGSSRCRIRVSPVSSVCRWSISRGPGVRSCCVDKQPAHGVQPSKGDAQNTEDQCRAAGCAQRCLNGTCSCLDGFKLKTDGKHCEDINECLLGPHHCVTGERCINTLGSYRCQREISCGTGYELTDNNKCKDIDECDLGTHNCAAEMECQNTAGSFRCRPRMQCAAGFIQDALGSCIDINECVSVTALSRGQMCFNTVGSFICQRHSVTCGRGYHLNAEGTRCVDIDECAGPDNSCDGHGCINLVGSYRCECRTGFIFNSISRSCEDIDECRNYPGRLCAHKCENILGSYKCSCTAGFKLADDGRNCDDVNECESSPCSQGCANVYGSYQSYCRRGYQLSDADGITCEDIDECALPTGGHICSYRCHNTPGSFHCTCPASGYTLAANGRSCQDIDECLTGTHSCSESESCFNIQGGFRCLSFDCPANYRRSGDTRPRVDRADIIRCVKSCQHNDISCVLNPILSHSHTAISLPTFREFNKPEEIVFLRSPTPTHLPHMDSPEIVYDILEGNIQNSFDIIKRLDHGMIVGVVKQVRPLVGPVRTVLKLAMNYVTNGVVSHRNIINVRIYVSEFWF

FBLN1

Fibulin-1

598 amino acids

Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. May serve to anchor the mature/soluble form of DTR to its fibers as it migrates through the extracellular matrix. The direct physical association with DTR may be useful in such tissue developmental processes as wound healing.

Belongs to the fibulin family.

65.517 kDa

single

ANEQDHCAAPRGDNASLEATFVKRCCHCCLLGRAAQAQGQSCEYNLMVGYQCGQVFRACCVKSQETGDLDVRSLQETDKITEVEEEQEDPYLNDRCRGGGPCKQQCRDTGDEVVCSCFVGYQLLSDGVSCEDVNECITGSHSCRLGESCINTVGSFRCQRDSSCGTGYELTEDNSCKDIDQCESGIHNCLPDFICQNTLGSFRCRPKLQCKNGFIQDALANCIDINECLSIVSAPCPTGHTCINTEGSYTQKNVPNCGRGYHLNEEGTRCDVNECAPPAEPCGKGHRCVNSPGSFRCECKTGYYFDGISRMCVDVNECQRYPGRLCGHKCENTLGSYVCSCSVGFRLSVDGRSCEDINECSSSPCSQECANVYGSYQCYCRRGYQLSDVDGVTCEDIDECALPTGGHICSYRCINIPGSFQCSCPASGYRLAPNGRNCQDIDECVTGIHNCSINETCFNIQGGFRCLAFECPENYRRSAATRCERLPCHENRECSKLPLRITYYHLSFPTNIQAPAVVFRMGPSSAVPGDSMQLAITGGNEEGFFTTRKVSPHSGVVALTKPVPEPRDLLLTVKMDLYRHGTVSSFVAKLFIFVSAEL