FAM83D

Protein FAM83D

585 amino acids

Probable proto-oncogene that regulates cell proliferation, growth, migration and epithelial to mesenchymal transition. Through the degradation of FBXW7, may act indirectly on the expression and downstream signaling of MTOR, JUN and MYC (PubMed:24344117). May play also a role in cell proliferation through activation of the ERK1/ERK2 signaling cascade (PubMed:25646692). May also be important for proper chromosome congression and alignment during mitosis through its interaction with KIF22.

Belongs to the FAM83 family.

64.424 kDa

MALLSEGLDEVPAACLSPCGPPNPTELFSESRRLALEELVAGGPEAFAAFLRRERLARFLNPDEVHAILRAAERPGEEGAAAAAAAEDSFGSSHDCSSGTYFPEQSDLEPPLLELGWPAFYQGAYRGATRVETHFQPRGAGEGGPYGCKDALRQQLRSAREVIAVVMDVFTDIDIFRDLQEICRKQGVAVYILLDQALLSQFLDMCMDLKVHPEQEKLMTVRTITGNIYYARSGTKIIGKVHEKFTLIDGIRVATGSYSFTWTDGKLNSSNLVILSGQVVEHFDLEFRILYAQSKPISPKLLSHFQSSNKFDHLTNRKPQSKELTLGNLLRMRLARLSSTPRKADLDPEMPAEGKAERKPHDCESSTVSEEDYFSSHRDELQSRKAIDAATQTEPGEEMPGLSVSEVGTQTSITTACAGTQTAVITRIASSQTTIWSRSTTTQTDMDENILFPRGTQSTEGSPVSKMSVSRSSSLKSSSSVSSQGSVASSTGSPASIRTTDFHNPGYPKYLGTPHLELYLSDSLRNLNKERQFHFAGIRSRLNHMLAMLSRRTLFTENHLGLHSGNFSRVNLLAVRDVALYPSYQ

Fam83d

Protein FAM83D

585 amino acids

Probable proto-oncogene that regulates cell proliferation, growth, migration and epithelial to mesenchymal transition. Through the degradation of FBXW7, may act indirectly on the expression and downstream signaling of MTOR, JUN and MYC. May play also a role in cell proliferation through activation of the ERK1/ERK2 signaling cascade. May also be important for proper chromosome congression and alignment during mitosis through its interaction with KIF22.

Belongs to the FAM83 family.

64.324 kDa

MAARFELLDDLPAACLSPCGPPNPTELFSEARRLALEQLLAGGPDAWAAFLRRERLGRFLNADEVREVLGAAERPGEDGAAVAEDSFGSSHECSSGTYFPEQSDLEPPALELGWPSFYQGAYRGATRVEAHFQPRGAGAGGPYGCKDALRQQLRSAREVIAVVMDVFSDIDIFRDLQESCRKRGVAVYILLDQTLLPHFLDMCMDLRVHPEQEKLMTVRTITGNIYYARSGTKVVGKVHEKFTLIDGIRVATGSYSFTWTDGKLNSSNLVILSGQVVEHFDLEFRILYAQSEPISSKLLSNFQINSKFDHLADRKPQSKEPTLGNLLRMRLARLSSTPRKSNLGPEEPPKDRAKPKRPDSEASTISDEDYFHSHKDQLEDSKVADAATQTEPREEMAAVSLSEVGTQTSSSMMCVGTQTTVVTRAASSQATVWSKSTTTQTEADESFLPQGAQSKEGSPASKMSVSRSSSVRSSSSVSSQGSLASSVSSHVSLTAADLHTPAYPKYLGLGTPHLDLCLRDSFRNLSKERQVHFTGIRSRLTQMLTVLSRRTLFTEHYLSYSPGSFTRASTNLVSVRDIALYPPYQ

FAM83D

Protein FAM83D

581 amino acids

Probable proto-oncogene that regulates cell proliferation, growth, migration and epithelial to mesenchymal transition. Through the degradation of FBXW7, may act indirectly on the expression and downstream signaling of MTOR, JUN and MYC. May play also a role in cell proliferation through activation of the ERK1/ERK2 signaling cascade. May also be important for proper chromosome congression and alignment during mitosis through its interaction with KIF22.

Belongs to the FAM83 family.

63.396 kDa

MALRYDGLDELPAACLSPCGPPNPAELYSEERRLALEELLAGGPGAFSAFLRRERLGRFLNPDEVRSILRAAERPGEEGAAAGAEDSFGSSHDCSSGTYFPEQSDLEPPLLELGWPAFYQGAYRGATRVEAHFQPRGAGAGGPYGCKDALRQQLRLAREVIAVVMDVFTDIDIFRDLQEISRKQGVAVYILLDQALLSQFLDMCMDLKVHPEEEKLMTVRTITGNIYYARSGTKIVGKVHEKFTLIDGIRVATGSYSFTWTDGKLNSSNLVILSGQVVEHFDLEFRILYAQSKPISSKLLSSFRISGRFDHLVDQKPLSKELTLGNLLRLRLARLSSTPRKVELGGEEGRAEAVCGASKTSTISEEDYFSSRKDRLEGRRVTDAATQTEPGETPAVSMSDVGTQASAATACTGTQTTVATRVVSSQTVVPTTSATTQTDVDEGVLASPGSQSKEGSPVSKMSVSRSSSLRSSSSLSSQGSVASSIGSQTSFRSTDFATPGPPKYQSTPHFDLCFRDSLRNLNKERQFHFAGIRSRLNHMLAMLSRKTFLTENYLSFNSGSFARSSANLLAVREIMLYPSYQ

fam83d

Protein FAM83D

534 amino acids

May regulate cell proliferation, growth, migration and epithelial to mesenchymal transition. May also be important for proper chromosome congression and alignment during mitosis.

Belongs to the FAM83 family.

60.002 kDa

MALSQCLEDSPGWRTPRKEQDSNLNELYNERHRLALEELVAGGVQSFMGFLKKERMPNFLSEDEIRRVSRAAVVPKTISINGDDSHLDQSGTLDCSSVTYFPEVSDIEPPVLENGWPAFTTGSYRGVTRAVAYFQPSYGECIYSCKEAARRMIRNAKEVIAIVTDSMTDLDIFHDLREACTRRRVPVYILLDQSSVASFLQMCKNLCVHLDELLQMKVRTITGSTYYMRSGARITGKVHERFMLIDGNKVATGSYRFNWTDGKLNSSNLIELSGQITEKFDEEFRILYAQSLPLPVNTRAPSSARNCSLYDHLVLKAPGTPPSYLARTTKPQAERLTSTPARLQTPEIQRMNKDIEEPDRKSNPVSDSSTLGEDLELPLASADPPRLPSTTVNSQTQTVDVTIVSCCDVSTQTTCHTADVSVQTCKEPQNSKPSSEHQEVDSCPPICPLPQDVNFRECFLKITKERQHHYSSIRSKLDHMVTLLSHKRELVDLTNLPLRPGLNRGRKAQQEARQPNTNIDSGIMGTWPKSRGLQ