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FAM162A

Gene
FAM162A
Protein
Protein FAM162A
Organism
Bos taurus
Length
156 amino acids
Function
Proposed to be involved in regulation of apoptosis; the exact mechanism may differ between cell types/tissues. May be involved in hypoxia-induced cell death of transformed cells implicating cytochrome C release and caspase activation (such as CASP9) and inducing mitochondrial permeability transition. May be involved in hypoxia-induced cell death of neuronal cells probably by promoting release of AIFM1 from mitochondria to cytoplasm and its translocation to the nucleus (By similarity).
Similarity
Belongs to the UPF0389 family.
Mass
17.737 kDa
Sequence
MGSLRGLRLVAGSCFRSCERDAFSSLRLTRNSDLKRTNGFCSKPQESPKPPDQHTYSHRVPLHKPTDWEKKILIWSGRFKKEDEIPETVSFEMLDAAKNKVRVKISYVMIALTVAGCVLMVIEGKKAARRNETLTSLNLEKKARLREEAAMKAKTE

Gene
Fam162a
Protein
Protein FAM162A
Organism
Mus musculus
Length
155 amino acids
Function
Proposed to be involved in regulation of apoptosis; the exact mechanism may differ between cell types/tissues. May be involved in hypoxia-induced cell death of transformed cells implicating cytochrome C release and caspase activation (such as CASP9) and inducing mitochondrial permeability transition. May be involved in hypoxia-induced cell death of neuronal cells probably by promoting release of AIFM1 from mitochondria to cytoplasm and its translocation to the nucleus; however, the involvement of caspases has been reported conflictingly.
Similarity
Belongs to the UPF0389 family.
Mass
17.725 kDa
Sequence
MWSLGGLRLAAGHCLRLYERNASSSLRFTRNTDLKRINGFCTKPQESPKTPTQSYRHGVPLHKPTDFEKKILLWSGRFKKEEEIPETISFEMLDAAKNKLRVKVSYLMIALTVAGCIYMVIEGKKAAKRHESLTSLNLERKARLREEAAMKAKTD

Gene
Fam162a
Protein
Protein FAM162A
Organism
Rattus norvegicus
Length
155 amino acids
Function
Proposed to be involved in regulation of apoptosis; the exact mechanism may differ between cell types/tissues. May be involved in hypoxia-induced cell death of transformed cells implicating cytochrome C release and caspase activation (such as CASP9) and inducing mitochondrial permeability transition. May be involved in hypoxia-induced cell death of neuronal cells probably by promoting release of AIFM1 from mitochondria to cytoplasm and its translocation to the nucleus.
Similarity
Belongs to the UPF0389 family.
Mass
17.827 kDa
Sequence
MWSLRGLRLAAGHCFRLCERNVSSPLRLTRNTDLKRINGFCTKPQESPKAPTQSYRHRVPLHKPTDFEKKILLWSGRFKKEEEIPETISFEMLDAAKNKIRVKVSYLMIALTVAGCVYMVIEGKKAAKRHESLTSLNLERKARLREEAAMKAKAD

Gene
FAM162A
Protein
Protein FAM162A
Organism
Homo sapiens
Length
154 amino acids
Function
Proposed to be involved in regulation of apoptosis; the exact mechanism may differ between cell types/tissues. May be involved in hypoxia-induced cell death of transformed cells implicating cytochrome C release and caspase activation (such as CASP9) and inducing mitochondrial permeability transition. May be involved in hypoxia-induced cell death of neuronal cells probably by promoting release of AIFM1 from mitochondria to cytoplasm and its translocation to the nucleus; however, the involvement of caspases has been reported conflictingly.
Similarity
Belongs to the UPF0389 family.
Mass
17.342 kDa
Sequence
MGSLSGLRLAAGSCFRLCERDVSSSLRLTRSSDLKRINGFCTKPQESPGAPSRTYNRVPLHKPTDWQKKILIWSGRFKKEDEIPETVSLEMLDAAKNKMRVKISYLMIALTVVGCIFMVIEGKKAAQRHETLTSLNLEKKARLKEEAAMKAKTE

Gene
FAM162A
Protein
Protein FAM162A
Organism
Pongo abelii
Length
154 amino acids
Function
Proposed to be involved in regulation of apoptosis; the exact mechanism may differ between cell types/tissues. May be involved in hypoxia-induced cell death of transformed cells implicating cytochrome C release and caspase activation (such as CASP9) and inducing mitochondrial permeability transition. May be involved in hypoxia-induced cell death of neuronal cells probably by promoting release of AIFM1 from mitochondria to cytoplasm and its translocation to the nucleus (By similarity).
Similarity
Belongs to the UPF0389 family.
Mass
17.502 kDa
Sequence
MGSLSGLRLAAGSCFRLCERDVFSSLRLTRSSDLKRINGFCTKPQESPRAPSRTYNRVPLHKPTEWQKKILVWSGRFKKEDEIPETVSLEMLDTAKNKMRVKISYLMIALTVVGCICMVIEGKKAAQRHESLTSLNLEKKARLREEAAMKAKTE