FAM126A

Hyccin

521 amino acids

Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane (PubMed:26571211). The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (PubMed:26571211). FAM126A plays a key role in oligodendrocytes formation, a cell type with expanded plasma membrane that requires generation of PtdIns(4)P (PubMed:26571211). Its role in oligodendrocytes formation probably explains its importance in myelination of the central and peripheral nervous system (PubMed:26571211, PubMed:16951682). May also have a role in the beta-catenin/Lef signaling pathway (Probable).

Belongs to the FAM126 family.

57.625 kDa

MFTSEKGVVEEWLSEFKTLPETSLPNYATNLKDKSSLVSSLYKVIQEPQSELLEPVCHQLFEFYRSGEEQLLQFTLQFLPELIWCYLAVSASRNVHSSGCIEALLLGVYNLEIVDKQGHTKVLSFTIPSLSKPSVYHEPSSIGSMALTESALSQHGLSKVVYSGPHPQREMLTAQNRFEVLTFLLLCYNAALTYMPSVSLQSLCQICSRICVCGYPRQHVRKYKGISSRIPVSSGFMVQMLTGIYFAFYNGEWDLAQKALDDIIYRAQLELYPEPLLVANAIKASLPHGPMKSNKEGTRCIQVEITPTSSRISRNAVTSMSIRGHRWKRHGNTELTGQEELMEISEVDEGFYSRAASSTSQSGLSNSSHNCSNKPSIGKNHRRSGGSKTGGKEKETTGESCKDHFARKQTQRAQSENLELLSLKRLTLTTSQSLPKPSSHGLAKTAATVFSKSFEQVSGVTVPHNPSSAVGCGAGTDANRFSACSLQEEKLIYVSERTELPMKHQSGQQRPPSISITLSTD

Fam126a

Hyccin

521 amino acids

Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis. FAM126A plays a key role in oligodendrocytes formation, a cell type with expanded plasma membrane that requires generation of PtdIns(4)P. Its role in oligodendrocytes formation probably explains its importance in myelination of the central and peripheral nervous system. May also have a role in the beta-catenin/Lef signaling pathway.

Belongs to the FAM126 family.

57.321 kDa

MFTSEIGVVEEWLSEFKTLPETSLPNYATNLKDKSSLVTSLYKVIQEPQSELLEPVCHQLFEFYRSGEEQLLRFTLQFLPELMWCYLAVSASRDVHSSGCIEALLLGVYNLEIVDKHGHSKVLSFTIPSLSKPSVYHEPSSIGSMALTESALSQHGLSKVVYSGPHPQREMLTAQNRFEVLTFLLLCYNAALTYMPSVSLQSLCQICSRICVCGYPRQHVRKYRGVSSRIPISSGFMVQMLTGVYFAIYNGEWDLAQKALDDIIYRAQLELYPEPLLVANAIKASLPHGAMKSSKEGTRCIQVEITPTSSRISRNAVTSMSIRGHRWKRHGDTELTGQEELMDITEVDEGFYSRAASSTSQSGLSNSSHNCSNKTSVGKNQRRSGGSKAGAKERETAGESCRDHFARKQTQRAQSENLELLSLKRLTLTSSQSLPKPSSQGLAKTAATVFSKSFEQVSGAPVPRSPSPAIGCVAGADANRFSACSLQEEKLIYVSERTELAVKCQAGQQGPPSISVTLSAE

fam126a

Hyccin

518 amino acids

Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis.

Belongs to the FAM126 family.

56.428 kDa

MLAMDQGVVEEWLSEFKTLEETAVYNYAVSLKEKGSLVPALYKVIRENYSDLLEPVCHQLFEFYRSGEPRLQRFTLQFLPELVWSYLSVTAARDPHCSGCIEALLLGIYNLEIVDKDGQSKVLSFTIPSLSKPSVYHEPSSIGSLALTEGALANHGLSRVVYSGPHLQRETFTAQNRFEVLTFLLLCYNASLSYMSGSSLQSLCQLSSRVSICGYPRQQVRRYKGISSRLMVTSEFLVQLITGIHFALCNGEVDLGSKALDDVLYRAQLELFPEALLVGNAIKSSLHGASLKSNKEGTRSIQVEITPTASRISRNAVTSLSIRGHRWKRHDAVDLGSPDELTEIAEVDEGICTQASGAQSSPPTIVISSSAGGAAAGAGKLAGKGLRRLTGRSSKEKDKEKDAATGMDQLTRKQAAVRAMSENLELLSLKRLTLTASQSVPKSGSLSLSRTASAVFSRSFEQVSNVFSGNQPSSRASSPTSNHVAEQDEGVAYLDHISPAHQHRQRSPTISIHVTSDL

FAM126A

Hyccin

515 amino acids

Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis.

Belongs to the FAM126 family.

56.995 kDa

MLAVDTGLVEEWLSEFKTLPEASISSYATNLKDKTALISSLYKVIQEPQSELLEPVCHQLFEFYRSGEEQLLRFTLQFLPELMWCYLAVSASRDLQSSGCIEALLLGVYNLEIVDKEGHSKVLSFTIPSLSKPSVYHEPSSIGSMALTEGALSQHGLSRVVYSGPHPQREMLTAQNRFEVLTFLLLCYNAALSYMPAISLQSLCQICSRICVCGYPRQQVRKYKGVNSRIPVSSEFMVQMLTGIYYAFYNGEWDLARKAMDDVLYRAQLELYPEPLLVANAIKASLPQGAMKSSKEGTKCIQVEITPTSSRISRNAVTSMSIRGHRWKRHGNADLGIEEELIEVSETDEGFYSRAASSTSQSALSNSSNTSSKNLLGKSQRRSGGSKAAGREKEGETCREHLSRKQTQRALSENLELVSLKRLTLTTSQSLPKPGSHSLARTTTTVFSKSFEQVSGVTVANNRGGVSGTEANRFSACSLQEEKLIYGTERTDLPVLSKQPNQQRPPSISITLSTD