FAF2

FAS-associated factor 2

445 amino acids

Plays an important role in endoplasmic reticulum-associated degradation (ERAD) that mediates ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway. Involved in inhibition of lipid droplet degradation by binding to phospholipase PNPL2 and inhibiting its activity by promoting dissociation of PNPL2 from its endogenous activator, ABHD5 which inhibits the rate of triacylglycerol hydrolysis.

52.664 kDa

MAAPEERDLTQEQTEKLLQFQDLTGIESMDQCRHTLEQHNWNIEAAVQDRLNEQEGVPSVFNPPPSRPLQVNTADHRIYSYVVSRPQPRGLLGWGYYLIMLPFRFTYYTILDIFRFALRFIRPDPRNRVTDPVGDIVSFMHSFEEKYGRAHPVFYLGTYSQALNDAKRELRFLLVYLHGDDHQDSDEFCRNTLCAPEVISLINTRMLFWACSTNKPEGYRVSQALRENTYPFLAMIMLKDRRMTVVGRLEGLIQPDDLINQLTFIMDANQTYLVSERLEREERNQTQVLRQQQDEAYLASLRADQEKERKKREERERKRRKEEEVQQQKLAEERRRRNLQEEKERKLECLPPEPSPDDPESVKIIFKLPNDSRVERRFHFSQSLTVIHDFLFSLKESPEKFQIEANFPRRVLPCLPSEEWPNPPTLQEAGLSHTEVLFVQDLTDE

FAF2

FAS-associated factor 2

445 amino acids

Plays an important role in endoplasmic reticulum-associated degradation (ERAD) that mediates ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins (PubMed:18711132, PubMed:24215460). By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333). Involved in inhibition of lipid droplet degradation by binding to phospholipase PNPL2 and inhibiting its activity by promoting dissociation of PNPL2 from its endogenous activator, ABHD5 which inhibits the rate of triacylglycerol hydrolysis (PubMed:23297223).

52.623 kDa

MAAPEERDLTQEQTEKLLQFQDLTGIESMDQCRHTLEQHNWNIEAAVQDRLNEQEGVPSVFNPPPSRPLQVNTADHRIYSYVVSRPQPRGLLGWGYYLIMLPFRFTYYTILDIFRFALRFIRPDPRSRVTDPVGDIVSFMHSFEEKYGRAHPVFYQGTYSQALNDAKRELRFLLVYLHGDDHQDSDEFCRNTLCAPEVISLINTRMLFWACSTNKPEGYRVSQALRENTYPFLAMIMLKDRRMTVVGRLEGLIQPDDLINQLTFIMDANQTYLVSERLEREERNQTQVLRQQQDEAYLASLRADQEKERKKREERERKRRKEEEVQQQKLAEERRRQNLQEEKERKLECLPPEPSPDDPESVKIIFKLPNDSRVERRFHFSQSLTVIHDFLFSLKESPEKFQIEANFPRRVLPCIPSEEWPNPPTLQEAGLSHTEVLFVQDLTDE

Faf2

FAS-associated factor 2

445 amino acids

Plays an important role in endoplasmic reticulum-associated degradation (ERAD) that mediates ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway. Involved in inhibition of lipid droplet degradation by binding to phospholipase PNPL2 and inhibiting its activity by promoting dissociation of PNPL2 from its endogenous activator, ABHD5 which inhibits the rate of triacylglycerol hydrolysis.

52.471 kDa

MAAPEEQDLTQEQTEKLLQFQDLTGIESMEQCRLALEQHNWNMEAAVQDRLNEQEGVPSVFNPPPARPLQVNTADHRIYSYVVSRPQPRGLLGWGYYLIMLPFRFTYYTILDIFRFALRFIRPDPRSRVTDPVGDIVSFMHSFEEKYGRAHPVFYQGTYSQALNDAKRELRFLLVYLHGDDHQDSDEFCRNALCAPEVISLINSRMLFWACSTNKPEGYRVSQALRENTYPFLAMIMLKDRRMTVVGRLEGLIQPDDLINQLTFIMDANQTYLVSERLEREERNQTQVLRQQQDEAYLASLRADQEKERKKREEKERKRRKEEEVQQQKLAEERRRQNLQEEKERKLECLPPEPSPDDPESVKIIFKLPNDSRVERRFHFSQSLTVIHDFLFSLKESPEKFQIEANFPRRVLPCVPSEEWPNPPTLQEAGLSHTEVLFVQDLTDE

faf2

FAS-associated factor 2

445 amino acids

Plays an important role in endoplasmic reticulum associated degradation (ERAD) that mediates ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Involved in inhibition of lipid droplet degradation.

52.395 kDa

MAAPEERELSQEQTEKLLQFQDLTGIESMDQCRQTLQQHNWNIEAAVQDRLNEQEGVPSVFNTTPNRPLQVNTADHRVYSYVVSRPQPRGLLGWGYYLIMLPFRITYYTLLDIFRFAVRFIRPDPRSRVTDPVGDVVSFIQLFEEKYGRIHPVFYQGTYSQALNDAKQELRFLLVYLHGEDHQDSDDFCRNTLCIPEVTNFLNSRMLFWACSTNKPEGFRVSQALRENTYPFLAMIMLKDRRMTVVGRLEGLIQPQDLINQLTFIVEANQTYLVSERLEREERNQTQVLRQQQDEAYLASLRADQEKERKKKEKQEQKRREEEEAQLKQMLEERKKRNLEEEKERKSECLPAEPVPDHPDNVKIIFKMPNGTRVERRFLFTQSLSVIHDFLFSLKETPEKFQIVTNFPRRVLPCLPSEEIPVPPTLQEAGLSQSQLLFVQDLTDD

Faf2

FAS-associated factor 2

346 amino acids

Plays an important role in endoplasmic reticulum-associated degradation (ERAD) that mediates ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway. Involved in inhibition of lipid droplet degradation by binding to phospholipase PNPL2 and inhibiting its activity by promoting dissociation of PNPL2 from its endogenous activator, ABHD5 which inhibits the rate of triacylglycerol hydrolysis.

41.08 kDa

MLPFRFTYYTILDIFRFALRFIRPDPRSRVTDPVGDIVSFMHSFEEKYGRAHPVFYQGTYSQALSDAKRELRFLLVYLHGDDHQDSDEFCRNALCAPEVISLINSRMLFWACSTNKPEGYRVSQALRENTYPFLAMIMLKDRRMTVVGRLEGLIQPDDLINQLTFIMDANQTYLVSERLEREERNQTQVLRQQQDEAYLASLRADQEKERKKREERERKRRKEEEVQQQKLAEERRRQNLQEEKERKLECLPPEPSPDDPDSVKIIFKLPNDSRVERRFHFSQSLTVIHDFLFSLKESPEKFQIEANFPRRVLPCVPSEEWPNPPTLQEAGLSHTEVLFVQDLTDE

FAF2

Protein FANTASTIC FOUR 2

240 amino acids

Regulates the size of the shoot meristem by modulating the CLV3-WUS feedback loop. Can repress WUS but is under negative control by CLV3.

Belongs to the fantastic four family.

27.255 kDa

MSLVVCQPQINESFYQKDDMGGLSFLQSMSDITSIAQTKEDKAYVHPMEKRSVSKLNEKSLEMCTESLGTETGSESGDELSLLAFEATTTPRAPPRQLKPQEDTNLPDKTPPMSRNNSFPPPIKFVEDSKYNRMVRWLGEDGRIVVQAIRVSSPPSCFVSERGEGRLRLILTSESSLLSHNHEEEEEEETEEGIDEETSENLEGKSGNKKFSRFSRRCKENGREPKPMLTWKQQQFWVAT

FAF2

Protein FANTASTIC FOUR 2

240 amino acids

Regulates the size of the shoot meristem by modulating the CLV3-WUS feedback loop. Can repress WUS but is under negative control by CLV3.

Belongs to the fantastic four family.

27.255 kDa

MSLVVCQPQINESFYQKDDMGGLSFLQSMSDITSIAQTKEDKAYVHPMEKRSVSKLNEKSLEMCTESLGTETGSESGDELSLLAFEATTTPRAPPRQLKPQEDTNLPDKTPPMSRNNSFPPPIKFVEDSKYNRMVRWLGEDGRIVVQAIRVSSPPSCFVSERGEGRLRLILTSESSLLSHNHEEEEEEETEEGIDEETSENLEGKSGNKKFSRFSRRCKENGREPKPMLTWKQQQFWVAT