FADX

Delta(12) acyl-lipid conjugase (11E,13E-forming)

399 amino acids

Converts linoleic acid to alpha-eleostearic acid (18:3(9Z,11E,13E)) and alpha-linolenic acid to alpha-parinaric acid (18:4(9Z,11E, 13E, 15Z)). Converts a single cis double bond at carbon 12 to two conjugated trans bonds at positions 11 and 13.

Belongs to the fatty acid desaturase type 1 family.

45.57 kDa

MGGRGAIGVLRNGGGPKKKMGPGQGLGPGERITHARPPFSISQIKKAIPPHCFQRSLRRSFSYLLSDIALVSAFYYVADTYFHRLPHPLLHYLAWPVYWFCQGAVLTGMWGIAHDCGHHAFSDYQLVDDVVGFLIHSLVFVPYFSFKISHRRHHSNTSSVDRDEVFVPKPKAKMPWYFKYLTNPPARVFIIFITLTLGWPMYLTFNISGRYYGRFTSHFDPNSPIFSPKERVLVHISNAGLVATGYLLYRIAMAKGVGWLIRLYGVPLIVLNACVVLITALQHTHPSFPYYDSTEWDWLRGNLVTVDRDYGPIMNRVFHHITDTHVVHHLFPSMPHYNGKEATVAAKRILGEYYQFDGTPIWKAAWREFRECVYVEPDEDDGATSGSSSKGVFWYHNKL

FADX

Bifunctional fatty acid conjugase/Delta(12)-oleate desaturase

395 amino acids

Converts a single cis double bond at position 12 of linoleate incorporated into phosphatidylcholine into conjugated 11-trans and 13-cis double bonds (PubMed:12354116, PubMed:12464604, PubMed:25000918). Produces punicic acid (18:3(9Z,11E,13Z)) from linoleic acid and conjugated octadecatetraenoic fatty acid from gamma-linolenic acid (PubMed:12354116, PubMed:25000918). No activity with cis- and trans-vaccenic acid, alpha-linolenic acid or homo-gamma-linolenic acid (PubMed:12354116). 16:2(9Z,12Z), 18:3(9Z,12Z,15Z) and 18:2(9Z,12Z) are substrates for the conjugase to form trans-Delta(11) and cis-Delta(13) double bonds (PubMed:12464604). No activity on the cis-Delta(9) double bonds of oleic and palmitoleic acids (PubMed:12464604).

Belongs to the fatty acid desaturase type 1 family.

45.828 kDa

MGADGTMSPVLTKRRPDQEINKLDIKPNHEVDIARRAPHSKPPFTLSDLRSAIPPHCFHRSLLMSSSYLIRDFALAFLFYHSAVTYIPLLPKPLACMAWPVYWFLQGSNMLGIWVIAHECGHQAFSNYGWVNDAVGFFLHTSLLVPYFPFKYSHRRHHSNTNSVEHDEVFVPRHKDGVQWYYRFFNNTPGRVLTLTLTLLVGWPSYLAFNASGRPYDGFASHYNPNAQIFNLRERFWVHVSNIGILAIYYILYRLATTKGLPWLLSIYGVPVLILNAFVVLITFLQHSHPALPHYNSDEWDWLRGALATVDRDYGFLNEVFHDITDTHVIHHLFPTMPHYNAKEATVSIRPILKDYYKFDRTPIWRALWREAKECLYVEADGTGSKGVLWFKSKF

FADX

Delta(12) acyl-lipid conjugase (11E,13E-forming)

383 amino acids

Converts linoleic acid to alpha-eleostearic acid (18:3(9Z,11E,13E)) and alpha-linolenic acid to alpha-parinaric acid (18:4(9Z,11E, 13E, 15Z)). Converts a single cis double bond at carbon 12 to two conjugated trans bonds at positions 11 and 13.

Belongs to the fatty acid desaturase type 1 family.

44.743 kDa

MGEVGPTNRTKTKLDKQQESENRVPHEPPPFTLSDLKKAIPPHCFERSLVKSFYHVIHDIIILSFFYYVAANYIPMLPQNLRYVAWPIYWAIQGCVQLGILVLGHECGHHAFSDYQWVDDMVGFVLHSSQLIPYFSWKHSHRRHHSNTASIERDEVYPPAYKNDLPWFAKYLRNPVGRFLMIFGALLFGWPSYLLFNANGRLYDRFASHYDPQSPIFNNRERLQVIASDVGLVFAYFVLYKIALAKGFVWLICVYGVPYVILNGLIVLITFLQHTHPNLPRYDLSEWDWLRGALSTVDRDYGMLNKVFHNVTDTHLVHHLFTTMPHYRAKEATEVIKPILGDYYKFDDTPFLKALWKDMGKCIYVESDVPGKNKGVYWYNNDI