F2R

Gene

F2r

Protein

Proteinase-activated receptor 1

Organism

Rattus norvegicus

Length

432 amino acids

Function

High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis.

Similarity

Belongs to the G-protein coupled receptor 1 family.

Mass

48.281 kDa

Sequence

MGPRRLLLVAVGLSLCGPLLSSRVPMRQPESERMYATPYATPNPRSFFLRNPSEDTFEQFPLGDEEEKNESIPLEGRAVYLNKSRFPPMPPPPFISEDASGYLTSPWLTLFIPSVYTFVFIVSLPLNILAIAVFVFRMKVKKPAVVYMLHLAMADVLFVSVLPFKISYYFSGTDWQFGSGMCRFATAACYCNMYASIMLMTVISIDRFLAVVYPIQSLSWRTLGRANFTCVVIWVMAIMGVVPLLLKEQTTQVPGLNITTCHDVLNETLLHGFYSYYFSAFSAIFFLVPLIISTVCYTSIIRCLSSSAVANRSKKSRALFLSAAVFCIFIVCFGPTNVLLIVHYLLLSDSPGTETAYFAYLLCVCVTSVASCIDPLIYYYASSECQKHLYSILCCRESSDSNSCNSTGQLMPSKMDTCSSHLNNSIYKKLLA

Protein

Proteinase-activated receptor 1: F2r

Gene

F2r

Protein

Proteinase-activated receptor 1

Organism

Mus musculus

Length

430 amino acids

Function

High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis.

Similarity

Belongs to the G-protein coupled receptor 1 family.

Mass

47.79 kDa

Sequence

MGPRRLLIVALGLSLCGPLLSSRVPMSQPESERTDATVNPRSFFLRNPSENTFELVPLGDEEEEEKNESVLLEGRAVYLNISLPPHTPPPPFISEDASGYLTSPWLTLFMPSVYTIVFIVSLPLNVLAIAVFVLRMKVKKPAVVYMLHLAMADVLFVSVLPFKISYYFSGTDWQFGSGMCRFATAAFYGNMYASIMLMTVISIDRFLAVVYPIQSLSWRTLGRANFTCVVIWVMAIMGVVPLLLKEQTTRVPGLNITTCHDVLSENLMQGFYSYYFSAFSAIFFLVPLIVSTVCYTSIIRCLSSSAVANRSKKSRALFLSAAVFCIFIVCFGPTNVLLIVHYLFLSDSPGTEAAYFAYLLCVCVSSVSCCIDPLIYYYASSECQRHLYSILCCKESSDPNSCNSTGQLMPSKMDTCSSHLNNSIYKKLLA

Protein

Proteinase-activated receptor 1: F2r

Gene

F2R

Protein

Proteinase-activated receptor 1

Organism

Cricetulus longicaudatus

Length

428 amino acids

Function

High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis.

Similarity

Belongs to the G-protein coupled receptor 1 family.

Mass

47.603 kDa

Sequence

MGPQRLLLVAAGLSLCGPLLSSRVPVRQPESEMTDATVNPRSFFLRNPGENTFELIPLGDEEEKNESTLPEGRAIYLNKSHSPPAPLAPFISEDASGYLTSPWLRLFIPSVYTFVFVVSLPLNILAIAVFVLKMKVKKPAVVYMLHLAMADVLFVSVLPLKISYYFSGSDWQFGSGMCRFATAAFYCNMYASIMLMTVISIDRFLAVVYPIQSLSWRTLGRANFTCLVIWVMAIMGVVPLLLKEQTTRVPGLNITTCHDVLNETLLQGFYSYYFSAFSAVFFLVPLIISTICYMSIIRCLSSSSVANRSKKSRALFLSAAVFCVFIVCFGPTNVLLIMHYLLLSDSPATEKAYFAYLLCVCVSSVSCCIDPLIYYYASSECQRHLYGILCCKESSDPNSYNSTGQLMPSKMDTCSSHLNNSIYKKLLA

Protein

Proteinase-activated receptor 1: F2R

Gene

F2R

Protein

Proteinase-activated receptor 1

Organism

Bos taurus

Length

427 amino acids

Function

High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis.

Similarity

Belongs to the G-protein coupled receptor 1 family.

Mass

46.818 kDa

Sequence

MGPRWLLLWAAGLGLCSPLVSARTRGPRPGTDPTNGTLGPRSFFLRNSNDGYEQIPLPEDEDSSEGEFTEDRLSSGNRSSPPQKSPPGFISKSASGYLTSAWLTVFIPSVYTGVFLVSLPLNIMAVVVFVLKMKVKKPAVVYMLHLAAADVLFVCVLPFKISYYFSGSDWRFGSAMCRFVTAAFYGNMYASIMLMTAISVDRFLAVVYPIQSLSWRTLGRASFICLAIWAMAIAGVAPLLLQEQATQVPGLNITACHDVLNQTLLEGYYSYYFSAFSAVFFFVPLTLSTVSYVSIIRCLSSSTVANQNKKSRALLLSAAVFCIFILCFGPTNILLLLHYAFLSSDPMTEAAYFAYLLCVCVSSISCCIDPLIYYYASSECQRHLFAILHCKESSDPGSCNSSGQLMPSKMDTCSSNLSSSLYKKLLT

Protein

Proteinase-activated receptor 1: F2R

Gene

F2R

Protein

Proteinase-activated receptor 1

Organism

Homo sapiens

Length

425 amino acids

Function

High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development.

Similarity

Belongs to the G-protein coupled receptor 1 family.

Mass

47.441 kDa

Sequence

MGPRRLLLVAACFSLCGPLLSARTRARRPESKATNATLDPRSFLLRNPNDKYEPFWEDEEKNESGLTEYRLVSINKSSPLQKQLPAFISEDASGYLTSSWLTLFVPSVYTGVFVVSLPLNIMAIVVFILKMKVKKPAVVYMLHLATADVLFVSVLPFKISYYFSGSDWQFGSELCRFVTAAFYCNMYASILLMTVISIDRFLAVVYPMQSLSWRTLGRASFTCLAIWALAIAGVVPLLLKEQTIQVPGLNITTCHDVLNETLLEGYYAYYFSAFSAVFFFVPLIISTVCYVSIIRCLSSSAVANRSKKSRALFLSAAVFCIFIICFGPTNVLLIAHYSFLSHTSTTEAAYFAYLLCVCVSSISCCIDPLIYYYASSECQRYVYSILCCKESSDPSSYNSSGQLMASKMDTCSSNLNNSIYKKLLT

Protein

Proteinase-activated receptor 1: F2R

Gene

F2R

Protein

Proteinase-activated receptor 1

Organism

Papio hamadryas

Length

425 amino acids

Function

High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis.

Similarity

Belongs to the G-protein coupled receptor 1 family.

Mass

47.253 kDa

Sequence

MGPRRLLLVAACLCLCGPLLSARTRARRPASKATNATLDPRSFLLRNPNDKYEPFWEDEEKNESGLTEYRLVSINKSSPLQKPLPAFISEDASGYLTSSWLTLFVPSVYTGVFVVSLPVNIMAIVVFILKMKVKKPAVVYMLHLATADVLFVSVLPFKISYYLSGSDWQFGSELCRFVTAAFYCNMYASILLMTVISIDRFLAVVYPMQSLSWRTLGRASFTCLAIWALAIAGVVPLLLKEQTIQVPGLNITTCHDVLNETLLEGYYAYYFSAFSAVFFFVPLIISTVCYVSIIRCLSSSTVANRSKKSRALFLSAAVFCIFIICFGPTNILLIAHYSFLSHTSTTEAAYFAYLLCVCVSSISCCIDPLIYYYASSECQRYVYSILCCKESSDPSSSNSSGQLMASKMDTCSSNLNNSIYKKLLT

Protein

Proteinase-activated receptor 1: F2R

Gene

f2r

Protein

Proteinase-activated receptor 1

Organism

Xenopus laevis

Length

420 amino acids

Function

High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis.

Similarity

Belongs to the G-protein coupled receptor 1 family.

Mass

47.436 kDa

Sequence

MMELRVLLLLLLLTLLGAMGSLCLANSDTQAKGAHSNNMTIKTFRIFDDSESEFEEIPWDELDESGEGSGDQAPVSRSARKPIRRNITKEAEQYLSSQWLTKFVPSLYTVVFIVGLPLNLLAIIIFLFKMKVRKPAVVYMLNLAIADVFFVSVLPFKIAYHLSGNDWLFGPGMCRIVTAIFYCNMYCSVLLIASISVDRFLAVVYPMHSLSWRTMSRAYMACSFIWLISIASTIPLLVTEQTQKIPRLDITTCHDVLDLKDLKDFYIYYFSSFCLLFFFVPFIITTICYIGIIRSLSSSSIENSCKKTRALFLAVVVLCVFIICFGPTNVLFLTHYLQEANEFLYFAYILSACVGSVSCCLDPLIYYYASSQCQRYLYSLLCCRKVSEPGSSTGQLMSTAMKNDNCSTNAKSSIYKKLLA

Protein

Proteinase-activated receptor 1: f2r