About Products Protein Database Contact

F11R

Gene
F11r
Protein
Junctional adhesion molecule A
Organism
Mus musculus
Length
300 amino acids
Function
Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3 (PubMed:11447115). The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly (PubMed:11447115). Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier (PubMed:9660867). Ligand for integrin alpha-L/beta-2 involved in memory T-cell and neutrophil transmigration (By similarity). Involved in platelet activation (By similarity).
Similarity
Belongs to the immunoglobulin superfamily.
Mass
32.424 kDa
Sequence
MGTEGKAGRKLLFLFTSMILGSLVQGKGSVYTAQSDVQVPENESIKLTCTYSGFSSPRVEWKFVQGSTTALVCYNSQITAPYADRVTFSSSGITFSSVTRKDNGEYTCMVSEEGGQNYGEVSIHLTVLVPPSKPTISVPSSVTIGNRAVLTCSEHDGSPPSEYSWFKDGISMLTADAKKTRAFMNSSFTIDPKSGDLIFDPVTAFDSGEYYCQAQNGYGTAMRSEAAHMDAVELNVGGIVAAVLVTLILLGLLIFGVWFAYSRGYFERTKKGTAPGKKVIYSQPSTRSEGEFKQTSSFLV

Gene
F11r
Protein
Junctional adhesion molecule A
Organism
Rattus norvegicus
Length
300 amino acids
Function
Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly. Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Ligand for integrin alpha-L/beta-2 involved in memory T-cell and neutrophil transmigration.
Similarity
Belongs to the immunoglobulin superfamily.
Mass
32.37 kDa
Sequence
MGTEGKAGSKLLFLFTSMILGSLVQGKGSVYSPQTAVQVPENDSVKLPCIYSGFSSPRVEWKFVQGSTTALVCYNNQITVPYADRVTFSSSGITFSSVTRKDNGEYTCMVSEDGGQNYGEVSIHLTVLVPPSKPTVSIPSSVTIGNRAVLTCSEHDGSPPSEYSWFKDGVPMLTADAKKTRAFINSSYTIDPKSGDLVFDPVSAFDSGEYYCEAQNGYGTAMRSEAVRMEAVELNVGGIVAAVLVTLILLGLLIFGIWFAYSRGYFERTKKGTAPGKKVIYSQPSARSEGEFKQTSSFLV

Gene
F11R
Protein
Junctional adhesion molecule A
Organism
Homo sapiens
Length
299 amino acids
Function
(Microbial infection) Acts as a receptor for Human Rotavirus strain Wa.
Similarity
Belongs to the immunoglobulin superfamily.
Mass
32.583 kDa
Sequence
MGTKAQVERKLLCLFILAILLCSLALGSVTVHSSEPEVRIPENNPVKLSCAYSGFSSPRVEWKFDQGDTTRLVCYNNKITASYEDRVTFLPTGITFKSVTREDTGTYTCMVSEEGGNSYGEVKVKLIVLVPPSKPTVNIPSSATIGNRAVLTCSEQDGSPPSEYTWFKDGIVMPTNPKSTRAFSNSSYVLNPTTGELVFDPLSASDTGEYSCEARNGYGTPMTSNAVRMEAVERNVGVIVAAVLVTLILLGILVFGIWFAYSRGHFDRTKKGTSSKKVIYSQPSARSEGEFKQTSSFLV

Gene
F11R
Protein
Junctional adhesion molecule A
Organism
Bos taurus
Length
298 amino acids
Function
Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly. Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Ligand for integrin alpha-L/beta-2 involved in memory T-cell and neutrophil transmigration. Involved in platelet activation.
Similarity
Belongs to the immunoglobulin superfamily.
Mass
32.456 kDa
Sequence
MGTKAKVGSTELLLFTSMILCSLALGRGAVQTYEPVVRVPENNPAKLSCSYSGFSSPRVEWKFTHGDIRGLVCYNNKITASYENRVTFSDTGITFHSVTRKDTGMYTCMVSDEGGNTYGEVTVQLIVLVPPSKPTINVPSSVTIGTRAVLTCSERDGSPPSEYKWFKDGVEMPLEPKSNRAFSNSSYTLNQKTGELIFDPVSASDTGDFTCQAQNGYASPVKSDTVHMDAVELNVGGIVAAVFVTLILLGALIFGIWFAYSRGYFDRAKKGTSNKKVIYSQPNARSDGEFRQTSSFLV

Gene
F11R
Protein
Junctional adhesion molecule A
Organism
Felis catus
Length
298 amino acids
Function
(Microbial infection) In case of orthoreovirus infection, serves as receptor for the virus.
Similarity
Belongs to the immunoglobulin superfamily.
Mass
32.579 kDa
Sequence
MGTEARAGRRQLLVFTSVVLSSLALGRGAVYTSEPDVRVPEDKPAKLSCSYSGFSNPRVEWKFAHGDITSLVCYKNKITASYADRVTFSHSGITFHSVTRKDTGTYTCMVSDDGGNTYGEVSVQLTVLVPPSKPTVHIPSSATIGSRAVLTCSEKDGSPPSEYYWFKDGVRMPLEPKGNRAFSNSSYSLNEKTGELVFDPVSAWDTGEYTCEAQNGYGMPMRSEAVRMEAAELNVGGIVAAVLVTLILLGFLILGIWFAYRRGYFDRTKKGTSSKKVIYSQPAARSEGEFRQTSSFLV