Protein
Histone-lysine N-methyltransferase EZA1
Organism
Arabidopsis thaliana
Function
Polycomb group (PcG) protein. Catalytic subunit of some PcG multiprotein complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target genes. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development (By similarity).
Similarity
Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. EZ subfamily.
Sequence
MVTDDSNSSGRIKSHVDDDDDGEEEEDRLEGLENRLSELKRKIQGERVRSIKEKFEANRKKVDAHVSPFSSAASSRATAEDNGNSNMLSSRMRMPLCKLNGFSHGVGDRDYVPTKDVISASVKLPIAERIPPYTTWIFLDRNQRMAEDQSVVGRRQIYYEQHGGETLICSDSEEEPEPEEEKREFSEGEDSIIWLIGQEYGMGEEVQDALCQLLSVDASDILERYNELKLKDKQNTEEFSNSGFKLGISLEKGLGAALDSFDNLFCRRCLVFDCRLHGCSQPLISASEKQPYWSDYEGDRKPCSKHCYLQLKAVREVPETCSNFASKAEEKASEEECSKAVSSDVPHAAASGVSLQVEKTDIGIKNVDSSSGVEQEHGIRGKREVPILKDSNDLPNLSNKKQKTAASDTKMSFVNSVPSLDQALDSTKGDQGGTTDNKVNRDSEADAKEVGEPIPDNSVHDGGSSICQPHHGSGNGAIIIAEMSETSRPSTEWNPIEKDLYLKGVEIFGRNSCLIARNLLSGLKTCLDVSNYMRENEVSVFRRSSTPNLLLDDGRTDPGNDNDEVPPRTRLFRRKGKTRKLKYSTKSAGHPSVWKRIAGGKNQSCKQYTPCGCLSMCGKDCPCLTNETCCEKYCGCSKSCKNRFRGCHCAKSQCRSRQCPCFAAGRECDPDVCRNCWVSCGDGSLGEAPRRGEGQCGNMRLLLRQQQRILLGKSDVAGWGAFLKNSVSKNEYLGEYTGELISHHEADKRGKIYDRANSSFLFDLNDQYVLDAQRKGDKLKFANHSAKPNCYAKVMFVAGDHRVGIFANERIEASEELFYDYRYGPDQAPVWARKPEGSKKDDSAITHRRARKHQSH