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EXD2

Gene
Exd2
Protein
Exonuclease 3'-5' domain-containing protein 2
Organism
Mus musculus
Length
650 amino acids
Function
Exonuclease required for double-strand breaks resection and efficient homologous recombination. Plays a key role in controlling the initial steps of chromosomal break repair, it is recruited to chromatin in a damage-dependent manner and functionally interacts with the MRN complex to accelerate resection through its 3'-5' exonuclease activity, which efficiently processes double-stranded DNA substrates containing nicks.
Similarity
Belongs to the EXD2 family.
Mass
74.332 kDa
Sequence
MSRQNLVALTVTTLLGVAMGGFVLWKGIQRRWSKTSRVMQQQPQQPQQPQQPQPQPQPQPQPQPEHPQPQQQVPGGREWPPPEDDQLPFGALRAPRASWEERILQAEVVTVSQEAEWNQIQPFLKRELEDFPVLGIDCEWVNLEGKASPLSLLQMASPSGFCALVRLPRLIYGGRTLPRTLLDILADGAILKVGVGCSEDANKLLQDYGLIVRGCLDLRYLAMKQGNNILCNGLSLKSLAETILNFPLDKSLLLRCSNWDAENLTEDQVTYAARDAQISVALFLHLLGYPFSRDSYEEESTDQINWQKALERCRNMVDIPFRSKGLGRLVEEVNGEALESQLKPRNRKAKTDRMVPGNNQGRDPRKHKRKPLGVGYSARKSPLYDNCFLQAPDGQPLCTCDRRKAQWYLDKGIGELVSKEPFVVRLQFEPAGRPESPGDYYLMVKENLCVVCGKTDTYIRKNIIPHEYRKHFPIEMKDHNSHDVLLLCTSCHAISNYYDNHLKQQLAKEFQAPIGSEEGLRLLEDLERRQVRSGARALLNAESLPAHRKEELLHALREFYNTDIITEEMLHEAASLETRIYNESYIPHGLKVVQRHTEGGLRSLMQLESRWRQHFLDSMQPKHLPQQWSVDHNHQKLLRKYGDDLPIKLS
Protein
Exonuclease 3'-5' domain-containing protein 2: Exd2

Gene
EXD2
Protein
Exonuclease 3'-5' domain-containing protein 2
Organism
Homo sapiens
Length
621 amino acids
Function
Exonuclease required for double-strand breaks resection and efficient homologous recombination. Plays a key role in controlling the initial steps of chromosomal break repair, it is recruited to chromatin in a damage-dependent manner and functionally interacts with the MRN complex to accelerate resection through its 3'-5' exonuclease activity, which efficiently processes double-stranded DNA substrates containing nicks.
Similarity
Belongs to the EXD2 family.
Mass
70.353 kDa
Sequence
MSRQNLVALTVTTLLGVAVGGFVLWKGIQRRRRSKTSPVTQQPQQKVLGSRELPPPEDDQLHSSAPRSSWKERILKAKVVTVSQEAEWDQIEPLLRSELEDFPVLGIDCEWVNLEGKASPLSLLQMASPSGLCVLVRLPKLICGGKTLPRTLLDILADGTILKVGVGCSEDASKLLQDYGLVVRGCLDLRYLAMRQRNNLLCNGLSLKSLAETVLNFPLDKSLLLRCSNWDAETLTEDQVIYAARDAQISVALFLHLLGYPFSRNSPGEKNDDHSSWRKVLEKCQGVVDIPFRSKGMSRLGEEVNGEATESQQKPRNKKSKMDGMVPGNHQGRDPRKHKRKPLGVGYSARKSPLYDNCFLHAPDGQPLCTCDRRKAQWYLDKGIGELVSEEPFVVKLRFEPAGRPESPGDYYLMVKENLCVVCGKRDSYIRKNVIPHEYRKHFPIEMKDHNSHDVLLLCTSCHAISNYYDNHLKQQLAKEFQAPIGSEEGLRLLEDPERRQVRSGARALLNAESLPTQRKEELLQALREFYNTDVVTEEMLQEAASLETRISNENYVPHGLKVVQCHSQGGLRSLMQLESRWRQHFLDSMQPKHLPQQWSVDHNHQKLLRKFGEDLPIQLS
Protein
Exonuclease 3'-5' domain-containing protein 2: EXD2